Strontium + Methylprednisolone
Methylprednisolone brand names: Medrol, Medrol Dosepak.
We found no known interaction between Strontium and Methylprednisolone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Strontium and Methylprednisolone
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Methylprednisolone and Strontium in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Strontium safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Why No Interaction Is Listed for Methylprednisolone
Interactions in our licensed database are recorded against drug classes, not just single drug names. Methylprednisolone is filed under 8 classifications — including prednisolone, corticosteroids, immunosuppressants. Strontium has documented interactions with 5 drug classes — the most serious being androgens (moderate), antacids (moderate) and estrogens (moderate) — and none of Methylprednisolone’s classifications are among them.
Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.
Strontium Does Interact With Other Medications
Strontium has 101 moderate known drug interactions in our database — Methylprednisolone isn’t one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Strontium
We haven’t checked that one against Strontium yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Strontium. Pick one to open its full report.
Strontium in Pregnancy & Breastfeeding
When consumed orally in food amounts. Strontium has not been linked to toxicity when consumed in dietary amounts, which are typically about 0.5 mg to 1.5 mg/day. ...when strontium chloride is used topically and appropriately as a toothpaste. Strontium chloride hexahydrate (Sensodyne-SC) is an FDA approved product.
When strontium-89 chloride is used during pregnancy or lactation. Strontium-89 chloride is a radioactive isotope which may cause fetal harm. It is FDA pregnancy risk category D; avoid using. Since strontium behaves similarly to calcium in the body, strontium-89 is likely to be excreted into breast milk; avoid using during lactation. There is insufficient reliable information about the safety of oral strontium when used in amounts exceeding typical dietary intake during pregnancy or lactation; avoid using.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
No Interaction — But Methylprednisolone May Lower Your Strontium Levels
These two do not interact. The relationship runs the other way: the licensed record lists Methylprednisolone as associated with lower Strontium levels — rated “Insufficient Evidence”.
Theoretically, corticosteroids might reduce strontium levels. Limited data suggest urinary strontium excretion is increased after 5-6 weeks of treatment with high doses of corticosteroids (e.g., hydrocortisone 80-120 mg/day, prednisone 20-30 mg/day, dexamethasone 3mg/day, triamcinolone 12-18 mg/day). The clinical significance of this is unknown.
STRONTIUM — Insufficient Evidence
See every medication linked to lower Strontium levels · See the full Methylprednisolone nutrient report
Disclaimer: This checker finds which nutrients might be depleted by prescription or over-the-counter medications. Each nutrient depletion issue is rated based on clinical significance. Use your own professional judgment prior to making clinical decisions.© 2026 Therapeutic Research Center
What Methylprednisolone Is Prescribed For, and What Strontium Has Been Studied For
These two come up together because they touch the same health topic — not because they do the same job. Methylprednisolone is a prescription medicine with approved uses on its FDA label. Strontium is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.
Methylprednisolone is prescribed for: Methylprednisolone tablets (Medrol, Methylpred DP) are used to treat a broad set of conditions including endocrine disorders, rheumatic and joint conditions, autoimmune diseases such as systemic lupus erythematosus, severe allergic states, skin diseases, eye inflammation, breathing disorders like asthma, blood and kidney diseases, and certain cancers. Methylprednisolone acetate injection (Depo-Medrol and others) is used by intramuscular injection when oral therapy isn't feasible, and can also be given directly into joints, soft tissue, or lesions to treat local inflammation from conditions such as rheumatoid arthritis, bursitis, and skin disorders. The injection is not approved for intrathecal (spinal) use.
Strontium has been studied for:
-
Cancer studied, not established Strontium has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows
Strontium for cancer
Although there has been interest in using oral strontium for metastatic cancer, there is insufficient reliable information about the clinical effects of strontium for this purpose.
Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Methylprednisolone on your own; if you are taking Strontium for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.
Questions About Strontium or Methylprednisolone
These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Strontium or Methylprednisolone, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:
- Help! I Missed A Tablet From My Medrol Dose Pack ›
- Can You Safely Use Flonase If You Have High Blood Pressure? ›
- Can You Take Amoxicillin And Prednisone Together? ›
Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.
See Every Supplement That Interacts With Methylprednisolone
This page covers Strontium only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Methylprednisolone page lists 207 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Grapefruit (major), Lily-of-the-valley (major), St. John's Wort (major) and Acacia Rigidula (moderate).
By severity: 4 major · 167 moderate · 36 minor.
From our pharmacist’s overview on the Methylprednisolone page
“Methylprednisolone (Medrol) is a steroid used for inflammation, allergic flares, and autoimmune disease, and its supplement interactions deserve real attention, not a quick skim. Of the 207 ingredients on file, four rate major, and those come first: grapefruit and St.”
Reviewed by 2 · Jul 18, 2026
Taking Strontium as Part of a Dietary Supplement Product? Check It for Interactions
We hold 347 real supplement products containing Strontium, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Strontium. Even though Strontium itself has no known interaction with Methylprednisolone, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Strontium and Methylprednisolone Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#385 of 1,452 supplements looked up here in the last 7 days
#771 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Strontium reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Strontium and Methylprednisolone records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Strontium
What is Strontium?
- Bone health and osteoporosis
- Reducing fracture risk
- Tooth sensitivity (in some toothpastes)
- Supporting bone density
Strontium is a mineral that has been studied mainly for bone health and osteoporosis. The prescription form (strontium ranelate) showed benefit for fracture risk but carries serious heart-related safety concerns, while the over-the-counter supplement form (strontium citrate) has much less evidence. Talk to your doctor or pharmacist before using it, especially if you have heart disease or are at risk for blood clots.
Mineral element (not a plant) · Capsules and tablets, usually as strontium citrate or strontium ranelate (prescription in some countries)
An interaction check asks whether these two react with each other — it does not ask whether Strontium is a good idea for someone in your situation. Here is what our Strontium record says about it on its own.
Strontium: dosing
There is no firmly established dose for over-the-counter strontium supplements. Strontium and calcium compete for absorption, so they are usually taken at different times of day. Do not assume more is better, since higher amounts may increase risks.
From our Strontium monograph — the full record covers uses, side effects and every documented interaction.
About Methylprednisolone
What Is Methylprednisolone Used For?
Brand names: Medrol, Medrol Dosepak
Methylprednisolone tablets (Medrol, Methylpred DP) are used to treat a broad set of conditions including endocrine disorders, rheumatic and joint conditions, autoimmune diseases such as systemic lupus erythematosus, severe allergic states, skin diseases, eye inflammation, breathing disorders like asthma, blood and kidney diseases, and certain cancers.
Methylprednisolone acetate injection (Depo-Medrol and others) is used by intramuscular injection when oral therapy isn't feasible, and can also be given directly into joints, soft tissue, or lesions to treat local inflammation from conditions such as rheumatoid arthritis, bursitis, and skin disorders. The injection is not approved for intrathecal (spinal) use.
Most-Reported Side Effects for Methylprednisolone
From FAERS, the FDA’s public side-effect reporting system (170,235 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.
Other Drugs & Strontium
Browse every other medication we’ve checked against Strontium — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
101 interactions
- Doxycycline ›
- Estradiol ›
- Minocycline ›
- Tetracycline ›
- Testosterone ›
- Methyltestosterone ›
- Ciprofloxacin ›
- Calcium Carbonate ›
- Conjugated Estrogens ›
- Ofloxacin ›
- Testosterone Undecanoate ›
- Aluminum Hydroxide ›
- Doxycycline Hyclate ›
- Levofloxacin ›
- Esterified Estrogens ›
- Estropipate ›
- Gatifloxacin ›
- Magnesium Sulfate (prescription Drug) ›
- Methyltestosterone Buccal ›
- Minocycline Hydrochloride ›
- Norfloxacin ›
- Retapamulin ›
- Trovafloxacin ›
- Chlortetracycline ›
- Cinoxacin ›
- Clinafloxacin ›
- Demeclocycline ›
- Dihydroxyaluminum Sodium Carbonate ›
- Doripenem ›
- Doxycycline Monohydrate ›
- Doxycyline ›
- Enoxacin ›
- Eravacycline ›
- Estrogen ›
- Estrone ›
- Ethinyl Estradiol ›
- Finafloxacin ›
- Gemifloxacin ›
- Grepafloxacin ›
- Levofloxacin (ophthalmic) ›
- Lomefloxacin ›
- Magaldrate ›
- Moxifloxacin ›
- Nalidixic Acid ›
- Oestrogen ›
- Omadacycline (iv) ›
- Omadacycline (oral) ›
- Oxytetracycline ›
- Ozenoxacin ›
- Prasterone (prescription Drug) ›
- Sodium Bicarbonate (otc Drug) ›
- Sparfloxacin ›
- Testosterone Enanthate ›
- Tibolone ›
- Tigecycline ›
- Ethinyl Estradiol, Norethindrone ›
- Ethinyl Estradiol, Levonorgestrel ›
- Ethinyl Estradiol, Norgestimate ›
- Ethinyl Estradiol, Desogestrel ›
- Ethinyl Estradiol, Norethindrone, Ferrous Fumarate ›
Showing 60 of 101 moderate interactions — see all 101 on the Strontium page.
No interaction 2,728 drugs checked — show the list
We also checked Strontium against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Losartan Potassium ›
- Ivermectin ›
- Aspirin ›
- Abemaciclib ›
- Metoprolol ›
- Acetaminophen ›
- Rosuvastatin ›
- Rivaroxaban ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Docusate ›
- Tadalafil ›
- Tirzepatide ›
- Methamphetamine ›
- Ibuprofen ›
- Warfarin Sodium ›
- Valacyclovir ›
- Sumatriptan ›
- Hydroxyurea ›
- Semaglutide ›
- Prednisone ›
- Lisdexamfetamine ›
- Propranolol ›
- Metformin ›
- Amitriptyline ›
- Amoxicillin ›
- Lisinopril ›
- Isotretinoin ›
- Amlodipine Besylate ›
- Methotrexate ›
- Bendamustine ›
- Bupropion ›
- Amphetamine ›
- Fluoxetine ›
- Acyclovir ›
- Azithromycin ›
- Lamotrigine ›
- Pregabalin ›
- Dextroamphetamine ›
- Gabapentin ›
- Acetaminophen, Codeine ›
- Levothyroxine, Liothyronine ›
- Clonazepam ›
- Quetiapine ›
- Naproxen ›
- Omeprazole ›
- Letrozole ›
- Duloxetine ›
- Methylene Blue ›
- Buspirone ›
- Citalopram ›
- Bisoprolol ›
- Candesartan Cilexetil ›
Showing the 60 most looked-up of 2,728 medications checked with no known interaction — see the full Strontium list.
Strontium References
The 22 references that drive our Strontium monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Martindale W. Martindale the Extra Pharmacopoeia. Pharmaceutical Press, 1999.
- Meunier PJ, Roux C, Seeman E, et al. The effects of strontium ranelate on the risk of vertebral fracture in women with postmenopausal osteoporosis. N Engl J Med 2004;350:459-68.. PubMed
- El-Hajj Fuleihan G. Strontium ranelate--a novel therapy for osteoporosis or a permutation of the same? N Engl J Med 2004;350:504-6. PubMed
- Verberckmoes SC, De Broe ME, D'Haese PC. Dose-dependent effects of strontium on osteoblast function and mineralization. Kidney Int 2003;64:534-43. . PubMed
- Meunier PJ, Slosman DO, Delmas PD, et al. Strontium ranelate: dose-dependent effects in established postmenopausal vertebral osteoporosis--a 2-year randomized placebo controlled trial. J Clin Endocrinol Metab 2002;87:2060-6.. DOI
- Brandi ML. New treatment strategies: ipriflavone, strontium, vitamin D metabolites and analogs. Am J Med 1993;95:69S-74S. . PubMed
- Eisenberg E. Effects of androgens, estrogens and corticoids on strontium kinetics in man. J Clin Endocrinol Metab 1966;26:566-72.
- Metastron prescribing information. Medi-Physics, Inc., Amersham Healthcare, Arlington Heights, IL, 1998. http://www.cancerpaintherapy.com/METATECHPAGE.htm. (Accessed 13 March 2004).
- Protelos European Summary of Product Characteristics. Les Laboratoires Servier, 2006. Available at: www.servier.com/pro/osteoporose/protelos/protelos_spc.asp. (Accessed 01 August 2006).
- US Department of Health and Human Services, Public Health Service. Agency for Toxic Substances and Disease Registry. Toxicological profile for strontium. April 2004. Available at: www.atsdr.cdc.gov/toxprofiles/tp159.pdf. (Accessed 8 August 2006).
- Apostolidis N, Paradellis T, Karydas A, et al. Calcium and strontium metabolic studies in patients on CAPD. Perit Dial Int 1998;18:410-4. DOI
- Ozgur S, Sumer H, Kocoglu G. Rickets and soil strontium. Arch Dis Child 1996;75:524-6. PubMed
- Schrooten I, Elseviers MM, Lamberts LV, et al. Increased serum strontium levels in dialysis patients: an epidemiological survey. Kidney Int 1999;56:1886-92. PubMed
- D'Haese PC, Couttenye MM, Lamberts LV, et al. Aluminum, iron, lead, cadmium, copper, zinc, chromium, magnesium, strontium, and calcium content in bone of end-stage renal failure patients. Clin Chem 1999;45:1548-56. DOI
- Pennington JA, Jones JW. Molybdenum, nickel, cobalt, vanadium, and strontium in total diets. J Am Diet Assoc 1987;87:1644-50. DOI
- O'Donnell S, Cranney A, Wells GA, et al. Strontium ranelate for preventing and treating postmenopausal osteoporosis. Cochrane Musculoskeletal Group. Cochrane Database Syst Rev 2006;(4):CD005326. PubMed
- Protelos European Public Assessment Report, Scientific Discussion. European Medicines Agency, 2005. Available at: www.emea.eu.int/humandocs/Humans/EPAR/protelos/protelos.htm. (Accessed 10 October 2006).
- Rousselet F, El Solh N, Maurat JP, et al. Strontium and calcium metabolism. Interaction of strontium and vitamin D. C R Seances Soc Biol Fil 1975;169:322-9.
- O'Donnell, S., Cranney, A., Wells, G. A., Adachi, J. D., and Reginster, J. Y. Strontium ranelate for preventing and treating postmenopausal osteoporosis. Cochrane.Database.Syst.Rev. 2006;3:CD005326. PubMed
- Rizzoli R, Chapurlat RD, Laroche JM, et al. Effects of strontium ranelate and alendronate on bone microstructure in women with osteoporosis. Results of a 2-year study. Osteoporosis Int. 2012. 23(1):305-315. doi: 10.1007/s00198-011-1758-z. PubMed
- Reginster JY, Kaufman JM, Goemaere S, et al. Maintenance of antifracture efficacy over 10 years with strontium ranelate in postmenopausal osteoporosis. Osteoporos Int. 2012;23(3):1115-1122. doi: 10.1007/s00198-011-1847-z. PubMed
- Protos [Product Information]. Available at: http://www.guildlink.com.au/gc/ws/servier/pi.cfm?product=sepproto. Accessed May 1, 2018.
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Methylprednisolone Is Linked to Lower Levels of 9 Nutrients
Natural Medicines records Methylprednisolone as a medicine that can lower these. This is not an interaction with Strontium — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Methylprednisolone nutrient depletion report ›
Strontium is itself a nutrient we track — see which medications may deplete STRONTIUM.
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Strontium and Methylprednisolone Together: Common Questions
Is it safe to take Strontium with Methylprednisolone?
Do Strontium and Methylprednisolone have any of the same side effects?
Can Methylprednisolone lower my Strontium levels?
Are Strontium and Methylprednisolone used for the same thing?
How was the Strontium and Methylprednisolone combination checked?
Does Strontium interact with any other medications?
Does Methylprednisolone interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Still Have a Question About Methylprednisolone and Strontium?
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.