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Dietary supplement

Fermented Royal Agaricus 500 mg Ingredients & Drug Interactions

by Solaray

Fermented Royal Agaricus 500 mg label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Fermented Royal Agaricus 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Fermented Royal Agaricus 500 mg is a dietary supplement by Solaray with 1 active ingredient. Its ingredients are commonly taken for immune support, general wellness and antioxidant, adjunct interest during cancer care.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are organic fermented Royal Agaricus Mushroom. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Fermented Royal Agaricus 500 mg by Solaray

Ask about any prescription or over-the-counter medication and we check it for interactions with Fermented Royal Agaricus 500 mg by Solaray — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Fermented Royal Agaricus 500 mg by Solaray

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 30, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: organic fermented Royal Agaricus Mushroom at 500 mg per capsule. The capsule itself is made from vegetable cellulose, an inert inactive ingredient.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Agaricus Mushroom product and its label doesn't state a use — see Agaricus Mushroom's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence we hold on agaricus mushroom doesn't establish reliable support for any of its common uses. The data rates its effectiveness for allergic rhinitis (hay fever), osteoporosis, cancer, cardiovascular disease, chemotherapy-induced adverse effects, and Crohn disease all as insufficient — meaning the science so far doesn't clearly show whether it works for these conditions.

If you're considering it for one of these purposes, talk it over with your doctor about what the current evidence actually supports.

The evidence, ingredient by ingredient Agaricus Mushroom

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Agaricus mushroom is generally well tolerated when taken by mouth, though some people report abdominal discomfort, diarrhea, or nausea. Rare but serious adverse effects have been reported, including allergic reactions, liver damage, and interstitial lung disease (a scarring condition in the lungs).

Three cases of severe liver damage occurred in women with ovarian or breast cancer who were undergoing chemotherapy and also took agaricus mushroom supplements; two of these cases were fatal. The safety data for pregnancy and breastfeeding is too limited to know whether it's safe, so the safety notes advise against supplement doses during pregnancy and while breastfeeding.

If you're pregnant, planning to become pregnant, or breastfeeding, talk with your doctor or pharmacist before taking this product.

Side effects, ingredient by ingredient Agaricus Mushroom

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Agaricus Mushroom.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before starting Fermented Royal Agaricus 500 mg, double-check all antidiabetes medications (insulin, metformin, sulfonylureas, and similar drugs) with your doctor or pharmacist. This product carries a moderate-severity risk of increasing low blood sugar episodes when combined with these drugs.

No other interactions are documented for the ingredients we could check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Agaricus mushroom is generally tolerated as food, but supplement safety and long-term effects aren't well established. If you take diabetes medications, this product requires a conversation with your doctor or pharmacist first because of the risk of low blood sugar.

If you have liver disease, a history of allergic reactions, or lung problems, mention those as well. The evidence for its intended uses is still uncertain, so clarity on why you're taking it matters.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 24, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Fermented Royal Agaricus 500 mg, straight from the product label.

Brand Solaray
Barcode (UPC) 076280153798
Net contents 60 Veg Cap(s)
Market status On market
Date entered into DSLD Mar 24, 2017
DSLD ID 71559
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Organic
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Fermented Royal Agaricus 500 mg by Solaray, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Veg Cap(s)
Maximum serving Sizes:
2 Veg Cap(s)
Servings per container
30
UPC/BARCODE
076280153798
IngredientAmount% DV
organic fermented Royal Agaricus Mushroom1000 mg--

Other ingredients: Vegetable Cellulose Capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

Dietary Supplement

Formulation

Organically grown

Discussion: Solaray organically grown mushrooms are 100% vegan, excipient-free and contain no fillers or additional ingredients.

Discussion: Solaray organically grown mushrooms are 100% vegan, excipient-free and contain no fillers or additional ingredients.

Discussion: Solaray organically grown mushrooms are 100% vegan, excipient-free and contain no fillers or additional ingredients.

Formula

Agaricus blazei 500 mg per capsule Mushroom

Seals/Symbols

Lab verified

Precautions

Warning: Do not us if safety seal is broken or missing.

Keep out of reach of children.

General Statements

Keep your licensed health care practitioner informed when using this product.

The organic mushroom mycelium biomass is cultured on organic gluten-free whole oats and then fermented. A mycelium is the vegetative portion of a fungus. It is through this root-like substance that the fungus absorbs nutrients.

Suggested/Recommended/Usage/Directions

Directions: Use only as directed. Take two VegCaps daily with meal or glass of water.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

General

3680586 0716

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Fermented Royal Agaricus 500 mg by Solaray label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Fermented Royal Agaricus 500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Fermented Royal Agaricus 500 mg by Solaray

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Veg Cap(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Organic fermented Royal Agaricus Mushroom

Interacts with
86 drugs
1000 mg per serving

Agaricus mushroom (often Agaricus blazei/subrufescens) is a culinary and medicinal mushroom studied mostly for possible immune and antioxidant effects...

Organic fermented Royal Agaricus Mushroom monograph & interactions

Other (inactive) ingredients: Vegetable Cellulose Capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

Fermented Royal Agaricus 500 mg by Solaray Drug Interactions

Want to check YOUR meds against Fermented Royal Agaricus 500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

organic fermented Royal Agaricus Mushroom 86

Individual Drug Interactions

The ingredients in Fermented Royal Agaricus 500 mg interact with 86 drugs. Click any drug to see the details.

1 of the 1 ingredient in Fermented Royal Agaricus 500 mg interact with drugs. Each result below shows which ingredient is responsible. organic fermented Royal Agaricus Mushroom

Each ingredient & the kinds of drugs it affects

For each ingredient in Fermented Royal Agaricus 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

organic fermented Royal Agaricus Mushroom1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking agaricus mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
In one clinical study in patients with type 2 diabetes who are stabilized on conventional oral hypoglycemic agents, 3 of 29 patients taking an agaricus mushroom extract 500 mg three times daily for 12 weeks reported hypoglycemia, compared to one of 29 patients in the placebo group.

Likelihood Possible Evidence D
organic fermented Royal Agaricus Mushroom full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Fermented Royal Agaricus 500 mg, from the product label.

Solaray

See all Solaray products
Name
Nutraceutical Corp.
Web Address
www.nutrafamily.com
Pharmacist Counseling Corner

Fermented Royal Agaricus 500 mg by Solaray: Common Questions

Does Fermented Royal Agaricus 500 mg by Solaray interact with any medications?
Yes. Based on its ingredients, Fermented Royal Agaricus 500 mg has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Fermented Royal Agaricus 500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
The safety data for pregnancy and breastfeeding is too limited to know whether it's safe. The safety notes advise against supplement doses in both situations. Talk with your doctor or pharmacist for personalized guidance.
What are the side effects?
Most people tolerate it well. The most common side effects are abdominal discomfort, diarrhea, and nausea. Rare but serious effects include allergic reactions, liver damage, and a lung scarring condition called interstitial lung disease.
Does it actually work for allergies, cancer, or bone health?
The evidence we hold doesn't clearly establish whether it works for allergic rhinitis, cancer, cardiovascular disease, osteoporosis, chemotherapy side effects, or Crohn disease. The data rates all of these as insufficient evidence.
What is agaricus mushroom?
It's a medicinal mushroom that's been used traditionally in some cultures. This product contains a fermented form at 500 mg per capsule.
Is there anything in this besides the mushroom?
The capsule itself is made from vegetable cellulose, which is just an inert container. The active ingredient is the fermented mushroom only.
I take diabetes medication. Is this safe to add?
Not without checking first. This mushroom has a documented moderate-severity interaction with diabetes drugs — it might increase your risk of low blood sugar. Talk with your doctor or pharmacist before starting it.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Fermented Royal Agaricus 500 mg is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Fermented Royal Agaricus 500 mg label
Go deeper

The Full Monographs Behind Fermented Royal Agaricus 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Agaricus Mushroom

Interacts with 86 drugs

Agaricus mushroom (often Agaricus blazei/subrufescens) is a culinary and medicinal mushroom studied mostly for possible immune and antioxidant effects. The human evidence is limited and not...

Read the full Agaricus Mushroom monograph →
Sources

Sources & How We Checked

Fermented Royal Agaricus 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Agaricus Mushroom 5 references
  1. Hsu CH, Liao YL, Lin SC, et al. The mushroom Agaricus Blazei Murill in combination with metformin and gliclazide improves insulin resistance in type 2 diabetes: a randomized, double-blinded, and placebo-controlled clinical trial. J Altern Complement Med 2
  2. Mukai H, Watanabe T, Ando M, Katsumata N. An alternative medicine, Agaricus blazei, may have induced severe hepatic dysfunction in cancer patients. Jpn J Clin Oncol 2006;36:808-10. PubMed
  3. Ohno S, Sumiyoshi Y, Hashine K, et al. Phase I clinical study of the dietary supplement, Agaricus blazei Murill, in cancer patients in remission. Evid Based Complement Alternat Med 2011, doi 10.1155/2011/192381.
  4. Suehiro M, Katoh N, Kishimoto S. Chelitis due to Agaricus blazei Murill mushroom extract. Contact Dermatitis 2007;56(5):293-4.
  5. Iwai N, Okuda T, Sawada R, et al. Interstitial lung disease associated with Agaricus blazei Murill in a patient with pancreatic ductal adenocarcinoma receiving gemcitabine-based therapy. Case Rep Gastroenterol 2022;16(1):229-234.

See these in context on the Agaricus Mushroom monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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