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Dietary supplement

DMAE L-Bitartrate Ingredients & Drug Interactions

by Hard Rhino

DMAE L-Bitartrate label
See full label image
Powder Category: Non-nutrient/non-botanical
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking DMAE L-Bitartrate against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

DMAE L-Bitartrate is a dietary supplement by Hard Rhino with 1 active ingredient. Its ingredients are commonly taken for memory and focus, mood and mental clarity, adhd-type symptoms.Based on those ingredients, 219 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are DMAE L-Bitartrate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against DMAE L-Bitartrate by Hard Rhino

Ask about any prescription or over-the-counter medication and we check it for interactions with DMAE L-Bitartrate by Hard Rhino — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of DMAE L-Bitartrate by Hard Rhino

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: DMAE L-Bitartrate (also known as deanol). DMAE is thought to work by raising acetylcholine levels in the brain — a chemical involved in nerve function and muscle control.

There are no inactive ingredients listed.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Deanol's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: memory, focus, and brain health.
  • We looked for evidence on: Cognitive function, Attention deficit-hyperactivity disorder (ADHD), Alzheimer disease, Mental clarity, Age-related cognitive decline.
  • The closest evidence on file: Deanol is rated "Likely Ineffective" for Alzheimer disease (Natural Medicines).
  • Also on file: Deanol is rated "Insufficient Reliable Evidence To Rate" for Attention deficit-hyperactivity disorder (ADHD), Cognitive function.

The evidence for DMAE's effectiveness is thin. It's rated likely ineffective for Alzheimer disease and tardive dyskinesia (involuntary movement disorder).

For aging skin, ADHD, and athletic performance, there isn't enough reliable evidence to say whether it works or doesn't. You won't find strong science backing this ingredient for any of those uses.

The evidence, ingredient by ingredient Deanol

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

DMAE is generally well tolerated by some adults, but the evidence is limited and side effects do happen. Common ones include abdominal cramps, pain, diarrhea, drowsiness, nausea, and vomiting.

Other reported effects are constipation, urticaria (hives), headache, insomnia, overstimulation, confusion, and mood changes including depression and hypomania. At doses above 1,000 mg daily, mood changes become more common, especially in people with existing psychiatric conditions; doses of 1,500 mg daily have increased schizophrenia symptoms in some patients.

The safety data for pregnancy and breastfeeding is not on file — do not use while breastfeeding.

Side effects, ingredient by ingredient Deanol

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Deanol.
  • The most serious interaction on file is rated Minor.
  • For scale: 219 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start, check with your doctor or pharmacist if you take anticholinergic drugs (like oxybutynin for overactive bladder) or cholinergic drugs (like pyridostigmine for myasthenia gravis, or pilocarpine for glaucoma). DMAE may interfere with how these work.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Only minor medication interactions are documented, and safety information is well characterized.

DMAE is not proven to work for any major condition and comes with a meaningful list of possible side effects. It's not recommended in pregnancy or while breastfeeding, and people with a history of mood or psychotic disorders should be especially cautious.

Talk to your doctor or pharmacist before you take it, especially if you're on any medications that affect how your nerves or muscles work.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 24, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about DMAE L-Bitartrate, straight from the product label.

Brand Hard Rhino
Barcode (UPC) 798711500239
Net contents 5 kg; 11 lbs
Market status On market
Date entered into DSLD Mar 24, 2017
DSLD ID 71872
Product type Non-nutrient/non-botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), No Allergies, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for DMAE L-Bitartrate by Hard Rhino, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.1 Gram(s)
Maximum serving Sizes:
0.1 Gram(s)
Servings per container
50000
UPC/BARCODE
798711500239
IngredientAmount% DV
DMAE L-Bitartrate100 mg--

Other ingredients: None

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

-Non-GMO -Gluten free -Allergen free

Allergens: This product contains no soy, dairy, dairy byproducts, eggs, shellfish, wheat, gluten, tree nuts, or sesame seeds.

General Statements

Bulk pail - Best value - Scoop inside - 50000 servings

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take 1 scant scoop (~100 mg) with 6-8 ounces of water or suitable beverage. Taken 1-3 times daily, preferably between meals or as recommended by your qualified health professional. A micro scale is recommended for accurate and precise measuring.

FDA Disclaimer Statement

These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any diseases.

Precautions

Warning: Keep out of the reach of children. Do not take this or any other supplement if under the age of 18, pregnant or nursing a baby, or if you have any known or suspected medical conditions and/or taking prescription drug(s) or OTC medication(s).

Do not take this or any other supplement if under the age of 18, pregnant or nursing a baby, or if you have any known or suspected medical conditions and/or taking prescription drug(s) or OTC medication(s).

Always consult with a qualified health physician before taking any new dietary supplement.

Do not use or consume if seal is broken.

FDA Statement of Identity

Dietary Supplement

Storage

Storage: Store in a cool, dry place. Re-seal inner bag immediately after use to preserve freshness.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

DMAE L-Bitartrate by Hard Rhino label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

DMAE L-Bitartrate label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in DMAE L-Bitartrate by Hard Rhino

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size0.1 Gram(s) Dosage formPowder Servings per container50000 Amounts shown are per serving.

DMAE L-Bitartrate

Interacts with
219 drugs
100 mg per serving

Deanol (DMAE) is a compound related to choline that is marketed for memory, focus, and mood, but solid human evidence for most of these uses is limite...

DMAE L-Bitartrate monograph & interactions

Other (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.

Interaction report

DMAE L-Bitartrate by Hard Rhino Drug Interactions

Want to check YOUR meds against DMAE L-Bitartrate?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
219Drugs
219 Minor

Ingredients driving the most interactions

DMAE L-Bitartrate 219

Individual Drug Interactions

The ingredients in DMAE L-Bitartrate interact with 219 drugs. Click any drug to see the details.

1 of the 1 ingredient in DMAE L-Bitartrate interact with drugs. Each result below shows which ingredient is responsible. DMAE L-Bitartrate

Each ingredient & the kinds of drugs it affects

For each ingredient in DMAE L-Bitartrate with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

DMAE L-Bitartrate2 drug types · 219 drugs

Anticholinergic Drugs

Theoretically, deanol might decrease the effectiveness of anticholinergic drugs.
Deanol is thought to increase acetylcholine levels.

Likelihood Unlikely Evidence D
Cholinergic Drugs

Theoretically, deanol might increase the effects and adverse effects of cholinergic drugs.
Deanol is thought to increase acetylcholine levels.

Likelihood Unlikely Evidence D
DMAE L-Bitartrate full monograph & interactions
The maker

Brand information

Manufacturer and brand details for DMAE L-Bitartrate, from the product label.

Hard Rhino

See all Hard Rhino products
Name
Guardian Wholesale
City
Phoenix
State
AZ
ZipCode
85085
Phone Number
(866)961-8378
Web Address
HardRhino.com
Pharmacist Counseling Corner

DMAE L-Bitartrate by Hard Rhino: Common Questions

Does DMAE L-Bitartrate by Hard Rhino interact with any medications?
Yes. Based on its ingredients, DMAE L-Bitartrate has a known interaction with 219 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
DMAE L-Bitartrate contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is DMAE and what's it supposed to do?
DMAE (also called deanol) is thought to raise acetylcholine levels, a brain chemical involved in nerve and muscle function. It's been studied for Alzheimer disease, ADHD, aging skin, and athletic performance, but the evidence is weak or absent.
Is DMAE safe to take?
DMAE is tolerated by some adults, but side effects are common and can include nausea, diarrhea, abdominal pain, drowsiness, and mood changes. People with psychiatric conditions should be cautious, especially at higher doses.
Can I take DMAE while pregnant or breastfeeding?
No safety data is on file for pregnancy. Do not use while breastfeeding — not enough is known about safety. Talk to your doctor or pharmacist for personalized advice if you're pregnant or considering pregnancy.
Does DMAE actually work for ADHD or Alzheimer disease?
The evidence doesn't support it for Alzheimer disease (rated likely ineffective) or ADHD (insufficient evidence to say). It's not an established treatment for either condition.
What are the most common side effects?
Abdominal cramps, abdominal pain, diarrhea, drowsiness, nausea, and vomiting are the ones reported most often. Others include headache, insomnia, and confusion.
Does it interact with many medications?
Yes — interactions are documented with anticholinergic and cholinergic medications (219 individual drugs total), though they're rated Minor in severity. Always check your exact medications before starting.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if DMAE L-Bitartrate is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

DMAE L-Bitartrate label
Go deeper

The Full Monographs Behind DMAE L-Bitartrate’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Deanol

Interacts with 219 drugs

Deanol (DMAE) is a compound related to choline that is marketed for memory, focus, and mood, but solid human evidence for most of these uses is limited or mixed. It can cause side effects in...

Read the full Deanol monograph →
Sources

Sources & How We Checked

DMAE L-Bitartrate's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Deanol 15 references
  1. Davies C, Maidment S, Hanley P, et al. Dimethylaminoethanol (DMAE). HSE. Risk assessment document; EH72/2;1997. (TOXLINE).
  2. Re O. 2-Dimethylaminoethanol (deanol): a brief review of its clinical efficacy and postulated mechanism of action. Curr Ther Res Clin Exp 1974;16:1238-42.
  3. Pieralisi G, Ripari P, Vecchiet L. Effects of a standardized ginseng extract combined with dimethylaminoethanol bitartrate, vitamins, minerals, and trace elements on physical performance during exercise. Clin Ther 1991;13:373-82.
  4. George J, Pridmore S, Aldous D. Double blind controlled trial of deanol in tardive dyskinesia. Aust N Z J Psychiatry 1981;15:68-71. PubMed
  5. Penovich P, Morgan JP, Kerzner B, et al. Double-blind evaluation of deanol in tardive dyskinesia. JAMA 1978;239:1997-8. DOI
  6. de Montigny C, Chouinard G, Annable L. Ineffectiveness of deanol in tardive dyskinesia: a placebo controlled study. Psychopharmacology (Berl) 1979;65:219-23. PubMed
  7. Lindeboom SF, Lakke JP. Deanol and physostigmine in the treatment of L-dopa-induced dyskinesias. Acta Neurol Scand 1978;58:134-8. PubMed
  8. Jus A, Villeneuve A, Gautier J, et al. Deanol, lithium and placebo in the treatment of tardive dyskinesia. A double-blind crossover study. Neuropsychobiology 1978;4:140-9. PubMed
  9. Lewis JA, Young R. Deanol and methylphenidate in minimal brain dysfunction. Clin Pharmacol Ther 1975;17:534-40. PubMed
  10. Fisman M, Mersky H, Helmes E. Double-blind trial of 2-dimethylaminoethanol in Alzheimer's disease. Am J Psychiatry 1981;138:970-2. PubMed
  11. Ferris SH, Sathananthan G, Gershon S, et al. Senile dementia: treatment with deanol. J Am Geriatr Soc 1977;25:241-4. PubMed
  12. Haug BA, Holzgraefe M. Orofacial and respiratory tardive dyskinesia: potential side effects of 2-dimethylaminoethanol (deanol)? Eur Neurol 1991;31:423-5. PubMed
  13. Casey DE. Mood alterations during deanol therapy. Psychopharmacology (Berl) 1979;62:187-91. PubMed
  14. Sergio W. Use of DMAE (2-dimethylaminoethanol) in the induction of lucid dreams. Med Hypotheses 1988;26:255-7. PubMed
  15. Osol A, Hoover JE, eds. Remington's Pharmaceutical Science, 15th ed. Easton, PA: Mack Publishing Company, 1975.

See these in context on the Deanol monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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