Interactions on record — worth a quick check against your medications. Based on 2 of 6 ingredients. Check your meds →
Dietary supplement

GRP-HD Ingredients & Drug Interactions

by Image Sports

Capsule Category: Botanical
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

GRP-HD is a dietary supplement by Image Sports with 6 active ingredients. Its ingredients are commonly taken for loss of appetite, indigestion and bloating, digestive bitter tonic.Based on those ingredients, 736 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Dolichos lobatus, Yellow Centiyane. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of GRP-HD by Image Sports

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 6 active ingredients.
  • “GRP-HD(TM) Advanced Training Blend” is a proprietary blend — the label gives one combined amount (445 mg) without saying how much of each component you get.

GRP-HD is a 6-ingredient capsule blend. The active ingredients are gentian (listed here as Yellow Centiyane), kudzu (Dolichos lobatus), Calea ternifolia, Eucommia ulmoides, Indian Banyan, and Southern Elder.

The product also contains inactive ingredients — gelatin capsule material, magnesium stearate, maltodextrin, microcrystalline cellulose, hydroxypropyl methylcellulose, chlorophyll, and titanium dioxide — which serve as binders, fillers, and colorants.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: increased lean muscle and decreased body fat.
  • We looked for evidence on: Athletic performance, Obesity, Muscle mass, Body composition.
  • The closest evidence on file: Gentian is rated "Insufficient Reliable Evidence To Rate" for Obesity (Natural Medicines).
  • Also on file: Kudzu is rated "Insufficient Reliable Evidence To Rate" for Athletic performance, Obesity.

The evidence we hold does not establish that these ingredients work for any of their claimed purposes. Gentian shows insufficient reliable evidence for wound healing, obesity, rhinosinusitis, and gastritis.

Kudzu is possibly effective for alcohol use disorder, but has insufficient evidence for allergic rhinitis, angina, and back pain. We have no effectiveness data on file for Calea ternifolia, Eucommia ulmoides, Indian Banyan, or Southern Elder.

The evidence, ingredient by ingredient Gentian Kudzu

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Gentian is generally tolerated in small amounts by healthy adults, but it can upset the stomach and is not well studied at high doses. In one clinical trial, gentian combined with turmeric and ginger caused nausea in 6 of 17 patients, vomiting in 3, diarrhea in 2, and bloating in 2.

Kudzu is generally well tolerated in short-term studies, though long-term safety isn't established. Kudzu trials have reported nausea, indigestion, bloating, hives, and dizziness, but these occurred no more often than with placebo.

One case report documented an allergic rash after a kudzu-containing herbal blend. Gentian should be avoided during pregnancy and breastfeeding due to insufficient safety data.

Kudzu should also be avoided in pregnancy and breastfeeding for the same reason. We hold no pregnancy or breastfeeding safety data for the other four ingredients.

Side effects, ingredient by ingredient Gentian Kudzu

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Gentian, Kudzu.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 737 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking GRP-HD, check your medications against these drug types: blood pressure medications (antihypertensive drugs), blood thinners and antiplatelet drugs, liver-damaging drugs, estrogen therapy, methotrexate, tamoxifen, diabetes medications, and caffeine-containing products — all carry documented interactions with gentian and/or kudzu. No interactions are documented for the other ingredients we checked our data against.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This product's ingredients have documented interactions with blood pressure drugs, blood thinners, estrogen therapy, cancer medications, diabetes drugs, and others — making it essential to run your exact medication list through the checker before starting. Gentian and kudzu also carry real risks of stomach upset.

If you take any prescription medication or are pregnant or breastfeeding, talk with your doctor or pharmacist before taking this product.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about GRP-HD, straight from the product label.

Brand Image Sports
Net contents 28 Capsule(s)
Market status On market
Date entered into DSLD Feb 25, 2013
DSLD ID 18652
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Qualified Health, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for GRP-HD by Image Sports, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
28
IngredientAmount% DV
GRP-HD(TM) Advanced Training Blend445 mg--
Calea ternifolia0 NP--
Yellow Centiyane0 NP--
Dolichos lobatus0 NP--
Eucommia ulmoides0 NP--
Indian Banyan0 NP--
Southern Elder0 NP--

Other ingredients: Gelatin, Magnesium Stearate, Maltodextrin, Microcrystalline Cellulose, Hydroxypropyl Methylcellulose, Chlorophyll, Titanium Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

GRP-HD(TM)

GRP-HD(TM) is intended to promote strength, muscle mass, fat loss, healthy joints, and rest.*† GRP-HD(TM) is a novel compound Growth Factor Peptide Releasing Matrix.*†

General Statements

Please read entire label before use.

BE POWERFUL

{Growth Factor Releasing Peptide} INCREASED LEAN MUSCLE *† DECREASED BODY FAT *† PRIMARY ANABOLIC MECHANISM *†

†When combined with a proper exercise and nutrition regimen. Statements based on early-stage independent 3rd party in vivo and / or in vitro model scientific research data findings.

Precautions

Warnings: Not intended for use by persons under age 18. Do not exceed recommended dose.

KEEP THIS PRODUCT AND ALL SUPPLEMENTS OUT OF THE REACH OF CHILDREN.

Get the consent of a licensed physician before using this product, especially if you are taking medication, have a medical condition, you are pregnant, nursing or thinking about becoming pregnant.

Storage

STORAGE: Room temperature (68(0)F to 80(0)F). DO NOT REFRIGERATE OR FREEZE. Keep away from direct sunlight and heat. When not in use, store in dark, dry place.

General

Rev. 01-001-GHD007 10/12

FDA Statement of Identity

DIETARY SUPPLEMENT

Suggested/Recommended/Usage/Directions

Suggested Use: Take one (1) capsule in the morning on an empty stomach, or as directed by a qualified healthcare practitioner. Not designed to be cycled — take daily.

FDA Disclaimer Statement

*THESE STATEMENTS HAVE NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION. THIS PRODUCT IS NOT INTENDED TO DIAGNOSE, TREAT, CURE, OR PREVENT ANY DISEASE.

See for yourself

GRP-HD by Image Sports label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in GRP-HD by Image Sports

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container28 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

GRP-HD(TM) Advanced Training Blend

445 mg per serving

Other (inactive) ingredients: Gelatin, Magnesium Stearate, Maltodextrin, Microcrystalline Cellulose, Hydroxypropyl Methylcellulose, Chlorophyll, Titanium Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

GRP-HD by Image Sports Drug Interactions

Want to check YOUR meds against GRP-HD?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
736Drugs
664 Moderate 72 Minor

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in GRP-HD with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Dolichos lobatus7 drug types · 584 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, kudzu may increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Kudzu isoflavones are reported to have antiplatelet activity.

Likelihood Possible Evidence D
Caffeine

Theoretically, taking kudzu with caffeine might increase levels of caffeine.
In healthy males injected with the kudzu constituent puerarin, caffeine clearance and metabolism is inhibited. This effect has been attributed to inhibition of cytochrome P450 1A2 (CYP1A2) enzyme, which is involved in caffeine metabolism. It is unclear if taking kudzu orally would have this same effect.

Likelihood Probable Evidence D
Estrogens

Theoretically, kudzu might alter the effects of estrogen therapy.
Some research suggests that kudzu has estrogenic effects. This may enhance or inhibit the effects of estrogen therapy.

Likelihood Possible Evidence B
Hepatotoxic Drugs

Theoretically, concomitant use might have additive hepatotoxic effects.
There is some concern that kudzu can adversely affect the liver.

Likelihood Possible Evidence D
Methotrexate (Trexall, Others)

Theoretically, taking kudzu with methotrexate might increase the risk of methotrexate toxicity.
Preclinical research suggests that kudzu extract greatly reduces the elimination and increases the toxicity of methotrexate. Kudzu might inhibit organic anion transporters (OATs) that are responsible for hepatobiliary and renal excretion of anions, similar to the interaction between methotrexate and non-steroidal anti-inflammatory drugs (NSAIDs).

Likelihood Possible Evidence D
Tamoxifen (Nolvadex)

Theoretically, kudzu might interfere with tamoxifen activity.
Some research suggests that kudzu may have estrogenic effects.

Likelihood Possible Evidence B
Antidiabetes Drugs

Theoretically, taking kudzu with antidiabetes drugs might increase the risk of hypoglycemia.
Kudzu might lower blood glucose levels and have additive effects in patients treated with antidiabetic agents. The dose of diabetes medications might need to be adjusted.

Likelihood Unlikely Evidence D

Yellow Centiyane1 drug type · 172 drugs

Antihypertensive Drugs

Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.
In vitro research shows that gentian can cause vasodilation and lower blood pressure.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for GRP-HD, from the product label.

Image Sports

See all Image Sports products
Name
BPI
Pharmacist Counseling Corner

GRP-HD by Image Sports: Common Questions

Does GRP-HD by Image Sports interact with any medications?
Yes. Based on its ingredients, GRP-HD has a known interaction with 736 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
GRP-HD contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does gentian in this product lower blood pressure?
Research shows gentian can cause blood vessels to widen and lower blood pressure in theory. The concern is that if you're already taking a blood pressure medication, combining them might lower your pressure too much. Talk with your doctor or pharmacist about whether it's safe for you.
What stomach side effects might I get from GRP-HD?
Gentian can upset your stomach, and kudzu trials reported nausea, indigestion, and bloating — though these happened no more often than placebo. One clinical trial of gentian with turmeric and ginger saw 6 of 17 patients quit due to nausea, 3 due to vomiting, 2 due to diarrhea, and 2 due to bloating.
Is it safe to take GRP-HD while pregnant?
No — both gentian and kudzu should be avoided in pregnancy because there isn't enough safety data. Talk with your doctor or pharmacist about what's right for you.
Can I breastfeed while taking this product?
The safety data advises against it. Both gentian and kudzu lack enough reliable information to recommend use while breastfeeding. Check with your doctor or pharmacist for personalized advice.
Does this product work for building muscle or improving athletic performance?
We have no effectiveness data on file for these ingredients and their use in athletic training. The individual components show insufficient evidence or no data we can verify for their claimed purposes.
What are the inactive ingredients, and is this product free of fillers?
The product contains gelatin, magnesium stearate, maltodextrin, microcrystalline cellulose, hydroxypropyl methylcellulose, chlorophyll, and titanium dioxide — these are the inactive ingredients that bind and fill the capsule. So it does contain fillers and binders, which is standard in capsule products.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if GRP-HD is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

GRP-HD label
Sources

Sources & How We Checked

GRP-HD's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 26 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Gentian 5 references
  1. Neubauer N, Marz RW. Placebo-controlled, randomized, double-blind, clincal trial with Sinupret sugar coated tablets on the basis of a therapy with antibiotics and decongestant nasal drops in acute sinusitis. Phytomedicine 1994;1:177-81.
  2. Marz RW, Ismail C, Popp MA. Action profile and efficacy of a herbal combination preparation for the treatment of sinusitis. Wien Med Wochenschr 1999;149:202-8.
  3. Uncini Manganelli RE, Chericoni S, Baragatti B. Ethnopharmacobotany in Tuscany: plants used as antihypertensives. Fitoterapia 2000;71:S95-100. PubMed
  4. Baragatti B, Calderone V, Testai L, et al. Vasodilator activity of crude methanolic extract of Gentiana kokiana Perr. et Song. (Gentianaceae). J Ethnopharmacol 2002;79:369-72. PubMed
  5. Sanatani M, Younus J, Stitt L, et al. Tolerability of the combination of ginger (Zingiber officinalis), gentian (Gentiana lutea) and turmeric (Curcuma longa) in patients with cancer-associated anorexia. J Complement Integr Med. 2015;12(1):57-60.

See these in context on the Gentian monograph →

Kudzu 21 references
  1. Woo J, Lau E, Ho SC, et al. Comparison of Pueraria lobata with hormone replacement therapy in treating the adverse health consequences of menopause. Menopause 2003;10:352-61. PubMed
  2. Akita H, Sowa J, Makiura M, et al. Maculopapular drug eruption due to the Japanese herbal medicine Kakkonto (kudzu or arrowroot decoction). Contact Dermatitis 2003;48:348-9. PubMed
  3. Luo ZR, Zheng B. [Effect of Puerarin on platelet activating factors CD63 and CD62P, plasminogen activator inhibitor and C-reactive protein in patients with unstable angia pectoris]. Zhongguo Zhong Xi Yi Jie He Za Zhi 2001;21:31-3 .
  4. Lee KT, Sohn IC, Kim DH, et al. Hypoglycemic and hypolipidemic effects of tectorigenin and kaikasaponin III in the streptozotocin-lnduced diabetic rat and their antioxidant activity in vitro. Arch Pharm Res 2000;23:461-6.
  5. Yu Z, Zhang G, Zhao H. [Effects of Puerariae isoflavone on blood viscosity, thrombosis and platelet function]. Zhong Yao Cai 1997;20:468-9.
  6. Hsu FL, Liu IM, Kuo DH, et al. Antihyperglycemic effect of puerarin in streptozotocin-induced diabetic rats. J Nat Prod 2003;66:788-92. PubMed
  7. Chiang HM, Fang SH, Wen KC, et al. Life-threatening interaction between the root extract of Pueraria lobata and methotrexate in rats. Toxicol Appl Pharmacol 2005;209:263-8.
  8. Zheng, J., Chen, B., Jiang, B., Zeng, L., Tang, Z. R., Fan, L., and Zhou, H. H. The effects of puerarin on CYP2D6 and CYP1A2 activities in vivo. Arch Pharm Res 2010;33(2):243-246. PubMed
  9. Hsu, H. H., Chang, C. K., Su, H. C., Liu, I. M., and Cheng, J. T. Stimulatory effect of puerarin on alpha1A-adrenoceptor to increase glucose uptake into cultured C2C12 cells of mice. Planta Med 2002;68(11):999-1003.
  10. Zheng, G., Zhang, X., Zheng, J., Meng, Q., and Zheng, D. [Estrogen-like effects of puerarin and total isoflavones from Pueraria lobata]. Zhong.Yao Cai. 2002;25(8):566-568.
  11. Qi, B. L. and Qi, B. M. [Effect of the purariae-isofiavones on estrogen level in normal and ovariectomized rats]. Zhongguo Zhong.Yao Za Zhi. 2002;27(11):850-852.
  12. Akita, H., Sowa, J., Makiura, M., Akamatsu, H., and Matsunaga, K. Maculopapular drug eruption due to the Japanese herbal medicine Kakkonto (kudzu or arrowroot decoction). Contact Dermatitis 2003;48(6):348-349. PubMed
  13. Manonai, J., Chittacharoen, A., Theppisai, U., and Theppisai, H. Effect of Pueraria mirifica on vaginal health. Menopause. 2007;14(5):919-924. PubMed
  14. Chandeying, V. and Sangthawan, M. Efficacy comparison of Pueraria mirifica (PM) against conjugated equine estrogen (CEE) with/without medroxyprogesterone acetate (MPA) in the treatment of climacteric symptoms in perimenopausal women: phase III study. J M
  15. Virojchaiwong, P., Suvithayasiri, V., and Itharat, A. Comparison of Pueraria mirifica 25 and 50 mg for menopausal symptoms. Arch.Gynecol.Obstet. 2011;284(2):411-419. PubMed
  16. Hou, Q., Ao, X., Li, G., and Zhang, Y. [Puerarin combined with avandia for diabetic nephropathy]. Zhong.Nan.Da.Xue Xue Bao Yi Xue Ban. 2012;37(1):73-77.
  17. Kim HJ, Kim H, Ahn JH, Suk JH. Liver injury induced by herbal extracts containing mistletoe and kudzu. J Altern Complement Med 2015;21(3):180-5. PubMed
  18. Santosh N, Mohan K, Royana S, Yamini TB. Hepatotoxicity of tubers of Indian Kudzu (Pueraria tuberosa) in rats. Food Chem Toxicol. 2010 Apr;48(4):1066-71. PubMed
  19. Teschke R, Zhang L, Long H, Schwarzenboeck A, Schmidt-Taenzer W, Genthner A, Wolff A, Frenzel C, Schulze J, Eickhoff A. Traditional Chinese Medicine and herbal hepatotoxicity: a tabular compilation of reported cases. Ann Hepatol. 2015 Jan-Feb;14(1):7-19. DOI
  20. Wang D, Qiu L, Wu X, Wei H, Xu F. Evaluation of kudzu root extract-induced hepatotoxicity. J Ethnopharmacol. 2015 Dec 24;176:321-6. PubMed
  21. Warinsiriruk P, Tantitham C, Cherdshewasart W, Shobeiri SA, Manonai J. Effects of Pueraria mirifica on vaginal artery vascularization in postmenopausal women with genitourinary syndrome of menopause. Maturitas 2022;160:4-10. PubMed

See these in context on the Kudzu monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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