Medication interaction hub

What Supplements Interact with Fondaparinux?

Fondaparinux brand name: Arixtra. Every interaction below applies to the brands too.

202 Interactions 2 Major 183 Moderate 17 Minor
Curated & coded by · Clinical Pharmacist · Updated September 15, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Fondaparinux? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Fondaparinux against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Most people on fondaparinux (Arixtra) are recovering from surgery or treating a blood clot, exactly the moment supplements for circulation and recovery come out of the cabinet. This pairing deserves real care, because nearly all 202 ingredients on this list share one problem: they thin the blood a little on their own, so adding them to an injectable anticoagulant raises the chance of bruising and bleeding. Danshen and piracetam are the two rated major, and the entries to understand first.

The other 183 moderate and 17 minor entries mostly show antiplatelet effects in lab or animal work rather than human trials, but weaker evidence is not permission to shrug on a drug whose whole job is stopping clots without causing bleeds. Bismuth is the odd one out and may blunt fondaparinux instead. Unusual bruising, blood in urine or stool, or a cut that will not stop deserves a same-day call to your prescriber.

— , Clinical Pharmacist · July 18, 2026

Major 2 Moderate 183 Minor 17 No known interaction 1,250

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Fondaparinux: Top Interactions at a Glance

The Fondaparinux supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 202 interacting ingredients — plus 1,250 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Fondaparinux Combinations Today

The Fondaparinux + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Bromelain + Fondaparinuxi

Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Read the full interaction Moderate Likelihood Possible Melatonin + Fondaparinuxi

Theoretically, melatonin may have anticoagulant effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Read the full interaction Moderate Likelihood Possible Reishi Mushroom + Fondaparinuxi

Theoretically, high doses of reishi mushroom might increase the risk of bleeding.

Read the full interaction Moderate Likelihood Possible Lion's Mane Mushroom + Fondaparinuxi

Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.

Read the full interaction Major Likelihood Probable Danshen + Fondaparinuxi

Theoretically, danshen may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Read the full interaction Major Likelihood Probable Piracetam + Fondaparinuxi

Theoretically, concomitant use of piracetam and anticoagulant/antiplatelet drugs might increase the risk of bleeding.

Read the full interaction
The complete list

Every Supplement Checked Against Fondaparinux

All 1,452 ingredients in our database, ranked by severity — 202 with a Fondaparinux interaction on file and 1,250 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Fondaparinux?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Bromelain with Fondaparinux?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Bromelain + Fondaparinux answer

Can you take Melatonin with Fondaparinux?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, melatonin may have anticoagulant effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet dru...

Full Melatonin + Fondaparinux answer

Can you take Reishi Mushroom with Fondaparinux?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, high doses of reishi mushroom might increase the risk of bleeding.

Full Reishi Mushroom + Fondaparinux answer

Can you take Lion's Mane Mushroom with Fondaparinux?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.

Full Lion's Mane Mushroom + Fondaparinux answer

Can you take Sweet Vernal Grass with Fondaparinux?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Hay prepared from dried sweet vernal grass contains an anticoagulant, dicoumarol, which has been associated with fatal hemorrhages in animal...

Full Sweet Vernal Grass + Fondaparinux answer

Can you take Tarragon with Fondaparinux?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from in vitro research suggests that tarragon extract inhibits platelet aggregation and adhesion.

Full Tarragon + Fondaparinux answer

Can you take Terminalia with Fondaparinux?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of Terminalia arjuna with anticoagulant or antiplatelet drugs may increase the risk of bleeding in some patie...

Full Terminalia + Fondaparinux answer

Can you take Thyme with Fondaparinux?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, thyme leaf extract might have additive effects with anticoagulant or antiplatelet drugs.

Full Thyme + Fondaparinux answer

Can you take Tiratricol with Fondaparinux?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tiratricol might increase the hypoprothrombinemic effects of oral anticoagulants.

Full Tiratricol + Fondaparinux answer

Can you take Tree Of Heaven with Fondaparinux?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or antic...

Full Tree Of Heaven + Fondaparinux answer

Can you take Tree Turmeric with Fondaparinux?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tree turmeric might have additive effects when used with anticoagulant and antiplatelet drugs and increase the risk of bleedi...

Full Tree Turmeric + Fondaparinux answer

Can you take Turmeric with Fondaparinux?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Turmeric may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Turmeric + Fondaparinux answer

Can you take Vanadium with Fondaparinux?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, vanadium might increase the risk of bleeding when taken with anticoagulant/antiplatelet drugs.

Full Vanadium + Fondaparinux answer

Can you take Vinpocetine with Fondaparinux?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Vinpocetine might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.

Full Vinpocetine + Fondaparinux answer

Can you take Vitamin E with Fondaparinux?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Concomitant use of vitamin E and anticoagulant or antiplatelet agents might increase the risk of bleeding.

Full Vitamin E + Fondaparinux answer

Can you take Wasabi with Fondaparinux?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, wasabi might increase the risk of bleeding with anticoagulant or antiplatelet drugs.

Full Wasabi + Fondaparinux answer

Can you take White Pepper with Fondaparinux?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro evidence suggests that piperine, a constituent of white pepper, inhibits platelet aggregation.

Full White Pepper + Fondaparinux answer

Can you take Yerba Mate with Fondaparinux?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, the caffeine in yerba mate may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Yerba Mate + Fondaparinux answer

Can you take Arnica with Fondaparinux?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, arnica might have additive effects with anticoagulant and antiplatelet drugs.

Full Arnica + Fondaparinux answer

Can you take Blue-green Algae with Fondaparinux?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, spirulina blue-green algae might increase the risk of bleeding if used with other anticoagulant or antiplatelet drugs.

Full Blue-green Algae + Fondaparinux answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Fondaparinux is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Fondaparinux, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Fondaparinux sits in 1 interaction category. Open any one to see what the group means:

Anticoagulant/Antiplatelet Drugs 202 ingredients

Blood-thinning medications. Supplements with their own effects on clotting or platelets can add up with these drugs and raise bleeding risk.

202 of the supplement ingredients on this page reach Fondaparinux through this category.

About Fondaparinux

Fondaparinux injection is a blood thinner (anticoagulant) used to prevent and treat dangerous blood clots, including deep vein thrombosis and pulmonary embolism, in adults and certain children.

Generic name: Fondaparinux  ·  Brand name: Arixtra.

See the full Fondaparinux Injection drug information
Check a real product

Take a Supplement Product? Check the Whole Bottle Against Fondaparinux

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Fondaparinux.

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Pharmacist Counseling Corner

Fondaparinux & Supplements: Common Questions

What supplements interact with Fondaparinux?
In our interaction database, 202 supplement and herbal ingredients have an interaction with Fondaparinux on file — 2 rated major, 183 moderate, and 17 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Danshen, Piracetam, Bridelia.
Which Fondaparinux supplement interactions are the most serious?
Focus on the major group: Danshen and Piracetam. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Fondaparinux?
That depends entirely on which supplement. The honest answer for Fondaparinux is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Arixtra have the same supplement interactions as Fondaparinux?
Yes — Arixtra all contain Fondaparinux, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Fondaparinux and my other medications?
This page covers Fondaparinux against supplements and herbal ingredients. Checking Fondaparinux against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Fondaparinux Injection drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 15, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.