Drug & supplement interaction

Pu-erh Tea + Chlorpheniramine, Phenylephrine, Phenyltoloxamine

Chlorpheniramine, Phenylephrine, Phenyltoloxamine brand names: Com Time, Q Hist LA, Comhist LA, Linhist LA, Comhist.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Pu-erh Tea has a moderate interaction with Chlorpheniramine, Phenylephrine, Phenyltoloxamine. Theoretically, concomitant use might increase stimulant adverse effects.

Read the full interaction report
SeverityModerate
LikelihoodProbable
EvidenceC
What do Severity, Likelihood & Evidence mean?
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Interaction report

Pu-erh Tea and Chlorpheniramine, Phenylephrine, Phenyltoloxamine

Here is the interaction we found between these two, with the evidence behind it.

Moderate

STIMULANT DRUGS

Why this applies to Chlorpheniramine, Phenylephrine, Phenyltoloxamine

Chlorpheniramine, Phenylephrine, Phenyltoloxamine falls under STIMULANT DRUGS — the group Pu-erh Tea interacts with.

Theoretically, concomitant use might increase stimulant adverse effects.
Pu-erh tea contains caffeine. Due to the central nervous system (CNS) stimulant effects of caffeine, concomitant use with stimulant drugs can increase the risk of adverse effects.
Severity Moderate Likelihood Probable Evidence C

Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

This combination product includes phenylephrine, a decongestant that mildly stimulates your system, along with two antihistamines. Pu-erh tea brings caffeine to the table, and caffeine is also a stimulant. When you stack the two, the worry is simply additive: you may notice more jitteriness, a faster or pounding heartbeat, restlessness, or trouble sleeping than you would from either one alone.

Honestly, this is mostly theory based on expert opinion, not strong human studies, so a cup or two probably won't cause trouble for most people. Still, if you tend to feel wired or have high blood pressure, go easy on the tea while taking this and check with your pharmacist or doctor if your heart races or you feel uneasy.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Institute of Medicine. Caffeine for the Sustainment of Mental Task Performance: Formulations for Military Operations. Washington, DC: National Academy Press, 2001. Available at: http://books.nap.edu/books/0309082587/html/index.html. DOI

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Pu-erh Tea Also Interacts With Other Medications

Pu-erh Tea has 9 major, 447 moderate, 210 minor known drug interactions in our database — the Chlorpheniramine, Phenylephrine, Phenyltoloxamine one above is one of them. If you take anything else, check it against the full list below.

Major 9 Moderate 447 Minor 210 No known interaction 2,164 (incl. Chlorpheniramine, Phenylephrine, Phenyltoloxamine)
Taking anything else?

Check Another of Your Medications Against Pu-erh Tea

Covers the 2,830 medications we’ve checked against Pu-erh Tea. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Chlorpheniramine, Phenylephrine, Phenyltoloxamine

This page covers Pu-erh Tea only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Chlorpheniramine, Phenylephrine, Phenyltoloxamine page lists 229 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Ephedra (major), Grapefruit (major), Henbane (major) and Lithium (major).

By severity: 10 major · 175 moderate · 44 minor.

From our pharmacist’s overview on the Chlorpheniramine, Phenylephrine, Phenyltoloxamine page

“If you take Comhist (chlorpheniramine, phenylephrine, and phenyltoloxamine, a cold and allergy combination), treat its supplement list with real care. Ten of the 229 ingredients on file carry a major rating, and the biggest patterns are worth knowing.”

Reviewed by 2 · Jul 18, 2026

Open the Chlorpheniramine, Phenylephrine, Phenyltoloxamine interaction page

How much people look this up

Where Pu-erh Tea and Chlorpheniramine, Phenylephrine, Phenyltoloxamine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Pu-erh Tea
Steady interest

#949 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Chlorpheniramine, Phenylephrine, Phenyltoloxamine
Steady interest

#1,435 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Pu-erh Tea

What is Pu-erh Tea?

  • Weight management
  • Cholesterol and heart health
  • Digestion after meals
  • Mental alertness
  • General antioxidant support

Pu-erh tea is a fermented, aged form of tea made from the same plant as green and black tea. It is enjoyed worldwide as a beverage and is sometimes promoted for weight loss, cholesterol, and digestion, but human evidence for these uses is limited. As a normal drink it is generally well tolerated, though it does contain caffeine.

Read the full Pu-erh Tea monograph & all interactions
Keep checking

Other Drugs & Pu-erh Tea

Browse every other medication we’ve checked against Pu-erh Tea — both the ones with a known interaction and the ones without. Select any drug for the full detail.

9Major
447Moderate
210Minor
2,163No known interaction
9 Major 447 Moderate 210 Minor 2,163 No interaction
Major

9 interactions

Moderate

447 interactions

Showing 60 of 447 moderate interactions — see all 447 on the Pu-erh Tea page.

Minor

210 interactions

Showing 60 of 210 minor interactions — see all 210 on the Pu-erh Tea page.

No interaction 2,163 drugs checked — show the list

We also checked Pu-erh Tea against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,163 medications checked with no known interaction — see the full Pu-erh Tea list.

See the full Pu-erh Tea interactions page
See every supplement checked against Chlorpheniramine, Phenylephrine, Phenyltoloxamine, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Pu-erh Tea monograph › Uses, safety, and every drug interaction in one place Chlorpheniramine, Phenylephrine, Phenyltoloxamine supplement interactions › Every supplement checked against Chlorpheniramine, Phenylephrine, Phenyltoloxamine, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Pu-erh Tea and Chlorpheniramine, Phenylephrine, Phenyltoloxamine Together: Common Questions

Can you take Pu-erh Tea with Chlorpheniramine, Phenylephrine, Phenyltoloxamine?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Pu-erh Tea and Chlorpheniramine, Phenylephrine, Phenyltoloxamine interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Chlorpheniramine, Phenylephrine, Phenyltoloxamine and Pu-erh Tea?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.