Alkaline Balance Ingredients & Drug Interactions
by Source Naturals
What is this page for?
First and foremost: checking Alkaline Balance against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Alkaline Balance is a dietary supplement by Source Naturals with 20 active ingredients. Its ingredients are commonly taken for replacing fluids and electrolytes, preventing dehydration during exercise or illness, treating low blood sodium (under medical care).Based on those ingredients, 1,521 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Ginger, Red Beet, Kudzu. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Alkaline Balance by Source Naturals
Ask about any prescription or over-the-counter medication and we check it for interactions with Alkaline Balance by Source Naturals — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Alkaline Balance by Source Naturals
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Alkaline Balance contains 20 active ingredients, a mix of minerals, vegetables, herbs, and plant extracts. The mineral backbone includes sodium, potassium, calcium, and magnesium—electrolytes that the product aims to balance.
The vegetable and plant components are red beet, chlorella, carrot, spirulina, barley, wheat grass, broccoli, cabbage, parsley, ginger, dandelion, and kudzu, along with burdock root and apple cider vinegar concentrate. The product also contains inactive ingredients (fillers and binders) such as sodium citrate, stearic acid, modified cellulose gum, hydroxypropyl cellulose, and silica.
Does it work?
Moderate evidence
The evidence for effectiveness is mixed across the ingredients. Barley shows likely effectiveness for high cholesterol and coronary heart disease.
Calcium is effective for kidney failure, indigestion, and osteoporosis, and likely effective for low blood calcium. Magnesium is effective for indigestion, constipation, low blood magnesium, and pre-eclampsia.
Red beet is possibly effective for athletic performance and muscle soreness. Ginger is possibly effective for pregnancy-related nausea, period pain, and osteoarthritis.
Chlorella is possibly effective for pregnancy-related iron deficiency. Spirulina is possibly effective for high blood pressure.
For many other ingredients and conditions—including the product's alkalinity claim—the evidence we hold is insufficient to rate effectiveness. Talk to your pharmacist about what goal you're trying to achieve with this product.
How safe is it?
Well-documented data
Most ingredients are generally well tolerated in food amounts. Sodium, when taken in excess above dietary levels, is linked to high blood pressure and kidney strain, so the product's sodium content matters if you're salt-sensitive or have heart or kidney disease.
Chlorella and spirulina vary widely in purity and can contain contaminants; quality control is a real concern. Burdock is likely safe as a food but has limited long-term safety data and rare allergic reactions.
Wheat grass and dandelion also lack robust safety data at supplement doses. Ginger is generally well tolerated but can cause heartburn, diarrhea, and (at higher doses) bleeding risk.
Parsley in large amounts may stimulate the uterus and is not safe in pregnancy. Pregnancy and lactation data are limited or absent for most ingredients; the few with ratings (sodium, carrot, calcium, magnesium, barley, ginger) are rated likely or possibly safe, but individual ingredients without pregnancy ratings lack sufficient safety information—discuss with your doctor if you're pregnant or nursing.
Meds to double-check
Major interaction found
Check with your pharmacist before taking this product if you use any of the following: HIV integrase inhibitors (dolutegravir, elvitegravir) or the antibiotic ceftriaxone—Major interactions with calcium. Parkinson's medications (levodopa/carbidopa)—Major interaction with magnesium.
Blood thinners or antiplatelet drugs (warfarin, aspirin, clopidogrel)—Moderate interactions with chlorella, burdock, spirulina, ginger, parsley, and dandelion. Diabetes medications—Moderate interactions with spirulina, wheat grass, cabbage, parsley, ginger, dandelion, and kudzu.
Antihypertensive drugs—Moderate interactions with sodium and red beet. Thyroid medication (levothyroxine)—Moderate interaction with calcium.
Lithium—Moderate interactions with sodium and dandelion. Diuretics, especially potassium-sparing types—Moderate interactions with potassium, apple cider vinegar, and dandelion.
Quinolone antibiotics—Moderate interactions with magnesium and dandelion. Muscle relaxants—Moderate interaction with magnesium.
The list is long; run your medications through the checker on this page.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.
Alkaline Balance might appeal to someone looking for a multi-mineral and plant-based supplement, especially one interested in barley for cholesterol or ginger for joint pain. However, the number and breadth of medication interactions—over 1,400 drugs across the ingredients—mean you absolutely must check your exact prescriptions before you start.
If you take blood thinners, diabetes drugs, thyroid medication, HIV treatments, or heart or kidney medications, talk to your pharmacist first. The sodium and potassium content also matter if you have high blood pressure, heart disease, or kidney problems.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 18 of 20 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 7, 2019.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Alkaline Balance, straight from the product label.
| Brand | Source Naturals |
|---|---|
| Barcode (UPC) | 021078016557 |
| Net contents | 60 Tablet(s) |
| Market status | On market |
| Date entered into DSLD | Jan 7, 2019 |
| DSLD ID | 181755 |
| Product type | Other Combinations |
| Supplement form | Tablet Or Pill |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Vegetarian, Adult (18 - 50 Years), Dairy Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Alkaline Balance by Source Naturals, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Calories | 10 Calorie(s) | -- |
| Total Carbohydrates | 1 Gram(s) | 1% |
| Sodium | 224 mg | 9% |
| Burdock | 200 mg | -- |
| Red Beet | 60 mg | -- |
| Chlorella | 100 mg | -- |
| Carrot | 100 mg | -- |
| Spirulina | 150 mg | -- |
| Barley | 120 mg | -- |
| Wheat Grass | 120 mg | -- |
| Potassium | 125 mg | 4% |
| Calcium | 400 mg | 40% |
| Magnesium | 50 mg | 13% |
| Apple Cider Vinegar concentrate | 400 mg | -- |
| Kudzu | 200 mg | -- |
| Broccoli | 200 mg | -- |
| Cabbage | 100 mg | -- |
| freeze dried Pea | 100 mg | -- |
| Oat Bran Fiber Blend | 100 mg | -- |
| Parsley | 100 mg | -- |
| Ginger | 60 mg | -- |
| Dandelion whole plant/root ext | 50 mg | -- |
Other ingredients: Sodium Citrate, Stearic Acid, modified Cellulose Gum, Hydroxypropyl Cellulose, Silica
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity
Dietary Supplement
General Statements
To support pH balance
Research shows that a more alkaline pH diet promotes general health and well-being, but many of us don't realize that our modern diets can prompt an acidic shift in urinary pH levels.
Formula
Contains wheat and soy.
It contains mineral citrates, which research has shown to be alkalinizing, as well as coral calcium and a proprietary blend of herbs and green food powders that complement the overall health benefits of the product.
Precautions
Contains wheat and soy.
Caution: If you are pregnant, may become pregnant, breastfeeding, taking prescription heart or blood pressure medication, or are on a low sodium diet, consult your health care professional before using this product.
Do not use if either tamper-evident seal is broken or missing.
Keep out of the reach of children.
Brand IP Statement(s)
Source Naturals Alkaline Balance is specifically designed to aid the body in supporting healthy acid/alkaline balance.
Suggested/Recommended/Usage/Directions
Suggested Use: 4 tablets daily with food.
Formulation
Suitable for Vegetarians.
Contains no yeast, dairy, egg, sugar, starch, preservatives, or artificial color, flavor or fragrance.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
General
SN1655 REV K173-K (49)
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Alkaline Balance by Source Naturals label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Alkaline Balance by Source Naturals
These are the 20 active ingredients this product is made of. Select any to open its full monograph.
Serving size4 Tablet(s) Dosage formTablet Or Pill Servings per container15 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Sodium
Interacts with205 drugs
Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...
Sodium monograph & interactionsBurdock
Interacts with122 drugs
Burdock is a traditional herb most often used for skin problems and as a so-called 'blood purifier,' but high-quality human studies are lacking and mo...
Burdock monograph & interactionsRed Beet
Interacts with861 drugs
Beet, especially beetroot juice, is a nitrate-rich food that may modestly lower blood pressure and slightly improve exercise performance in some peopl...
Red Beet monograph & interactionsChlorella
Interacts with337 drugs
Chlorella is a nutrient-rich freshwater green algae taken as a supplement for general wellness, immune support, and 'detox.' Some small studies sugges...
Chlorella monograph & interactionsCarrot
No knowninteractions
Carrot is a common food vegetable that is a rich source of beta-carotene (which the body turns into vitamin A) and other nutrients. Eating carrots is...
Carrot monograph & interactionsSpirulina
Interacts with327 drugs
Blue-green algae are nutrient-rich aquatic microorganisms (such as spirulina and Klamath Lake algae) taken as a supplement for energy, nutrition, and...
Spirulina monograph & interactionsBarley
Interacts with1 drug
Barley is a nutritious whole grain that is a good source of soluble fiber called beta-glucan, which has solid evidence for modestly lowering LDL ('bad...
Barley monograph & interactionsWheat Grass
Interacts with272 drugs
Wheatgrass is the young grass of the wheat plant, taken as a juice or powder, and is mainly used as a concentrated source of vitamins and plant nutrie...
Wheat Grass monograph & interactionsPotassium
Interacts with62 drugs
Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanc...
Potassium monograph & interactionsCalcium
Interacts with168 drugs
Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet f...
Calcium monograph & interactionsMagnesium
Interacts with295 drugs
Magnesium is an essential mineral your body needs for muscles, nerves, blood pressure, and many other functions, and supplements are useful for preven...
Magnesium monograph & interactionsApple Cider Vinegar concentrate
Interacts with162 drugs
Apple cider vinegar is a fermented apple product that many people use hoping to help with blood sugar, weight, or digestion. The evidence for most of...
Apple Cider Vinegar concentrate monograph & interactionsKudzu
Interacts with584 drugs
Kudzu is a fast-growing vine whose root has long been used in traditional Chinese medicine and is now studied mostly for reducing alcohol intake. Earl...
Kudzu monograph & interactionsBroccoli
Interacts with187 drugs
Broccoli is a nutritious cruciferous vegetable rich in fiber, vitamins, and plant compounds like sulforaphane that have drawn scientific interest for...
Broccoli monograph & interactionsCabbage
Interacts with325 drugs
Cabbage is a nutritious, low-calorie vegetable that is safe to eat as food and is sometimes applied to the skin as a leaf wrap for breast engorgement...
Cabbage monograph & interactionsFreeze dried Pea
Oat Bran Fiber Blend
Parsley
Interacts with443 drugs
Parsley is a popular culinary herb that is safe to eat in normal food amounts and is a good source of vitamins K and C. It is traditionally used as a...
Parsley monograph & interactionsGinger
Interacts with1,007 drugs
Ginger is a widely used culinary spice with a long history in traditional medicine, and it has the strongest evidence for helping with nausea and vomi...
Ginger monograph & interactionsDandelion whole plant/root ext
Interacts with457 drugs
Dandelion is a common plant used in food and traditional medicine, often promoted as a natural 'water pill' and digestive aid. Human evidence for thes...
Dandelion whole plant/root ext monograph & interactionsOther (inactive) ingredients: Sodium Citrate, Stearic Acid, Modified Cellulose Gum, Hydroxypropyl Cellulose, Silica. These complete the product’s ingredient list but are not active constituents.
Alkaline Balance by Source Naturals Drug Interactions
HelloPharmacist Interaction Report
Alkaline Balance by Source Naturals contains 20 ingredients, several of which interact with medications.
The most serious interaction is calcium with HIV integrase inhibitors—specifically dolutegravir and elvitegravir—where calcium can reduce drug levels by up to 40%, potentially undermining viral control. This is a Major severity interaction requiring careful timing: dolutegravir must be taken 2 hours before or 6 hours after calcium, and elvitegravir 2 hours before or 2 hours after.
Read the full breakdown — every affected drug type, severity by severity
Other Major interactions include calcium with the antibiotic ceftriaxone (risk of dangerous precipitation in lungs and kidneys if given intravenously together) and magnesium with levodopa/carbidopa (magnesium reduces levodopa levels by 35%), which may worsen Parkinson's symptoms.
Moderate interactions are extensive across the product. Sodium affects blood pressure drugs, corticosteroids, lithium, and several others by altering electrolyte balance or drug excretion.
Calcium interacts with levothyroxine (thyroid medication), beta-blockers like sotalol, and calcium channel blockers. Magnesium affects muscle relaxants, quinolone antibiotics, bisphosphonates, and sulfonylureas.
Burdock, red beet, chlorella, spirulina, wheat grass, ginger, parsley, and dandelion all carry Moderate interactions with blood thinners, diabetes drugs, or CYP enzyme substrates that alter how your body processes other medications.
Carrot and several other ingredients were checked and show no documented interactions. Freeze-dried pea and oat bran fiber blend could not be checked against our data.
Altogether, these interactions span 1,498 individual medications. Run your exact prescriptions through the medication checker below before starting this product.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Alkaline Balance?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Alkaline Balance interact with 1,521 drugs. Click any drug to see the details.
17 of the 20 ingredients in Alkaline Balance interact with drugs. Each result below shows which ingredient is responsible. Ginger Red Beet Kudzu Dandelion whole plant/root ext Parsley Chlorella Spirulina Cabbage Magnesium Wheat Grass Sodium Broccoli Calcium Apple Cider Vinegar concentrate Burdock Potassium Barley
AlogliptinNesina
How Alogliptin interacts with Alkaline Balance — through 9 ingredients. Tap an ingredient for the detail:
GingerCytochrome P450 3a4 (cyp3a4) Substrates, Antidiabetes Drugs Moderate
Interaction Summary
Ginger might increase or decrease the levels of CYP3A4 substrates.
Read the full Ginger + Alogliptin interactionWheat GrassAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking wheatgrass with antidiabetes drugs might lower blood glucose levels and increase the risk of hypoglycemia.
Read the full Wheat Grass + Alogliptin interactionCabbageAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, cabbage might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Cabbage + Alogliptin interactionRed BeetCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, beet might increase the levels of CYP3A4 substrates.
Read the full Red Beet + Alogliptin interactionKudzuAntidiabetes Drugs, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking kudzu with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Kudzu + Alogliptin interactionDandelion Whole Plant/root ExtAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, dandelion might increase the risk for hypoglycemia when used with antidiabetes drugs.
Read the full Dandelion Whole Plant/root Ext + Alogliptin interactionParsleyAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, parsley might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Parsley + Alogliptin interactionSpirulinaAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking blue-green algae with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Spirulina + Alogliptin interactionApple Cider Vinegar ConcentrateAntidiabetes Drugs Minor
Interaction Summary
Theoretically, taking apple cider vinegar with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Apple Cider Vinegar Concentrate + Alogliptin interactionAlogliptin, MetforminKazano
How Alogliptin, Metformin interacts with Alkaline Balance — through 8 ingredients. Tap an ingredient for the detail:
ParsleyAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, parsley might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Parsley + Alogliptin, Metformin interactionGingerAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking ginger with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Ginger + Alogliptin, Metformin interactionSpirulinaAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking blue-green algae with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Spirulina + Alogliptin, Metformin interactionCabbageAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, cabbage might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Cabbage + Alogliptin, Metformin interactionWheat GrassAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking wheatgrass with antidiabetes drugs might lower blood glucose levels and increase the risk of hypoglycemia.
Read the full Wheat Grass + Alogliptin, Metformin interactionDandelion Whole Plant/root ExtAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, dandelion might increase the risk for hypoglycemia when used with antidiabetes drugs.
Read the full Dandelion Whole Plant/root Ext + Alogliptin, Metformin interactionApple Cider Vinegar ConcentrateAntidiabetes Drugs Minor
Interaction Summary
Theoretically, taking apple cider vinegar with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Apple Cider Vinegar Concentrate + Alogliptin, Metformin interactionKudzuAntidiabetes Drugs Minor
Interaction Summary
Theoretically, taking kudzu with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Kudzu + Alogliptin, Metformin interactionAlogliptin, PioglitazoneOseni
How Alogliptin, Pioglitazone interacts with Alkaline Balance — through 9 ingredients. Tap an ingredient for the detail:
KudzuAntidiabetes Drugs, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking kudzu with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Kudzu + Alogliptin, Pioglitazone interactionDandelion Whole Plant/root ExtAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, dandelion might increase the risk for hypoglycemia when used with antidiabetes drugs.
Read the full Dandelion Whole Plant/root Ext + Alogliptin, Pioglitazone interactionCabbageAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, cabbage might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Cabbage + Alogliptin, Pioglitazone interactionRed BeetCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, beet might increase the levels of CYP3A4 substrates.
Read the full Red Beet + Alogliptin, Pioglitazone interactionSpirulinaAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking blue-green algae with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Spirulina + Alogliptin, Pioglitazone interactionGingerAntidiabetes Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, taking ginger with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Ginger + Alogliptin, Pioglitazone interactionParsleyAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, parsley might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Parsley + Alogliptin, Pioglitazone interactionWheat GrassAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking wheatgrass with antidiabetes drugs might lower blood glucose levels and increase the risk of hypoglycemia.
Read the full Wheat Grass + Alogliptin, Pioglitazone interactionApple Cider Vinegar ConcentrateAntidiabetes Drugs Minor
Interaction Summary
Theoretically, taking apple cider vinegar with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Apple Cider Vinegar Concentrate + Alogliptin, Pioglitazone interactionAlpelisibPiqray
How Alpelisib interacts with Alkaline Balance — through 2 ingredients. Tap an ingredient for the detail:
GingerCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Ginger might increase or decrease the levels of CYP3A4 substrates.
Read the full Ginger + Alpelisib interactionRed BeetCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, beet might increase the levels of CYP3A4 substrates.
Read the full Red Beet + Alpelisib interactionAlprazolamNiravam, Xanax
How Alprazolam interacts with Alkaline Balance — through 2 ingredients. Tap an ingredient for the detail:
Red BeetCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, beet might increase the levels of CYP3A4 substrates.
Read the full Red Beet + Alprazolam interactionGingerCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Ginger might increase or decrease the levels of CYP3A4 substrates.
Read the full Ginger + Alprazolam interactionAlteplase, TpaActilyse, Activase
How Alteplase, Tpa interacts with Alkaline Balance — through 7 ingredients. Tap an ingredient for the detail:
BurdockAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking burdock with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
Read the full Burdock + Alteplase, Tpa interactionDandelion Whole Plant/root ExtAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking dandelion root along with anticoagulant or antiplatelet drugs might increase the risk of bruising and bleeding.
Read the full Dandelion Whole Plant/root Ext + Alteplase, Tpa interactionKudzuAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, kudzu may increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Kudzu + Alteplase, Tpa interactionParsleyAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, parsley might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Parsley + Alteplase, Tpa interactionGingerAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Ginger may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Ginger + Alteplase, Tpa interactionSpirulinaAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, spirulina blue-green algae might increase the risk of bleeding if used with other anticoagulant or antiplatelet drugs.
Read the full Spirulina + Alteplase, Tpa interactionMagnesiumAnticoagulant/antiplatelet Drugs Minor
Interaction Summary
Theoretically, magnesium may have antiplatelet effects, but the evidence is conflicting.
Read the full Magnesium + Alteplase, Tpa interactionAluminum Acetate, Benzethonium ChlorideBuro-Sol Otic Solution
How Aluminum Acetate, Benzethonium Chloride interacts with Alkaline Balance — through 1 ingredient. Tap an ingredient for the detail:
CalciumAluminum Moderate
Interaction Summary
Calcium citrate might increase aluminum absorption and toxicity.
Read the full Calcium + Aluminum Acetate, Benzethonium Chloride interactionAluminum ChlorideAluminum Chloride, Anhydrol Forte, Driclor, Drysol
How Aluminum Chloride interacts with Alkaline Balance — through 1 ingredient. Tap an ingredient for the detail:
CalciumAluminum Moderate
Interaction Summary
Calcium citrate might increase aluminum absorption and toxicity.
Read the full Calcium + Aluminum Chloride interactionAluminum HydroxideAlu-Cap, Amphojel, Gaviscon
How Aluminum Hydroxide interacts with Alkaline Balance — through 2 ingredients. Tap an ingredient for the detail:
CalciumAluminum Moderate
Interaction Summary
Calcium citrate might increase aluminum absorption and toxicity.
Read the full Calcium + Aluminum Hydroxide interactionMagnesiumAntacids Moderate
Interaction Summary
Use of acid reducers may reduce the laxative effect of magnesium oxide.
Read the full Magnesium + Aluminum Hydroxide interactionAluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #2
How Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interacts with Alkaline Balance — through 8 ingredients. Tap an ingredient for the detail:
MagnesiumAnticoagulant/antiplatelet Drugs, Antacids Moderate
Interaction Summary
Theoretically, magnesium may have antiplatelet effects, but the evidence is conflicting.
Read the full Magnesium + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionCalciumAluminum Moderate
Interaction Summary
Calcium citrate might increase aluminum absorption and toxicity.
Read the full Calcium + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionKudzuAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, kudzu may increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Kudzu + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionDandelion Whole Plant/root ExtAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking dandelion root along with anticoagulant or antiplatelet drugs might increase the risk of bruising and bleeding.
Read the full Dandelion Whole Plant/root Ext + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionBurdockAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking burdock with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
Read the full Burdock + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionSpirulinaAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, spirulina blue-green algae might increase the risk of bleeding if used with other anticoagulant or antiplatelet drugs.
Read the full Spirulina + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionGingerAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Ginger may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Ginger + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionParsleyAnticoagulant/antiplatelet Drugs, Aspirin Moderate
Interaction Summary
Theoretically, parsley might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Parsley + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionAluminum Hydroxide, Aspirin, Magnesium HydroxideAscriptin
How Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interacts with Alkaline Balance — through 8 ingredients. Tap an ingredient for the detail:
ParsleyAspirin, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, aspirin might increase the severity of allergic reactions to parsley.
Read the full Parsley + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionGingerAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Ginger may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Ginger + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionSpirulinaAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, spirulina blue-green algae might increase the risk of bleeding if used with other anticoagulant or antiplatelet drugs.
Read the full Spirulina + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionDandelion Whole Plant/root ExtAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking dandelion root along with anticoagulant or antiplatelet drugs might increase the risk of bruising and bleeding.
Read the full Dandelion Whole Plant/root Ext + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionCalciumAluminum Moderate
Interaction Summary
Calcium citrate might increase aluminum absorption and toxicity.
Read the full Calcium + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionKudzuAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, kudzu may increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Kudzu + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionMagnesiumAnticoagulant/antiplatelet Drugs, Antacids Moderate
Interaction Summary
Theoretically, magnesium may have antiplatelet effects, but the evidence is conflicting.
Read the full Magnesium + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionBurdockAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking burdock with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
Read the full Burdock + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionAluminum Hydroxide, Magnesium Hydroxide (otc Drug)Maalox, Mucogel
How Aluminum Hydroxide, Magnesium Hydroxide (otc Drug) interacts with Alkaline Balance — through 2 ingredients. Tap an ingredient for the detail:
CalciumAluminum Moderate
Interaction Summary
Calcium citrate might increase aluminum absorption and toxicity.
Read the full Calcium + Aluminum Hydroxide, Magnesium Hydroxide (otc Drug) interactionMagnesiumAntacids Moderate
Interaction Summary
Use of acid reducers may reduce the laxative effect of magnesium oxide.
Read the full Magnesium + Aluminum Hydroxide, Magnesium Hydroxide (otc Drug) interactionAluminum Hydroxide, Magnesium Hydroxide, Simethicone (otc Drug)Mylanta
How Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (otc Drug) interacts with Alkaline Balance — through 2 ingredients. Tap an ingredient for the detail:
MagnesiumAntacids Moderate
Interaction Summary
Use of acid reducers may reduce the laxative effect of magnesium oxide.
Read the full Magnesium + Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (otc Drug) interactionCalciumAluminum Moderate
Interaction Summary
Calcium citrate might increase aluminum absorption and toxicity.
Read the full Calcium + Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (otc Drug) interactionAluminum, CalciumDomeboro
How Aluminum, Calcium interacts with Alkaline Balance — through 1 ingredient. Tap an ingredient for the detail:
CalciumAluminum Moderate
Interaction Summary
Calcium citrate might increase aluminum absorption and toxicity.
Read the full Calcium + Aluminum, Calcium interactionAluminum, Magnesium (otc Drug)Almagel
How Aluminum, Magnesium (otc Drug) interacts with Alkaline Balance — through 2 ingredients. Tap an ingredient for the detail:
CalciumAluminum Moderate
Interaction Summary
Calcium citrate might increase aluminum absorption and toxicity.
Read the full Calcium + Aluminum, Magnesium (otc Drug) interactionMagnesiumAntacids Moderate
Interaction Summary
Use of acid reducers may reduce the laxative effect of magnesium oxide.
Read the full Magnesium + Aluminum, Magnesium (otc Drug) interactionAluminum, Magnesium Hydroxide (otc Drug)Wingel
How Aluminum, Magnesium Hydroxide (otc Drug) interacts with Alkaline Balance — through 1 ingredient. Tap an ingredient for the detail:
CalciumAluminum Moderate
Interaction Summary
Calcium citrate might increase aluminum absorption and toxicity.
Read the full Calcium + Aluminum, Magnesium Hydroxide (otc Drug) interactionAlvimopanEntereg
How Alvimopan interacts with Alkaline Balance — through 1 ingredient. Tap an ingredient for the detail:
GingerP-glycoprotein Substrates Moderate
Interaction Summary
Ginger might increase the absorption and blood levels of P-glycoprotein (P-gp) substrates.
Read the full Ginger + Alvimopan interactionAmbrisentanLetairis, Volibris
How Ambrisentan interacts with Alkaline Balance — through 4 ingredients. Tap an ingredient for the detail:
GingerP-glycoprotein Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Ginger might increase the absorption and blood levels of P-glycoprotein (P-gp) substrates.
Read the full Ginger + Ambrisentan interactionSodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Ambrisentan interactionRed BeetCytochrome P450 3a4 (cyp3a4) Substrates, Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, beet might increase the levels of CYP3A4 substrates.
Read the full Red Beet + Ambrisentan interactionKudzuHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive hepatotoxic effects.
Read the full Kudzu + Ambrisentan interactionAmikacinAmikin, Arikayce
How Amikacin interacts with Alkaline Balance — through 1 ingredient. Tap an ingredient for the detail:
MagnesiumAminoglycoside Antibiotics Moderate
Interaction Summary
Concomitant use of aminoglycoside antibiotics and magnesium can increase the risk for neuromuscular weakness.
Read the full Magnesium + Amikacin interactionAmilorideAmilamont, Midamor
How Amiloride interacts with Alkaline Balance — through 5 ingredients. Tap an ingredient for the detail:
SodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Amiloride interactionMagnesiumPotassium-sparing Diuretics Moderate
Interaction Summary
Potassium-sparing diuretics decrease excretion of magnesium, possibly increasing magnesium levels.
Read the full Magnesium + Amiloride interactionDandelion Whole Plant/root ExtPotassium-sparing Diuretics Moderate
Interaction Summary
Theoretically, dandelion might increase the risk of hyperkalemia when taken with potassium-sparing diuretics.
Read the full Dandelion Whole Plant/root Ext + Amiloride interactionPotassiumPotassium-sparing Diuretics Moderate
Interaction Summary
Concomitant use increases the risk of hyperkalemia.
Read the full Potassium + Amiloride interactionRed BeetAntihypertensive Drugs Minor
Interaction Summary
Beet and beetroot contain nitrates, which can cause vasodilation, potentially leading to lower blood pressure.
Read the full Red Beet + Amiloride interactionAmiloride, HydrochlorothiazideAmil-Co, Amilzide, Moduret 25, Moduretic
How Amiloride, Hydrochlorothiazide interacts with Alkaline Balance — through 9 ingredients. Tap an ingredient for the detail:
Dandelion Whole Plant/root ExtPotassium-sparing Diuretics Moderate
Interaction Summary
Theoretically, dandelion might increase the risk of hyperkalemia when taken with potassium-sparing diuretics.
Read the full Dandelion Whole Plant/root Ext + Amiloride, Hydrochlorothiazide interactionCalciumThiazide Diuretics Moderate
Interaction Summary
Taking calcium along with thiazides might increase the risk of hypercalcemia and renal failure.
Read the full Calcium + Amiloride, Hydrochlorothiazide interactionMagnesiumPotassium-sparing Diuretics Moderate
Interaction Summary
Potassium-sparing diuretics decrease excretion of magnesium, possibly increasing magnesium levels.
Read the full Magnesium + Amiloride, Hydrochlorothiazide interactionSodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Amiloride, Hydrochlorothiazide interactionPotassiumPotassium-sparing Diuretics Moderate
Interaction Summary
Concomitant use increases the risk of hyperkalemia.
Read the full Potassium + Amiloride, Hydrochlorothiazide interactionChlorellaPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, chlorella might have additive effects with photosensitizing drugs.
Read the full Chlorella + Amiloride, Hydrochlorothiazide interactionApple Cider Vinegar ConcentrateDiuretic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of apple cider vinegar with diuretic drugs might increase the risk of hypokalemia.
Read the full Apple Cider Vinegar Concentrate + Amiloride, Hydrochlorothiazide interactionParsleyDiuretic Drugs Moderate
Interaction Summary
Theoretically, parsley might enhance or interfere with the effects of diuretic drugs.
Read the full Parsley + Amiloride, Hydrochlorothiazide interactionRed BeetAntihypertensive Drugs Minor
Interaction Summary
Beet and beetroot contain nitrates, which can cause vasodilation, potentially leading to lower blood pressure.
Read the full Red Beet + Amiloride, Hydrochlorothiazide interactionAminolevulinic Acid HydrochlorideAmeluz, Gleolan
How Aminolevulinic Acid Hydrochloride interacts with Alkaline Balance — through 1 ingredient. Tap an ingredient for the detail:
ChlorellaPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, chlorella might have additive effects with photosensitizing drugs.
Read the full Chlorella + Aminolevulinic Acid Hydrochloride interactionAminosalicylic AcidPaser
How Aminosalicylic Acid interacts with Alkaline Balance — through 1 ingredient. Tap an ingredient for the detail:
KudzuHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive hepatotoxic effects.
Read the full Kudzu + Aminosalicylic Acid interactionAmiodaroneCordarone, Pacerone
How Amiodarone interacts with Alkaline Balance — through 4 ingredients. Tap an ingredient for the detail:
KudzuHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive hepatotoxic effects.
Read the full Kudzu + Amiodarone interactionChlorellaPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, chlorella might have additive effects with photosensitizing drugs.
Read the full Chlorella + Amiodarone interactionRed BeetCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, beet might increase the levels of CYP3A4 substrates.
Read the full Red Beet + Amiodarone interactionGingerCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Ginger might increase or decrease the levels of CYP3A4 substrates.
Read the full Ginger + Amiodarone interactionAmitriptylineElavil
How Amitriptyline interacts with Alkaline Balance — through 8 ingredients. Tap an ingredient for the detail:
GingerCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2c9 (cyp2c9) Substrates +1 Moderate
Interaction Summary
Ginger might increase or decrease the levels of CYP3A4 substrates.
Read the full Ginger + Amitriptyline interactionWheat GrassCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, wheatgrass might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Wheat Grass + Amitriptyline interactionBroccoliCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP1A2.
Read the full Broccoli + Amitriptyline interactionChlorellaPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, chlorella might have additive effects with photosensitizing drugs.
Read the full Chlorella + Amitriptyline interactionDandelion Whole Plant/root ExtCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, dandelion might increase levels of drugs metabolized by CYP1A2.
Read the full Dandelion Whole Plant/root Ext + Amitriptyline interactionParsleyCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, parsley might increase serum levels of CYP1A2 substrates.
Read the full Parsley + Amitriptyline interactionRed BeetCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, beet might increase the levels of CYP3A4 substrates.
Read the full Red Beet + Amitriptyline interactionCabbageCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, cabbage might decrease levels of drugs metabolized by CYP1A2.
Read the full Cabbage + Amitriptyline interactionAmitriptyline, ChlordiazepoxideLimbitrol DS
How Amitriptyline, Chlordiazepoxide interacts with Alkaline Balance — through 8 ingredients. Tap an ingredient for the detail:
Red BeetCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, beet might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Red Beet + Amitriptyline, Chlordiazepoxide interactionCabbageCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, cabbage might decrease levels of drugs metabolized by CYP1A2.
Read the full Cabbage + Amitriptyline, Chlordiazepoxide interactionGingerCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, ginger might increase the levels of CYP1A2 substrates.
Read the full Ginger + Amitriptyline, Chlordiazepoxide interactionChlorellaPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, chlorella might have additive effects with photosensitizing drugs.
Read the full Chlorella + Amitriptyline, Chlordiazepoxide interactionBroccoliCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP1A2.
Read the full Broccoli + Amitriptyline, Chlordiazepoxide interactionWheat GrassCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, wheatgrass might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Wheat Grass + Amitriptyline, Chlordiazepoxide interactionParsleyCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, parsley might increase serum levels of CYP1A2 substrates.
Read the full Parsley + Amitriptyline, Chlordiazepoxide interactionDandelion Whole Plant/root ExtCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, dandelion might increase levels of drugs metabolized by CYP1A2.
Read the full Dandelion Whole Plant/root Ext + Amitriptyline, Chlordiazepoxide interactionAmitriptyline, PerphenazineEtrafon, Etrafon-A, Etrafon-Forte, Triavil
How Amitriptyline, Perphenazine interacts with Alkaline Balance — through 8 ingredients. Tap an ingredient for the detail:
Dandelion Whole Plant/root ExtCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, dandelion might increase levels of drugs metabolized by CYP1A2.
Read the full Dandelion Whole Plant/root Ext + Amitriptyline, Perphenazine interactionParsleyCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, parsley might increase serum levels of CYP1A2 substrates.
Read the full Parsley + Amitriptyline, Perphenazine interactionChlorellaPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, chlorella might have additive effects with photosensitizing drugs.
Read the full Chlorella + Amitriptyline, Perphenazine interactionRed BeetCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, beet might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Red Beet + Amitriptyline, Perphenazine interactionCabbageCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, cabbage might decrease levels of drugs metabolized by CYP1A2.
Read the full Cabbage + Amitriptyline, Perphenazine interactionGingerCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2c9 (cyp2c9) Substrates +1 Moderate
Interaction Summary
Theoretically, ginger might increase the levels of CYP1A2 substrates.
Read the full Ginger + Amitriptyline, Perphenazine interactionWheat GrassCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, wheatgrass might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Wheat Grass + Amitriptyline, Perphenazine interactionBroccoliCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP1A2.
Read the full Broccoli + Amitriptyline, Perphenazine interactionAmlodipineNorliqva
How Amlodipine interacts with Alkaline Balance — through 5 ingredients. Tap an ingredient for the detail:
SodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Amlodipine interactionGingerCytochrome P450 3a4 (cyp3a4) Substrates, Calcium Channel Blockers Moderate
Interaction Summary
Ginger might increase or decrease the levels of CYP3A4 substrates.
Read the full Ginger + Amlodipine interactionMagnesiumCalcium Channel Blockers Moderate
Interaction Summary
Magnesium can have additive effects with calcium channel blockers, although evidence is conflicting.
Read the full Magnesium + Amlodipine interactionRed BeetCytochrome P450 3a4 (cyp3a4) Substrates, Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, beet might increase the levels of CYP3A4 substrates.
Read the full Red Beet + Amlodipine interactionCalciumCalcium Channel Blockers Minor
Interaction Summary
Intravenous calcium may decrease the effects of calcium channel blockers; oral calcium is unlikely to have this effect.
Read the full Calcium + Amlodipine interactionAmlodipine BenzoateKaterzia
How Amlodipine Benzoate interacts with Alkaline Balance — through 5 ingredients. Tap an ingredient for the detail:
Red BeetAntihypertensive Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Beet and beetroot contain nitrates, which can cause vasodilation, potentially leading to lower blood pressure.
Read the full Red Beet + Amlodipine Benzoate interactionGingerCalcium Channel Blockers, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, taking ginger with calcium channel blockers might increase the risk of hypotension.
Read the full Ginger + Amlodipine Benzoate interactionMagnesiumCalcium Channel Blockers Moderate
Interaction Summary
Magnesium can have additive effects with calcium channel blockers, although evidence is conflicting.
Read the full Magnesium + Amlodipine Benzoate interactionSodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Amlodipine Benzoate interactionCalciumCalcium Channel Blockers Minor
Interaction Summary
Intravenous calcium may decrease the effects of calcium channel blockers; oral calcium is unlikely to have this effect.
Read the full Calcium + Amlodipine Benzoate interactionAmlodipine BesilateIstin
How Amlodipine Besilate interacts with Alkaline Balance — through 5 ingredients. Tap an ingredient for the detail:
GingerCalcium Channel Blockers, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, taking ginger with calcium channel blockers might increase the risk of hypotension.
Read the full Ginger + Amlodipine Besilate interactionRed BeetAntihypertensive Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Beet and beetroot contain nitrates, which can cause vasodilation, potentially leading to lower blood pressure.
Read the full Red Beet + Amlodipine Besilate interactionMagnesiumCalcium Channel Blockers Moderate
Interaction Summary
Magnesium can have additive effects with calcium channel blockers, although evidence is conflicting.
Read the full Magnesium + Amlodipine Besilate interactionSodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Amlodipine Besilate interactionCalciumCalcium Channel Blockers Minor
Interaction Summary
Intravenous calcium may decrease the effects of calcium channel blockers; oral calcium is unlikely to have this effect.
Read the full Calcium + Amlodipine Besilate interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Alkaline Balance with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Ginger
Anticoagulant/Antiplatelet Drugs
Ginger may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs. However, research is conflicting.
Laboratory research suggests that ginger inhibits thromboxane synthetase and decreases platelet aggregation. However, this has not been demonstrated unequivocally in humans, with mixed results from clinical trials. Theoretically, excessive amounts of ginger might increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
Antidiabetes Drugs
Theoretically, taking ginger with antidiabetes drugs might increase the risk of hypoglycemia.
Animal and human research suggests that ginger might increase insulin levels and/or decrease blood glucose levels.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Ginger might increase or decrease the levels of CYP3A4 substrates.
In vitro research and some case reports suggest that ginger inhibits CYP3A4 activity. Three case reports from the World Health Organization (WHO) adverse drug reaction database describe increased toxicity in patients taking ginger and cancer medications that are CYP3A4 substrates (imatinib, dabrafenib, and crizotinib). However, the causality of this interaction is unclear due to the presence of multiple interacting drugs and routes of administration.
Conversely, other in vitro research suggests that ginger induces CYP3A4 activity, leading to reduced levels of CYP3A4 substrates. However, this interaction has not been reported in humans.
Losartan (Cozaar)
Theoretically, ginger might increase levels of losartan and the risk of hypotension.
In animal research, ginger increased the levels and hypotensive effects of a single dose of losartan. It is not clear if ginger alters the concentration or effects of losartan when taken continuously. Additionally, this interaction has not been shown in humans.
Nifedipine (Procardia)
Ginger may have antiplatelet effects and increase the risk of bleeding if used with nifedipine.
Clinical research shows that combined treatment with ginger 1 gram plus nifedipine 10 mg significantly inhibits platelet aggregation when compared to nifedipine or ginger alone.
P-Glycoprotein Substrates
Ginger might increase the absorption and blood levels of P-glycoprotein (P-gp) substrates.
In vitro research and case reports suggest that ginger inhibits drug efflux by P-gp, potentially increasing absorption and serum levels of P-gp substrates. Two case reports from the World Health Organization (WHO) adverse drug reaction database describe increased toxicity in patients taking ginger and cancer medications that are P-gp substrates (trametinib, crizotinib). However, the causality of this interaction is unclear due to the presence of multiple interacting drugs and routes of administration.
Phenprocoumon (Marcoumar, Others)
Ginger might increase the risk of bleeding with phenprocoumon.
Phenprocoumon, a warfarin-related anticoagulant, might increase the international normalized ratio (INR) when taken with ginger. There is one case report of a 76-year-old woman with a stable INR on phenprocoumon that increased to greater than 10 when she began consuming dried ginger and ginger tea.
Warfarin (Coumadin)
Ginger might increase the risk of bleeding with warfarin.
Laboratory research suggests that ginger might inhibit thromboxane synthetase and decrease platelet aggregation. In one case report, ginger increased the INR when taken with phenprocoumon, which has similar pharmacological effects as warfarin. In another case report, ginger increased the INR when taken with a combination of warfarin, hydrochlorothiazide, and acetaminophen. A longitudinal analysis suggests that taking ginger increases the risk of bleeding in patients taking warfarin for at least 4 months. However, research in healthy people suggests that ginger has no effect on INR, or the pharmacokinetics or pharmacodynamics of warfarin. Until more is known, monitor INRs closely in patients taking large amounts of ginger.
Calcium Channel Blockers
Theoretically, taking ginger with calcium channel blockers might increase the risk of hypotension.
Some animal and in vitro research suggests that ginger has hypotensive and calcium channel-blocking effects. Another animal study shows that concomitant administration of ginger and the calcium channel blocker amlodipine leads to greater reductions in blood pressure when compared with amlodipine alone.
Cyclosporine (Neoral, Sandimmune)
Theoretically, when taken prior to cyclosporine, ginger might decrease cyclosporine levels.
In an animal model, ginger juice taken 2 hours prior to cyclosporine administration reduced the maximum concentration and area under the curve of cyclosporine by 51% and 40%, respectively. This effect was not observed when ginger juice and cyclosporine were administered at the same time.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, ginger might increase the levels of CYP1A2 substrates.
In vitro research shows that ginger inhibits CYP1A2 activity. However, this interaction has not been reported in humans.
Cytochrome P450 2B6 (Cyp2B6) Substrates
Theoretically, ginger might increase the levels of CYP2B6 substrates.
In vitro research shows that ginger inhibits CYP2B6 activity. However, this interaction has not been reported in humans.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, ginger might increase the levels of CYP2C9 substrates.
In vitro research shows that ginger inhibits CYP2C9 activity. However, this interaction has not been reported in humans.
Metronidazole (Flagyl)
Theoretically, ginger might increase levels of metronidazole.
In an animal model, ginger increased the absorption and plasma half-life of metronidazole. In addition, the elimination rate and clearance of metronidazole was significantly reduced.
Red Beet
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, beet might increase the levels of CYP3A4 substrates.
In vitro research suggests that betanin, the major pigment in beet, competitively inhibits CYP3A4 in a dose-dependent manner similarly to strong CYP3A4 inhibitor ketoconazole.
Antihypertensive Drugs
Beet and beetroot contain nitrates, which can cause vasodilation, potentially leading to lower blood pressure. However, a study published in the European Journal of Clinical Nutrition using concentrated beetroot juice found no significant impact on blood pressure or heart rate in different age groups. Other small clinical studies suggest that while beet consumption might transiently lower blood pressure due to vessel dilation, there's no consistent evidence of a lasting effect. Overall, the theoretical risk of reduced blood pressure due to beet's nitrate content exists, but studies generally indicate a low and temporary impact rather than a sustained decrease.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, beet might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research suggests that beet induces CYP1A2 enzymes.
Kudzu
Anticoagulant/Antiplatelet Drugs
Theoretically, kudzu may increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Kudzu isoflavones are reported to have antiplatelet activity.
Caffeine
Theoretically, taking kudzu with caffeine might increase levels of caffeine.
In healthy males injected with the kudzu constituent puerarin, caffeine clearance and metabolism is inhibited. This effect has been attributed to inhibition of cytochrome P450 1A2 (CYP1A2) enzyme, which is involved in caffeine metabolism. It is unclear if taking kudzu orally would have this same effect.
Estrogens
Theoretically, kudzu might alter the effects of estrogen therapy.
Some research suggests that kudzu has estrogenic effects. This may enhance or inhibit the effects of estrogen therapy.
Hepatotoxic Drugs
Theoretically, concomitant use might have additive hepatotoxic effects.
There is some concern that kudzu can adversely affect the liver.
Methotrexate (Trexall, Others)
Theoretically, taking kudzu with methotrexate might increase the risk of methotrexate toxicity.
Preclinical research suggests that kudzu extract greatly reduces the elimination and increases the toxicity of methotrexate. Kudzu might inhibit organic anion transporters (OATs) that are responsible for hepatobiliary and renal excretion of anions, similar to the interaction between methotrexate and non-steroidal anti-inflammatory drugs (NSAIDs).
Tamoxifen (Nolvadex)
Theoretically, kudzu might interfere with tamoxifen activity.
Some research suggests that kudzu may have estrogenic effects.
Antidiabetes Drugs
Theoretically, taking kudzu with antidiabetes drugs might increase the risk of hypoglycemia.
Kudzu might lower blood glucose levels and have additive effects in patients treated with antidiabetic agents. The dose of diabetes medications might need to be adjusted.
Dandelion whole plant/root ext
Anticoagulant/Antiplatelet Drugs
Theoretically, taking dandelion root along with anticoagulant or antiplatelet drugs might increase the risk of bruising and bleeding.
In vitro research suggests that dandelion root inhibits platelet aggregation.
Antidiabetes Drugs
Theoretically, dandelion might increase the risk for hypoglycemia when used with antidiabetes drugs.
Laboratory research suggests that dandelion extract may have moderate alpha-glucosidase inhibitor activity and might also increase insulin secretion. Also, in a case report, a 58-year-old woman with type 2 diabetes who was being treated with insulin developed hypoglycemia 2 weeks after beginning to eat salads containing dandelion.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, dandelion might increase levels of drugs metabolized by CYP1A2.
Laboratory research suggests that dandelion might inhibit CYP1A2. So far, this interaction has not been reported in humans. However, until more is known, watch for an increase in the levels of drugs metabolized by CYP1A2 in patients taking dandelion.
Glucuronidated Drugs
Theoretically, dandelion might increase the clearance of drugs that are UDP-glucuronosyltransferase substrates.
There is some preliminary evidence that dandelion might induce UDP-glucuronosyltransferase, a phase II enzyme.
Lithium
Theoretically, through diuretic effects, dandelion might reduce excretion and increase levels of lithium.
Animal research suggests that dandelion has diuretic properties. As diuretics can increase serum lithium levels, the dose of lithium might need to be decreased when taken with dandelion.
Potassium-Sparing Diuretics
Theoretically, dandelion might increase the risk of hyperkalemia when taken with potassium-sparing diuretics.
Dandelion contains significant amounts of potassium.
Quinolone Antibiotics
Theoretically, dandelion might lower fluoroquinolone levels.
Animal research shows that dandelion reduces absorption of ciprofloxacin and can lower levels by 73%. However, this effect has not been reported in humans.
Parsley
Anticoagulant/Antiplatelet Drugs
Theoretically, parsley might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Animal research suggests that parsley has antiplatelet effects.
Antidiabetes Drugs
Theoretically, parsley might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research suggests that parsley might decrease blood glucose. Monitor blood glucose levels closely. Dose adjustments might be necessary.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, parsley might increase serum levels of CYP1A2 substrates.
Laboratory research suggests that parsley can inhibit CYP1A2.
Diuretic Drugs
Theoretically, parsley might enhance or interfere with the effects of diuretic drugs.
Animal research suggests that parsley seed extract increases urine elimination. Parsley leaf and root might also interfere with diuretic therapy due their purported aquaretic effects.
Pentobarbital (Nembutal)
Theoretically, parsley might increase the duration of pentobarbital effects.
Animal research suggests that parsley juice prolongs the action of pentobarbital, perhaps by decreasing cytochrome P450 levels. It is not known if this occurs in humans or if this applies to other barbiturates or sedatives.
Sirolimus (Rapamune)
Theoretically, large quantities of parsley might increase sirolimus levels.
In one case report, an adult female with a history of kidney transplant presented with elevated blood sirolimus levels, approximately 4-7 times greater than previous measures, after daily consumption of a juice containing approximately 30 grams of parsley for 7 days. Sirolimus levels returned to normal a week after the parsley juice was discontinued.
Warfarin (Coumadin)
Theoretically, large amounts of parsley leaf and root might decrease the effects of warfarin.
Parlsey contains vitamin K.
Aspirin
Theoretically, aspirin might increase the severity of allergic reactions to parsley.
In one case, severe urticaria and swelling were reported after taking aspirin with parsley in an individual with a known mild parsley allergy.
Chlorella
Photosensitizing Drugs
Theoretically, chlorella might have additive effects with photosensitizing drugs.
Chlorella has been reported to cause photosensitization. In five case reports, patients who had ingested chlorella exhibited swelling followed by erythematopurpuric lesions on sun-exposed areas of the body. Theoretically, concomitant use with photosensitizing drugs may exacerbate effects.
Warfarin (Coumadin)
Theoretically, chlorella might reduce the clinical effects of warfarin.
Chlorella contains significant amounts of vitamin K. There is at least one case report of warfarin therapy becoming sub-therapeutic after initiation of chlorella supplements.
Spirulina
Anticoagulant/Antiplatelet Drugs
Theoretically, spirulina blue-green algae might increase the risk of bleeding if used with other anticoagulant or antiplatelet drugs. However, this is unlikely.
Spirulina blue-green algae have shown antiplatelet and anticoagulant effects in vitro. However, one preliminary study in 24 patients receiving spirulina blue-green algae 2.3 grams daily for 2 weeks showed no effect on platelet activation or measures of clotting time.
Antidiabetes Drugs
Theoretically, taking blue-green algae with antidiabetes drugs might increase the risk of hypoglycemia.
Human research shows that spirulina blue-green algae can have hypoglycemic effects in patients with diabetes, at least some of whom were using antidiabetes drugs. However, blue-green algae does not seem to improve glycated hemoglobin (HbA1c) levels in patients with diabetes. A meta-analysis of animal studies also suggests that spirulina blue-green algae have hypoglycemic effects.
Immunosuppressants
Theoretically, concurrent use of blue-green algae might interfere with immunosuppressive therapy.
Blue-green algae have been shown to stimulate the immune system.
Cabbage
Acetaminophen (Tylenol, Others)
Cabbage might increase clearance and reduce the effects of acetaminophen.
A small clinical study shows that daily consumption of cabbage and Brussels sprout decreases acetaminophen levels by as much as 16%, with some evidence suggesting that this effect is due to increased elimination through glucuronide conjugation.
Antidiabetes Drugs
Theoretically, cabbage might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal and in vivo research suggests that cabbage might have hypoglycemic effects.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, cabbage might decrease levels of drugs metabolized by CYP1A2.
Some animal research suggests that cabbage or its constituent indole-3-carbinol might increase drug metabolism and elimination by stimulating CYP1A2 activity.
Glucuronidated Drugs
Theoretically, cabbage might increase clearance and decrease the effects of drugs metabolized through glucuronide conjugation.
A small clinical study shows that daily consumption of cabbage and Brussels sprout decreases levels of some drugs metabolized through glucuronide conjugation.
Oxazepam (Serax)
Cabbage might increase clearance and reduce the effects of oxazepam.
A small clinical study shows that daily consumption of cabbage and brussels sprout decreases oxazepam levels by as much as 17%, with some evidence suggesting that this effect is due to increased elimination through glucuronide conjugation.
Warfarin (Coumadin)
Theoretically, cabbage might decrease the anticoagulant effects of warfarin.
Cabbage contains vitamin K. If consumed in large quantities, cabbage might decrease the anticoagulant effects of warfarin.
Magnesium
Levodopa/Carbidopa (Sinemet)
Magnesium can reduce the bioavailability of levodopa/carbidopa.
Clinical research in healthy volunteers shows that taking magnesium oxide 1000 mg with levodopa 100 mg/carbidopa 10 mg reduces the area under the curve (AUC) of levodopa by 35% and of carbidopa by 81%. In vitro and animal research shows that magnesium produces an alkaline environment in the digestive tract, which might lead to degradation and reduced bioavailability of levodopa/carbidopa.
Aminoglycoside Antibiotics
Concomitant use of aminoglycoside antibiotics and magnesium can increase the risk for neuromuscular weakness.
Both aminoglycosides and magnesium reduce presynaptic acetylcholine release, which can lead to neuromuscular blockade and possible paralysis. This is most likely to occur with high doses of magnesium given intravenously.
Antacids
Use of acid reducers may reduce the laxative effect of magnesium oxide.
A retrospective analysis shows that, in the presence of H2 receptor antagonists (H2RAs) or proton pump inhibitors (PPIs), a higher dose of magnesium oxide is needed for a laxative effect. This may also occur with antacids. Under acidic conditions, magnesium oxide is converted to magnesium chloride and then to magnesium bicarbonate, which has an osmotic laxative effect. By reducing acidity, antacids may reduce the conversion of magnesium oxide to the active bicarbonate salt.
Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)
Magnesium might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide should be taken at least 2 hours before or 6 hours after magnesium containing products.
Bisphosphonates
Magnesium can decrease absorption of bisphosphonates.
Cations, including magnesium, can decrease bisphosphonate absorption. Advise patients to separate doses of magnesium and these drugs by at least 2 hours.
Calcium Channel Blockers
Magnesium can have additive effects with calcium channel blockers, although evidence is conflicting.
Magnesium inhibits calcium entry into smooth muscle cells and may therefore have additive effects with calcium channel blockers. Severe hypotension and neuromuscular blockades may occur when nifedipine is used with intravenous magnesium, although some contradictory evidence suggests that concurrent use of magnesium with nifedipine does not increase the risk of neuromuscular weakness. High doses of magnesium could theoretically have additive effects with other calcium channel blockers.
Digoxin
Magnesium salts may reduce absorption of digoxin.
Clinical evidence suggests that treatment with oral magnesium hydroxide or magnesium trisilicate reduces absorption of digoxin from the intestines. This may reduce the blood levels of digoxin and decrease its therapeutic effects.
Potassium-Sparing Diuretics
Potassium-sparing diuretics decrease excretion of magnesium, possibly increasing magnesium levels.
Potassium-sparing diuretics also have magnesium-sparing properties, which can counteract the magnesium losses associated with loop and thiazide diuretics. Theoretically, increased magnesium levels could result from concomitant use of potassium-sparing diuretics and magnesium supplements.
Quinolone Antibiotics
Magnesium decreases absorption of quinolones.
Magnesium can form insoluble complexes with quinolones and decrease their absorption. Advise patients to take these drugs at least 2 hours before, or 4 to 6 hours after, magnesium supplements.
Skeletal Muscle Relaxants
Parenteral magnesium alters the pharmacokinetics of skeletal muscle relaxants, increasing their effects and accelerating the onset of effect.
Parenteral magnesium shortens the time to onset of skeletal muscle relaxants by about 1 minute and prolongs the duration of action by about 2 minutes. Magnesium potentiates the effects of skeletal muscle relaxants by decreasing calcium-mediated release of acetylcholine from presynaptic nerve terminals, reducing postsynaptic sensitivity to acetylcholine, and having a direct effect on the membrane potential of myocytes. Magnesium also has vasodilatory actions and increases cardiac output, allowing a greater amount of muscle relaxant to reach the motor end plate. A clinical study found that low-dose rocuronium (0.45 mg/kg), when given after administration of magnesium 30 mg/kg over 10 minutes, has an accelerated onset of effect, which matches the onset of effect seen with a full-dose rocuronium regimen (0.6 mg/kg). In another clinical study, onset times for rocuronium doses of 0.3, 0.6, and 1.2 mg/kg were 86, 76, and 50 seconds, respectively, when given alone, but were reduced to 66, 44, and 38 seconds, respectively, when the doses were given after a 15-minute infusion of magnesium sulfate 60 mg/kg. Giving intraoperative intravenous magnesium sulfate, 50 mg/kg loading dose followed by 15 mg/kg/hour, reduces the onset time of rocuronium, enhances its clinical effects, reduces the dose of intraoperative opiates, and prolongs the spontaneous recovery time. It does not affect the activity of subsequently administered neostigmine.
Sulfonylureas
Magnesium increases the systemic absorption of sulfonylureas, increasing their effects and side effects.
Clinical research shows that administration of magnesium hydroxide with glyburide increases glyburide absorption, increases maximal insulin response by 35-fold, and increases the risk of hypoglycemia, when compared with glyburide alone. A similar interaction occurs between magnesium hydroxide and glipizide. The mechanism of this effect appears to be related to the elevation of gastrointestinal pH by magnesium-based antacids, increasing solubility and enhancing absorption of sulfonylureas.
Tetracycline Antibiotics
Magnesium decreases absorption of tetracyclines.
Magnesium can form insoluble complexes with tetracyclines in the gut and decrease their absorption and antibacterial activity. Advise patients to take these drugs 1 hour before or 2 hours after magnesium supplements.
Anticoagulant/Antiplatelet Drugs
Theoretically, magnesium may have antiplatelet effects, but the evidence is conflicting.
In vitro evidence shows that magnesium sulfate inhibits platelet aggregation, even at low concentrations. Some preliminary clinical evidence shows that infusion of magnesium sulfate increases bleeding time by 48% and reduces platelet activity. However, other clinical research shows that magnesium does not affect platelet aggregation, although inhibition of platelet-dependent thrombosis can occur.
Gabapentin (Neurontin)
Gabapentin absorption can be decreased by magnesium.
Clinical research shows that giving magnesium oxide orally along with gabapentin decreases the maximum plasma concentration of gabapentin by 33%, time to maximum concentration by 36%, and area under the curve by 43%. Advise patients to take gabapentin at least 2 hours before, or 4 to 6 hours after, magnesium supplements.
Sevelamer (Renagel, Renvela)
Sevelamer may increase serum magnesium levels.
In patients on hemodialysis, sevelamer use was associated with a 0.28 mg/dL increase in serum magnesium. The mechanism of this interaction remains unclear.
Wheat Grass
Antidiabetes Drugs
Theoretically, taking wheatgrass with antidiabetes drugs might lower blood glucose levels and increase the risk of hypoglycemia.
Animal research shows that taking wheatgrass stimulates the release of insulin from beta-cells and lowers blood glucose.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, wheatgrass might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that wheatgrass induces CYP1A2 enzymes.
Sodium
Antihypertensive Drugs
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.
Corticosteroids
Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.
Didanosine (Videx)
Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.
Lithium
Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.
Sodium Phosphates
Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.
Sodium-Containing Drugs
Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.
Tolvaptan (Samsca)
Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.
Broccoli
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP1A2.
Pharmacokinetic research in humans shows that eating 500 grams of fresh broccoli daily for 6-12 days can increase CYP1A2 activity by 10% to 200%. Induction of CYP1A2 activity by broccoli is attributed to its glucosinolate constituents.
Cytochrome P450 2A6 (Cyp2A6) Substrates
Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP2A6.
Pharmacokinetic research in humans shows that eating 500 grams of broccoli daily for 6 days increases CYP2A6 activity by 135% to 550%. Induction of CYP2A6 activity is attributed to its glucosinolate constituents.
Calcium
Ceftriaxone (Rocephin)
Co-administration of intravenous calcium and ceftriaxone can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys.
Avoid administering intravenous calcium in any form, such as parenteral nutrition or Lactated Ringers, within 48 hours of intravenous ceftriaxone. Case reports in neonates show that administering intravenous ceftriaxone and calcium can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys. In several cases, neonates have died as a result of this interaction. So far there are no reports in adults; however, there is still concern that this interaction might occur in adults.
Dolutegravir (Tivicay)
Calcium seems to reduce levels of dolutegravir.
Advise patients to take dolutegravir either 2 hours before or 6 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium carbonate 1200 mg concomitantly with dolutegravir 50 mg reduces plasma levels of dolutegravir by almost 40%. Calcium appears to decrease levels of dolutegravir through chelation.
Elvitegravir (Vitekta)
Calcium seems to reduce levels of elvitegravir.
Advise patients to take elvitegravir either 2 hours before or 2 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium along with elvitegravir can reduce blood levels of elvitegravir through chelation.
Aluminum
Calcium citrate might increase aluminum absorption and toxicity. Other types of calcium do not increase aluminum absorption.
Calcium citrate can increase the absorption of aluminum when taken with aluminum hydroxide. The increase in aluminum levels may become toxic, particularly in individuals with kidney disease. However, the effect of calcium citrate on aluminum absorption is due to the citrate anion rather than calcium cation. Calcium acetate does not appear to increase aluminum absorption.
Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)
Calcium might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption when taken in a fasting state.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide and calcium can be taken together if taken with food. However, if taken on an empty stomach, bictegravir/emtricitabine/tenofovir alafenamide should not be taken with, or 2 hours after, calcium containing products.
Bisphosphonates
Calcium reduces the absorption of bisphosphonates.
Advise patients to take bisphosphonates at least 30 minutes before calcium, but preferably at a different time of day. Calcium supplements decrease absorption of bisphosphonates.
Calcipotriene (Dovonex)
Taking calcipotriene with calcium might increase the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with calcium supplements might increase the risk of hypercalcemia.
Digoxin (Lanoxin)
Using intravenous calcium with digoxin might increase the risk of fatal cardiac arrhythmias.
Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. However, one retrospective analysis of clinical data suggests that intravenous calcium does not increase the risk of dysrhythmias or mortality in patients receiving digoxin.
Diltiazem (Cardizem, Others)
Theoretically, calcium may reduce the therapeutic effects of diltiazem.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, calcium might increase this risk of hypercalcemia and reduce the effectiveness of diltiazem.
Levothyroxine (Synthroid, Others)
Calcium seems to reduce the absorption and effectiveness of levothyroxine.
Advise patients to take levothyroxine and calcium supplements at least 4 hours apart. Calcium reduces levothyroxine absorption, probably by forming insoluble complexes. Calcium carbonate supplements reduce effectiveness of levothyroxine in patients with hypothyroidism.
Lithium
Theoretically, concomitant use of calcium and lithium may increase this risk of hypercalcemia.
Clinical research suggests that long-term use of lithium may cause hypercalcemia in 10% to 60% of patients. Theoretically, concomitant use of lithium and calcium supplements may further increase this risk.
Quinolone Antibiotics
Calcium seems to reduce the absorption of quinolone antibiotics.
Advise patients to take oral quinolones at least 2 hours before or 4-6 hours after calcium supplements or calcium-fortified foods. Taking calcium at the same time as oral quinolones can reduce quinolone absorption. Calcium binds to quinolones in the gut.
Raltegravir (Isentress)
Calcium may reduce levels of raltegravir.
Pharmacokinetic research shows that taking a single dose of calcium carbonate 3000 mg along with raltegravir 400 mg twice daily modestly decreases the mean area under the curve of raltegravir, but the decrease does not necessitate a dose adjustment of raltegravir. However, a case of elevated HIV-1 RNA levels and documented resistance to raltegravir has been reported for a patient taking calcium carbonate 1 gram three times daily plus vitamin D3 (cholecalciferol) 400 IU three times daily in combination with raltegravir 400 mg twice daily for 11 months. It is thought that calcium reduced raltegravir levels by chelation, leading to treatment failure.
Sotalol (Betapace)
Calcium seems to reduce the absorption of sotalol.
Advise patients to separate doses by at least 2 hours before or 4-6 hours after calcium. Calcium appears to reduce the absorption of sotalol, probably by forming insoluble complexes.
Tetracycline Antibiotics
Calcium seems to reduce the absorption of tetracycline antibiotics.
Advise patients to take oral tetracyclines at least 2 hours before, or 4-6 hours after calcium supplements. Taking calcium at the same time as oral tetracyclines can reduce tetracycline absorption. Calcium binds to tetracyclines in the gut.
Thiazide Diuretics
Taking calcium along with thiazides might increase the risk of hypercalcemia and renal failure.
Thiazides reduce calcium excretion by the kidneys. Using thiazides along with moderately large amounts of calcium carbonate increases the risk of milk-alkali syndrome (hypercalcemia, metabolic alkalosis, renal failure). Patients may need to have their serum calcium levels and/or parathyroid function monitored regularly.
Verapamil (Calan, Others)
Theoretically, calcium may reduce the therapeutic effects of verapamil.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, use of calcium supplements may increase this risk of hypercalcemia and reduce the effectiveness of verapamil.
Calcium Channel Blockers
Intravenous calcium may decrease the effects of calcium channel blockers; oral calcium is unlikely to have this effect.
Intravenous calcium is used to decrease the effects of calcium channel blockers in the management of overdose. Intravenous calcium gluconate has been used before intravenous verapamil (Isoptin) to prevent or reduce the hypotensive effects without affecting the antiarrhythmic effects. But there is no evidence that dietary or supplemental calcium when taken orally interacts with calcium channel blockers.
Apple Cider Vinegar concentrate
Digoxin (Lanoxin)
Theoretically, concomitant use of apple cider vinegar with digoxin might increase the risk of cardiac toxicity.
A case of hypokalemia related to chronic use of apple cider vinegar has been reported. Theoretically, overuse of apple cider vinegar could decrease potassium levels, increasing the risk of toxicity with digoxin.
Diuretic Drugs
Theoretically, concomitant use of apple cider vinegar with diuretic drugs might increase the risk of hypokalemia.
A case of hypokalemia related to chronic use of apple cider vinegar has been reported. There is some concern that people taking apple cider vinegar along with potassium depleting diuretics might have an increased risk for hypokalemia.
Insulin
Theoretically, concomitant use of apple cider vinegar with insulin might increase the risk of hypokalemia.
A case of hypokalemia related to chronic use of apple cider vinegar has been reported. Theoretically, overuse of apple cider vinegar concomitantly with insulin might increase the risk of hypokalemia.
Antidiabetes Drugs
Theoretically, taking apple cider vinegar with antidiabetes drugs might increase the risk of hypoglycemia.
Apple cider vinegar might reduce fasting and postprandial blood glucose levels and decrease gastric emptying in people with diabetes. However, not all research agrees. Theoretically, it might have additive effects on glucose levels when used with antidiabetes drugs.
Burdock
Anticoagulant/Antiplatelet Drugs
Theoretically, taking burdock with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
In vitro research shows that lignans from burdock reduce rabbit platelet aggregation by inhibiting platelet activating factor. This interaction has not been reported in humans.
Potassium
Ace Inhibitors (Aceis)
Using ACEIs with high doses of potassium increases the risk of hyperkalemia.
ACEIs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.
Angiotensin Receptor Blockers (Arbs)
Using ARBs with high doses of potassium increases the risk of hyperkalemia.
ARBs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.
Potassium-Sparing Diuretics
Concomitant use increases the risk of hyperkalemia.
Using potassium-sparing diuretics with potassium supplements increases the risk of hyperkalemia.
Barley
Triclabendazole (Egaten)
Theoretically, barley might decrease the clinical effects of triclabendazole.
Animal research suggests that a diet supplemented with barley can reduce the bioavailability of triclabendazole when taken concomitantly. This effect has not been shown in humans.
Brand information
Manufacturer and brand details for Alkaline Balance, from the product label.
Source Naturals
- Name
- Source Naturals, Inc.
- Street Address
- P. O. Box 2118
- City
- Santa Cruz
- State
- CA
- ZipCode
- 95062
- Web Address
- www.sourcenaturals.com
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Alkaline Balance’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sodium
Interacts with 205 drugsSodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...
Read the full Sodium monograph → Herb & supplement monographBurdock
Interacts with 122 drugsBurdock is a traditional herb most often used for skin problems and as a so-called 'blood purifier,' but high-quality human studies are lacking and most claims are not well proven. It is wid...
Read the full Burdock monograph → Herb & supplement monographBeet
Interacts with 861 drugsBeet, especially beetroot juice, is a nitrate-rich food that may modestly lower blood pressure and slightly improve exercise performance in some people. It is generally safe as a food, but s...
Read the full Beet monograph → Herb & supplement monographChlorella
Interacts with 337 drugsChlorella is a nutrient-rich freshwater green algae taken as a supplement for general wellness, immune support, and 'detox.' Some small studies suggest possible benefits for cholesterol, blo...
Read the full Chlorella monograph → Herb & supplement monographCarrot
Carrot is a common food vegetable that is a rich source of beta-carotene (which the body turns into vitamin A) and other nutrients. Eating carrots is safe and nutritious for most people, but...
Read the full Carrot monograph → Herb & supplement monographBlue-green Algae
Interacts with 327 drugsBlue-green algae are nutrient-rich aquatic microorganisms (such as spirulina and Klamath Lake algae) taken as a supplement for energy, nutrition, and general wellness. Evidence for most heal...
Read the full Blue-green Algae monograph → Herb & supplement monographBarley
Interacts with 1 drugBarley is a nutritious whole grain that is a good source of soluble fiber called beta-glucan, which has solid evidence for modestly lowering LDL ('bad') cholesterol when eaten regularly. It...
Read the full Barley monograph → Herb & supplement monographWheatgrass
Interacts with 272 drugsWheatgrass is the young grass of the wheat plant, taken as a juice or powder, and is mainly used as a concentrated source of vitamins and plant nutrients. Solid scientific evidence for most...
Read the full Wheatgrass monograph → Herb & supplement monographPotassium
Interacts with 62 drugsPotassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanced diet rich in fruits and vegetables. P...
Read the full Potassium monograph → Herb & supplement monographCalcium
Interacts with 168 drugsCalcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet falls short. Most people do best getting...
Read the full Calcium monograph → Herb & supplement monographMagnesium
Interacts with 295 drugsMagnesium is an essential mineral your body needs for muscles, nerves, blood pressure, and many other functions, and supplements are useful for preventing or correcting deficiency. Some othe...
Read the full Magnesium monograph → Herb & supplement monographApple Cider Vinegar
Interacts with 162 drugsApple cider vinegar is a fermented apple product that many people use hoping to help with blood sugar, weight, or digestion. The evidence for most of these uses is limited and mixed, and the...
Read the full Apple Cider Vinegar monograph → Herb & supplement monographKudzu
Interacts with 584 drugsKudzu is a fast-growing vine whose root has long been used in traditional Chinese medicine and is now studied mostly for reducing alcohol intake. Early research is promising for cutting back...
Read the full Kudzu monograph → Herb & supplement monographBroccoli
Interacts with 187 drugsBroccoli is a nutritious cruciferous vegetable rich in fiber, vitamins, and plant compounds like sulforaphane that have drawn scientific interest for health benefits. Eating broccoli as food...
Read the full Broccoli monograph → Herb & supplement monographCabbage
Interacts with 325 drugsCabbage is a nutritious, low-calorie vegetable that is safe to eat as food and is sometimes applied to the skin as a leaf wrap for breast engorgement or sore joints. Most medicinal claims ar...
Read the full Cabbage monograph → Herb & supplement monographParsley
Interacts with 443 drugsParsley is a popular culinary herb that is safe to eat in normal food amounts and is a good source of vitamins K and C. It is traditionally used as a diuretic and for digestion, but solid hu...
Read the full Parsley monograph → Herb & supplement monographGinger
Interacts with 1,007 drugsGinger is a widely used culinary spice with a long history in traditional medicine, and it has the strongest evidence for helping with nausea and vomiting, including from motion sickness, pr...
Read the full Ginger monograph → Herb & supplement monographDandelion
Interacts with 457 drugsDandelion is a common plant used in food and traditional medicine, often promoted as a natural 'water pill' and digestive aid. Human evidence for these uses is very limited, so its benefits...
Read the full Dandelion monograph →Sources & How We Checked
Alkaline Balance's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 452 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Sodium 38 references
- Garabedian-Ruffalo SM, Ruffalo RL. Drug and nutrient interactions. Am Fam Physician 1986;33:165-74.
- Food and Drug Administration Science Background: Safety of Sodium Phosphates Oral Solution. September 17, 2001. Available at: http://www.fda.gov/cder/drug/safety/sodiumphospate.htm
- Coton T, Mallaret C, Coilliot C, Carre D, Guisset M. Severe acute ulcerated gastritis induced by salt. Presse Med 2009;38(3):499-500. PubMed
- Frings-Meuthen P, Buehlmeier J, Baecker N, et al. High sodium chloride intake exacerbates immobilization-induced bone resorption and protein losses. J Appl Physiol 2011;111(2):537-542. PubMed
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