Medication interaction hub

What Supplements Interact with Mesoridazine Besylate?

Mesoridazine Besylate brand name: Serentil. Every interaction below applies to the brands too.

66 Interactions 11 Major 43 Moderate 12 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Mesoridazine Besylate? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Mesoridazine Besylate against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Mesoridazine (Serentil) is an older antipsychotic already known for disturbing heart rhythm on its own, so I read its interaction list with genuine concern. Of the 66 supplements and herbs on file, 11 are rated major, and most of those do one of two things: deepen the drug's effect on the heart's electrical timing (QT prolongation) or pile on its drying anticholinergic side effects, meaning constipation, blurred vision, and confusion. Grapefruit, the most everyday item in the major group, sits on the heart-rhythm side.

The 43 moderate and 12 minor entries mostly echo those same patterns at lower intensity. Thirty ingredients here carry anticholinergic activity of their own, and eight can strengthen the antipsychotic effect itself. A separate cluster of 17, activated charcoal chief among them, can keep the tablet from being absorbed; space those well apart from your dose, and read the eleven major write-ups first.

— , Clinical Pharmacist · July 18, 2026

Major 11 Moderate 43 Minor 12 No known interaction 1,386

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Mesoridazine Besylate: Top Interactions at a Glance

The Mesoridazine Besylate supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 66 interacting ingredients — plus 1,386 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Mesoridazine Besylate Combinations Today

The Mesoridazine Besylate + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Minor Likelihood Possible Black Psyllium + Mesoridazine Besylatei

Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Read the full interaction Minor Likelihood Unlikely Cannabis + Mesoridazine Besylatei

Cannabis does not seem to affect blood levels or effects of some antipsychotic drugs.

Read the full interaction Major Likelihood Probable Indian Snakeroot + Mesoridazine Besylatei

Theoretically, concomitant use might increase the risk of adverse effects.

Read the full interaction Moderate Likelihood Possible Bacopa + Mesoridazine Besylatei

Theoretically, concurrent use might decrease the effectiveness of both agents.

Read the full interaction Minor Likelihood Unlikely Calabar Bean + Mesoridazine Besylatei

Theoretically, taking calabar bean might reduce the effects of anticholinergic drugs.

Read the full interaction Major Likelihood Probable Activated Charcoal + Mesoridazine Besylatei

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction
The complete list

Every Supplement Checked Against Mesoridazine Besylate

All 1,452 ingredients in our database, ranked by severity — 66 with a Mesoridazine Besylate interaction on file and 1,386 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Mesoridazine Besylate?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Black Psyllium with Mesoridazine Besylate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Black Psyllium + Mesoridazine Besylate answer

Can you take Cannabis with Mesoridazine Besylate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Cannabis does not seem to affect blood levels or effects of some antipsychotic drugs.

Full Cannabis + Mesoridazine Besylate answer

Can you take Indian Snakeroot with Mesoridazine Besylate?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, concomitant use might increase the risk of adverse effects.

Full Indian Snakeroot + Mesoridazine Besylate answer

Can you take Bacopa with Mesoridazine Besylate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use might decrease the effectiveness of both agents.

Full Bacopa + Mesoridazine Besylate answer

Can you take Calabar Bean with Mesoridazine Besylate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, taking calabar bean might reduce the effects of anticholinergic drugs.

Full Calabar Bean + Mesoridazine Besylate answer

Can you take Carob with Mesoridazine Besylate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, carob might also impair the absorption of oral drugs.

Full Carob + Mesoridazine Besylate answer

Can you take Karaya Gum with Mesoridazine Besylate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Co-administration of oral drugs with bulk forming laxatives such as karaya gum may decrease, increase, or have no effect on the absorption o...

Full Karaya Gum + Mesoridazine Besylate answer

Can you take Marshmallow with Mesoridazine Besylate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, mucilage in marshmallow might impair absorption of oral drugs.

Full Marshmallow + Mesoridazine Besylate answer

Can you take Xanthan Gum with Mesoridazine Besylate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, xanthan gum can alter the absorption of oral drugs due to its fiber qualities.

Full Xanthan Gum + Mesoridazine Besylate answer

Can you take Deanol with Mesoridazine Besylate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, deanol might decrease the effectiveness of anticholinergic drugs.

Full Deanol + Mesoridazine Besylate answer

Can you take Activated Charcoal with Mesoridazine Besylate?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the rout...

Full Activated Charcoal + Mesoridazine Besylate answer

Can you take Arsenic with Mesoridazine Besylate?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Arsenic trioxide can prolong the QT interval.

Full Arsenic + Mesoridazine Besylate answer

Can you take Cesium with Mesoridazine Besylate?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, taking cesium concomitantly with other drugs that prolong the QT interval may increase the risk of ventricular arrhythmias an...

Full Cesium + Mesoridazine Besylate answer

Can you take Ephedra with Mesoridazine Besylate?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, ephedra might have an additive effect with drugs that prolong the QT interval.

Full Ephedra + Mesoridazine Besylate answer

Can you take Grapefruit with Mesoridazine Besylate?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Grapefruit or grapefruit juice, especially if consumed in large amounts, can cause additive QT interval prolongation when taken with QT inte...

Full Grapefruit + Mesoridazine Besylate answer

Can you take Henbane with Mesoridazine Besylate?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Concomitant use of henbane can have additive anticholinergic effects and adverse effects with amantadine, antihistamines, atropine, belladon...

Full Henbane + Mesoridazine Besylate answer

Can you take Rauvolfia Vomitoria with Mesoridazine Besylate?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, concomitant use might increase the risk of adverse effects.

Full Rauvolfia Vomitoria + Mesoridazine Besylate answer

Can you take Scopolia with Mesoridazine Besylate?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. The alkaloid constituents of scopolia, including hyoscyamine, scopolamine, and atropine, could potentiate the effects and adverse effects of...

Full Scopolia + Mesoridazine Besylate answer

Can you take Sida Cordifolia with Mesoridazine Besylate?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, Sida cordifolia might increase the risk of additive QT interval prolongation when taken with QT interval-prolonging drugs.

Full Sida Cordifolia + Mesoridazine Besylate answer

Can you take American Hellebore with Mesoridazine Besylate?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. American hellebore, also known as Veratrum viride, contains alkaloids that can potentially prolong the QT interval on an electrocardiogram (...

Full American Hellebore + Mesoridazine Besylate answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Mesoridazine Besylate is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Mesoridazine Besylate, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Mesoridazine Besylate sits in 4 interaction categories. Open any one to see what the group means:

Anticholinergic Drugs 30 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

30 of the supplement ingredients on this page reach Mesoridazine Besylate through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Mesoridazine Besylate through this category.

Qt Interval-Prolonging Drugs 13 ingredients

Medications that can affect the heart's electrical rhythm (the QT interval). Supplements with similar effects can add to that risk.

13 of the supplement ingredients on this page reach Mesoridazine Besylate through this category.

Antipsychotic Drugs 8 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

8 of the supplement ingredients on this page reach Mesoridazine Besylate through this category.

About Mesoridazine Besylate

Mesoridazine Besylate is a prescription medication also sold under the brand name Serentil. Because supplements and herbal products can change how medications work — or how strongly — every ingredient on this page has been checked against it in our interaction database.

Generic name: Mesoridazine Besylate  ·  Brand name: Serentil.

See the full Mesoridazine drug information
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Take a Supplement Product? Check the Whole Bottle Against Mesoridazine Besylate

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Mesoridazine Besylate.

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Pharmacist Counseling Corner

Mesoridazine Besylate & Supplements: Common Questions

What supplements interact with Mesoridazine Besylate?
In our interaction database, 66 supplement and herbal ingredients have an interaction with Mesoridazine Besylate on file — 11 rated major, 43 moderate, and 12 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Activated Charcoal, Arsenic, Cesium.
Which Mesoridazine Besylate supplement interactions are the most serious?
The 11 major-rated combinations — led by Activated Charcoal, Arsenic, Cesium, Ephedra and Grapefruit — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Mesoridazine Besylate?
That depends entirely on which supplement. The honest answer for Mesoridazine Besylate is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Serentil have the same supplement interactions as Mesoridazine Besylate?
Yes — Serentil all contain Mesoridazine Besylate, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Mesoridazine Besylate and my other medications?
This page covers Mesoridazine Besylate against supplements and herbal ingredients. Checking Mesoridazine Besylate against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Mesoridazine drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.