Interactions on record — worth a quick check against your medications. Based on 5 of 6 ingredients. Check your meds →
Dietary supplement

Balance Capsules Ingredients & Drug Interactions

by Alani Nu Self

Balance Capsules label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Balance Capsules against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Balance Capsules is a dietary supplement by Alani Nu Self with 6 active ingredients. Its ingredients are commonly taken for estrogen/hormone balance, acne and hormonal skin issues, prostate health support.Based on those ingredients, 533 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are 3,3'-Diindolylmethane, Sodium R-Alpha Lipoic Acid, Chromium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Balance Capsules by Alani Nu Self

Ask about any prescription or over-the-counter medication and we check it for interactions with Balance Capsules by Alani Nu Self — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Balance Capsules by Alani Nu Self

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 6 of its 6 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Balance Capsules contains 6 ingredients. The active ones are diindolylmethane (a compound from cruciferous vegetables), myo-inositol (a carbohydrate your body makes), chromium (a mineral), glutathione (an antioxidant), and alpha-lipoic acid (an antioxidant).

The inactive ingredients — hypromellose, silica, vitamin C, and titanium dioxide — are fillers and capsule material.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: support hormonal balance weight management and fertility.
  • We looked for evidence on: Infertility, Male infertility, Metabolic syndrome, Dyslipidemia, Diabetes, Impaired glucose tolerance (prediabetes) — and 4 related terms.
  • The strongest evidence on file: Chromium is rated "Likely Effective" for Chromium deficiency (Natural Medicines).
  • Also on file: Inositol is rated "Possibly Effective" for Polycystic ovary syndrome (PCOS), Metabolic syndrome.
  • Also on file: Chromium is rated "Possibly Effective" for Diabetes.

The evidence for these ingredients is mixed. Myo-inositol is possibly effective for polycystic ovary syndrome (PCOS) and metabolic syndrome, and possibly effective for preterm labor.

Chromium is likely effective for chromium deficiency and possibly effective for diabetes. Alpha-lipoic acid is possibly effective for diabetic nerve damage and possibly effective for high cholesterol and weight management.

Glutathione is possibly effective for nerve damage from the chemotherapy drug cisplatin. Diindolylmethane has insufficient evidence for breast cancer, colorectal cancer, and other conditions — we don't yet know if it works for these.

The evidence, ingredient by ingredient Diindolylmethane Inositol Chromium Glutathione Alpha-lipoic Acid

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

These ingredients are generally well tolerated short-term. Common side effects from myo-inositol, diindolylmethane, chromium, and alpha-lipoic acid include diarrhea, gas, nausea, and headache.

Diindolylmethane is rated likely safe in pregnancy and lactation. Myo-inositol is possibly safe in pregnancy but use only under medical supervision.

Chromium is likely safe in pregnancy and lactation at typical doses, but extra supplemental chromium beyond what's in prenatal vitamins should be avoided unless your doctor recommends it. Glutathione and alpha-lipoic acid should be avoided in pregnancy and lactation — there isn't enough reliable safety data.

Long-term safety of diindolylmethane and glutathione oral forms hasn't been well established.

Side effects, ingredient by ingredient Diindolylmethane Inositol Chromium Glutathione Alpha-lipoic Acid

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 5 matched ingredients can interact with medications — Inositol, Alpha-lipoic Acid, Chromium, Diindolylmethane.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; cancer treatments; diabetes medications.
  • For scale: 533 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Balance Capsules, check with your pharmacist if you take blood thinners or antiplatelet drugs (alpha-lipoic acid raises bleeding risk — Moderate), estrogen or hormone replacement therapy (diindolylmethane may interfere — Moderate), insulin or diabetes medications (chromium, myo-inositol, and alpha-lipoic acid may lower blood sugar — Moderate), thyroid hormone like levothyroxine (chromium and alpha-lipoic acid may decrease its effect — Moderate), chemotherapy drugs like alkylating agents or antitumor antibiotics (alpha-lipoic acid's antioxidant effects may interfere — Moderate), water pills/diuretics especially sodium-depleting ones (diindolylmethane raises low sodium risk — Moderate), or NSAIDs and aspirin (chromium absorption may increase — Minor).

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Balance Capsules may be worth considering if you have PCOS, metabolic syndrome, diabetes, or diabetic nerve damage and want support from myo-inositol, chromium, or alpha-lipoic acid. If you take any blood thinners, insulin, diabetes medications, thyroid hormone, estrogen therapy, diuretics, or chemotherapy, talk with your pharmacist before adding this product — the interactions are real and need individual review.

Avoid it if you're pregnant (alpha-lipoic acid and glutathione) or breastfeeding (glutathione and alpha-lipoic acid).

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 22, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Balance Capsules, straight from the product label.

Brand Alani Nu Self
Barcode (UPC) 850645008134
Net contents 120 Veggie Capsule(s)
Market status On market
Date entered into DSLD Mar 22, 2023
DSLD ID 277631
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Balance Capsules by Alani Nu Self, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
4 Veggie Capsule(s)
Maximum serving Sizes:
4 Veggie Capsule(s)
Servings per container
30
UPC/BARCODE
850645008134
IngredientAmount% DV
3,3'-Diindolylmethane150 mg--
Myo-Inositol2 Gram(s)--
Chromium120 mcg343%
Setria L-Glutathione250 mg--
Sodium R-Alpha Lipoic Acid100 mg--
Folate400 mcg DFE100%

Other ingredients: Hypromellose, Silica, Vitamin C, Titanium Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Balance is strategically designed to support hormonal balance, weight management, complexion, and fertility. Enjoy restorative sleep, improved energy levels, and more.

Sugar free Gluten free

Vegan

Brighter skin Clear complexion Hormonal balance

Precautions

Caution: Do not exceed the recommended dose.

Pregnant or nursing mothers, children under the age of 18, and individuals with a known medical condition should consult a physician before using this or any dietary supplement.

Pregnant or nursing mothers, children under the age of 18, and individuals with a known medical condition should consult a physician before using this or any dietary supplement.

Keep out of reach of children.

Do not use if safety seal is damaged or missing.

Allergen Warning: This product is manufactured in a facility which may also process milk, soy, wheat, egg, peanuts, tree nuts, fish and shellfish.

Storage

Store at room temperature.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take 4 capsules once a day with a morning meal.

General Statements

30 day supply

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Balance Capsules by Alani Nu Self label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Balance Capsules label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Balance Capsules by Alani Nu Self

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size4 Veggie Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

3,3'-Diindolylmethane

Interacts with
269 drugs
150 mg per serving

Diindolylmethane (DIM) is a compound made when your body digests cruciferous vegetables, and it is sold as a supplement mainly for hormone balance and...

3,3'-Diindolylmethane monograph & interactions

Myo-Inositol

Interacts with
86 drugs
2 Gram(s) per serving

Inositol is a sugar alcohol made naturally in the body and found in many foods, and it is sold as a supplement (often myo-inositol) mainly for PCOS, m...

Myo-Inositol monograph & interactions

Chromium

Interacts with
178 drugs
120 mcg per serving Form: TRAACS Nicotinate Glycinate Chelate

Chromium is an essential trace mineral involved in how the body handles sugar and fat. Some studies suggest it may modestly help blood sugar control i...

Chromium monograph & interactions

Setria L-Glutathione

No known
interactions
250 mg per serving

Glutathione is a powerful antioxidant your body makes naturally, and many people take it as a supplement hoping for skin, detox, or anti-aging benefit...

Setria L-Glutathione monograph & interactions

Sodium R-Alpha Lipoic Acid

Interacts with
263 drugs
100 mg per serving

Alpha-lipoic acid (ALA) is an antioxidant made naturally by the body and found in small amounts in foods. It is most studied for diabetic nerve pain,...

Sodium R-Alpha Lipoic Acid monograph & interactions

Folate

400 mcg DFE per serving Form: 5-Methyltetrahydrofolate Calcium

Other (inactive) ingredients: Hypromellose, Silica, Vitamin C, Titanium Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Balance Capsules by Alani Nu Self Drug Interactions

Want to check YOUR meds against Balance Capsules?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
533Drugs
378 Moderate 155 Minor

Ingredients driving the most interactions

3,3'-Diindolylmethane 269
Sodium R-Alpha Lipoic Acid 263
Chromium 178
Myo-Inositol 86

Individual Drug Interactions

The ingredients in Balance Capsules interact with 533 drugs. Click any drug to see the details.

4 of the 6 ingredients in Balance Capsules interact with drugs. Each result below shows which ingredient is responsible. 3,3'-Diindolylmethane Sodium R-Alpha Lipoic Acid Chromium Myo-Inositol

Each ingredient & the kinds of drugs it affects

For each ingredient in Balance Capsules with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

3,3'-Diindolylmethane3 drug types · 269 drugs

Diuretic Drugs

Theoretically, diindolylmethane might increase the risk of hyponatremia if used with sodium-depleting diuretics.
Large doses of diindolylmethane (600 mg daily) have been associated with two cases of asymptomatic hyponatremia in clinical research.

Likelihood Possible Evidence B
Estrogens

Theoretically, diindolylmethane might increase or decrease the effects of estrogens.
Diindolylmethane might have mild estrogenic or antiestrogenic effects. Theoretically, large amounts of diindolylmethane might interfere with hormone replacement therapy.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, diindolylmethane might lower serum levels of CYP1A2 substrates.
In vitro evidence suggests that diindolylmethane can induce CYP1A2. Theoretically, it might increase metabolism of CYP1A2 substrates and lower serum concentrations. This interaction has not been reported in humans.

Likelihood Unlikely Evidence D
3,3'-Diindolylmethane full monograph & interactions

Sodium R-Alpha Lipoic Acid5 drug types · 263 drugs

Alkylating Agents

Theoretically, the antioxidant effects of alpha-lipoic acid might alter the effectiveness of alkylating agents.
The use of antioxidants like alpha-lipoic acid during chemotherapy is controversial. There are concerns that antioxidants could reduce the activity of chemotherapy drugs that generate free radicals. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as alpha-lipoic acid have on chemotherapy. Advise patients to consult their oncologist before using alpha-lipoic acid.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, alpha-lipoic acid may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro, alpha-lipoic acid inhibits platelet aggregation.

Likelihood Possible Evidence D
Antitumor Antibiotics

Theoretically, the antioxidant effects of alpha-lipoic acid might alter the effectiveness of antitumor antibiotics.
The use of antioxidants like alpha-lipoic acid during chemotherapy is controversial. There are concerns that antioxidants could reduce the activity of antitumor antibiotic drugs, which work by generating free radicals. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as alpha-lipoic acid have on chemotherapy involving antitumor antibiotics. Advise patients to consult their oncologist before using alpha-lipoic acid.

Likelihood Possible Evidence D
Thyroid Hormone

Theoretically, alpha-lipoic acid might decrease the effects of thyroid hormone drugs.
Animal research suggests that co-administration of thyroxine with alpha-lipoic acid reduces conversion into the active T3 form.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking alpha-lipoic acid with antidiabetes drugs might increase the risk of hypoglycemia.
Although some small clinical studies have suggested that alpha-lipoic acid can lower blood glucose levels, larger clinical studies in patients with diabetes have shown no clinically meaningful effect. Additionally, co-administration of single doses of alpha-lipoic acid and glyburide or acarbose did not cause detectable drug interactions in healthy volunteers.

Likelihood Unlikely Evidence B
Sodium R-Alpha Lipoic Acid full monograph & interactions

Chromium5 drug types · 178 drugs

Antidiabetes Drugs

Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Some research shows that taking chromium might lower blood glucose levels, especially in patients with poorly controlled type 2 diabetes.

Likelihood Possible Evidence A
Insulin

Theoretically, concomitant use of chromium and insulin might increase the risk of hypoglycemia.
In clinical research, chromium has been shown to increase insulin sensitivity,

Likelihood Possible Evidence B
Levothyroxine (Synthroid, Others)

Chromium might bind levothyroxine in the intestinal tract and decrease levothyroxine absorption.
Clinical research in healthy volunteers shows that taking chromium picolinate 1000 mcg with levothyroxine 1 mg decreases serum levels of levothyroxine by 17% when compared to taking levothyroxine alone. Advise patients to take levothyroxine at least 30 minutes before or 3-4 hours after taking chromium.

Likelihood Probable Evidence B
Aspirin

Theoretically, aspirin might increase chromium absorption.
Animal research suggests that aspirin may increase chromium absorption and chromium levels in the blood.

Likelihood Possible Evidence D
Nonsteroidal Anti-Inflammatory Drugs (Nsaids)

NSAIDs might increase chromium levels in the body.
Drugs that are prostaglandin inhibitors, such as NSAIDs, seem to increase chromium absorption and retention.

Likelihood Possible Evidence D
Chromium full monograph & interactions

Myo-Inositol1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking inositol with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that inositol lowers blood glucose levels and glycated hemoglobin (HbA1c) levels in patients with diabetes.

Likelihood Possible Evidence A
Myo-Inositol full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Balance Capsules, from the product label.

Alani Nu Self

See all Alani Nu Self products
Name
Alani Nutrition LLC
Street Address
7201 Intermodal Dr. Ste A.
City
Louisville
State
KY
ZipCode
40258
Web Address
alaninu.com
Pharmacist Counseling Corner

Balance Capsules by Alani Nu Self: Common Questions

Does Balance Capsules by Alani Nu Self interact with any medications?
Yes. Based on its ingredients, Balance Capsules has a known interaction with 533 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Balance Capsules contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Balance Capsules if I'm pregnant?
Diindolylmethane is rated likely safe in pregnancy, and myo-inositol is possibly safe (though only under medical supervision). However, alpha-lipoic acid and glutathione lack enough safety data and should be avoided in pregnancy. Talk with your doctor or pharmacist before taking this product while pregnant — they can weigh the individual ingredients and your situation.
Can I take this while breastfeeding?
No — glutathione and alpha-lipoic acid should be avoided while breastfeeding because there isn't enough safety data. Myo-inositol safety data during breastfeeding is also limited. Talk with your pharmacist or doctor before taking this product if you're nursing.
What's myo-inositol for?
Myo-inositol is a carbohydrate your body makes naturally. In this product, it's likely included because it's possibly effective for PCOS and metabolic syndrome — two conditions linked to insulin resistance. Research also suggests it may help with preterm labor prevention, though that would require medical supervision.
Can diindolylmethane really help prevent cancer?
The evidence isn't there yet. Diindolylmethane has been studied for breast cancer, colorectal cancer, and cervical dysplasia, but we don't have enough reliable evidence to say it works for any of them. If you're taking it for cancer prevention, that's a personal choice — just know the science doesn't yet support it.
What are the most common side effects?
Diarrhea, gas, nausea, and headache are the most common side effects across these ingredients. They're usually mild and related to the digestive effects of myo-inositol, diindolylmethane, chromium, and alpha-lipoic acid. Most people tolerate them well in the short term.
Why do I need to space this apart from my thyroid medicine?
Both chromium and alpha-lipoic acid may theoretically decrease how well your body absorbs or uses thyroid hormone. If you take levothyroxine, space this product away from it by a few hours and let your pharmacist know — they may suggest a specific timing to protect your thyroid levels.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Balance Capsules label
Go deeper

The Full Monographs Behind Balance Capsules’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Diindolylmethane

Interacts with 269 drugs

Diindolylmethane (DIM) is a compound made when your body digests cruciferous vegetables, and it is sold as a supplement mainly for hormone balance and cancer prevention. Although early lab s...

Read the full Diindolylmethane monograph → Herb & supplement monograph

Inositol

Interacts with 86 drugs

Inositol is a sugar alcohol made naturally in the body and found in many foods, and it is sold as a supplement (often myo-inositol) mainly for PCOS, mood, and metabolic concerns. The stronge...

Read the full Inositol monograph → Herb & supplement monograph

Chromium

Interacts with 178 drugs

Chromium is an essential trace mineral involved in how the body handles sugar and fat. Some studies suggest it may modestly help blood sugar control in certain people with type 2 diabetes, b...

Read the full Chromium monograph → Herb & supplement monograph

Glutathione

Glutathione is a powerful antioxidant your body makes naturally, and many people take it as a supplement hoping for skin, detox, or anti-aging benefits. However, strong human evidence is lim...

Read the full Glutathione monograph → Herb & supplement monograph

Alpha-lipoic Acid

Interacts with 263 drugs

Alpha-lipoic acid (ALA) is an antioxidant made naturally by the body and found in small amounts in foods. It is most studied for diabetic nerve pain, where some evidence suggests it may help...

Read the full Alpha-lipoic Acid monograph →
Sources

Sources & How We Checked

Balance Capsules's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 130 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Diindolylmethane 14 references
  1. Natl Inst Health, Natl Inst Environmental Health Sci. Indole-3-carbinol. Available at: http://ntp-server.niehs.nih.gov.
  2. Balk JL. Indole-3-carbinol for cancer prevention. Altern Med Alert 2000; 3:105-7.
  3. Riby JE, Chang GHF, Firestone GL, Bjeldanes LF. Ligand-independent activation of estrogen receptor function by 3,3'-diindolylmethane in human breast cancer cells. Biochem Pharmacol 2000;60:167-77. PubMed
  4. Lake BG, Tredger JM, Renwick AB, et al. 3'3-diindolylmethane induces CYP1A2 in cultured precision-cut human liver slices. Xenobiotica 1998;28:803-11. PubMed
  5. Dalessandri, K. M., Firestone, G. L., Fitch, M. D., Bradlow, H. L., and Bjeldanes, L. F. Pilot study: effect of 3,3'-diindolylmethane supplements on urinary hormone metabolites in postmenopausal women with a history of early-stage breast cancer. Nutr Canc PubMed
  6. Reed, G. A., Arneson, D. W., Putnam, W. C., Smith, H. J., Gray, J. C., Sullivan, D. K., Mayo, M. S., Crowell, J. A., and Hurwitz, A. Single-dose and multiple-dose administration of indole-3-carbinol to women: pharmacokinetics based on 3,3'-diindolylmetha
  7. Reed, G. A., Sunega, J. M., Sullivan, D. K., Gray, J. C., Mayo, M. S., Crowell, J. A., and Hurwitz, A. Single-dose pharmacokinetics and tolerability of absorption-enhanced 3,3'-diindolylmethane in healthy subjects. Cancer Epidemiol.Biomarkers Prev. 2008; PubMed
  8. Del Priore G., Gudipudi, D. K., Montemarano, N., Restivo, A. M., Malanowska-Stega, J., and Arslan, A. A. Oral diindolylmethane (DIM): pilot evaluation of a nonsurgical treatment for cervical dysplasia. Gynecol.Oncol. 2010;116(3):464-467. PubMed
  9. Heath, E. I., Heilbrun, L. K., Li, J., Vaishampayan, U., Harper, F., Pemberton, P., and Sarkar, F. H. A phase I dose-escalation study of oral BR-DIM (BioResponse 3,3'- Diindolylmethane) in castrate-resistant, non-metastatic prostate cancer. Am.J.Transl.R
  10. Jellinck, P. H., Forkert, P. G., Riddick, D. S., Okey, A. B., Michnovicz, J. J., and Bradlow, H. L. Ah receptor binding properties of indole carbinols and induction of hepatic estradiol hydroxylation. Biochem.Pharmacol. 3-9-1993;45(5):1129-1136. PubMed
  11. Bui PV, Moualla M, Upson DJ. A Possible Association of Diindolylmethane with Pulmonary Embolism and Deep Venous Thrombosis. Case Rep Med. 2016;2016:7527098. PubMed
  12. Castañon A, Tristram A, Mesher D, Powell N, Beer H, Ashman S, Rieck G, Fielder H, Fiander A, Sasieni P. Effect of diindolylmethane supplementation on low-grade cervical cytological abnormalities: double-blind, randomised, controlled trial. Br J Cancer. 20 PubMed
  13. Le TM, Sanders CJ, van de Corput L, van Erpecum KJ, Röckmann H. Drug rash with eosinophilia and systemic symptoms caused by the dietary supplement diindolylmethane. J Allergy Clin Immunol Pract. 2016 Jan-Feb;4(1):175-6. PubMed
  14. Pence ST, Mehta K, Crum-Bailey J. The Serious Side of Supplements: An Ischemic Stroke in a Healthy 38-year-old Female. Mil Med 2022. PubMed

See these in context on the Diindolylmethane monograph →

Inositol 14 references
  1. Palatnik A, Frolov K, Fux M, Benjamin J. Double-blind, controlled, crossover trial of inositol versus fluvoxamine for the treatment of panic disorder. J Clin Psychopharmacol 2001;21:335-9.. PubMed
  2. Allan SJ, Kavanagh GM, Herd RM, Savin JA. The effect of inositol supplements on the psoriasis of patients taking lithium: a randomized, placebo-controlled trial. Br J Dermatol 2004;150:966-9. PubMed
  3. Machado-Vieira R, Viale CI, Kapczinski F. Mania associated with an energy drink: the possible role of caffeine, taurine, and inositol. Can J Psychiatry 2001;46:454-5. PubMed
  4. Kamenov Z, Kolarov G, Gateva A, Carlomagno G, Genazzani AD. Ovulation induction with myo-inositol alone and in combination with clomiphene citrate in polycystic ovarian syndrome patients with insulin resistance. Gynecol Endocrinol 2015;31(2):131-5. PubMed
  5. Matarrelli B, Vitacolonna E, D'Angelo M, et al. Effect of dietary myo-inositol supplementation in pregnancy on the incidence of maternal gestational diabetes mellitus and fetal outcomes: a randomized controlled trial. J Matern Fetal Neonatal Med 2013;26(1 PubMed
  6. Mukai T, Kishi T, Matsuda Y, Iwata N. A meta-analysis of inositol for depression and anxiety disorders. Hum Psychopharmacol 2014;29(1):55-63. PubMed
  7. Farren M, Daly N, McKeating A, Kinsley B, Turner MJ, Daly S. The Prevention of Gestational Diabetes Mellitus With Antenatal Oral Inositol Supplementation: A Randomized Controlled Trial. Diabetes Care. 2017;40(6):759-63. PubMed
  8. Zheng X, Liu Z, Zhang Y, et al. Relationship Between Myo-Inositol Supplementary and Gestational Diabetes Mellitus: A Meta-Analysis. Medicine (Baltimore). 2015;94(42):e1604. PubMed
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