Interactions on record — worth a quick check against your medications. Based on 4 of 6 ingredients. Check your meds →
Dietary supplement

Collagen Plus Hydration Vanilla Bean Ingredients & Drug Interactions

by Evogen Naturals

Collagen Plus Hydration Vanilla Bean label
See full label image
Powder Category: Botanical With Nutrients
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Collagen Plus Hydration Vanilla Bean against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Collagen Plus Hydration Vanilla Bean is a dietary supplement by Evogen Naturals with 6 active ingredients. Its ingredients are commonly taken for replacing fluids and electrolytes, preventing dehydration during exercise or illness, treating low blood sodium (under medical care).Based on those ingredients, 901 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitamin D, Sodium, Coconut Water, Powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Collagen Plus Hydration Vanilla Bean by Evogen Naturals

Ask about any prescription or over-the-counter medication and we check it for interactions with Collagen Plus Hydration Vanilla Bean by Evogen Naturals — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Collagen Plus Hydration Vanilla Bean by Evogen Naturals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 5 of its 5 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This powder has 5 ingredients. The active ones are sodium, vitamin D, coconut water powder, and bovine collagen peptides.

Sodium is an electrolyte your body needs in small amounts; vitamin D supports bone health and calcium absorption; coconut water provides hydration and minerals; and collagen is a structural protein that may support skin and connective tissue. Silica is listed as an inactive ingredient.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Collagen for skin, joint and bone health.
  • We looked for evidence on: Aging skin, Joint pain, Brittle nails, Fractures, Exercise-induced muscle damage, Exercise-induced muscle soreness — and 4 related terms.
  • The strongest evidence on file: Collagen Peptides is rated "Possibly Effective" for Aging skin (Natural Medicines).
  • Also on file: Collagen Peptides is rated "Possibly Effective" for Dry skin.
  • Also on file: Vitamin D is rated "Possibly Ineffective" for Fractures.

Vitamin D is established as effective for treating familial hypophosphatemia, osteomalacia (soft bones from vitamin D deficiency), renal bone disease, rickets, and hypoparathyroidism. Bovine collagen peptides show possibly effective evidence for aging skin and dry skin, though it appears possibly ineffective for muscle strength.

The evidence isn't established for coconut water or sodium in this product's likely intended uses—the data we hold rates them as insufficient to say whether they work for diabetes, weight, or cholesterol.

The evidence, ingredient by ingredient Sodium Vitamin D Coconut Collagen Peptides

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Sodium is well tolerated at normal dietary amounts, but high intake is linked to high blood pressure and heart strain; avoid sodium supplements and very high intakes without medical advice. Vitamin D is generally safe at recommended doses, though excessive doses over time can cause toxicity with symptoms like high calcium levels.

Bovine collagen peptides are generally well tolerated as a protein source with rare mild side effects like nausea or diarrhea. Coconut is likely safe in normal food amounts, but concentrated supplements aren't well studied; also note that coconut can trigger allergic reactions ranging from hives to anaphylaxis in people with tree nut or coconut hypersensitivity.

Side effects, ingredient by ingredient Sodium Vitamin D Coconut Collagen Peptides

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 4 matched ingredients can interact with medications — Vitamin D, Coconut, Sodium.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications; heart-rhythm medications; lithium.
  • For scale: 902 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your medications carefully if you take blood pressure drugs, lithium, or heart rhythm medications like digoxin, verapamil, or diltiazem (sodium and vitamin D can interfere with all of these). Also flag any corticosteroids, the cholesterol drug atorvastatin, or diabetes medications before you start.

If you use didanosine for HIV, sodium phosphate laxatives, or tolvaptan, talk to your pharmacist about the sodium content too.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you take blood pressure medications, lithium, heart rhythm drugs, or diabetes medications, talk to your pharmacist before adding this product—the sodium and vitamin D content need a closer look with your specific prescriptions. This powder is likely fine for general hydration and collagen support in people without those medication concerns, but the sodium content makes it important to check first if you have high blood pressure or heart disease.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 14, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Collagen Plus Hydration Vanilla Bean, straight from the product label.

Brand Evogen Naturals
Barcode (UPC) 817189024242
Net contents 13 Ounce(s); 369 Gram(s)
Market status On market
Date entered into DSLD Dec 14, 2023
DSLD ID 300199
Product type Botanical With Nutrients
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Collagen Plus Hydration Vanilla Bean by Evogen Naturals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
11.7 Gram(s)
Maximum serving Sizes:
11.7 Gram(s)
Servings per container
30
UPC/BARCODE
817189024242
IngredientAmount% DV
Calories40 Calorie(s)--
Sodium20 mg1%
Vitamin D25 mcg125%
Protein10 Gram(s)--
Coconut Water, Powder500 mg--
Aquamin100 mg--
Bovine Collagen, Hydrolyzed11 Gram(s)--

Other ingredients: Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Evogen's COLLAGEN PLUS is uniquely formulated using only the highest quality formulated using only the highest quality type I & III grass-fed collagen peptides to deliver maximum health benefits and physique results. Not only is the formula enhanced with vitamin D and algae-based minerals to increase the effects of the collagen peptide amino acids, we also combine coconut water powder to make you feel refreshed, rejuvenated, and rehydrated. Evogen's COLLAGEN PLUS provides your body with the primary building blocks to maximize your health and physique potential.

Aquamin Vanilla bean naturally flavored

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, mix 1 scoop with 8 fluid ounces or more of cold water, juice or your favorite beverage. Stir briskly or shake briefly in a closed container until mixed.

Mixes instantly Mix with only drink

Precautions

Warning: This product is intended for healthy adults only.

Do not use if pregnant or nursing. Consult a health care practitioner prior to use if you are taking any medication or have any medical issues.

Do not exceed recommended dosage.

Keep out of reach of children.

Do not use if the safety seal is damaged or missing.

Allergen warning: Contains treenuts (coconut).

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formulation

Made in the USA with Domestic & International ingredients

Grass-fed

Gluten free Soy free Synthetic flavor free Synthetic flavor free

Premium grass-fed peptide formula Maximum Skin vitality Joint & tissue health Rehydration & rejuvenation

Seals/Symbols

The Pro Creator Designed by Hany Rambod Seal of Quality & Potency

FDA Statement of Identity

Dietary Supplement

Storage

Proper care & storage: Please store Collagen Plus in your refrigerator after opening.

General Statements

Filled by weight, not by volume. Contents may settle.

Follow us @EvogenNutrition #EvogenElite

Brand IP Statement(s)

Evogen is a registered trademark of Evogen Nutrition, Inc. Copyright Evogen Nutrition, all rights reserved. Aquamin is a registered trademark of Marigot Limited.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Collagen Plus Hydration Vanilla Bean by Evogen Naturals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Collagen Plus Hydration Vanilla Bean label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Collagen Plus Hydration Vanilla Bean by Evogen Naturals

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size11.7 Gram(s) Dosage formPowder Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sodium

Interacts with
205 drugs
20 mg per serving

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...

Sodium monograph & interactions

Vitamin D

Interacts with
715 drugs
25 mcg per serving Form: Cholecalciferol

Vitamin D is a fat-soluble vitamin that helps your body absorb calcium and is important for healthy bones, muscles, and immune function. Many people,...

Vitamin D monograph & interactions

Protein

10 Gram(s) per serving

Coconut Water, Powder

Interacts with
86 drugs
500 mg per serving

Coconut is a nutritious tropical food enjoyed as oil, water, milk, and flesh, and it is generally safe to eat in normal food amounts. While some uses...

Coconut Water, Powder monograph & interactions

Aquamin

100 mg per serving Form: Calcareous Marine Algae

Bovine Collagen, Hydrolyzed

No known
interactions
11 Gram(s) per serving Form: Collagen Type I, Collagen Type III

Collagen peptides are a well-absorbed form of protein that may modestly improve skin elasticity and joint comfort for some people, though evidence is...

Bovine Collagen, Hydrolyzed monograph & interactions

Other (inactive) ingredients: Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Collagen Plus Hydration Vanilla Bean by Evogen Naturals Drug Interactions

Want to check YOUR meds against Collagen Plus Hydration Vanilla Bean?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
901Drugs
225 Moderate 676 Minor

Ingredients driving the most interactions

Vitamin D 715
Sodium 205
Coconut Water, Powder 86

Individual Drug Interactions

The ingredients in Collagen Plus Hydration Vanilla Bean interact with 901 drugs. Click any drug to see the details.

3 of the 6 ingredients in Collagen Plus Hydration Vanilla Bean interact with drugs. Each result below shows which ingredient is responsible. Vitamin D Sodium Coconut Water, Powder

Each ingredient & the kinds of drugs it affects

For each ingredient in Collagen Plus Hydration Vanilla Bean with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin D8 drug types · 715 drugs

Aluminum

Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
The protein that transports calcium across the intestinal wall can also bind and transport aluminum. This protein is stimulated by vitamin D, which may therefore increase aluminum absorption. This mechanism may contribute to increased aluminum levels and toxicity in people with renal failure, when they take vitamin D and aluminum-containing phosphate binders chronically.

Likelihood Probable Evidence B
Atorvastatin (Lipitor)

Vitamin D might reduce absorption of atorvastatin.
A small, low-quality clinical study shows that taking vitamin D reduces levels of atorvastatin and its active metabolites by up to 55%. However, while atorvastatin levels decreased, total cholesterol, low-density lipoprotein (LDL) cholesterol, and high-density lipoprotein (HDL) cholesterol levels did not substantially change. Atorvastatin is metabolized in the gut by CYP3A4 enzymes, and researchers theorized that vitamin D might induce CYP3A4, causing reduced levels of atorvastatin. However, this proposed mechanism was not specifically studied.

Likelihood Probable Evidence B
Calcipotriene (Dovonex)

Taking calcipotriene with vitamin D increases the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with vitamin D supplements might increase the risk of hypercalcemia.

Likelihood Probable Evidence D
Digoxin (Lanoxin)

Theoretically, hypercalcemia induced by high-dose vitamin D can increase the risk of arrhythmia from digoxin.
High doses of vitamin D can cause hypercalcemia. Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and digoxin concurrently.

Likelihood Possible Evidence D
Diltiazem (Cardizem, Others)

Theoretically, hypercalcemia induced by high-dose vitamin D can reduce the therapeutic effects of diltiazem for arrhythmia.
High doses of vitamin D can cause hypercalcemia. Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically this could also occur with diltiazem. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and diltiazem concurrently.

Likelihood Probable Evidence B
Thiazide Diuretics

Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Thiazide diuretics decrease urinary calcium excretion, which could lead to hypercalcemia if vitamin D supplements are taken concurrently. This has been reported in people being treated with vitamin D for hypoparathyroidism, and also in elderly people with normal parathyroid function who were taking a thiazide, vitamin D, and calcium-containing antacids daily.

Likelihood Probable Evidence D
Verapamil (Calan, Others)

Hypercalcemia induced by high-dose vitamin D can reduce the therapeutic effects of verapamil for arrhythmia.
Hypercalcemia due to high doses of vitamin D can reduce the effectiveness of verapamil in atrial fibrillation. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and verapamil concurrently.

Likelihood Probable Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
There is some concern that vitamin D might induce CYP3A4. In vitro research suggests that vitamin D induces CYP3A4 transcription. Additionally, observational research has found that increased UV light exposure and serum vitamin D levels are associated with decreased serum levels of CYP3A4 substrates such as tacrolimus and sirolimus, while no association between UV light exposure or vitamin D levels and levels of mycophenolic acid, a non-CYP3A4 substrate, was found. A small, low-quality clinical study shows that taking vitamin D reduces levels of the CYP3A4 substrate atorvastatin and its active metabolites by up to 55%; however, the clinical effects of atorvastatin were not reduced. While researchers theorized that vitamin D might induce CYP3A4, this proposed mechanism was not specifically studied.

Likelihood Possible Evidence D
Vitamin D full monograph & interactions

Sodium7 drug types · 205 drugs

Antihypertensive Drugs

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.

Likelihood Probable Evidence A
Corticosteroids

Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D
Didanosine (Videx)

Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.

Likelihood Probable Evidence C
Lithium

Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.

Likelihood Probable Evidence B
Sodium Phosphates

Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Tolvaptan (Samsca)

Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.

Likelihood Probable Evidence C
Sodium full monograph & interactions

Coconut Water, Powder1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking coconut with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research suggests that coconut milk might increase insulin levels and/or decrease blood glucose levels.

Likelihood Unlikely Evidence D
Coconut Water, Powder full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Collagen Plus Hydration Vanilla Bean, from the product label.

Evogen Naturals

See all Evogen Naturals products
Name
Evogen Inc.
Street Address
271 E. Hacienda Ave.
City
Campbell
State
CA
ZipCode
95008
Phone Number
1.408.364.1650
Web Address
EvogenNutrition.com
Pharmacist Counseling Corner

Collagen Plus Hydration Vanilla Bean by Evogen Naturals: Common Questions

Does Collagen Plus Hydration Vanilla Bean by Evogen Naturals interact with any medications?
Yes. Based on its ingredients, Collagen Plus Hydration Vanilla Bean has a known interaction with 901 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Collagen Plus Hydration Vanilla Bean contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
Vitamin D is likely safe in pregnancy at recommended amounts but should be used only under your doctor's guidance. Sodium has mixed safety data in pregnancy—some evidence suggests likely safety, other data suggests possibly unsafe. Coconut is likely safe, and collagen peptides aren't well studied in pregnancy or breastfeeding, so ask your doctor or pharmacist for personalized advice before using any of them.
Does this really have collagen in it?
Yes—bovine collagen peptides are the fourth ingredient. Collagen is a structural protein that some research suggests may help with aging skin and dry skin, though the evidence for muscle strength is weak.
Can this help me lose weight?
The evidence we have doesn't establish whether coconut water helps with weight loss. For that question, you'd be better off talking to your doctor or a dietitian about your personal health.
What if I'm allergic to tree nuts?
Coconut is grouped with tree nuts for allergen labeling in the US, and it can cause allergic reactions ranging from hives to anaphylaxis in people with coconut hypersensitivity. If you have a tree nut allergy, check with your allergist before trying this product.
Can this cause side effects?
Collagen peptides rarely cause nausea, heartburn, diarrhea, or gas. Coconut is generally well tolerated but can trigger allergies in sensitive people. Sodium and vitamin D at the doses in this product are unlikely to cause problems on their own, but the sodium content could be an issue if you have high blood pressure or take certain medications.
Is the sodium in here a problem?
Normal dietary sodium is fine, but this product adds extra sodium on top of what you eat. If you have high blood pressure, take blood pressure drugs, or have heart disease, the added sodium matters—run it by your pharmacist before you start.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Collagen Plus Hydration Vanilla Bean label
Go deeper

The Full Monographs Behind Collagen Plus Hydration Vanilla Bean’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Sodium

Interacts with 205 drugs

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...

Read the full Sodium monograph → Herb & supplement monograph

Vitamin D

Interacts with 715 drugs

Vitamin D is a fat-soluble vitamin that helps your body absorb calcium and is important for healthy bones, muscles, and immune function. Many people, especially those with low sun exposure,...

Read the full Vitamin D monograph → Herb & supplement monograph

Coconut

Interacts with 86 drugs

Coconut is a nutritious tropical food enjoyed as oil, water, milk, and flesh, and it is generally safe to eat in normal food amounts. While some uses (like skin moisturizing and hydration) h...

Read the full Coconut monograph → Herb & supplement monograph

Collagen Peptides

Collagen peptides are a well-absorbed form of protein that may modestly improve skin elasticity and joint comfort for some people, though evidence is still developing and results vary. They...

Read the full Collagen Peptides monograph →
Sources

Sources & How We Checked

Collagen Plus Hydration Vanilla Bean's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 76 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Sodium 38 references
  1. Garabedian-Ruffalo SM, Ruffalo RL. Drug and nutrient interactions. Am Fam Physician 1986;33:165-74.
  2. Food and Drug Administration Science Background: Safety of Sodium Phosphates Oral Solution. September 17, 2001. Available at: http://www.fda.gov/cder/drug/safety/sodiumphospate.htm
  3. Coton T, Mallaret C, Coilliot C, Carre D, Guisset M. Severe acute ulcerated gastritis induced by salt. Presse Med 2009;38(3):499-500. PubMed
  4. Frings-Meuthen P, Buehlmeier J, Baecker N, et al. High sodium chloride intake exacerbates immobilization-induced bone resorption and protein losses. J Appl Physiol 2011;111(2):537-542. PubMed
  5. Frings-Meuthen P, Baecker N, Heer M. Low-grade metabolic acidosis may be the cause of sodium chloride-induced exaggerated bone resorption. J Bone Miner Res 2008;23(4):517-524. PubMed
  6. Alam S, Johnson AG. A meta-analysis of randomised controlled trials (RCT) among healthy normotensive and essential hypertensive elderly patients to determine the effect of high salt (NaCl) diet of blood pressure. J Hum Hypertens 1999;13(6):367-74.
  7. Boudville N, Ward S, Benaroia M, House AA. Increased sodium intake correlates with greater use of antihypertensive agents by subjects with chronic kidney disease. Am J Hypertens 2005;18(10):1300-5. PubMed
  8. Bennett WM. Drug interactions and consequences of sodium restriction. Am J Clin Nutr 1997;65(2 Suppl):678S-681S. PubMed
  9. Okusa MD, Crystal LJ. Clinical manifestations and management of acute lithium intoxication. Am J Med 1994;97(4):383-9. PubMed
  10. Food and Nutrition Board, Institute of Medicine. Dietary reference intakes for water, potassium, sodium, chloride, and sulfate. Washington, DC: National Academy Press, 2005. Available at: http://www.nap.edu/openbook.php?record_id=10925. DOI
  11. D'Elia L, Rossi G, Ippolito R, Cappuccio FP, Strazzullo P. Habitual salt intake and risk of gastric cancer: a meta-analysis of prospective studies. Clin Nutr 2012;31(4):489-98. PubMed
  12. Goldsmith SR. Hyponatremia in heart failure: time for a trial. J Card Fail 2013;19(6):398-400. PubMed
  13. Willocks L, Brettle R, Keen J, Valentine C, Pinching AJ. Formulations of didanosine (ddI) and salt overload. Lancet 1992;339(8786):190.
  14. Chen L, Zhang Z, Chen W, Whelton PK, Appel LJ. Lower Sodium Intake and Risk of Headaches: Results From the Trial of Nonpharmacologic Interventions in the Elderly. Am J Public Health. 2016;106(7):1270-5. PubMed
  15. Cook NR, Appel LJ, Whelton PK. Lower levels of sodium intake and reduced cardiovascular risk. Circulation. 2014;129(9):981-9. PubMed
  16. Cook NR, Appel LJ, Whelton PK. Sodium Intake and All-Cause Mortality Over 20 Years in the Trials of Hypertension Prevention. J Am Coll Cardiol. 2016;68(15):1609-1617. PubMed
  17. Mente A, O'Donnell M, Rangarajan S, et al. Associations of urinary sodium excretion with cardiovascular events in individuals with and without hypertension: a pooled analysis of data from four studies. Lancet. 2016;388(10043):465-75. PubMed
  18. Moosavian SP, Haghighatdoost F, Surkan PJ, Azadbakht L. Salt and obesity: a systematic review and meta-analysis of observational studies. Int J Food Sci Nutr. 2017;68(3):265-277. PubMed
  19. O'Donnell M, Mente A, Rangarajan S, et al. Urinary sodium and potassium excretion, mortality, and cardiovascular events. N Engl J Med. 2014;371(7):612-23. DOI
  20. Poggio R, Gutierrez L, Matta MG, Elorriaga N, Irazola V, Rubinstein A. Daily sodium consumption and CVD mortality in the general population: systematic review and meta-analysis of prospective studies. Public Health Nutr. 2015;18(4):695-704. PubMed
  21. Stallings VA, Harrison M, Oria M; Committee to Review the Dietary Reference Intakes for Sodium and Potassium, Food and Nutrition Board, Health and Medicine Division, National Academies of Sciences, Engineering, and Medicine. Washington (DC): National Acad
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Vitamin D 26 references
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Coconut 10 references
  1. Teuber SS, Peterson WR. Systemic allergic reaction to coconut (Cocos nucifera) in 2 subjects with hypersensitivity to tree nut and demonstration of cross-reactivity to legumin-like seed storage proteins: new coconut and walnut food allergens. J Allergy Cl PubMed
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See these in context on the Coconut monograph →

Collagen Peptides 2 references
  1. Trc T, Bohmová J. Efficacy and tolerance of enzymatic hydrolysed collagen (EHC) vs. glucosamine sulphate (GS) in the treatment of knee osteoarthritis (KOA). Int Orthop. 2011;35(3):341-8. PubMed
  2. Evans M, Lewis ED, Zakaria N, Pelipyagina T, Guthrie N. A randomized, triple-blind, placebo-controlled, parallel study to evaluate the efficacy of a freshwater marine collagen on skin wrinkles and elasticity. J Cosmet Dermatol. 2021;20(3):825-834. PubMed

See these in context on the Collagen Peptides monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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