Drug & supplement interaction

Securinega Suffruticosa + Raltegravir

Raltegravir brand name: Isentress.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Securinega Suffruticosa and Raltegravir in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Securinega Suffruticosa and Raltegravir

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Raltegravir and Securinega Suffruticosa in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Securinega Suffruticosa safety at a glance

Securinega Suffrut... overall Avoid It contains potent, potentially toxic alkaloids and has no established safe supplement dose.
Pregnancy Avoid No safety data; its stimulant alkaloids make it unsafe during pregnancy.
Breastfeeding Avoid No safety data and potential transfer of toxic alkaloids; avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Raltegravir and Securinega Suffruticosa? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Raltegravir

Interactions in our licensed database are recorded against drug classes, not just single drug names. Raltegravir is filed under 4 classifications — including integrase inhibitors, glucuronidated drugs, oral drugs. Securinega Suffruticosa has documented interactions with 1 drug class — the most serious being stimulant drugs (moderate) — and none of Raltegravir’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Securinega Suffruticosa Does Interact With Other Medications

Securinega Suffruticosa has 172 moderate known drug interactions in our database — Raltegravir isn’t one of them. If you take anything else, check it against the full list below.

Moderate 172 No known interaction 2,658 (incl. Raltegravir)
Taking anything else?

Check Another of Your Medications Against Securinega Suffruticosa

Covers the 2,830 medications we’ve checked against Securinega Suffruticosa. Pick one to open its full report.

What to actually watch for

What Raltegravir’s Own FDA Label Lists

This is not an interaction — none of it involves Securinega Suffruticosa. These are the most notable effects listed in the ADVERSE REACTIONS section of Raltegravir’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 3 of them are worth acting on rather than waiting out — marked below.

  • Low mood Worth acting on mentioned in 10.5% of FDA reports for Raltegravir
  • Severe muscle breakdown Worth acting on
  • Muscle weakness Worth acting on
  • Vivid dreams or nightmares
  • Bloating or gas
  • Reduced appetite
  • Trouble sleeping
  • Stomach pain
  • Tiredness
  • Dizziness

Showing the 10 most notable of 14 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Raltegravir. Read the label on DailyMed › Where a percentage is shown, it is the share of 16,361 voluntary FDA FAERS reports for Raltegravir that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Securinega Suffruticosa’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Securinega Suffruticosa side to compare — that is a limit of the record, not a statement that Securinega Suffruticosa has no side effects.

Everything else you take

See Every Supplement That Interacts With Raltegravir

This page covers Securinega Suffruticosa only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Raltegravir page lists 33 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Breadfruit (moderate), Brussels Sprout (moderate), Cabbage (moderate) and Calcium (moderate).

By severity: 1 major · 22 moderate · 10 minor.

From our pharmacist’s overview on the Raltegravir page

“For someone taking raltegravir (Isentress) to keep HIV suppressed, a steady drug level is what blocks rebound and resistance, and this list deserves genuine vigilance. The lone major-rated entry is activated charcoal, which can soak up the medicine in the gut and cut what reaches your blood.”

Reviewed by 2 · Jul 18, 2026

Open the Raltegravir interaction page

How much people look this up

Where Securinega Suffruticosa and Raltegravir Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Securinega Suffruticosa
Steady interest

#1,115 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Raltegravir
Steady interest

#1,644 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Securinega Suffruticosa reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Securinega Suffruticosa and Raltegravir records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Securinega Suffruticosa

What is Securinega Suffruticosa?

  • Nerve and muscle weakness
  • Fatigue and low energy
  • Nerve-related conditions in traditional medicine
  • Childhood paralysis (historical traditional use)
  • General tonic

Securinega suffruticosa is a shrub used in traditional East Asian medicine, best known for an alkaloid called securinine that strongly stimulates the nervous system. Because securinine is powerful and can cause seizures and serious toxicity, this plant is not a safe or well-studied dietary supplement, and it should not be used for self-treatment. Talk to a doctor or pharmacist before considering anything containing this plant.

Securinega suffruticosa · Phyllanthaceae · Leaves, twigs, and aerial parts (roots in some traditional preparations) · Dried herb decoction, tinctures, and isolated alkaloid extracts (mainly used in research settings)

An interaction check asks whether these two react with each other — it does not ask whether Securinega Suffruticosa is a good idea for someone in your situation. Here is what our Securinega Suffruticosa record says about it on its own.

Securinega Suffruticosa: dosing

There is no established, standardized safe dose of Securinega suffruticosa for use as a supplement. The plant's alkaloid content can vary, and the active compound securinine has a narrow margin between any effect and toxic effects.Because of these safety concerns, we cannot recommend a specific amount.

From our Securinega Suffruticosa monograph — the full record covers uses, side effects and every documented interaction.

Read the full Securinega Suffruticosa monograph & all interactions
Medication

About Raltegravir

What Is Raltegravir Used For?

Brand name: Isentress

Raltegravir — available as Isentress and as the generic raltegravir tablet — is used to treat HIV-1 (human immunodeficiency virus) infection. It is always used together with other antiretroviral (anti-HIV) medicines, never on its own.

Isentress is approved for adults and for children weighing at least 2 kg. Raltegravir tablets are approved for adults and for children weighing at least 25 kg who can swallow a tablet whole.

Most-Reported Side Effects for Raltegravir

From FAERS, the FDA’s public side-effect reporting system (16,418 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Foetal exposure during pregnancy 1,078 reports
Depression 1,017 reports
Anxiety 966 reports
Emotional distress 789 reports
Anhedonia 708 reports
See full Raltegravir drug information
Keep checking

Other Drugs & Securinega Suffruticosa

Browse every other medication we’ve checked against Securinega Suffruticosa — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
172Moderate
0Minor
2,657No known interaction
172 Moderate 2,657 No interaction
Moderate

172 interactions

Showing 60 of 172 moderate interactions — see all 172 on the Securinega Suffruticosa page.

No interaction 2,657 drugs checked — show the list

We also checked Securinega Suffruticosa against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,657 medications checked with no known interaction — see the full Securinega Suffruticosa list.

See the full Securinega Suffruticosa interactions page
See every supplement checked against Raltegravir, ranked by severity
Evidence & sources

Securinega Suffruticosa References

The 2 references that drive our Securinega Suffruticosa monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Holmes M, Crater AK, Dhudshia B, Thadani AN, Ananvoranich S. Toxoplasma gondii: inhibitory activity and encystation effect of securinine and pyrrolidine derivatives on Toxoplasma growth. Exp Parasitol. 2011;127(2):370-5. PubMed
  2. Raj D, Luczkiewicz M. Securinega suffruticosa. Fitoterapia. 2008;79(6):419-27. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Securinega Suffruticosa and Raltegravir Together: Common Questions

Is it safe to take Securinega Suffruticosa with Raltegravir?
We do not list a known interaction between Securinega Suffruticosa and Raltegravir. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Securinega Suffruticosa and Raltegravir combination checked?
Interactions in our licensed database are recorded against drug classes. Raltegravir is filed under 4 classifications, and Securinega Suffruticosa has documented interactions with 1 drug class — none of Raltegravir's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Securinega Suffruticosa interact with any other medications?
Yes. Securinega Suffruticosa has 172 documented drug interactions in our database — Raltegravir is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Raltegravir interact with any supplements?
Yes. Raltegravir has documented interactions with 33 supplements in our database — Securinega Suffruticosa is not one of them. The Raltegravir interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Securinega Suffruticosa monograph Uses, safety profile, and every drug interaction in one place Raltegravir drug information The full plain-English guide to this medication Raltegravir supplement interactions Every supplement checked against Raltegravir, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Raltegravir and Securinega Suffruticosa?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.