Drug & supplement interaction

Saccharomyces Boulardii + Dexamethasone

Dexamethasone brand names: Decadron, Hexadrol, Dexone, Ozurdex, Dexycu, and others.

No Known Interaction
The bottom line No known interaction

We found no known interaction between Saccharomyces Boulardii and Dexamethasone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Saccharomyces Boulardii and Dexamethasone

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Dexamethasone and Saccharomyces Boulardii in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Saccharomyces Boulardii safety at a glance

Saccharomyces Boul... overall Use caution Generally safe for healthy adults but should be avoided by people who are critically ill or immunocompromised.
Pregnancy Use caution Not enough reliable safety data; speak with your doctor before use.
Breastfeeding Use caution Limited safety information is available, so use only with medical advice.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Dexamethasone and Saccharomyces Boulardii? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Dexamethasone

Interactions in our licensed database are recorded against drug classes, not just single drug names. Dexamethasone is filed under 8 classifications — including corticosteroids, cytochrome p450 2b6 (cyp2b6) substrates, cytochrome p450 3a4 (cyp3a4) inducers. Saccharomyces Boulardii has documented interactions with 1 drug class — the most serious being antifungals (minor) — and none of Dexamethasone’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Saccharomyces Boulardii Does Interact With Other Medications

Saccharomyces Boulardii has 40 minor known drug interactions in our database — Dexamethasone isn’t one of them. If you take anything else, check it against the full list below.

Taking anything else?

Check Another of Your Medications Against Saccharomyces Boulardii

Covers the 2,830 medications we’ve checked against Saccharomyces Boulardii. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Saccharomyces Boulardii and Dexamethasone May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • A higher chance of infection Worth acting on reported in 4.6% of FDA reports for Dexamethasone Additional detail

    Saccharomyces Boulardii

    “Rarely, oral use of Saccharomyces boulardii has been associated with fungemia in both immunocompromised and immunocompetent patients. Numerous cases of Saccharomyces fungemia have been reported in critically ill intensive care unit (ICU) patients, particularly those with indwelling or central venous catheters, those receiving enteral feeding, or those receiving broad-spectrum antibiotics.”

    Saccharomyces Boulardii · Natural Medicines adverse-effect record, reported in crohn disease.

    6 sources cited
    1. 1247. Niault M, Thomas F, Prost J, et al. Fungemia due to Saccharomyces species in a patient treated with enteral Saccharomyces boulardii. Clin Infect Dis 1999;28:930.
    2. 4357. Pletinex M, Legein J, Vandenplas Y. Fungemia with Saccharomyces boulardii in a 1-year-old girl with protracted diarrhea. J Pediatr Gastroenterol Nutr 1995;21:113-5. DOI
    3. 4358. Fredenucci I, Chomarat M, Boucaud C, et al. Saccharomyces boulardii fungemia in a patient receiving ultra-levure therapy. Clin Infect Dis 1998;27:222-3.
    4. 4360. Elmer GW, McFarland LV, Surawicz CM, et al. Behaviour of Saccharomyces boulardii in recurrent Clostridium difficile disease patients. Aliment Pharmacol Ther 1999;13:1663-8.
    5. 7329. Cesaro S, Chinello P, Rossi L, Zanesco L. Saccharomyces cerevisiae fungemia in a neutropenic patient treated with Saccharomyces boulardii. Support Care Cancer 2000;8:504-5. PubMed
    6. 14459. Munoz P, Bouza E, Cuenca-Estrella M, et al. Saccharomyces cerevisiae fungemia: an emerging infectious disease. Clin Infect Dis 2005;40:1625-34. PubMed

    Dexamethasone

    Listed in the ADVERSE REACTIONS section of the FDA label for Dexamethasone, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

  • Nausea / Vomiting reported in 4.8% of FDA reports for Dexamethasone Additional detail

    Saccharomyces Boulardii

    “Rarely, oral use of Saccharomyces boulardii has caused gastrointestinal complaints, such as abdominal cramps, flatulence, nausea, vomiting, and decreased appetite.”

    Saccharomyces Boulardii · Natural Medicines adverse-effect record, reported in flatulence.

    2 sources cited
    1. 98731. Flatley EA, Wilde AM, Nailor MD. Saccharomyces boulardii for the prevention of hospital onset Clostridium difficile infection. J Gastrointestin Liver Dis. 2015;24(1):21-4. PubMed
    2. 107608. Awoyemi A, Mayerhofer C, Felix AS, et al. Rifaximin or Saccharomyces boulardii in heart failure with reduced ejection fraction: Results from the randomized GutHeart trial. EBioMedicine 2021;70:103511. PubMed

    Dexamethasone

    Listed in the ADVERSE REACTIONS section of the FDA label for Dexamethasone, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Reported for Saccharomyces Boulardii but not commonly for Dexamethasone: reduced appetite, stomach pain, bloating or gas and diarrhea.

Effects for Dexamethasone come from the ADVERSE REACTIONS section of its FDA label; effects for Saccharomyces Boulardii come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 308,307 voluntary FDA FAERS reports for Dexamethasone that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Overlapping uses

What Dexamethasone Is Prescribed For, and What Saccharomyces Boulardii Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Dexamethasone is a prescription medicine with approved uses on its FDA label. Saccharomyces Boulardii is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Dexamethasone is prescribed for: Dexamethasone is used to treat a wide range of conditions depending on the form and route. Oral tablets and solutions treat severe allergic reactions (such as asthma, contact dermatitis, and seasonal allergic rhinitis), inflammatory skin diseases, endocrine disorders including adrenal insufficiency and congenital adrenal hyperplasia, gastrointestinal diseases such as ulcerative colitis and regional enteritis, blood disorders, rheumatic conditions, kidney disease, and respiratory conditions including tuberculosis complications. Hemady (oral tablet) is specifically approved, in combination with other medicines, for multiple myeloma in adults. TaperDex (6-day and 12-day oral tablet packs) are used for the same broad range of allergic, inflammatory, and endocrine conditions.

Read the rest of what Dexamethasone is prescribed for

Injectable forms (intramuscular and intravenous) are used when oral treatment is not possible, covering endocrine emergencies, shock, rheumatic disorders, and more. Eye-specific products treat different conditions: Dextenza (intracanalicular insert) treats eye inflammation and pain after eye surgery and itching from allergic conjunctivitis. Ozurdex (intravitreal implant) treats macular edema from retinal vein occlusion and diabetic macular edema, and non-infectious uveitis in the back of the eye. Dexycu (intraocular injection) treats inflammation after eye surgery. Maxidex (ophthalmic suspension) and dexamethasone sodium phosphate eye drops treat steroid-responsive inflammatory conditions of the eye. The opht

Saccharomyces Boulardii has been studied for:

  • Ulcerative colitis studied, not established Saccharomyces Boulardii has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Saccharomyces Boulardii for ulcerative colitis

    It is unclear if oral Saccharomyces boulardii is beneficial for ulcerative colitis.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Dexamethasone on your own; if you are taking Saccharomyces Boulardii for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

From our Q&A

Questions About Saccharomyces Boulardii or Dexamethasone

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Saccharomyces Boulardii or Dexamethasone, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Dexamethasone

This page covers Saccharomyces Boulardii only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Dexamethasone page lists 221 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), Lily-of-the-valley (major), St. John's Wort (major) and Acacia Rigidula (moderate).

By severity: 4 major · 182 moderate · 35 minor.

From our pharmacist’s overview on the Dexamethasone page

“People take dexamethasone for serious reasons, a chemotherapy course, an autoimmune flare, brain swelling, so I want anyone on it to give its 221 supplement interactions genuine attention, starting with the four rated major. Grapefruit and St.”

Reviewed by 2 · Jul 18, 2026

Open the Dexamethasone interaction page

One more smart check

Taking Saccharomyces Boulardii as Part of a Dietary Supplement Product? Check It for Interactions

We hold 608 real supplement products containing Saccharomyces Boulardii, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Saccharomyces Boulardii. Even though Saccharomyces Boulardii itself has no known interaction with Dexamethasone, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Saccharomyces Boulardii and Dexamethasone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Saccharomyces Boulardii
Top 25%

#251 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Dexamethasone
Top 25%

#385 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Saccharomyces Boulardii reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Saccharomyces Boulardii and Dexamethasone records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Saccharomyces Boulardii

What is Saccharomyces Boulardii?

Saccharomyces Boulardii
  • Acute diarrhea
  • Antibiotic-associated diarrhea
  • Traveler's diarrhea
  • Preventing C. difficile recurrence
  • General gut health

Saccharomyces boulardii is a beneficial yeast used as a probiotic, with the strongest evidence for preventing and treating certain types of diarrhea, including antibiotic-associated diarrhea. It is generally well tolerated in healthy people, but those who are seriously ill or have weakened immune systems should avoid it because of rare but serious bloodstream infections. Talk with your pharmacist or doctor before starting it.

Saccharomyces cerevisiae var. boulardii · Saccharomycetaceae · Whole yeast cells (probiotic microorganism) · Capsules, tablets, powders (often sold as lyophilized/freeze-dried yeast)

An interaction check asks whether these two react with each other — it does not ask whether Saccharomyces Boulardii is a good idea for someone in your situation. Here is what our Saccharomyces Boulardii record says about it on its own.

Saccharomyces Boulardii: dosing

There is no single official standardized dose for S. boulardii. Products are often measured in milligrams of freeze-dried yeast or in colony-forming units (CFU), and amounts vary widely between brands.The best approach is to follow the directions on the product label and to choose a reputable brand.

From our Saccharomyces Boulardii monograph — the full record covers uses, side effects and every documented interaction.

Read the full Saccharomyces Boulardii monograph & all interactions
Medication

About Dexamethasone

What Is Dexamethasone Used For?

Brand names: Decadron, Hexadrol, Dexone, Ozurdex, Dexycu, Hemady, Dextenza

Dexamethasone is used to treat a wide range of conditions depending on the form and route. Oral tablets and solutions treat severe allergic reactions (such as asthma, contact dermatitis, and seasonal allergic rhinitis), inflammatory skin diseases, endocrine disorders including adrenal insufficiency and congenital adrenal hyperplasia, gastrointestinal diseases such as ulcerative colitis and regional enteritis, blood disorders, rheumatic conditions, kidney disease, and respiratory conditions including tuberculosis complications. Hemady (oral tablet) is specifically approved, in combination with other medicines, for multiple myeloma in adults. TaperDex (6-day and 12-day oral tablet packs) are used for the same broad range of allergic, inflammatory, and endocrine conditions.

Injectable forms (intramuscular and intravenous) are used when oral treatment is not possible, covering endocrine emergencies, shock, rheumatic disorders, and more. Eye-specific products treat different conditions: Dextenza (intracanalicular insert) treats eye inflammation and pain after eye surgery and itching from allergic conjunctivitis. Ozurdex (intravitreal implant) treats macular edema from retinal vein occlusion and diabetic macular edema, and non-infectious uveitis in the back of the eye. Dexycu (intraocular injection) treats inflammation after eye surgery. Maxidex (ophthalmic suspension) and dexamethasone sodium phosphate eye drops treat steroid-responsive inflammatory conditions of the eye. The ophthalmic/otic solution also treats steroid-responsive inflammation of the outer ear canal. A topical ointment (Seacall) is used for skin conditions including contact dermatitis, eczema, and neurodermatitis.

Most-Reported Side Effects for Dexamethasone

From FAERS, the FDA’s public side-effect reporting system (308,307 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 17,772 reports
Diarrhea 17,597 reports
Nausea 14,727 reports
Plasma cell myeloma 14,363 reports
Pneumonia 14,122 reports
See full Dexamethasone drug information
Keep checking

Other Drugs & Saccharomyces Boulardii

Browse every other medication we’ve checked against Saccharomyces Boulardii — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
40Minor
2,789No known interaction
Minor

40 interactions

No interaction 2,789 drugs checked — show the list
Evidence & sources

Saccharomyces Boulardii References

The 26 references that drive our Saccharomyces Boulardii monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Niault M, Thomas F, Prost J, et al. Fungemia due to Saccharomyces species in a patient treated with enteral Saccharomyces boulardii. Clin Infect Dis 1999;28:930.
  2. Pletinex M, Legein J, Vandenplas Y. Fungemia with Saccharomyces boulardii in a 1-year-old girl with protracted diarrhea. J Pediatr Gastroenterol Nutr 1995;21:113-5. DOI
  3. Fredenucci I, Chomarat M, Boucaud C, et al. Saccharomyces boulardii fungemia in a patient receiving ultra-levure therapy. Clin Infect Dis 1998;27:222-3.
  4. Elmer GW, McFarland LV, Surawicz CM, et al. Behaviour of Saccharomyces boulardii in recurrent Clostridium difficile disease patients. Aliment Pharmacol Ther 1999;13:1663-8.
  5. Lewis SJ, Freedman AR. Review article: the use of biotherapeutic agents in the prevention and treatment of gastrointestinal disease. Aliment Pharmacol Ther 1998;12:807-22. PubMed
  6. Cesaro S, Chinello P, Rossi L, Zanesco L. Saccharomyces cerevisiae fungemia in a neutropenic patient treated with Saccharomyces boulardii. Support Care Cancer 2000;8:504-5. PubMed
  7. Hennequin C, Thierry A, Richard GF, et al. Microsatellite typing as a new tool for identification of Saccharomyces cerevisiae strains. J Clin Microbiol 2001;39:551-9.
  8. Plein K, Hotz J. Therapeutic effects of Saccharomyces boulardii on mild residual symptoms in a stable phase of Crohn's disease with special respect to chronic diarrhea - a pilot study. Z Gastroenterol 1993;31:129-34.
  9. Borriello SP, Hammes WP, Holzapfel W, et al. Safety of probiotics that contain lactobacilli or bifidobacteria. Clin Infect Dis 2003;36:775-80. PubMed
  10. Marteau P, Seksik P. Tolerance of probiotics and prebiotics. J Clin Gastroenterol 2004;38:S67-9. PubMed
  11. Munoz P, Bouza E, Cuenca-Estrella M, et al. Saccharomyces cerevisiae fungemia: an emerging infectious disease. Clin Infect Dis 2005;40:1625-34. PubMed
  12. Lherm, T., Monet, C., Nougiere, B., Soulier, M., Larbi, D., Le Gall, C., Caen, D., and Malbrunot, C. Seven cases of fungemia with Saccharomyces boulardii in critically ill patients. Intensive Care Med 2002;28(6):797-801. PubMed
  13. Riquelme, A. J., Calvo, M. A., Guzman, A. M., Depix, M. S., Garcia, P., Perez, C., Arrese, M., and Labarca, J. A. Saccharomyces cerevisiae fungemia after Saccharomyces boulardii treatment in immunocompromised patients. J Clin.Gastroenterol. 2003;36(1):41- PubMed
  14. Cherifi, S., Robberecht, J., and Miendje, Y. Saccharomyces cerevisiae fungemia in an elderly patient with Clostridium difficile colitis. Acta Clin Belg. 2004;59(4):223-224. PubMed
  15. Ellouze O, Berthoud V, Mervant M, Parthiot JP, Girard C. Septic shock due to Sacccaromyces boulardii. Med Mal Infect. 2016;46(2):104-105.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Saccharomyces Boulardii and Dexamethasone Together: Common Questions

Is it safe to take Saccharomyces Boulardii with Dexamethasone?
We do not list a known interaction between Saccharomyces Boulardii and Dexamethasone. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Saccharomyces Boulardii and Dexamethasone have any of the same side effects?
Yes — our sources link each of them separately to 3 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Are Saccharomyces Boulardii and Dexamethasone used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Saccharomyces Boulardii in each. That is a conversation for your prescriber, especially if Dexamethasone is being adjusted to a target.
How was the Saccharomyces Boulardii and Dexamethasone combination checked?
Interactions in our licensed database are recorded against drug classes. Dexamethasone is filed under 8 classifications, and Saccharomyces Boulardii has documented interactions with 1 drug class — none of Dexamethasone's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Saccharomyces Boulardii interact with any other medications?
Yes. Saccharomyces Boulardii has 40 documented drug interactions in our database — Dexamethasone is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Dexamethasone interact with any supplements?
Yes. Dexamethasone has documented interactions with 221 supplements in our database — Saccharomyces Boulardii is not one of them. The Dexamethasone interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Dexamethasone and Saccharomyces Boulardii?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.