Medication interaction hub

What Supplements Interact with Dihydroergotamine Mesylate?

Dihydroergotamine Mesylate brand name: Trudhesa. Every interaction below applies to the brands too.

139 Interactions 3 Major 103 Moderate 33 Minor
Curated & coded by · Clinical Pharmacist · Updated October 1, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Dihydroergotamine Mesylate? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Dihydroergotamine Mesylate against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Before you pair any supplement with dihydroergotamine mesylate (Trudhesa), a migraine medicine that works partly by tightening blood vessels, understand that this list deserves genuine care. Of the 139 ingredients on file, three rate major: grapefruit, St. John's wort, and lithium. Grapefruit blocks the CYP3A4 enzyme that clears the drug, so blood levels can climb, and more of a vessel-tightening drug in your system is exactly what you do not want. St. John's wort does the reverse and speeds the drug's breakdown, while lithium adds to its serotonin activity.

The rest of the list mostly repeats those same two mechanisms at lower intensity. Roughly 121 ingredients can nudge the drug's level up or down through CYP3A4, and about 20 add serotonin effects that can stack toward serotonin syndrome. A few ephedrine-containing herbs push blood pressure higher on top of an ergot drug. The 103 moderate and 33 minor entries matter less than the three majors, so if grapefruit juice or St. John's wort is already in your cabinet, start there.

— , Clinical Pharmacist · July 18, 2026

Major 3 Moderate 103 Minor 33 No known interaction 1,313

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Dihydroergotamine Mesylate: Top Interactions at a Glance

The most significant Dihydroergotamine Mesylate supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 139 interacting ingredients — plus 1,313 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Dihydroergotamine Mesylate + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely Grapefruit + Dihydroergotamine Mesylatei

Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Read the full interaction Major Likelihood Probable Lithium + Dihydroergotamine Mesylatei

Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.

Read the full interaction Major Likelihood Probable St. John's Wort + Dihydroergotamine Mesylatei

St.

Read the full interaction
The complete list

Every Supplement Checked Against Dihydroergotamine Mesylate

All 1,452 ingredients in our database, ranked by severity — 139 with a Dihydroergotamine Mesylate interaction on file and 1,313 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Dihydroergotamine Mesylate?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Cubebs with Dihydroergotamine Mesylate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Several compounds isolated from cubebs can inhibit cytochrome P450 3A4 (CYP3A4) in vitro.

Full Cubebs + Dihydroergotamine Mesylate answer

Can you take Danshen with Dihydroergotamine Mesylate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Danshen might alter the levels and clinical effects of drugs metabolized by CYP3A4.

Full Danshen + Dihydroergotamine Mesylate answer

Can you take Devil's Claw with Dihydroergotamine Mesylate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.

Full Devil's Claw + Dihydroergotamine Mesylate answer

Can you take Dhea with Dihydroergotamine Mesylate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.

Full Dhea + Dihydroergotamine Mesylate answer

Can you take Diosmin with Dihydroergotamine Mesylate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, diosmin might inhibit the metabolism of CYP3A4 substrates.

Full Diosmin + Dihydroergotamine Mesylate answer

Can you take Echinacea with Dihydroergotamine Mesylate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Echinacea may induce hepatic CYP3A4 and inhibit intestinal CYP3A4.

Full Echinacea + Dihydroergotamine Mesylate answer

Can you take Ergot with Dihydroergotamine Mesylate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Certain ergot alkaloids, such as dihydroergotamine, act as serotonin agonists.

Full Ergot + Dihydroergotamine Mesylate answer

Can you take Eucalyptus with Dihydroergotamine Mesylate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, eucalyptus might increase the levels of CYP3A4 substrates.

Full Eucalyptus + Dihydroergotamine Mesylate answer

Can you take European Barberry with Dihydroergotamine Mesylate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, European barberry might increase the levels and clinical effects of CYP3A4 substrates.

Full European Barberry + Dihydroergotamine Mesylate answer

Can you take Evodia with Dihydroergotamine Mesylate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, evodia might increase the levels and clinical effects of CYP3A4 substrates.

Full Evodia + Dihydroergotamine Mesylate answer

Can you take False Unicorn with Dihydroergotamine Mesylate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro, false unicorn extract inhibits cytochrome P450 3A4 (CYP3A4) activity.

Full False Unicorn + Dihydroergotamine Mesylate answer

Can you take Fennel with Dihydroergotamine Mesylate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.

Full Fennel + Dihydroergotamine Mesylate answer

Can you take Fermented Wheat Germ Extract with Dihydroergotamine Mesylate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of fermented wheat germ extract with serotonergic medications may increase the risk of serotonergic adverse e...

Full Fermented Wheat Germ Extract + Dihydroergotamine Mesylate answer

Can you take Feverfew with Dihydroergotamine Mesylate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, feverfew might increase levels of drugs metabolized by CYP3A4.

Full Feverfew + Dihydroergotamine Mesylate answer

Can you take Fo-ti with Dihydroergotamine Mesylate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, fo-ti might increase the levels and clinical effects of drugs metabolized by CYP3A4.

Full Fo-ti + Dihydroergotamine Mesylate answer

Can you take Garcinia with Dihydroergotamine Mesylate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, combining garcinia with other serotonergic drugs might increase the risk of serotonergic side effects, including serotonin sy...

Full Garcinia + Dihydroergotamine Mesylate answer

Can you take Garlic with Dihydroergotamine Mesylate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.

Full Garlic + Dihydroergotamine Mesylate answer

Can you take German Chamomile with Dihydroergotamine Mesylate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, German chamomile might inhibit CYP3A4 and increase levels of drugs metabolized by these enzymes.

Full German Chamomile + Dihydroergotamine Mesylate answer

Can you take Ginger with Dihydroergotamine Mesylate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Ginger might increase or decrease the levels of CYP3A4 substrates.

Full Ginger + Dihydroergotamine Mesylate answer

Can you take Ginkgo with Dihydroergotamine Mesylate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, ginkgo might decrease levels of drugs metabolized by CYP3A4.

Full Ginkgo + Dihydroergotamine Mesylate answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Dihydroergotamine Mesylate is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Dihydroergotamine Mesylate, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Dihydroergotamine Mesylate sits in 4 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Dihydroergotamine Mesylate through this category.

Serotonergic Drugs 20 ingredients

Medications that raise serotonin activity. Combining them with serotonin-active supplements can, in rare cases, push serotonin too high.

20 of the supplement ingredients on this page reach Dihydroergotamine Mesylate through this category.

Ergot Derivatives 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Dihydroergotamine Mesylate through this category.

Serotonergic Drugs 1 ingredient

Medications that raise serotonin activity. Combining them with serotonin-active supplements can, in rare cases, push serotonin too high.

1 of the supplement ingredient on this page reaches Dihydroergotamine Mesylate through this category.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Dihydroergotamine Mesylate

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Dihydroergotamine Mesylate.

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Pharmacist Counseling Corner

Dihydroergotamine Mesylate & Supplements: Common Questions

What supplements interact with Dihydroergotamine Mesylate?
Our database currently documents 139 ingredients with a known Dihydroergotamine Mesylate interaction (3 major, 103 moderate, 33 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 139. The highest-ranked right now: Grapefruit, Lithium, St. John's Wort.
Which Dihydroergotamine Mesylate supplement interactions are the most serious?
The 3 major-rated combinations — led by Grapefruit, Lithium and St. John's Wort — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Dihydroergotamine Mesylate?
Plenty of supplements coexist fine with Dihydroergotamine Mesylate; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Trudhesa have the same supplement interactions as Dihydroergotamine Mesylate?
Yes — Trudhesa all contain Dihydroergotamine Mesylate, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Dihydroergotamine Mesylate and my other medications?
This page covers Dihydroergotamine Mesylate against supplements and herbal ingredients. Checking Dihydroergotamine Mesylate against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of October 1, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.