Drug & supplement interaction

Sesame + Orlistat

Orlistat brand names: Xenical, Alli.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Sesame and Orlistat in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Sesame and Orlistat

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Orlistat and Sesame in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Sesame safety at a glance

Sesame overall Use caution Food amounts are generally safe for most people, but sesame is a major allergen and concentrated supplements are less studied.
Pregnancy Use caution Normal food amounts are likely fine, but concentrated supplements are not well studied, so check with your doctor.
Breastfeeding Use caution Food amounts are generally considered fine, but safety of concentrated supplements while breastfeeding is unknown.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Orlistat and Sesame? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Orlistat

Interactions in our licensed database are recorded against drug classes, not just single drug names. Orlistat is filed under 2 classifications — including oral drugs. Sesame has documented interactions with 5 drug classes — the most serious being antidiabetes drugs (moderate), antihypertensive drugs (moderate) and cytochrome p450 2c9 (cyp2c9) substrates (moderate) — and none of Orlistat’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Sesame Does Interact With Other Medications

Sesame has 343 moderate, 185 minor known drug interactions in our database — Orlistat isn’t one of them. If you take anything else, check it against the full list below.

Moderate 343 Minor 185 No known interaction 2,302 (incl. Orlistat)
Taking anything else?

Check Another of Your Medications Against Sesame

Covers the 2,830 medications we’ve checked against Sesame. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Sesame and Orlistat May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. 5 of them are worth acting on rather than waiting out — marked below.

  • Wheezing / A severe allergic reaction / Hives / Bleeding or bruising / An allergic reaction Worth acting on Additional detail

    Sesame

    “Multiple cases of allergic response to sesame seed occurring after occupational, topical, intramuscular, or oral exposure have been reported. One study found that up to 0.5% of the United States population reports having a sesame allergy, and 0.23% of the population meets criteria for an IgE-mediated allergic reaction to sesame.”

    Sesame · Natural Medicines adverse-effect record, reported in allergic rhinitis (hay fever).

    6 sources cited
    1. 28157. Panizzolo, C., Tura, M., and Barbato, A. Anaphylaxis to sesame paste. Eur Ann Allergy Clin Immunol 2005;37(1):34-35.
    2. 28158. Leduc, V., Moneret-Vautrin, D. A., Tzen, J. T., Morisset, M., Guerin, L., and Kanny, G. Identification of oleosins as major allergens in sesame seed allergic patients. Allergy 2006;61(3):349-356. PubMed
    3. 28159. Agne, P. S., Bidat, E., Agne, P. S., Rance, F., and Paty, E. Sesame seed allergy in children. Eur Ann Allergy Clin Immunol 2004;36(8):300-305.
    4. 28160. Dalal, I., Binson, I., Levine, A., Somekh, E., Ballin, A., and Reifen, R. The pattern of sesame sensitivity among infants and children. Pediatr Allergy Immunol 2003;14(4):312-316. PubMed
    5. 28161. Moneret-Vautrin, D. A., Kanny, G., and Lagrange, A. [Occupational asthma caused by organic substances]. Rev Med Interne 1994;15 Suppl 2:216s-225s.
    6. 28162. Keskinen, H., Ostman, P., Vaheri, E., Tarvainen, K., Grenquist-Norden, B., Karppinen, O., and Nordman, H. A case of occupational asthma, rhinitis and urticaria due to sesame seed. Clin Exp Allergy 1991;21(5):623-624. PubMed

    Orlistat

    Listed in the ADVERSE REACTIONS section of the FDA label for Orlistat. Read the label on DailyMed ›

  • Diarrhea reported in 7.6% of FDA reports for Orlistat Additional detail

    Sesame

    “There was a single case of diarrhea associated with oral sesame in a clinical trial.”

    Sesame · Natural Medicines adverse-effect record, reported in diarrhea.

    1 source cited
    1. 108356. Khani B, Bidgoli SR, Moattar F, Hassani H. Effect of sesame on sperm quality of infertile men. J Res Med Sci. 2013;18(3):184-7.

    Orlistat

    Listed in the ADVERSE REACTIONS section of the FDA label for Orlistat, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

  • Swelling / A skin rash / Vomiting Additional detail

    Sesame

    Recorded for Sesame in the same Natural Medicines adverse-effect record shown under Wheezing / A severe allergic reaction / Hives / Bleeding or bruising / An allergic reaction above.

    Orlistat

    Listed in the ADVERSE REACTIONS section of the FDA label for Orlistat. Read the label on DailyMed ›

Reported for Sesame but not commonly for Orlistat: a stuffy or runny nose and flushing.

Effects for Orlistat come from the ADVERSE REACTIONS section of its FDA label; effects for Sesame come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 25,755 voluntary FDA FAERS reports for Orlistat that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Everything else you take

See Every Supplement That Interacts With Orlistat

This page covers Sesame only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Orlistat page lists 18 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Fish Oil (moderate) and Glucomannan (moderate).

By severity: 1 major · 8 moderate · 9 minor.

From our pharmacist’s overview on the Orlistat page

“People who take Orlistat (Xenical, Alli) for weight loss often browse the very supplement aisle where fiber products and fish oil sit, and both show up on this page, so it deserves genuine attention before you mix anything in. Nearly all 18 ingredients on file can change how oral medications absorb from the gut, and the single major-ra…”

Reviewed by 2 · Jul 18, 2026

Open the Orlistat interaction page

One more smart check

Taking Sesame as Part of a Dietary Supplement Product? Check It for Interactions

We hold 434 real supplement products containing Sesame, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Sesame. Even though Sesame itself has no known interaction with Orlistat, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Sesame and Orlistat Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Sesame
Top half

#494 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Orlistat
Top 25%

#519 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Sesame reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Sesame and Orlistat records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Sesame

What is Sesame?

  • Heart and cholesterol health
  • Blood pressure support
  • Source of healthy fats and minerals
  • Skin and hair care (topical oil)
  • Antioxidant support
  • Cooking and nutrition

Sesame is a nutritious seed and oil widely used in cooking and traditional medicine, and it provides healthy fats, fiber, and antioxidant compounds called lignans. Some early research suggests sesame may modestly help with cholesterol and blood pressure, but the evidence is limited. Sesame is also a common, sometimes serious, food allergen, so people with seed allergies should be careful.

Sesamum indicum · Pedaliaceae · Seeds and seed oil · Whole seeds, sesame oil (cooking and topical), tahini, capsules/softgels, sesame extract (sesamin/lignans)

An interaction check asks whether these two react with each other — it does not ask whether Sesame is a good idea for someone in your situation. Here is what our Sesame record says about it on its own.

Sesame: dosing

There is no official or standardized dose of sesame as a supplement. As a food, sesame seeds, tahini, and sesame oil are used in normal culinary amounts.For capsules or extracts, the right amount has not been clearly established by research. Do not assume more is better.

From our Sesame monograph — the full record covers uses, side effects and every documented interaction.

Read the full Sesame monograph & all interactions
Medication

About Orlistat

What Is Orlistat Used For?

Brand names: Xenical, Alli

Xenical and prescription-strength orlistat are approved to help obese adults lose weight and keep it off when used with a reduced-calorie diet. They are intended for people with a body mass index (BMI) of 30 or higher, or 27 or higher if other risk factors such as high blood pressure, diabetes, or dyslipidemia (abnormal cholesterol or fat levels in the blood) are present.

Alli is the over-the-counter version, approved for weight loss in overweight adults 18 and older when used with a reduced-calorie, low-fat diet and exercise program.

Most-Reported Side Effects for Orlistat

From FAERS, the FDA’s public side-effect reporting system (25,755 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Rectal discharge 2,434 reports
Gastrointestinal disorder 2,186 reports
Constipation 1,991 reports
Diarrhea 1,960 reports
Weight increased 1,944 reports
See full Orlistat drug information
Keep checking

Other Drugs & Sesame

Browse every other medication we’ve checked against Sesame — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
343Moderate
185Minor
2,301No known interaction
343 Moderate 185 Minor 2,301 No interaction
Moderate

343 interactions

Showing 60 of 343 moderate interactions — see all 343 on the Sesame page.

Minor

185 interactions

Showing 60 of 185 minor interactions — see all 185 on the Sesame page.

No interaction 2,301 drugs checked — show the list

We also checked Sesame against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,301 medications checked with no known interaction — see the full Sesame list.

See the full Sesame interactions page
See every supplement checked against Orlistat, ranked by severity
Evidence & sources

Sesame References

The 53 references that drive our Sesame monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. von Moltke LL, Weemhoff JL, Bedir E, et al. Inhibition of human cytochromes P450 by components of Ginkgo biloba. J Pharm Pharmacol 2004;56:1039-44.
  2. Sankar, D., Sambandam, G., Ramakrishna, Rao M., and Pugalendi, K. V. Modulation of blood pressure, lipid profiles and redox status in hypertensive patients taking different edible oils. Clin Chim Acta 2005;355(1-2):97-104. PubMed
  3. Sankar, D., Rao, M. R., Sambandam, G., and Pugalendi, K. V. A pilot study of open label sesame oil in hypertensive diabetics. J Med Food 2006;9(3):408-412. PubMed
  4. Sankar, D., Rao, M. R., Sambandam, G., and Pugalendi, K. V. Effect of sesame oil on diuretics or Beta-blockers in the modulation of blood pressure, anthropometry, lipid profile, and redox status. Yale J Biol.Med. 2006;79(1):19-26.
  5. Sacco, S. M., Chen, J., Power, K. A., Ward, W. E., and Thompson, L. U. Lignan-rich sesame seed negates the tumor-inhibitory effect of tamoxifen but maintains bone health in a postmenopausal athymic mouse model with estrogen-responsive breast tumors. Menop PubMed
  6. Sacco, S. M., Power, K. A., Chen, J., Ward, W. E., and Thompson, L. U. Interaction of sesame seed and tamoxifen on tumor growth and bone health in athymic mice. Exp Biol Med (Maywood) 2007;232(6):754-761.
  7. Hsiao, E. S., Lin, L. J., Li, F. Y., Wang, M. M., Liao, M. Y., and Tzen, J. T. Gene families encoding isoforms of two major sesame seed storage proteins, 11S globulin and 2S albumin. J Agric Food Chem 2006;54(25):9544-9550. PubMed
  8. Ramesh, B., Saravanan, R., and Pugalendi, K. V. Influence of sesame oil on blood glucose, lipid peroxidation, and antioxidant status in streptozotocin diabetic rats. J Med Food 2005;8(3):377-381. PubMed
  9. Panizzolo, C., Tura, M., and Barbato, A. Anaphylaxis to sesame paste. Eur Ann Allergy Clin Immunol 2005;37(1):34-35.
  10. Leduc, V., Moneret-Vautrin, D. A., Tzen, J. T., Morisset, M., Guerin, L., and Kanny, G. Identification of oleosins as major allergens in sesame seed allergic patients. Allergy 2006;61(3):349-356. PubMed
  11. Agne, P. S., Bidat, E., Agne, P. S., Rance, F., and Paty, E. Sesame seed allergy in children. Eur Ann Allergy Clin Immunol 2004;36(8):300-305.
  12. Dalal, I., Binson, I., Levine, A., Somekh, E., Ballin, A., and Reifen, R. The pattern of sesame sensitivity among infants and children. Pediatr Allergy Immunol 2003;14(4):312-316. PubMed
  13. Moneret-Vautrin, D. A., Kanny, G., and Lagrange, A. [Occupational asthma caused by organic substances]. Rev Med Interne 1994;15 Suppl 2:216s-225s.
  14. Keskinen, H., Ostman, P., Vaheri, E., Tarvainen, K., Grenquist-Norden, B., Karppinen, O., and Nordman, H. A case of occupational asthma, rhinitis and urticaria due to sesame seed. Clin Exp Allergy 1991;21(5):623-624. PubMed
  15. Alday, E., Curiel, G., Lopez-Gil, M. J., Carreno, D., and Moneo, I. Occupational hypersensitivity to sesame seeds. Allergy 1996;51(1):69-70. DOI

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Sesame and Orlistat Together: Common Questions

Is it safe to take Sesame with Orlistat?
We do not list a known interaction between Sesame and Orlistat. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Sesame and Orlistat have any of the same side effects?
Yes — our sources link each of them separately to 9 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Sesame and Orlistat combination checked?
Interactions in our licensed database are recorded against drug classes. Orlistat is filed under 2 classifications, and Sesame has documented interactions with 5 drug classes — none of Orlistat's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Sesame interact with any other medications?
Yes. Sesame has 528 documented drug interactions in our database — Orlistat is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Orlistat interact with any supplements?
Yes. Orlistat has documented interactions with 18 supplements in our database — Sesame is not one of them. The Orlistat interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Sesame monograph Uses, safety profile, and every drug interaction in one place Orlistat drug information The full plain-English guide to this medication Orlistat supplement interactions Every supplement checked against Orlistat, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 53 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Orlistat and Sesame?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.