Medication interaction hub

What Supplements Interact with Loperamide?

Loperamide brand names: Imodium, Loperamide. Every interaction below applies to the brands too.

82 Interactions 4 Major 59 Moderate 19 Minor
Curated & coded by · Clinical Pharmacist · Updated September 24, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Loperamide? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Loperamide against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Loperamide (Imodium) works safely in part because a gut transporter, P-glycoprotein, keeps most of each dose out of the bloodstream, and the biggest group on this list, 37 ingredients, acts on that transporter. St. John's wort revs the pump up and can wash out loperamide's antidiarrheal effect, while others block it and can raise the drug's levels. I'd read this page carefully, not skim it, before adding any herbal product to regular loperamide use.

Another 30 ingredients, henbane among them, layer anticholinergic effects onto a drug that already slows the gut, so constipation, dry mouth, and grogginess can pile up. A smaller set interferes with absorbing anything swallowed; activated charcoal leads it, and spacing doses well apart is the practical fix. Four of the 82 entries rate major, and those deserve your attention first; the 59 moderate and 19 minor ones mostly repeat the same themes in softer form.

— , Clinical Pharmacist · July 18, 2026

Major 4 Moderate 59 Minor 19 No known interaction 1,370

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Loperamide: Top Interactions at a Glance

The Loperamide supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 82 interacting ingredients — plus 1,370 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Loperamide Combinations Today

The Loperamide + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Minor Likelihood Possible Devil's Claw + Loperamidei

Theoretically, devil's claw might increase levels of P-glycoprotein substrates.

Read the full interaction Minor Likelihood Possible Black Psyllium + Loperamidei

Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Read the full interaction Moderate Likelihood Possible Jimson Weed + Loperamidei

Theoretically, jimson weed may increase anticholinergic effects and adverse effects.

Read the full interaction Major Likelihood Probable Henbane + Loperamidei

Concomitant use of henbane can have additive anticholinergic effects and adverse effects with amantadine, antihistamines, atropine, belladonna alkaloids, hyoscy...

Read the full interaction Moderate Likelihood Possible Bitter Melon + Loperamidei

Theoretically, bitter melon might increase levels of P-glycoprotein substrates.

Read the full interaction Minor Likelihood Possible Turmeric + Loperamidei

Theoretically, turmeric might increase the absorption of P-glycoprotein substrates.

Read the full interaction
The complete list

Every Supplement Checked Against Loperamide

All 1,452 ingredients in our database, ranked by severity — 82 with a Loperamide interaction on file and 1,370 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Loperamide?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Devil's Claw with Loperamide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, devil's claw might increase levels of P-glycoprotein substrates.

Full Devil's Claw + Loperamide answer

Can you take Black Psyllium with Loperamide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Black Psyllium + Loperamide answer

Can you take Jimson Weed with Loperamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, jimson weed may increase anticholinergic effects and adverse effects.

Full Jimson Weed + Loperamide answer

Can you take Henbane with Loperamide?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Concomitant use of henbane can have additive anticholinergic effects and adverse effects with amantadine, antihistamines, atropine, belladon...

Full Henbane + Loperamide answer

Can you take Bitter Melon with Loperamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, bitter melon might increase levels of P-glycoprotein substrates.

Full Bitter Melon + Loperamide answer

Can you take Baikal Skullcap with Loperamide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, Baikal skullcap might increase levels of drugs transported by P-glycoprotein.

Full Baikal Skullcap + Loperamide answer

Can you take Blond Psyllium with Loperamide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Blond Psyllium + Loperamide answer

Can you take Carob with Loperamide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, carob might also impair the absorption of oral drugs.

Full Carob + Loperamide answer

Can you take Grapefruit with Loperamide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Grapefruit juice does not seem to affect renal P-glycoprotein (P-gp).

Full Grapefruit + Loperamide answer

Can you take Karaya Gum with Loperamide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Co-administration of oral drugs with bulk forming laxatives such as karaya gum may decrease, increase, or have no effect on the absorption o...

Full Karaya Gum + Loperamide answer

Can you take Marshmallow with Loperamide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, mucilage in marshmallow might impair absorption of oral drugs.

Full Marshmallow + Loperamide answer

Can you take Puravive with Loperamide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Puravive contains quercetin.

Full Puravive + Loperamide answer

Can you take Sesame with Loperamide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, sesame might alter the transport of P-glycoprotein substrates.

Full Sesame + Loperamide answer

Can you take Turmeric with Loperamide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, turmeric might increase the absorption of P-glycoprotein substrates.

Full Turmeric + Loperamide answer

Can you take Uva Ursi with Loperamide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, uva ursi may alter the levels of drugs transported by P-glycoprotein.

Full Uva Ursi + Loperamide answer

Can you take Xanthan Gum with Loperamide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, xanthan gum can alter the absorption of oral drugs due to its fiber qualities.

Full Xanthan Gum + Loperamide answer

Can you take Calabar Bean with Loperamide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, taking calabar bean might reduce the effects of anticholinergic drugs.

Full Calabar Bean + Loperamide answer

Can you take Deanol with Loperamide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, deanol might decrease the effectiveness of anticholinergic drugs.

Full Deanol + Loperamide answer

Can you take Milk Thistle with Loperamide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, milk thistle might increase the absorption of P-glycoprotein substrates.

Full Milk Thistle + Loperamide answer

Can you take Activated Charcoal with Loperamide?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the rout...

Full Activated Charcoal + Loperamide answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Loperamide is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Loperamide, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Loperamide sits in 3 interaction categories. Open any one to see what the group means:

P-Glycoprotein Substrates 37 ingredients

A drug-transport group: these medications are moved in and out of cells by the P-glycoprotein pump. Supplements that affect the pump can change how much of the drug is absorbed or kept in the body.

37 of the supplement ingredients on this page reach Loperamide through this category.

Anticholinergic Drugs 30 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

30 of the supplement ingredients on this page reach Loperamide through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Loperamide through this category.

About Loperamide

Loperamide is an antidiarrheal medication used to control acute diarrhea and reduce bowel movements.

Generic name: Loperamide  ·  Brand names: Imodium, Loperamide.

See the full Loperamide drug information
Check a real product

Take a Supplement Product? Check the Whole Bottle Against Loperamide

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Loperamide.

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Pharmacist Counseling Corner

Loperamide & Supplements: Common Questions

What supplements interact with Loperamide?
Our database currently documents 82 ingredients with a known Loperamide interaction (4 major, 59 moderate, 19 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 82. The highest-ranked right now: Activated Charcoal, Henbane, Scopolia.
Which Loperamide supplement interactions are the most serious?
Focus on the major group: Activated Charcoal, Henbane, Scopolia and St. John's Wort. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Loperamide?
Plenty of supplements coexist fine with Loperamide; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Imodium have the same supplement interactions as Loperamide?
Yes — Imodium, Loperamide all contain Loperamide, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Loperamide and my other medications?
This page covers Loperamide against supplements and herbal ingredients. Checking Loperamide against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Loperamide drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 24, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.