Herb & supplement monograph

Lactobacillus Delbrueckii Drug Interactions, Uses, Effectiveness, Safety & More

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS ·Updated July 2026

What is this page for?

First and foremost: how Lactobacillus Delbrueckii interacts with medications. The heart of this page is the interaction list — every drug Lactobacillus Delbrueckii is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Lactobacillus Delbrueckii is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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Lactobacillus Delbrueckii Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated August 2026

Based on the available evidence, the overall risk of a clinically significant Lactobacillus Delbrueckii drug interaction appears low for most people. None of the listed interactions are rated major, and every one is the same moderate-level concern involving a single group of medicines.

Interactions deserving the most attention

The only interaction that stands out involves antibiotics. Because Lactobacillus delbrueckii supplements contain live bacteria, an antibiotic taken at the same time can kill many of those organisms and blunt the probiotic's benefit. Importantly, this works in one direction: it is the supplement that loses effectiveness, not the antibiotic, so your prescribed treatment is not expected to be weakened. This concern is graded probable, meaning it rests on reasonable but limited evidence rather than large human trials.

What the rest of the list means

The long list of interacting medications looks bigger than it really is. It simply reflects that this same basic concern applies to many individual antibiotic products, not that dozens of different problems exist. Outside of antibiotics, no medication categories are flagged, and there is no evidence here of effects on bleeding, blood sugar, or other closely monitored therapies.

Check your medications against Lactobacillus Delbrueckii

Based on HelloPharmacist’s Lactobacillus Delbrueckii interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with Lactobacillus Delbrueckii

182 medications have a known interaction with Lactobacillus Delbrueckii, graded by severity. Select any drug for the full evidence-based detail.

Don’t want to scroll the list? Just ask.

Tell us the medications you take and we’ll check each one against Lactobacillus Delbrueckii using our pharmacist-reviewed interaction data.

AI summaries are generated from our Lactobacillus Delbrueckii interaction data for education only — always confirm with your pharmacist. How we use AI

2,830 drugs

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
Each drug listed above links to the full report for that exact Lactobacillus Delbrueckii combination — clinical detail, likelihood, evidence level, and citations.
Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

The big picture

The kinds of drugs Lactobacillus Delbrueckii affects

Every type of medication (drug category) Lactobacillus Delbrueckii is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 1 drug category Lactobacillus Delbrueckii interacts with

Antibiotic Drugs

Theoretically, taking Lactobacillus delbrueckii with antibiotic drugs might decrease the effectiveness of L. delbrueckii.
Lactobacillus delbrueckii preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. delbrueckii preparations by at least two hours.

Likelihood Probable Evidence D

Monograph

Lactobacillus Delbrueckii: Uses, Safety & Side Effects

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Reviewed July 2026 ·

The bottom line

Lactobacillus delbrueckii is a 'friendly' bacterium used in food fermentation and sold as a probiotic, often as part of multi-strain products. It is generally considered safe for healthy people, but solid human evidence for most specific health claims is limited. Talk to a pharmacist or doctor before using it, especially if you have a weakened immune system or serious illness.

Scientific name: Lactobacillus delbrueckii
Family: Lactobacillaceae
Part used: Live bacterial cultures (the whole microorganism)
Common forms: Capsules, tablets, powders, fermented dairy products (yogurt, cheese), and multi-strain probiotic blends

People commonly use it for

Digestive health
Lactose digestion support
Diarrhea
Gut microbiome balance
Immune support

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance

OverallUse caution

Generally well tolerated in healthy people, but people who are very ill or immunocompromised should be cautious.

PregnancyUse caution

Probiotics in food are likely fine, but supplement safety in pregnancy is not well studied, so check with your doctor.

BreastfeedingInsufficient reliable information

There is insufficient reliable information available about the safety of Lactobacillus delbrueckii during pregnancy and lactation. However, there are...

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

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Overview

Lactobacillus delbrueckii is a type of lactic acid bacteria, a group of microbes often called 'good' or 'friendly' bacteria. It is widely used in the food industry to make fermented dairy products like yogurt and certain cheeses. One of its well-known subspecies, Lactobacillus delbrueckii subsp. bulgaricus, is a classic starter culture for yogurt.

As a supplement, it is sold as a probiotic, usually in capsules, tablets, or powders. It is often combined with other probiotic strains rather than sold by itself. People take it hoping to support digestion and overall gut health.

Like other lactobacilli, this bacterium naturally lives in some fermented foods and can pass through the human digestive tract. It is not a plant or herb but a living microorganism.

How it works

Like other probiotics, Lactobacillus delbrueckii is thought to work by adding helpful bacteria to the gut. It ferments sugars and produces lactic acid, which lowers the pH of its surroundings. This more acidic environment may make it harder for some harmful bacteria to grow.

Researchers also believe probiotics may help by competing with unwanted microbes for space and nutrients, supporting the gut lining, and interacting with the immune system. Some lab studies suggest these bacteria produce compounds that can influence the gut environment.

It is important to know that many of these mechanisms come from laboratory and animal research, and effects can differ from strain to strain. What is true for one probiotic strain does not automatically apply to another.

Effectiveness

Does Lactobacillus Delbrueckii work?

Here’s what the research actually shows for each use — graded by Natural Medicines and reviewed by Dr. Brian Staiger, PharmD.

Evidence overview · 28 uses evaluated

28 Insufficient evidence

How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.

2Likely EffectiveGood evidence, though not yet conclusive.

3Possibly EffectiveSome evidence suggests a benefit.

4Possibly IneffectiveSome evidence it may not help.

5Likely IneffectiveFairly strong evidence it doesn’t help.

6IneffectiveStrong evidence it doesn’t work.

7Insufficient Reliable Evidence to RateToo little research to say either way.

For Lactobacillus Delbrueckii, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.

Also studied for 28 conditions — evidence insufficient to rate

Insufficient Reliable Evidence To Rate Acne