Major interaction on record — check this product against your medications before combining. Check your meds →
Dietary supplement

Amped Up Energy Ingredients & Drug Interactions

by MET-Rx

Amped Up Energy label
See full label image
Softgel Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Amped Up Energy against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Amped Up Energy is a dietary supplement by MET-Rx with 1 active ingredient. Its ingredients are commonly taken for mental alertness and reducing fatigue, improving athletic performance, headache and migraine relief.Based on those ingredients, 1,465 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Caffeine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Amped Up Energy by MET-Rx

Ask about any prescription or over-the-counter medication and we check it for interactions with Amped Up Energy by MET-Rx — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Amped Up Energy by MET-Rx

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 7 active ingredients.
  • “Caffeine” is listed as a grouped ingredient — the label gives one combined amount (300 mg) without saying how much of each component you get.
  • “Amped Up AdrenaBuzz Complex” is a proprietary blend — the label gives one combined amount (1,320 mg) without saying how much of each component you get.

Amped Up Energy contains 7 ingredients. The active ones are L-tyrosine (an amino acid), white willow extract, L-taurine (an amino acid), caffeine, vinpocetine (a plant alkaloid), yohimbine HCl, green tea extract, and a proprietary blend called Amped Up AdrenaBuzz Complex containing chocamine (cocoa extract).

These are designed to support energy, focus, and mental clarity. The product also contains inactive ingredients: soybean oil, gelatin, glycerin, and soy lecithin.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: energy and thermogenic support for pre-workout.
  • We looked for evidence on: Athletic performance, Fatigue, Exercise-induced muscle damage, Exercise-induced muscle soreness, Cognitive function, Endurance — and 2 related terms.
  • The strongest evidence on file: Tyrosine is rated "Possibly Effective" for Cognitive function (Natural Medicines).
  • Also on file: Tyrosine is rated "Possibly Ineffective" for Athletic performance.
  • Also on file: Vinpocetine is rated "Insufficient Reliable Evidence To Rate" for Chronic fatigue syndrome (CFS).

The evidence on this product's individual ingredients is mixed. L-tyrosine is possibly effective for cognitive function and memory, but only possibly ineffective for athletic performance.

L-taurine is possibly effective for congestive heart failure and hepatitis, but possibly ineffective for obesity. Vinpocetine is possibly effective for dementia, but evidence is insufficient to rate it for tinnitus, motion sickness, stroke, or chronic fatigue.

Green tea extract is likely effective for human papillomavirus (HPV) and possibly effective for ovarian cancer and high cholesterol. Cocoa is possibly effective for cardiovascular disease but possibly ineffective for stretch marks.

Overall effectiveness for general energy support is not established in the data we hold.

The evidence, ingredient by ingredient Caffeine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 6 of the 6 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 6 of 6.
  • General safety write-ups exist for 6 of 6.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-tyrosine is generally well tolerated but has not been thoroughly evaluated for long-term safety; most common side effects are fatigue, headache, heartburn, and nausea. L-taurine is generally well tolerated short-term but long-term safety is unclear; constipation, diarrhea, and indigestion are common, and rare hypersensitivity reactions have been reported in people with sulfonamide or sulfite allergies.

Vinpocetine is generally well tolerated short-term, with common effects being anxiety, dizziness, headache, and sleep disturbances; rare serious effects include arrhythmias and seizures. Green tea extract is generally well tolerated but high-dose concentrated extracts have rarely been linked to liver injury.

Cocoa is generally well tolerated and contains caffeine, which can cause headaches, nausea, and gastrointestinal upset, especially at higher doses. Pregnancy safety data for L-tyrosine and vinpocetine are not on file; the FDA advises against vinpocetine during pregnancy, and green tea should be moderate during pregnancy.

Breastfeeding safety is insufficient for L-tyrosine; L-taurine is likely safe, but vinpocetine should be avoided, and green tea caffeine should be kept moderate.

Side effects, ingredient by ingredient Caffeine

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 6 of the 6 matched ingredients can interact with medications — Vinpocetine, Yohimbe, Cocoa, Green Tea, Taurine, among others.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; lithium; Parkinson's medications.
  • For scale: 1,466 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Double-check this product against nadolol, ephedrine, atorvastatin, anti-seizure medications (felbamate, valproate, ethosuximide, phenytoin), blood thinners and warfarin, blood pressure medications, levodopa, thyroid hormones, lithium, liver enzyme substrates (CYP2C9), dipyridamole, pentobarbital, quinolone antibiotics, beta-agonists, flutamide, and disulfiram — all carry documented interactions of Moderate or Major severity. No interactions are documented for the ingredients we could check against pentobarbital and several other drug types, but absence of documented interaction is not a guarantee none exist.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This product is marketed for energy and mental focus but combines multiple stimulating ingredients with serious potential interactions — especially if you take heart medications, blood thinners, anti-seizure drugs, or blood pressure medications. If you're on any prescription medication, check it against our tool below before you start.

Even if you're not on medications, talk to your pharmacist about whether the caffeine and other stimulants in this product suit your health.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 21, 2012.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Amped Up Energy, straight from the product label.

Brand MET-Rx
Barcode (UPC) 786560157841
Net contents 90 Rapid Release Softgel(s)
Market status On market
Date entered into DSLD Nov 21, 2012
DSLD ID 15577
Product type Other Combinations
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Amped Up Energy by MET-Rx, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
3 Softgel(s)
Servings per container
30
UPC/BARCODE
786560157841
IngredientAmount% DV
L-Tyrosine0 NP--
White Willow extract0 NP--
L-Taurine0 NP--
Caffeine300 mg--
Vinpocetine0 NP--
Yohimbine HCl0 NP--
Green Tea extract0 NP--
Amped Up AdrenaBuzz Complex1320 mg--
Chocamine0 NP--

Other ingredients: Soybean Oil, Gelatin, Glycerin, Soy Lecithin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

FOR MAXIMUM RESULTS, TAKE UP TO THREE (3) SOFTGELS 30-60 MINUTES BEFORE YOUR WORKOUT.

Directions: For adults, take up to three (3) softgels 30-60 minutes before your workout. Limit use to no more than 6 softgels in a 24-hour period. Individuals sensitive to caffeine should begin with 1-2 softgels to assess individual tolerance.

General Statements

CHECK OUT THESE HARD-HITTING FEATURES: RAPID IMPACT - WE DESIGNED THIS FORMULA TO AMP UP BOTH MENTAL AND PHYSICAL ENERGY LEVELS RIGHT BEFORE YOU START TRAINING.* HEAT INDUCER - FEEL THE HEAT COURSING THROUGH YOUR VEINS. MET-RX(R) AMPED UP’S THERMOGENIC PROPERTIES HELP GET YOU READY TO DO BATTLE IN THE GYM OR DURING COMPETITION.* PRE-WORKOUT FOCUS AND INTENSITY BOOSTER - TO HELP YOU TEAR THROUGH THE GYM AT A BLISTERING PACE.* UNLEASH THE FURY ON THE IRON AND ANYTHING ELSE THAT GETS IN YOUR WAY! MAX ENERGY MOBILIZER - SUPPORTS METABOLISM TO PROMOTE MAXIMAL ENERGY AVAILABILITY DURING ALL-OUT TRAINING SESSIONS.*

PRE-WORKOUT

DESIGNED WITH ONE PURPOSE IN MIND - TO DELIVER THE STRONGEST THERMOGENIC, ENERGY-ENHANCING FORMULA AVAILABLE.* DUE TO INCREASING DEMANDS FROM SERIOUS BODYBUILDERS AND ATHLETES ACROSS THE COUNTRY, THE MET-Rx(R) RESEARCH TEAM WENT BACK TO THE LAB TO DEVELOP OUR MOST POWERFUL FORMULA TO DATE!

>>ULTRA STRENGTH THERMOGENIC FORMULA TO HELP BOOST ENERGY AND FOCUS*

Precautions

Not intended for use by persons under the age of 18. KEEP OUT OF REACH OF CHILDREN.

WARNING: Not intended for use by pregnant or nursing women. If you are taking any medications or have any medical condition, consult your doctor before use.

Avoid this product if you have liver or kidney disease, high blood pressure or are allergic to aspirin.

TAMPER RESISTANT: DO NOT USE IF SEAL UNDER CAP IS BROKEN OR MISSING.

CAUTION: DO NOT EXCEED RECOMMENDED DOSE

ENERGY

As a reminder, discuss the supplements and medications you take with your health care providers.

Avoid additional consumption of caffeine, which may intensify adverse effects. Discontinue use and consult your doctor if any adverse reactions occur.

Storage

STORE AT ROOM TEMPERATURE AND AVOID EXCESSIVE HEAT.

Formula

Contains <2% of: FD&C Red No. 40, FD&C Yellow No. 6, Titanium Dioxide Color.

This product contains caffeine.

Brand IP Statement(s)

MET-Rx(R) Shaping Every Body(TM).

MET-Rx(R) AMPED UP ENERGY

MET-Rx(R) AMPED UP ENERGY IS AN EXCLUSIVE BLEND THAT SHOULD ONLY BE USED BY THOSE WHO NEED AN ULTRA-INTENSE FORMULA TO TAKE THEIR WORKOUTS TO THE NEXT LEVEL.*

General

15784 04E B15784 HAB

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

DIETARY SUPPLEMENT

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Amped Up Energy by MET-Rx label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Amped Up Energy label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Amped Up Energy by MET-Rx

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container30 Amounts shown are per serving.

Amped Up AdrenaBuzz Complex

1320 mg per serving

Other (inactive) ingredients: Soybean Oil, Gelatin, Glycerin, Soy Lecithin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Amped Up Energy by MET-Rx Drug Interactions

Want to check YOUR meds against Amped Up Energy?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,465Drugs
22 Major 1,197 Moderate 246 Minor

Ingredients driving the most interactions

Caffeine 655

Individual Drug Interactions

The ingredients in Amped Up Energy interact with 1,465 drugs. Click any drug to see the details.

1 of the 1 ingredient in Amped Up Energy interact with drugs. Each result below shows which ingredient is responsible. Caffeine

Each ingredient & the kinds of drugs it affects

For each ingredient in Amped Up Energy with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Caffeine41 drug types · 655 drugs

Ephedrine

Theoretically, concomitant use might increase the risk for stimulant adverse effects.
Use of ephedrine with caffeine can increase the risk of stimulatory adverse effects. There is evidence that using ephedrine with caffeine might increase the risk of serious life-threatening or debilitating adverse effects such as hypertension, myocardial infarction, stroke, seizures, and death.

Likelihood Probable Evidence D
Adenosine (Adenocard)

Theoretically, caffeine might decrease the vasodilatory effects of adenosine and interfere with its use prior to stress testing.
Some evidence shows that caffeine is a competitive inhibitor of adenosine and can reduce the vasodilatory effects of adenosine in humans. However, other research shows that caffeine does not seem to affect supplemental adenosine because high interstitial levels of adenosine overcome the antagonistic effects of caffeine. It is recommended that methylxanthines and methylxanthine-containing products be stopped 24 hours prior to pharmacological stress tests. However, methylxanthines appear more likely to interfere with dipyridamole (Persantine) than adenosine-induced stress testing.

Likelihood Possible Evidence B
Anticoagulant/Antiplatelet Drugs

Theoretically, caffeine may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Caffeine is reported to have antiplatelet activity. Theoretically, it might increase the risk of bleeding when used concomitantly with these agents; however, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Beta-Adrenergic Agonists

Theoretically, large amounts of caffeine might increase the cardiac inotropic effects of beta-agonists.

Likelihood Probable Evidence D
Carbamazepine (Tegretol)

Theoretically, caffeine might reduce the effects of carbamazepine and increase the risk for convulsions.
Animal research suggests that taking caffeine can lower the anticonvulsant effects of carbamazepine and can induce seizures when taken in doses above 400 mg/kg. Human research has shown that taking caffeine 300 mg in three divided doses along with carbamazepine 200 mg reduces the bioavailability of carbamazepine by 32% and prolongs the plasma half-life of carbamazepine 2-fold in healthy individuals.

Likelihood Possible Evidence D
Cimetidine (Tagamet)

Theoretically, cimetidine might increase the levels and adverse effects of caffeine.
Cimetidine decreases the rate of caffeine clearance by 31% to 42%.

Likelihood Likely Evidence B
Clozapine (Clozaril)

Caffeine might increase the levels and adverse effects of clozapine and acutely exacerbate psychotic symptoms.
Caffeine might increase the effects and toxicity of clozapine. Caffeine doses of 400-1000 mg per day inhibit clozapine metabolism. Clozapine is metabolized by cytochrome P450 1A2 (CYP1A2). Although researchers speculate that caffeine might inhibit CYP1A2, there is no reliable evidence that caffeine affects CYP1A2. There is also speculation that genetic factors might make some patients more sensitive to an interaction between clozapine and caffeine. In one case report, severe, life-threatening clozapine toxicity and multiorgan system failure occurred in a patient with schizophrenia stabilized on clozapine who consumed caffeine 600 mg daily.

Likelihood Possible Evidence B
Dipyridamole (Persantine)

Theoretically, caffeine might decrease the vasodilatory effects of dipyridamole and interfere with its use prior to stress testing.
Caffeine inhibits dipyridamole-induced vasodilation. It is recommended that methylxanthines and methylxanthine-containing products be stopped 24 hours prior to pharmacological stress tests. Methylxanthines appear more likely to interfere with dipyridamole (Persantine) than adenosine-induced stress testing.

Likelihood Probable Evidence B
Disulfiram (Antabuse)

Theoretically, disulfiram use might increase the levels and adverse effects of caffeine.
Disulfiram decreases the rate of caffeine clearance.

Likelihood Probable Evidence B
Diuretic Drugs

Theoretically, using caffeine with diuretic drugs might increase the risk of hypokalemia.
Caffeine, especially in excessive amounts, can reduce potassium levels due to stimulation of the sodium-potassium pump. Diuretics can also cause lower potassium levels.

Likelihood Possible Evidence D
Estrogens

Theoretically, estrogens might increase the levels and adverse effects of caffeine.
Estrogen inhibits caffeine metabolism.

Likelihood Probable Evidence B
Ethosuximide (Zarontin)

Theoretically, caffeine might reduce the effects of ethosuximide and increase the risk for convulsions.
Animal research suggests that caffeine 92.4 mg/kg can decrease the anticonvulsant activity of ethosuximide. However, this effect has not been reported in humans.

Likelihood Possible Evidence D
Felbamate (Felbatol)

Theoretically, caffeine might reduce the effects of felbamate and increase the risk for convulsions.
Animal research suggests that a high dose of caffeine 161.7 mg/kg can decreases the anticonvulsant activity of felbamate. However, this effect has not been reported in humans.

Likelihood Possible Evidence D
Flutamide (Eulexin)

Theoretically, caffeine might increase the levels and adverse effects of flutamide.
In vitro evidence suggests that caffeine can inhibit the metabolism of flutamide. However, this effect has not been reported in humans.

Likelihood Probable Evidence D
Fluvoxamine (Luvox)

Theoretically, fluvoxamine might increase the levels and adverse effects of caffeine.
Fluvoxamine reduces caffeine metabolism.

Likelihood Probable Evidence D
Lithium

Abrupt caffeine withdrawal might increase the levels and adverse effects of lithium.
Caffeine has diuretic activity. When abruptly discontinued, caffeine may alter the clearance of lithium. There are two case reports of lithium tremor that worsened upon abrupt coffee withdrawal and 6 case reports of elevated serum lithium levels after reducing or eliminating caffeine intake. In one case, a male with schizoaffective disorder stabilized on lithium had an elevated lithium level after reducing his caffeine intake by 87%. At a later date, he increased his caffeine intake by 6-fold, resulting in a subtherapeutic lithium level and a recurrence of psychiatric symptoms.

Likelihood Probable Evidence D
Monoamine Oxidase Inhibitors (Maois)

Theoretically, concomitant use might increase the risk of a hypertensive crisis.
Caffeine has been shown to inhibit monoamine oxidase (MAO) A and B in laboratory studies. Concomitant intake of large amounts of caffeine with MAOIs might precipitate a hypertensive crisis. In a case report, a patient that consumed 10-12 cups of caffeinated coffee and took the MAOI tranylcypromine presented with severe hypertension. Hypertension was resolved after the patient switched to drinking decaffeinated coffee.

Likelihood Possible Evidence D
Nicotine

Theoretically, concomitant use might increase the risk of hypertension.
Concomitant use of caffeine and nicotine has been shown to have additive cardiovascular effects, including increased heart rate and blood pressure. Blood pressure was increased by 10.8/12.4 mmHg when the agents were used concomitantly.

Likelihood Probable Evidence B
Pentobarbital (Nembutal)

Theoretically, caffeine might decrease the effects of pentobarbital.
Caffeine might negate the hypnotic effects of pentobarbital.

Likelihood Possible Evidence B
Phenobarbital (Luminal)

Theoretically, caffeine might reduce the effects of phenobarbital and increase the risk for convulsions.
Animal research suggests that caffeine can decrease the anticonvulsant activity of phenobarbital. However, the exact mechanism of this interaction is unclear.

Likelihood Possible Evidence D
Phenylpropanolamine

Theoretically, phenylpropanolamine might increase the risk of hypertension, as well as the levels and adverse effects of caffeine.
Concomitant use of phenylpropanolamine and caffeine might cause an additive increase in blood pressure. Phenylpropanolamine also seems to increase caffeine serum levels.

Likelihood Probable Evidence B
Phenytoin (Dilantin)

Theoretically, caffeine might reduce the effects of phenytoin and increase the risk for convulsions.
Animal research suggests that caffeine can decrease the anticonvulsant activity of phenytoin. The effect does not seem to be related to the seizure threshold-lowering effects of caffeine. However, the exact mechanism of this interaction is unclear.

Likelihood Possible Evidence D
Pioglitazone (Actos)

Theoretically, caffeine might increase the levels and clinical effects of pioglitazone.
Animal research suggests that caffeine can modestly increase the maximum concentration, area under the curve, and half-life of pioglitazone, and also reduce its clearance. This increased the antidiabetic effects of pioglitazone. However, the exact mechanism of this interaction is unclear.

Likelihood Possible Evidence D
Quinolone Antibiotics

Theoretically, quinolone antibiotics might increase the levels and adverse effects of caffeine.
Quinolones (also called fluoroquinolones) can decrease caffeine clearance by inhibiting cytochrome P450 1A2 (CYP1A2) enzyme.

Likelihood Probable Evidence B
Riluzole (Rilutek)

Theoretically, concomitant use might increase the levels and adverse effects of both caffeine and riluzole.
Caffeine and riluzole are both metabolized by cytochrome P450 1A2 (CYP1A2), and concomitant use might reduce the metabolism of one or both agents.

Likelihood Possible Evidence D
Caffeine full monograph & all 41 interactions
The maker

Brand information

Manufacturer and brand details for Amped Up Energy, from the product label.

MET-Rx

See all MET-Rx products
Web Address
www.MET-Rx.com
Pharmacist Counseling Corner

Amped Up Energy by MET-Rx: Common Questions

Does Amped Up Energy by MET-Rx interact with any medications?
Yes. Based on its ingredients, Amped Up Energy has a known interaction with 1,465 medications, including 22 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Amped Up Energy contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this contain stimulants?
Yes. The product contains caffeine from green tea extract and chocamine (cocoa), plus L-tyrosine and other ingredients aimed at boosting energy and mental alertness. If you're sensitive to stimulants or have heart conditions, talk to your pharmacist first.
What are the most common side effects?
From the individual ingredients: headache, nausea, heartburn, fatigue, dizziness, anxiety, sleep disturbances, and gastrointestinal upset (constipation, diarrhea, indigestion). Higher doses tend to trigger more side effects; starting low is wise.
Is this safe during pregnancy?
The safety data for most ingredients are not established. Vinpocetine is specifically advised against during pregnancy. Talk with your doctor or pharmacist about whether this product is right for you if you're pregnant or could become pregnant.
Is this safe while breastfeeding?
Caffeine passes into breast milk and may cause fussiness in infants if intake is high. Safety data for L-tyrosine and vinpocetine are not on file, and vinpocetine should be avoided. Keep intake moderate and discuss with your pharmacist if you're nursing.
What is L-tyrosine for?
L-tyrosine is an amino acid your body uses to make neurotransmitters and thyroid hormones. It's possibly effective for memory and cognitive function, but evidence for athletic performance is weak. It's effective only for the rare condition phenylketonuria (PKU).
What about the green tea extract — does it actually do anything?
Green tea extract is likely effective for human papillomavirus (HPV) and possibly effective for ovarian cancer risk and cholesterol levels. For general energy, evidence isn't established in our data. Keep in mind it contains caffeine, which is a stimulant.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Amped Up Energy label
Go deeper

The Full Monographs Behind Amped Up Energy’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Caffeine

Interacts with 655 drugs

Caffeine is a natural stimulant found in coffee, tea, and many other plants and products. In moderate amounts it can boost alertness and reduce tiredness for most healthy adults, but too muc...

Read the full Caffeine monograph →
Sources

Sources & How We Checked

Amped Up Energy's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 692 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Tyrosine 4 references
  1. Meyer JS, Welch KM, Deshmukh VD, et al. Neurotransmitter precursor amino acids in the treatment of multi-infarct dementia and Alzheimer's disease. J Amer Geriat Soc 1977;25:289-98.
  2. DiPiro JT, Talbert RL, Yee GC, et al; eds. Pharmacotherapy: A pathophysiologic approach. 4th ed. Stamford, CT: Appleton & Lange, 1999.
  3. Wood DR, Reimherr FW, Wender PH. Amino acid precursors for the treatment of attention deficit disorder, residual type. Psychopharmacol Bull 1985;21:146-9.
  4. van Spronsen FJ, van Rijn M, Bekhof J. Phenylketonuria: tyrosine supplementation in phenylalanine-restricted diets. Am J Clin Nutr 2001;73:153-7. PubMed

See these in context on the Tyrosine monograph →

Taurine 21 references
  1. Ahmad S, Robertson HT, Golper TA, et al. Multicenter trial of L-carnitine in maintenance hemodialysis patients. II. Clinical and biochemical effects. Kidney Int 1990;38:912-8. PubMed
  2. Machado-Vieira R, Viale CI, Kapczinski F. Mania associated with an energy drink: the possible role of caffeine, taurine, and inositol. Can J Psychiatry 2001;46:454-5. PubMed
  3. Obermann M, Schorn CF, Mummel P, et al. Taurine induced toxic encephalopathy? Clin Neurol Neurosurg 2006;108:812-3. PubMed
  4. Bichler, A., Swenson, A., and Harris, M. A. A combination of caffeine and taurine has no effect on short term memory but induces changes in heart rate and mean arterial blood pressure. Amino Acids 2006;31(4):471-476. PubMed
  5. Iyadurai, S. J. and Chung, S. S. New-onset seizures in adults: possible association with consumption of popular energy drinks. Epilepsy Behav 2007;10(3):504-508. PubMed
  6. Berger, A. J. and Alford, K. Cardiac arrest in a young man following excess consumption of caffeinated "energy drinks". Med J Aust. 1-5-2009;190(1):41-43. PubMed
  7. Worthley, M. I., Prabhu, A., De, Sciscio P., Schultz, C., Sanders, P., and Willoughby, S. R. Detrimental effects of energy drink consumption on platelet and endothelial function. Am J Med 2010;123(2):184-187. PubMed
  8. Morchon, Simon D. and Perez Castrillon, J. L. [Hypoglycemia by intake of taurine]. Rev.Clin Esp. 2010;210(1):49.
  9. Livshits, Z., Hoffman, R. S., Hymes, K. B., and Nelson, L. S. If vitamins could kill: massive hemolysis following naturopathic vitamin infusion. J Med Toxicol. 2011;7(3):224-226. PubMed
  10. Schoffl, I., Kothmann, J. F., Schoffl, V., Rupprecht, H. D., and Rupprecht, T. "Vodka energy": too much for the adolescent nephron? Pediatrics 2011;128(1):e227-e231. PubMed
  11. Calabro, R. S., Italiano, D., Gervasi, G., and Bramanti, P. Single tonic-clonic seizure after energy drink abuse. Epilepsy Behav 2012;23(3):384-385. PubMed
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  17. Sun Q, Wang B, Li Y, Sun F, et al. Taurine supplementation lowers blood pressure and improves vascular function in prehypertension: randomized, double-blind, placebo-controlled study. Hypertension 2016 Mar;67(3):541-9. PubMed
  18. Jang ES, Hwang SH, Kim JW, Jeong SH. Effectiveness of 4-week oral taurine treatment for muscle cramps in patients with liver cirrhosis: a single-arm pilot study. Yonsei Med J 2021;62(1):21-8. PubMed
  19. Guan L, Miao P. The effects of taurine supplementation on obesity, blood pressure and lipid profile: A meta-analysis of randomized controlled trials. Eur J Pharmacol 2020;885:173533. PubMed
  20. Higgins JP, Liras GN, Liras IN, et al. Energy Drink Effects on Hemodynamics and Endothelial Function in Young Adults. Cardiology. 2021;146(2):258-262. PubMed
  21. Pallangyo P, Bhalia SV, Komba M, et al. Acute Myocardial Infarction Following the Consumption of Energy Drink in a 28-Year-Old Male: A Case Report. J Investig Med High Impact Case Rep. 2023 Jan-Dec;11:23247096231168811. PubMed

See these in context on the Taurine monograph →

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See these in context on the Green Tea monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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