Major interaction on record — check this product against your medications before combining. Based on 1 of 4 ingredients. Check your meds →
Dietary supplement

Diablos Hyperburn 6.0 Ingredients & Drug Interactions

by Innovative Laboratories

Diablos Hyperburn 6.0 label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Diablos Hyperburn 6.0 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Diablos Hyperburn 6.0 is a dietary supplement by Innovative Laboratories with 4 active ingredients. Its ingredients are commonly taken for mental alertness and reducing fatigue, improving athletic performance, headache and migraine relief.Based on those ingredients, 1,489 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Caffeine Anhydrous. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Diablos Hyperburn 6.0 by Innovative Laboratories

Ask about any prescription or over-the-counter medication and we check it for interactions with Diablos Hyperburn 6.0 by Innovative Laboratories — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Diablos Hyperburn 6.0 by Innovative Laboratories

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 20 active ingredients.
  • “Total Blend” is a proprietary blend — the label gives one combined amount (530 mg) without saying how much of each component you get.
  • “Amine Matrix” is a proprietary blend — the label gives one combined amount (100 mg) without saying how much of each component you get.
  • “Teamine(TM)” is listed as a grouped ingredient — the label gives one combined amount (125 mg) without saying how much of each component you get.

Diablos Hyperburn 6.0 contains 20 active ingredients. The main ones are caffeine (in two forms — caffeine anhydrous and 1,3,7-trimethylxanthine) for energy and alertness, plus vitamin B6 for metabolism and nerve function.

You'll also find phosphatidylcholine and phosphatidylserine (brain-supporting compounds), sulbutiamine (a form of thiamine), theanine (an amino acid that may promote calm focus), yohimbine and phenethylamine-related compounds (stimulants), coleus forskohlii (an herbal extract), banaba and guggul plant extracts, hordenine, and adenosine. The product also contains several inactive ingredients — gelatin capsule, magnesium stearate, and food colorants (FD&C Blue #1, Red #3, Red #40, Yellow #6) and titanium dioxide.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: fat loss energy mental focus appetite control.
  • We looked for evidence on: Anxiety, Athletic performance, Attention deficit-hyperactivity disorder (ADHD), Cognitive function, Fatigue, Generalized anxiety disorder (GAD) — and 3 related terms.
  • The strongest evidence on file: Caffeine is rated "Likely Effective" for Athletic performance (Natural Medicines).
  • Also on file: Theanine is rated "Possibly Effective" for Cognitive function.
  • Also on file: Caffeine is rated "Possibly Ineffective" for Attention deficit-hyperactivity disorder (ADHD).

Effectiveness evidence varies widely by ingredient. Vitamin B6 is effective for certain anemias and B6 deficiency, and possibly effective for pregnancy nausea and high homocysteine levels.

Caffeine is effective for staying alert and athletic performance. Theanine is possibly effective for cognitive function.

Most other active ingredients — phosphatidylserine, sulbutiamine, coleus, banaba, guggul, phenethylamine, and adenosine in oral form — lack sufficient reliable evidence in our data to establish whether they work for weight loss, energy, or fat burning. The evidence we hold does not establish this product's overall effectiveness for its intended use.

The evidence, ingredient by ingredient Caffeine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 14 of the 14 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 12 of 14.
  • General safety write-ups exist for 14 of 14.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Caffeine is generally well tolerated in moderate amounts but can cause anxiety, insomnia, nausea, tremors, and headache — and at high doses, rarely, stroke. Vitamin B6 is safe at normal doses but can damage nerves (sensory neuropathy) at very high doses over time.

Phosphatidylcholine may cause bloating, nausea, or diarrhea, especially at high doses. Phosphatidylserine can cause headache, insomnia, or upset stomach.

Coleus may cause diarrhea or nausea. Guggul can cause skin rashes, bloating, or nausea.

Hordenine, phenethylamine, tyramine, and yohimbine are stimulants with limited human safety data — theoretically they could raise heart rate and blood pressure. Theanine may cause drowsiness or headache.

Adenosine in oral supplement form has not been thoroughly studied for safety. Several ingredients (phosphatidylserine, sulbutiamine, coleus, yohimbine, theanine, banaba, hordenine, adenosine) lack sufficient data on pregnancy and breastfeeding; discuss with your doctor or pharmacist before use if you are pregnant or nursing.

Side effects, ingredient by ingredient Caffeine

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 12 of the 14 matched ingredients can interact with medications — Guggul, Yohimbe, Vitamin B6, Caffeine, Phosphatidylserine, among others.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; lithium; Parkinson's medications.
  • For scale: 1,490 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your exact medications before starting — especially if you take: ephedrine or other stimulants (Major); nitrates or calcium channel blockers for the heart (Major); MAOIs for depression (Major); dipyridamole for heart testing (Major); blood pressure medications; seizure drugs; heart rhythm medications; blood thinners or antiplatelet drugs; stomach acid reducers; antibiotics (especially fluoroquinolones); antipsychotics; sleep aids; antidepressants; or thyroid hormone. If you're unsure whether any of your drugs interact, run them through the checker on this page.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This is a multi-ingredient stimulant and fat-loss formula with significant drug interaction potential — especially if you take blood pressure medications, heart drugs, antidepressants, seizure medications, blood thinners, or MAOIs. The overall effectiveness for weight loss or fat burning is not established in the data we hold.

Talk to your pharmacist or doctor before using this product, particularly to check your specific medications against the interaction list.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 15 of 20 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 23, 2014.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Diablos Hyperburn 6.0, straight from the product label.

Brand Innovative Laboratories
Barcode (UPC) 827912085723
Net contents 100 Capsule(s)
Market status On market
Date entered into DSLD May 23, 2014
DSLD ID 33365
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Diablos Hyperburn 6.0 by Innovative Laboratories, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
100
UPC/BARCODE
827912085723
IngredientAmount% DV
Vitamin B60 NP--
Caffeine Anhydrous200 mg--
Phosphatidylcholine0 NP--
Phosphatidylserine0 NP--
Sulbutiamine0 NP--
Vitamin B50 NP--
1,3,7-Trimethylxanthine0 NP--
DL-Phenylalanine0 NP--
Theanine0 NP--
Total Blend530 mg--
Yohimbine HCl0 NP--
Coleus Forskohlii0 NP--
Amine Matrix100 mg--
B-Aminoethylbenzene HCl0 NP--
O-Methoxphenyl-ethylamine0 NP--
4-Hydroxyphenethylamine0 NP--
4-(2-Dimethylaminoethyl)phenol0 NP--
Teamine(TM)125 mg--
1,3 Dimethylxanthine0 NP--
3, 7-Dimethylxanthine0 NP--
Cortiven-Oxy cAMP(TM)105 mg--
Banaba PE0 NP--
Commiphora mukul PE0 NP--
Andenosine monophosphate0 NP--

Other ingredients: Gelatin, Magnesium Stearate, FD&C Blue #1, Red #3, Red #40, Yellow #6, Ti02

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

FAT INCINERATION COMPLEX ~Intense Energy ~Mental Focus ~Fat Burner ~Antioxidant ~Appetite Control ~Anti-Cortisol

FAT LOSS & ENERGY SERIES

FDA Statement of Identity

DIETARY SUPPLEMENT

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, TEST your tolerance level by consuming 1 capsule in the AM with 8 oz. of water and food for 7-10 days. After performing test, you may consider 1-2 capsule 1 time daily.

Precautions

DO NOT exceed 2 capsule daily.

FDA Disclaimer Statement

These statement have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

General

ITEM# IL-DHB-02

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Diablos Hyperburn 6.0 by Innovative Laboratories label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Diablos Hyperburn 6.0 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Diablos Hyperburn 6.0 by Innovative Laboratories

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container100 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Total Blend

530 mg per serving

Other (inactive) ingredients: Gelatin, Magnesium Stearate, FD&C Blue #1, Red #3, Red #40, Yellow #6, Ti02. These complete the product’s ingredient list but are not active constituents.

Interaction report

Diablos Hyperburn 6.0 by Innovative Laboratories Drug Interactions

Want to check YOUR meds against Diablos Hyperburn 6.0?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,489Drugs
199 Major 1,198 Moderate 92 Minor

Ingredients driving the most interactions

Caffeine Anhydrous 655

Individual Drug Interactions

The ingredients in Diablos Hyperburn 6.0 interact with 1,489 drugs. Click any drug to see the details.

1 of the 4 ingredients in Diablos Hyperburn 6.0 interact with drugs. Each result below shows which ingredient is responsible. Caffeine Anhydrous

Each ingredient & the kinds of drugs it affects

For each ingredient in Diablos Hyperburn 6.0 with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Caffeine Anhydrous41 drug types · 655 drugs

Ephedrine

Theoretically, concomitant use might increase the risk for stimulant adverse effects.
Use of ephedrine with caffeine can increase the risk of stimulatory adverse effects. There is evidence that using ephedrine with caffeine might increase the risk of serious life-threatening or debilitating adverse effects such as hypertension, myocardial infarction, stroke, seizures, and death.

Likelihood Probable Evidence D
Adenosine (Adenocard)

Theoretically, caffeine might decrease the vasodilatory effects of adenosine and interfere with its use prior to stress testing.
Some evidence shows that caffeine is a competitive inhibitor of adenosine and can reduce the vasodilatory effects of adenosine in humans. However, other research shows that caffeine does not seem to affect supplemental adenosine because high interstitial levels of adenosine overcome the antagonistic effects of caffeine. It is recommended that methylxanthines and methylxanthine-containing products be stopped 24 hours prior to pharmacological stress tests. However, methylxanthines appear more likely to interfere with dipyridamole (Persantine) than adenosine-induced stress testing.

Likelihood Possible Evidence B
Anticoagulant/Antiplatelet Drugs

Theoretically, caffeine may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Caffeine is reported to have antiplatelet activity. Theoretically, it might increase the risk of bleeding when used concomitantly with these agents; however, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Beta-Adrenergic Agonists

Theoretically, large amounts of caffeine might increase the cardiac inotropic effects of beta-agonists.

Likelihood Probable Evidence D
Carbamazepine (Tegretol)

Theoretically, caffeine might reduce the effects of carbamazepine and increase the risk for convulsions.
Animal research suggests that taking caffeine can lower the anticonvulsant effects of carbamazepine and can induce seizures when taken in doses above 400 mg/kg. Human research has shown that taking caffeine 300 mg in three divided doses along with carbamazepine 200 mg reduces the bioavailability of carbamazepine by 32% and prolongs the plasma half-life of carbamazepine 2-fold in healthy individuals.

Likelihood Possible Evidence D
Cimetidine (Tagamet)

Theoretically, cimetidine might increase the levels and adverse effects of caffeine.
Cimetidine decreases the rate of caffeine clearance by 31% to 42%.

Likelihood Likely Evidence B
Clozapine (Clozaril)

Caffeine might increase the levels and adverse effects of clozapine and acutely exacerbate psychotic symptoms.
Caffeine might increase the effects and toxicity of clozapine. Caffeine doses of 400-1000 mg per day inhibit clozapine metabolism. Clozapine is metabolized by cytochrome P450 1A2 (CYP1A2). Although researchers speculate that caffeine might inhibit CYP1A2, there is no reliable evidence that caffeine affects CYP1A2. There is also speculation that genetic factors might make some patients more sensitive to an interaction between clozapine and caffeine. In one case report, severe, life-threatening clozapine toxicity and multiorgan system failure occurred in a patient with schizophrenia stabilized on clozapine who consumed caffeine 600 mg daily.

Likelihood Possible Evidence B
Dipyridamole (Persantine)

Theoretically, caffeine might decrease the vasodilatory effects of dipyridamole and interfere with its use prior to stress testing.
Caffeine inhibits dipyridamole-induced vasodilation. It is recommended that methylxanthines and methylxanthine-containing products be stopped 24 hours prior to pharmacological stress tests. Methylxanthines appear more likely to interfere with dipyridamole (Persantine) than adenosine-induced stress testing.

Likelihood Probable Evidence B
Disulfiram (Antabuse)

Theoretically, disulfiram use might increase the levels and adverse effects of caffeine.
Disulfiram decreases the rate of caffeine clearance.

Likelihood Probable Evidence B
Diuretic Drugs

Theoretically, using caffeine with diuretic drugs might increase the risk of hypokalemia.
Caffeine, especially in excessive amounts, can reduce potassium levels due to stimulation of the sodium-potassium pump. Diuretics can also cause lower potassium levels.

Likelihood Possible Evidence D
Estrogens

Theoretically, estrogens might increase the levels and adverse effects of caffeine.
Estrogen inhibits caffeine metabolism.

Likelihood Probable Evidence B
Ethosuximide (Zarontin)

Theoretically, caffeine might reduce the effects of ethosuximide and increase the risk for convulsions.
Animal research suggests that caffeine 92.4 mg/kg can decrease the anticonvulsant activity of ethosuximide. However, this effect has not been reported in humans.

Likelihood Possible Evidence D
Felbamate (Felbatol)

Theoretically, caffeine might reduce the effects of felbamate and increase the risk for convulsions.
Animal research suggests that a high dose of caffeine 161.7 mg/kg can decreases the anticonvulsant activity of felbamate. However, this effect has not been reported in humans.

Likelihood Possible Evidence D
Flutamide (Eulexin)

Theoretically, caffeine might increase the levels and adverse effects of flutamide.
In vitro evidence suggests that caffeine can inhibit the metabolism of flutamide. However, this effect has not been reported in humans.

Likelihood Probable Evidence D
Fluvoxamine (Luvox)

Theoretically, fluvoxamine might increase the levels and adverse effects of caffeine.
Fluvoxamine reduces caffeine metabolism.

Likelihood Probable Evidence D
Lithium

Abrupt caffeine withdrawal might increase the levels and adverse effects of lithium.
Caffeine has diuretic activity. When abruptly discontinued, caffeine may alter the clearance of lithium. There are two case reports of lithium tremor that worsened upon abrupt coffee withdrawal and 6 case reports of elevated serum lithium levels after reducing or eliminating caffeine intake. In one case, a male with schizoaffective disorder stabilized on lithium had an elevated lithium level after reducing his caffeine intake by 87%. At a later date, he increased his caffeine intake by 6-fold, resulting in a subtherapeutic lithium level and a recurrence of psychiatric symptoms.

Likelihood Probable Evidence D
Monoamine Oxidase Inhibitors (Maois)

Theoretically, concomitant use might increase the risk of a hypertensive crisis.
Caffeine has been shown to inhibit monoamine oxidase (MAO) A and B in laboratory studies. Concomitant intake of large amounts of caffeine with MAOIs might precipitate a hypertensive crisis. In a case report, a patient that consumed 10-12 cups of caffeinated coffee and took the MAOI tranylcypromine presented with severe hypertension. Hypertension was resolved after the patient switched to drinking decaffeinated coffee.

Likelihood Possible Evidence D
Nicotine

Theoretically, concomitant use might increase the risk of hypertension.
Concomitant use of caffeine and nicotine has been shown to have additive cardiovascular effects, including increased heart rate and blood pressure. Blood pressure was increased by 10.8/12.4 mmHg when the agents were used concomitantly.

Likelihood Probable Evidence B
Pentobarbital (Nembutal)

Theoretically, caffeine might decrease the effects of pentobarbital.
Caffeine might negate the hypnotic effects of pentobarbital.

Likelihood Possible Evidence B
Phenobarbital (Luminal)

Theoretically, caffeine might reduce the effects of phenobarbital and increase the risk for convulsions.
Animal research suggests that caffeine can decrease the anticonvulsant activity of phenobarbital. However, the exact mechanism of this interaction is unclear.

Likelihood Possible Evidence D
Phenylpropanolamine

Theoretically, phenylpropanolamine might increase the risk of hypertension, as well as the levels and adverse effects of caffeine.
Concomitant use of phenylpropanolamine and caffeine might cause an additive increase in blood pressure. Phenylpropanolamine also seems to increase caffeine serum levels.

Likelihood Probable Evidence B
Phenytoin (Dilantin)

Theoretically, caffeine might reduce the effects of phenytoin and increase the risk for convulsions.
Animal research suggests that caffeine can decrease the anticonvulsant activity of phenytoin. The effect does not seem to be related to the seizure threshold-lowering effects of caffeine. However, the exact mechanism of this interaction is unclear.

Likelihood Possible Evidence D
Pioglitazone (Actos)

Theoretically, caffeine might increase the levels and clinical effects of pioglitazone.
Animal research suggests that caffeine can modestly increase the maximum concentration, area under the curve, and half-life of pioglitazone, and also reduce its clearance. This increased the antidiabetic effects of pioglitazone. However, the exact mechanism of this interaction is unclear.

Likelihood Possible Evidence D
Quinolone Antibiotics

Theoretically, quinolone antibiotics might increase the levels and adverse effects of caffeine.
Quinolones (also called fluoroquinolones) can decrease caffeine clearance by inhibiting cytochrome P450 1A2 (CYP1A2) enzyme.

Likelihood Probable Evidence B
Riluzole (Rilutek)

Theoretically, concomitant use might increase the levels and adverse effects of both caffeine and riluzole.
Caffeine and riluzole are both metabolized by cytochrome P450 1A2 (CYP1A2), and concomitant use might reduce the metabolism of one or both agents.

Likelihood Possible Evidence D
Caffeine Anhydrous full monograph & all 41 interactions
The maker

Brand information

Manufacturer and brand details for Diablos Hyperburn 6.0, from the product label.

Innovative Laboratories

See all Innovative Laboratories products
Web Address
www.INNOVATIVEBIOLABS.com
Pharmacist Counseling Corner

Diablos Hyperburn 6.0 by Innovative Laboratories: Common Questions

Does Diablos Hyperburn 6.0 by Innovative Laboratories interact with any medications?
Yes. Based on its ingredients, Diablos Hyperburn 6.0 has a known interaction with 1,489 medications, including 199 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Diablos Hyperburn 6.0 contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this have a lot of caffeine?
Yes — it contains caffeine in two forms (caffeine anhydrous and 1,3,7-trimethylxanthine). The exact total dose per serving isn't listed in the facts we have, so check the label. High caffeine can cause jitteriness, insomnia, anxiety, nausea, and heart palpitations, especially if you're sensitive or combine it with other stimulants.
Is it safe to take with blood pressure medication?
Not without checking first. Multiple ingredients — caffeine, vitamin B6, theanine, coleus, and banaba — may lower blood pressure, so combining them with blood pressure drugs could cause your pressure to drop too much. Tyramine in this product can also raise blood pressure and counteract your medication. Talk to your pharmacist before taking this.
Can I take this if I'm pregnant or breastfeeding?
Most ingredients in this product lack enough safety data for pregnancy or breastfeeding — the safety information advises against use or recommends avoiding them. Caffeine at high doses may be linked to pregnancy risks. Talk to your doctor or pharmacist for personalized advice; don't start this product on your own.
What's in this for weight loss or fat burning?
The product contains caffeine for energy, coleus, banaba, guggul, and stimulant compounds like hordenine and phenethylamine. However, the evidence in our data does not establish that these ingredients are effective for weight loss or fat burning — most are rated as having insufficient reliable evidence.
Are there any side effects I should know about?
Yes. Common side effects from caffeine include anxiety, insomnia, nausea, tremors, and headache. Stimulants like phenethylamine, hordenine, and tyramine may raise heart rate and blood pressure. Coleus and guggul can cause diarrhea or nausea. At high doses, vitamin B6 can damage nerves. High doses of caffeine can rarely cause stroke.
Can I take this with my antidepressant?
Not safely without checking first. Phenethylamine and tyramine in this product interact with certain antidepressants (especially serotonergic drugs and MAOIs), raising the risk of serotonin syndrome or dangerous blood pressure spikes. Check your exact medication with a pharmacist before taking this.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Diablos Hyperburn 6.0 label
Go deeper

The Full Monographs Behind Diablos Hyperburn 6.0’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Caffeine

Interacts with 655 drugs

Caffeine is a natural stimulant found in coffee, tea, and many other plants and products. In moderate amounts it can boost alertness and reduce tiredness for most healthy adults, but too muc...

Read the full Caffeine monograph →
Sources

Sources & How We Checked

Diablos Hyperburn 6.0's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 449 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin B6 32 references
  1. Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
  2. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  3. Geerling BJ, Dagnelie PC, Badart-Smook A, et al. Diet as a risk factor for the development of ulcerative colitis. Am J Gastroenterol 2000;95:1008-13. PubMed
  4. South M. Neonatal seizures after pyridoxine use -- reply. Lancet 1999;354:2083. PubMed
  5. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  6. Baxter P, Aicardi J. Neonatal seizures after pyridoxine use. Lancet 1999;354:2082-3. PubMed
  7. Bendich A, Cohen M. Vitamin B6 safety issues. Ann N Y Acad Sci 1990;585:321-30.
  8. Schaumburg H, Kaplan J, Windebank A. Sensory neuropathy from pyridoxine abuse. A new megavitamin syndrome. N Engl J Med 1983;309:445-8. PubMed
  9. Gordon N. Pyridoxine dependency: an update. Dev Med Child Neurol 1997;39:63-5. PubMed
  10. Lewis PJ. Pain in the hand and wrist. Pyridoxine supplements may help patients with carpal tunnel syndrome. BMJ 1995;310:1534. PubMed
  11. Kaufman G. Pyridoxine against amiodarone-induced photosensitivity (letter). Lancet 1984;1:51-2. PubMed
  12. Mulrow JP, Mulrow CD, McKenna WJ. Pyridoxine and amiodarone-induced photosensitivity. Ann Intern Med 1985;103:68-9. PubMed
  13. Kawada A, Kashima A, Shiraishi H, et al. Pyridoxine-induced photosensitivity and hypophosphatasia. Dermatology 2000;201:356-60.. PubMed
  14. Vasile A, Goldberg R, Kornberg B. Pyridoxine toxicity: report of a case. J Am Osteopath Assoc 1984;83:790-1. DOI
  15. Hansson O, Sillanpaa M. Pyridoxine and serum concentration of phenytoin and phenobarbitone. Lancet 1976;1:256. DOI
  16. Jansen T, Romiti R, Kreuter A, Altmeyer P. Rosacea fulminans triggered by high-dose vitamins B6 and B12. J Eur Acad Dermatol Venereol 2001;15:484-5..
  17. Chittumma P, Kaewkiattikun K, Wiriyasiriwach B. Comparison of the effectiveness of ginger and vitamin B6 for treatment of nausea and vomiting in early pregnancy: a randomized double-blind controlled trial. J Med Assoc Thai 2007;90:15-20.
  18. Hatzitolios, A., Iliadis, F., Katsiki, N., and Baltatzi, M. Is the anti-hypertensive effect of dietary supplements via aldehydes reduction evidence based? A systematic review. Clin Exp.Hypertens. 2008;30(7):628-639. PubMed
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See these in context on the Vitamin B6 monograph →

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Yohimbe 66 references
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Hordenine 3 references
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Banaba 7 references
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Guggul 21 references
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Adenosine 10 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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