Medication interaction hub

What Supplements Interact with Canagliflozin, Metformin?

Canagliflozin, Metformin brand names: Invokamet, Invokamet XR. Every interaction below applies to the brands too.

257 Interactions 2 Major 217 Moderate 38 Minor
Curated & coded by · Clinical Pharmacist · Updated September 15, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Canagliflozin, Metformin? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Canagliflozin, Metformin against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Invokamet combines canagliflozin and metformin, two medicines that lower blood sugar by different routes, so nearly everything here, 239 of the 257 ingredients on file, touches glucose control in one direction or the other. Most add their own sugar-lowering effect and can stack with the drug to drop blood sugar too far, while a few push it higher and work against treatment. This list warrants real care, and the two entries rated major come first. Siberian cocklebur has caused severe low blood sugar in people, and activated charcoal can soak up oral medicines and blunt their effect.

The quieter risk sits with absorption. Seventeen entries can change how oral drugs get into the body, and guar gum specifically slows metformin uptake, so space bulky fibers and charcoal products well apart from your dose. Beyond the two majors sit 217 moderate and 38 minor entries, so closer glucose checks make sense whenever you add a supplement. Shakiness, sweating, or sudden hunger can mean a combination has pushed your sugar too low.

— , Clinical Pharmacist · July 18, 2026

Major 2 Moderate 217 Minor 38 No known interaction 1,195

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Canagliflozin, Metformin: Top Interactions at a Glance

The Canagliflozin, Metformin supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 257 interacting ingredients — plus 1,195 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Canagliflozin, Metformin Combinations Today

The Canagliflozin, Metformin + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Minor Likelihood Unlikely Alpha-lipoic Acid + Canagliflozin, Metformini

Theoretically, taking alpha-lipoic acid with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full interaction Moderate Likelihood Possible Radish + Canagliflozin, Metformini

Theoretically, radish might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Read the full interaction Moderate Likelihood Possible Chromium + Canagliflozin, Metformini

Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.

Read the full interaction Moderate Likelihood Possible Damiana + Canagliflozin, Metformini

Theoretically, taking damiana with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full interaction Minor Likelihood Possible Carob + Canagliflozin, Metformini

Theoretically, carob might also impair the absorption of oral drugs.

Read the full interaction Major Likelihood Likely Siberian Cocklebur + Canagliflozin, Metformini

Siberian cocklebur seedlings and seeds have caused severe hypoglycemia in humans.

Read the full interaction
The complete list

Every Supplement Checked Against Canagliflozin, Metformin

All 1,452 ingredients in our database, ranked by severity — 257 with a Canagliflozin, Metformin interaction on file and 1,195 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Canagliflozin, Metformin?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Alpha-lipoic Acid with Canagliflozin, Metformin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, taking alpha-lipoic acid with antidiabetes drugs might increase the risk of hypoglycemia.

Full Alpha-lipoic Acid + Canagliflozin, Metformin answer

Can you take Radish with Canagliflozin, Metformin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, radish might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Radish + Canagliflozin, Metformin answer

Can you take Chromium with Canagliflozin, Metformin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.

Full Chromium + Canagliflozin, Metformin answer

Can you take Damiana with Canagliflozin, Metformin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking damiana with antidiabetes drugs might increase the risk of hypoglycemia.

Full Damiana + Canagliflozin, Metformin answer

Can you take Carob with Canagliflozin, Metformin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, carob might also impair the absorption of oral drugs.

Full Carob + Canagliflozin, Metformin answer

Can you take Cashew with Canagliflozin, Metformin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Eating a diet that consists of high amounts of cashew might increase fasting blood glucose levels.

Full Cashew + Canagliflozin, Metformin answer

Can you take Cassia Auriculata with Canagliflozin, Metformin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Cassia auriculata may reduce blood glucose levels and might have additive effects on glucose levels when used with antidiabet...

Full Cassia Auriculata + Canagliflozin, Metformin answer

Can you take Cassia Cinnamon with Canagliflozin, Metformin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cassia cinnamon may have additive effects with antidiabetes drugs.

Full Cassia Cinnamon + Canagliflozin, Metformin answer

Can you take Ceylon Cinnamon with Canagliflozin, Metformin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Ceylon cinnamon may have additive effects with antidiabetes drugs.

Full Ceylon Cinnamon + Canagliflozin, Metformin answer

Can you take Ceylon Leadwort with Canagliflozin, Metformin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Ceylon leadwort root extract has been shown to both increase and decrease blood glucose levels in animal research.

Full Ceylon Leadwort + Canagliflozin, Metformin answer

Can you take Chaga with Canagliflozin, Metformin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking chaga with antidiabetes drugs might increase the risk of hypoglycemia.

Full Chaga + Canagliflozin, Metformin answer

Can you take Chicory with Canagliflozin, Metformin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, chicory might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Chicory + Canagliflozin, Metformin answer

Can you take Chinese Cucumber with Canagliflozin, Metformin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of Chinese cucumber with antidiabetic drugs may have additive effects and adverse effects.

Full Chinese Cucumber + Canagliflozin, Metformin answer

Can you take Chinese Mallow with Canagliflozin, Metformin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with Chinese mallow might increase the risk for hypoglycemia.

Full Chinese Mallow + Canagliflozin, Metformin answer

Can you take Chirata with Canagliflozin, Metformin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking chirata concomitantly with antidiabetes drugs may increase the risk of hypoglycemia.

Full Chirata + Canagliflozin, Metformin answer

Can you take Chokeberry with Canagliflozin, Metformin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, chokeberry might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Chokeberry + Canagliflozin, Metformin answer

Can you take Cissus Quadrangularis with Canagliflozin, Metformin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Cissus quadrangularis might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Cissus Quadrangularis + Canagliflozin, Metformin answer

Can you take Clove with Canagliflozin, Metformin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of clove extracts with antidiabetes drugs might increase the risk of hypoglycemia.

Full Clove + Canagliflozin, Metformin answer

Can you take Coca with Canagliflozin, Metformin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, coca might reduce the effects of antidiabetes drugs.

Full Coca + Canagliflozin, Metformin answer

Can you take Cod Liver Oil with Canagliflozin, Metformin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking cod liver oil with antidiabetes drugs might increase the risk of hypoglycemia.

Full Cod Liver Oil + Canagliflozin, Metformin answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Canagliflozin, Metformin is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Canagliflozin, Metformin, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Canagliflozin, Metformin sits in 4 interaction categories. Open any one to see what the group means:

Antidiabetes Drugs 239 ingredients

Blood-sugar-lowering medications. Supplements that also lower glucose can push blood sugar too low when combined.

239 of the supplement ingredients on this page reach Canagliflozin, Metformin through this category.

Metformin (Glucophage) 18 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

18 of the supplement ingredients on this page reach Canagliflozin, Metformin through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Canagliflozin, Metformin through this category.

Organic Cation Transporter 2 (Oct2) Substrates 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Canagliflozin, Metformin through this category.

Related: does Canagliflozin, Metformin deplete any nutrients?

Canagliflozin, Metformin has 4 reported nutrient associations in the research literature — see the Canagliflozin, Metformin nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Canagliflozin, Metformin

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Canagliflozin, Metformin.

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Pharmacist Counseling Corner

Canagliflozin, Metformin & Supplements: Common Questions

What supplements interact with Canagliflozin, Metformin?
More than you might expect — 257 in total, though they are far from equal: 2 are rated major, 217 moderate, and 38 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Siberian Cocklebur, Activated Charcoal, American Ginseng.
Which Canagliflozin, Metformin supplement interactions are the most serious?
The 2 major-rated combinations — led by Siberian Cocklebur and Activated Charcoal — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Canagliflozin, Metformin?
Usually yes — most people on Canagliflozin, Metformin can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Invokamet have the same supplement interactions as Canagliflozin, Metformin?
Yes — Invokamet, Invokamet XR all contain Canagliflozin, Metformin, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Canagliflozin, Metformin deplete any vitamins or nutrients?
It might — Canagliflozin, Metformin has 4 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Canagliflozin, Metformin nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Canagliflozin, Metformin and my other medications?
This page covers Canagliflozin, Metformin against supplements and herbal ingredients. Checking Canagliflozin, Metformin against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 15, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.