Drug & supplement interaction

Tree Turmeric + Sulfacetamide

Sulfacetamide brand name: AK-Sulf.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Tree Turmeric and Sulfacetamide in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Tree Turmeric and Sulfacetamide

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Sulfacetamide and Tree Turmeric in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Tree Turmeric safety at a glance

Tree Turmeric overall Use caution Generally used in traditional medicine, but human safety data are limited.
Pregnancy Likely Unsafe When used orally. The berberine constituent of tree turmeric is thought to cross the placenta and may cause harm to the fetus. Kernicterus has developed in newb... Read the full pregnancy detail
Breastfeeding Likely Unsafe When used orally. The berberine constituent of tree turmeric and other harmful constituents can be transferred to the infant through breast milk. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Sulfacetamide and Tree Turmeric? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Sulfacetamide

Interactions in our licensed database are recorded against drug classes, not just single drug names. Sulfacetamide is filed under a single classification — photosensitizing drugs. Tree Turmeric has documented interactions with 12 drug classes — the most serious being cyclosporine (neoral, sandimmune) (major), tacrolimus (prograf) (major) and anticoagulant/antiplatelet drugs (moderate) — and none of Sulfacetamide’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Tree Turmeric Does Interact With Other Medications

Tree Turmeric has 2 major, 1,158 moderate known drug interactions in our database — Sulfacetamide isn’t one of them. If you take anything else, check it against the full list below.

Major 2 Moderate 1,158 No known interaction 1,670 (incl. Sulfacetamide)
Taking anything else?

Check Another of Your Medications Against Tree Turmeric

Covers the 2,830 medications we’ve checked against Tree Turmeric. Pick one to open its full report.

What to actually watch for

What Tree Turmeric Itself Has Been Linked To

This is not an interaction — nothing below involves Sulfacetamide. It is the side-effect record for Tree Turmeric on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Tree Turmeric, this list is the first place to look.

  • Nausea Additional detail

    “Orally, the most common adverse effects of a specific product (Berberol, PharmExtracta) containing tree turmeric and milk thistle extracts include gastrointestinal symptoms, especially nausea.”

    Tree Turmeric · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    4 sources cited
    1. 95019. Derosa G, Romano D, D'Angelo A, Maffioli P. Berberis aristata/Silybum marianum fixed combination (Berberol(®)) effects on lipid profile in dyslipidemic patients intolerant to statins at high dosages: a randomized, placebo-controlled, clinical trial. Phyto PubMed
    2. 96140. Di Pierro F, Bellone I, Rapacioli G, Putignano P. Clinical role of a fixed combination of standardized Berberis aristata and Silybum marianum extracts in diabetic and hypercholesterolemic patients intolerant to statins. Diabetes Metab Syndr Obes. 2015;8:8 PubMed
    3. 96141. Di Pierro F, Villanova N, Agostini F, Marzocchi R, Soverini V, Marchesini G. Pilot study on the additive effects of berberine and oral type 2 diabetes agents for patients with suboptimal glycemic control. Diabetes Metab Syndr Obes. 2012;5:213-7. PubMed
    4. 96142. Derosa G, D'Angelo A, Maffioli P. The role of a fixed Berberis aristata/Silybum marianum combination in the treatment of type 1 diabetes mellitus. Clin Nutr. 2016;35(5):1091-5. PubMed

Everything above comes from the Natural Medicines adverse-effect record for Tree Turmeric — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Sulfacetamide’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Sulfacetamide column appears here.

Special populations

Tree Turmeric in Pregnancy & Breastfeeding

Pregnancy Likely Unsafe

When used orally. The berberine constituent of tree turmeric is thought to cross the placenta and may cause harm to the fetus. Kernicterus has developed in newborn infants exposed to berberine.

Lactation Likely Unsafe

When used orally. The berberine constituent of tree turmeric and other harmful constituents can be transferred to the infant through breast milk.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Overlapping uses

What Sulfacetamide Is Prescribed For, and What Tree Turmeric Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Sulfacetamide is a prescription medicine with approved uses on its FDA label. Tree Turmeric is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Sulfacetamide is prescribed for: Sulfacetamide Sodium Ophthalmic Solution USP, 10% is used to treat conjunctivitis (pink eye) and other superficial infections on the surface of the eye caused by susceptible bacteria. These include bacteria such as Staphylococcus aureus, Streptococcus pneumoniae, Haemophilus influenzae, Klebsiella species, and others. It is also used alongside systemic (oral or injectable) sulfonamide antibiotic therapy in the treatment of trachoma, a serious bacterial eye infection. It is important to note that this medication does not work against all types of bacteria — it does not provide adequate coverage against Neisseria species, Serratia marcescens, or Pseudomonas aeruginosa, and some staph bacteria are fully resistant to it.

Tree Turmeric has been studied for:

  • Trachoma studied, not established Tree Turmeric has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Tree Turmeric for trachoma

    Although there has been interest in using oral tree turmeric for trachoma, there is insufficient reliable information about the clinical effects of tree turmeric for this purpose.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Sulfacetamide on your own; if you are taking Tree Turmeric for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

Everything else you take

See Every Supplement That Interacts With Sulfacetamide

This page covers Tree Turmeric only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Sulfacetamide page lists 20 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Alfalfa (moderate), Angelica Archangelica (moderate), Arrach (moderate), Bergamot (moderate) and Bishop's Weed (moderate).

By severity: 19 moderate · 1 minor.

From our pharmacist’s overview on the Sulfacetamide page

“Every one of the 20 supplement interactions on file for sulfacetamide (AK-Sulf), a sulfa antibiotic used in eye drops and skin preparations, comes down to the same issue, added sun sensitivity. Sulfa drugs can make skin react more strongly to sunlight, and each ingredient below, St.”

Reviewed by 2 · Jul 18, 2026

Open the Sulfacetamide interaction page

One more smart check

Taking Tree Turmeric as Part of a Dietary Supplement Product? Check It for Interactions

We hold 51 real supplement products containing Tree Turmeric, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Tree Turmeric. Even though Tree Turmeric itself has no known interaction with Sulfacetamide, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Tree Turmeric and Sulfacetamide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Tree Turmeric
Top half

#564 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Sulfacetamide
Steady interest

#2,284 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Tree Turmeric reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Tree Turmeric and Sulfacetamide records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Tree Turmeric

What is Tree Turmeric?

  • Blood sugar support
  • High cholesterol
  • Digestive complaints
  • Skin and eye conditions
  • Antimicrobial uses
  • Liver support

Tree turmeric (Berberis aristata) is a shrub used in traditional Indian (Ayurvedic) medicine, valued mainly for its berberine content. Early research suggests possible benefits for blood sugar and cholesterol, but high-quality human evidence is limited. Talk with your pharmacist or doctor before using it, and avoid it during pregnancy and breastfeeding.

Berberis aristata · Berberidaceae · Root, stem, and bark · Capsules, tablets, powder, extracts, and traditional decoctions

An interaction check asks whether these two react with each other — it does not ask whether Tree Turmeric is a good idea for someone in your situation. Here is what our Tree Turmeric record says about it on its own.

Tree Turmeric: dosing

There is no well-established standard dose for tree turmeric. They can help you decide whether it is appropriate for you and what amount, if any, is reasonable. Do not assume that a higher dose is safer or more effective.

From our Tree Turmeric monograph — the full record covers uses, side effects and every documented interaction.

Read the full Tree Turmeric monograph & all interactions
Medication

About Sulfacetamide Ophthalmic

What Is Sulfacetamide Ophthalmic Used For?

Brand name: AK-Sulf

Sulfacetamide Sodium Ophthalmic Solution USP, 10% is used to treat conjunctivitis (pink eye) and other superficial infections on the surface of the eye caused by susceptible bacteria. These include bacteria such as Staphylococcus aureus, Streptococcus pneumoniae, Haemophilus influenzae, Klebsiella species, and others.

It is also used alongside systemic (oral or injectable) sulfonamide antibiotic therapy in the treatment of trachoma, a serious bacterial eye infection. It is important to note that this medication does not work against all types of bacteria — it does not provide adequate coverage against Neisseria species, Serratia marcescens, or Pseudomonas aeruginosa, and some staph bacteria are fully resistant to it.

Most-Reported Side Effects for Sulfacetamide

From FAERS, the FDA’s public side-effect reporting system (736 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Drug hypersensitivity 68 reports
Nausea 45 reports
Headache 36 reports
Dyspnea 35 reports
Rash 35 reports
See full Sulfacetamide Ophthalmic drug information
Keep checking

Other Drugs & Tree Turmeric

Browse every other medication we’ve checked against Tree Turmeric — both the ones with a known interaction and the ones without. Select any drug for the full detail.

2Major
1,158Moderate
0Minor
1,669No known interaction
2 Major 1,158 Moderate 1,669 No interaction
Major

2 interactions

Moderate

1,158 interactions

Showing 60 of 1,158 moderate interactions — see all 1,158 on the Tree Turmeric page.

No interaction 1,669 drugs checked — show the list

We also checked Tree Turmeric against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,669 medications checked with no known interaction — see the full Tree Turmeric list.

See the full Tree Turmeric interactions page
See every supplement checked against Sulfacetamide, ranked by severity
Evidence & sources

Tree Turmeric References

The 25 references that drive our Tree Turmeric monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Chan E. Displacement of bilirubin from albumin by berberine. Biol Neonate 1993;63:201-8. PubMed
  2. Janbaz KH, Gilani AH. Studies on preventive and curative effects of berberine on chemical-induced hepatotoxicity in rodents. Fitoterapia 2000;71:25-33.. PubMed
  3. Wu X, Li Q, Xin H, Yu A, Zhong M. Effects of berberine on the blood concentration of cyclosporin A in renal transplanted recipients: clinical and pharmacokinetic study. Eur J Clin Pharmacol 2005;61:567-72. PubMed
  4. Zhang Y, Li X, Zou D, et al. Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine. J Clin Endocrinol Metab 2008;93:2559-65. PubMed
  5. Huang XS, Yang GF, Pan YC. Effect of berberin hydrochloride on blood concentration of cyclosporine A in cardiac transplanted patients. Zhongguo Zhong Xi Yi Jie He Za Zhi 2008;28:702-4.
  6. Budzinski JW, Foster BC, Vandenhoek S, Arnason JT. An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures. Phytomedicine 2000;7:273-82. PubMed
  7. Chatterjee P, Franklin MR. Human cytochrome p450 inhibition and metabolic-intermediate complex formation by goldenseal extract and its methylenedioxyphenyl components. Drug Metab Dispos 2003;31:1391-7. PubMed
  8. Shanbhag, S. M., Kulkarni, H. J., and Gaitonde, B. B. Pharmacological actions of berberine on the central nervous system. Jpn.J Pharmacol 1970;20(4):482-487. PubMed
  9. Wu, J. F. and Liu, T. P. [Effects of berberine on platelet aggregation and plasma levels of TXB2 and 6-keto-PGF1 alpha in rats with reversible middle cerebral artery occlusion]. Yao Xue.Xue.Bao. 1995;30(2):98-102.
  10. Peng, W. H., Hsieh, M. T., and Wu, C. R. Effect of long-term administration of berberine on scopolamine-induced amnesia in rats. Jpn J Pharmacol 1997;74(3):261-266. DOI
  11. Sabir M and Bhide NK. Study of some pharmacological actions of berberine. Ind J Physiol & Pharmac 1971;15(3):111-132.
  12. Tripathi YB and Shukla SD. Berberis artistata inhibits PAF induced aggregation of rabbit platelets. Phytotherapy Research 1996;10:628-630.
  13. Xin, H. W., Wu, X. C., Li, Q., Yu, A. R., Zhong, M. Y., and Liu, Y. Y. The effects of berberine on the pharmacokinetics of cyclosporin A in healthy volunteers. Methods Find.Exp.Clin Pharmacol 2006;28(1):25-29.
  14. Yin, J., Xing, H., and Ye, J. Efficacy of berberine in patients with type 2 diabetes mellitus. Metabolism 2008;57(5):712-717. PubMed
  15. Zhang, H., Wei, J., Xue, R., Wu, J. D., Zhao, W., Wang, Z. Z., Wang, S. K., Zhou, Z. X., Song, D. Q., Wang, Y. M., Pan, H. N., Kong, W. J., and Jiang, J. D. Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin re

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Tree Turmeric and Sulfacetamide Together: Common Questions

Is it safe to take Tree Turmeric with Sulfacetamide?
We do not list a known interaction between Tree Turmeric and Sulfacetamide. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Are Tree Turmeric and Sulfacetamide used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Tree Turmeric in each. That is a conversation for your prescriber, especially if Sulfacetamide is being adjusted to a target.
How was the Tree Turmeric and Sulfacetamide combination checked?
Interactions in our licensed database are recorded against drug classes. Sulfacetamide is filed under 1 classification, and Tree Turmeric has documented interactions with 12 drug classes — none of Sulfacetamide's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Tree Turmeric interact with any other medications?
Yes. Tree Turmeric has 1,160 documented drug interactions in our database — Sulfacetamide is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Sulfacetamide interact with any supplements?
Yes. Sulfacetamide has documented interactions with 20 supplements in our database — Tree Turmeric is not one of them. The Sulfacetamide interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Tree Turmeric monograph Uses, safety profile, and every drug interaction in one place Sulfacetamide Ophthalmic drug information The full plain-English guide to this medication Sulfacetamide supplement interactions Every supplement checked against Sulfacetamide, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 25 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Sulfacetamide and Tree Turmeric?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.