GRP-HD Ingredients & Drug Interactions
by Image Sports
What is this page for?
First and foremost: checking GRP-HD against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
GRP-HD is a dietary supplement by Image Sports with 6 active ingredients. Its ingredients are commonly taken for loss of appetite, indigestion and bloating, digestive bitter tonic.Based on those ingredients, 736 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Dolichos lobatus, Yellow Centiyane. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against GRP-HD by Image Sports
Ask about any prescription or over-the-counter medication and we check it for interactions with GRP-HD by Image Sports — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of GRP-HD by Image Sports
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
GRP-HD is a 6-ingredient capsule blend. The active ingredients are gentian (listed here as Yellow Centiyane), kudzu (Dolichos lobatus), Calea ternifolia, Eucommia ulmoides, Indian Banyan, and Southern Elder.
The product also contains inactive ingredients — gelatin capsule material, magnesium stearate, maltodextrin, microcrystalline cellulose, hydroxypropyl methylcellulose, chlorophyll, and titanium dioxide — which serve as binders, fillers, and colorants.
Does it work?
Not established
The evidence we hold does not establish that these ingredients work for any of their claimed purposes. Gentian shows insufficient reliable evidence for wound healing, obesity, rhinosinusitis, and gastritis.
Kudzu is possibly effective for alcohol use disorder, but has insufficient evidence for allergic rhinitis, angina, and back pain. We have no effectiveness data on file for Calea ternifolia, Eucommia ulmoides, Indian Banyan, or Southern Elder.
How safe is it?
Well-documented data
Gentian is generally tolerated in small amounts by healthy adults, but it can upset the stomach and is not well studied at high doses. In one clinical trial, gentian combined with turmeric and ginger caused nausea in 6 of 17 patients, vomiting in 3, diarrhea in 2, and bloating in 2.
Kudzu is generally well tolerated in short-term studies, though long-term safety isn't established. Kudzu trials have reported nausea, indigestion, bloating, hives, and dizziness, but these occurred no more often than with placebo.
One case report documented an allergic rash after a kudzu-containing herbal blend. Gentian should be avoided during pregnancy and breastfeeding due to insufficient safety data.
Kudzu should also be avoided in pregnancy and breastfeeding for the same reason. We hold no pregnancy or breastfeeding safety data for the other four ingredients.
Meds to double-check
Moderate interaction found
Before taking GRP-HD, check your medications against these drug types: blood pressure medications (antihypertensive drugs), blood thinners and antiplatelet drugs, liver-damaging drugs, estrogen therapy, methotrexate, tamoxifen, diabetes medications, and caffeine-containing products — all carry documented interactions with gentian and/or kudzu. No interactions are documented for the other ingredients we checked our data against.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.
This product's ingredients have documented interactions with blood pressure drugs, blood thinners, estrogen therapy, cancer medications, diabetes drugs, and others — making it essential to run your exact medication list through the checker before starting. Gentian and kudzu also carry real risks of stomach upset.
If you take any prescription medication or are pregnant or breastfeeding, talk with your doctor or pharmacist before taking this product.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2013.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about GRP-HD, straight from the product label.
| Brand | Image Sports |
|---|---|
| Net contents | 28 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Feb 25, 2013 |
| DSLD ID | 18652 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Qualified Health, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for GRP-HD by Image Sports, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| GRP-HD(TM) Advanced Training Blend | 445 mg | -- |
| Calea ternifolia | 0 NP | -- |
| Yellow Centiyane | 0 NP | -- |
| Dolichos lobatus | 0 NP | -- |
| Eucommia ulmoides | 0 NP | -- |
| Indian Banyan | 0 NP | -- |
| Southern Elder | 0 NP | -- |
Other ingredients: Gelatin, Magnesium Stearate, Maltodextrin, Microcrystalline Cellulose, Hydroxypropyl Methylcellulose, Chlorophyll, Titanium Dioxide
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)
GRP-HD(TM)
GRP-HD(TM) is intended to promote strength, muscle mass, fat loss, healthy joints, and rest.*† GRP-HD(TM) is a novel compound Growth Factor Peptide Releasing Matrix.*†
General Statements
Please read entire label before use.
BE POWERFUL
{Growth Factor Releasing Peptide} INCREASED LEAN MUSCLE *† DECREASED BODY FAT *† PRIMARY ANABOLIC MECHANISM *†
†When combined with a proper exercise and nutrition regimen. Statements based on early-stage independent 3rd party in vivo and / or in vitro model scientific research data findings.
Precautions
Warnings: Not intended for use by persons under age 18. Do not exceed recommended dose.
KEEP THIS PRODUCT AND ALL SUPPLEMENTS OUT OF THE REACH OF CHILDREN.
Get the consent of a licensed physician before using this product, especially if you are taking medication, have a medical condition, you are pregnant, nursing or thinking about becoming pregnant.
Storage
STORAGE: Room temperature (68(0)F to 80(0)F). DO NOT REFRIGERATE OR FREEZE. Keep away from direct sunlight and heat. When not in use, store in dark, dry place.
General
Rev. 01-001-GHD007 10/12
FDA Statement of Identity
DIETARY SUPPLEMENT
Suggested/Recommended/Usage/Directions
Suggested Use: Take one (1) capsule in the morning on an empty stomach, or as directed by a qualified healthcare practitioner. Not designed to be cycled — take daily.
FDA Disclaimer Statement
*THESE STATEMENTS HAVE NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION. THIS PRODUCT IS NOT INTENDED TO DIAGNOSE, TREAT, CURE, OR PREVENT ANY DISEASE.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
GRP-HD by Image Sports label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in GRP-HD by Image Sports
These are the 6 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container28 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
GRP-HD(TM) Advanced Training Blend
- › Calea ternifolia
- › Yellow Centiyane
- › Dolichos lobatus
- › Eucommia ulmoides
- › Indian Banyan
- › Southern Elder
Other (inactive) ingredients: Gelatin, Magnesium Stearate, Maltodextrin, Microcrystalline Cellulose, Hydroxypropyl Methylcellulose, Chlorophyll, Titanium Dioxide. These complete the product’s ingredient list but are not active constituents.
GRP-HD by Image Sports Drug Interactions
HelloPharmacist Interaction Report
GRP-HD by Image Sports contains ingredients with documented interactions with medications.
The most serious concern is through its gentian and kudzu content: gentian may increase the risk of low blood pressure (hypotension) if you're taking blood pressure medications (antihypertensive drugs), and kudzu carries multiple moderate-severity interactions that warrant careful review.
Read the full breakdown — every affected drug type, severity by severity
Kudzu's interactions span several drug types. It may increase bleeding risk with blood thinners and antiplatelet drugs (like warfarin or aspirin).
It can theoretically worsen liver damage if combined with hepatotoxic drugs, interfere with estrogen therapy or tamoxifen (a breast cancer drug), raise caffeine levels in your system, increase the toxicity risk of methotrexate (a cancer and autoimmune drug), and add to the blood-sugar-lowering effect of diabetes medications.
We were not able to check three other ingredients in this product: Calea ternifolia, Eucommia ulmoides, and Indian Banyan — no interaction data is on file for them. Southern Elder also could not be checked.
To see whether your specific medications are affected, use the interaction checker on this page with your exact drug names.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against GRP-HD?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in GRP-HD interact with 736 drugs. Click any drug to see the details.
2 of the 6 ingredients in GRP-HD interact with drugs. Each result below shows which ingredient is responsible. Dolichos lobatus Yellow Centiyane
6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with GRP-HD — through 1 ingredient. Tap an ingredient for the detail:
Dolichos LobatusHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive hepatotoxic effects.
Read the full Dolichos Lobatus + 6-mercaptopurine interactionAbacavir Sulfate, Dolutegravir, LamivudineTriumeq
How Abacavir Sulfate, Dolutegravir, Lamivudine interacts with GRP-HD — through 1 ingredient. Tap an ingredient for the detail:
Dolichos LobatusHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive hepatotoxic effects.
Read the full Dolichos Lobatus + Abacavir Sulfate, Dolutegravir, Lamivudine interactionAbacavir, LamivudineEpzicom
How Abacavir, Lamivudine interacts with GRP-HD — through 1 ingredient. Tap an ingredient for the detail:
Dolichos LobatusHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive hepatotoxic effects.
Read the full Dolichos Lobatus + Abacavir, Lamivudine interactionAbciximabReoPro
How Abciximab interacts with GRP-HD — through 1 ingredient. Tap an ingredient for the detail:
Dolichos LobatusAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, kudzu may increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Dolichos Lobatus + Abciximab interactionAbiraterone
How Abiraterone interacts with GRP-HD — through 1 ingredient. Tap an ingredient for the detail:
Dolichos LobatusHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive hepatotoxic effects.
Read the full Dolichos Lobatus + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with GRP-HD — through 1 ingredient. Tap an ingredient for the detail:
Dolichos LobatusHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive hepatotoxic effects.
Read the full Dolichos Lobatus + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with GRP-HD — through 1 ingredient. Tap an ingredient for the detail:
Dolichos LobatusAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, kudzu may increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Dolichos Lobatus + Abrocitinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with GRP-HD — through 1 ingredient. Tap an ingredient for the detail:
Dolichos LobatusAntidiabetes Drugs, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking kudzu with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Dolichos Lobatus + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with GRP-HD — through 2 ingredients. Tap an ingredient for the detail:
Yellow CentiyaneAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.
Read the full Yellow Centiyane + Acebutolol interactionDolichos LobatusHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive hepatotoxic effects.
Read the full Dolichos Lobatus + Acebutolol interactionAcenocoumarolSintrom
How Acenocoumarol interacts with GRP-HD — through 1 ingredient. Tap an ingredient for the detail:
Dolichos LobatusAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, kudzu may increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Dolichos Lobatus + Acenocoumarol interactionAcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
How Acetaminophen interacts with GRP-HD — through 1 ingredient. Tap an ingredient for the detail:
Dolichos LobatusHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive hepatotoxic effects.
Read the full Dolichos Lobatus + Acetaminophen interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with GRP-HD — through 1 ingredient. Tap an ingredient for the detail:
Dolichos LobatusAnticoagulant/antiplatelet Drugs, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, kudzu may increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Dolichos Lobatus + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with GRP-HD — through 1 ingredient. Tap an ingredient for the detail:
Dolichos LobatusHepatotoxic Drugs, Caffeine +1 Moderate
Interaction Summary
Theoretically, concomitant use might have additive hepatotoxic effects.
Read the full Dolichos Lobatus + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with GRP-HD — through 1 ingredient. Tap an ingredient for the detail:
Dolichos LobatusHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive hepatotoxic effects.
Read the full Dolichos Lobatus + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with GRP-HD — through 1 ingredient. Tap an ingredient for the detail:
Dolichos LobatusHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive hepatotoxic effects.
Read the full Dolichos Lobatus + Acetaminophen, Butalbital interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with GRP-HD — through 1 ingredient. Tap an ingredient for the detail:
Dolichos LobatusHepatotoxic Drugs, Caffeine Moderate
Interaction Summary
Theoretically, concomitant use might have additive hepatotoxic effects.
Read the full Dolichos Lobatus + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with GRP-HD — through 1 ingredient. Tap an ingredient for the detail:
Dolichos LobatusCaffeine, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking kudzu with caffeine might increase levels of caffeine.
Read the full Dolichos Lobatus + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with GRP-HD — through 1 ingredient. Tap an ingredient for the detail:
Dolichos LobatusHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive hepatotoxic effects.
Read the full Dolichos Lobatus + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with GRP-HD — through 1 ingredient. Tap an ingredient for the detail:
Dolichos LobatusHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive hepatotoxic effects.
Read the full Dolichos Lobatus + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with GRP-HD — through 1 ingredient. Tap an ingredient for the detail:
Dolichos LobatusCaffeine, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking kudzu with caffeine might increase levels of caffeine.
Read the full Dolichos Lobatus + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with GRP-HD — through 1 ingredient. Tap an ingredient for the detail:
Dolichos LobatusHepatotoxic Drugs, Caffeine Moderate
Interaction Summary
Theoretically, concomitant use might have additive hepatotoxic effects.
Read the full Dolichos Lobatus + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with GRP-HD — through 1 ingredient. Tap an ingredient for the detail:
Dolichos LobatusCaffeine, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking kudzu with caffeine might increase levels of caffeine.
Read the full Dolichos Lobatus + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with GRP-HD — through 1 ingredient. Tap an ingredient for the detail:
Dolichos LobatusCaffeine, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking kudzu with caffeine might increase levels of caffeine.
Read the full Dolichos Lobatus + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with GRP-HD — through 1 ingredient. Tap an ingredient for the detail:
Dolichos LobatusHepatotoxic Drugs, Caffeine Moderate
Interaction Summary
Theoretically, concomitant use might have additive hepatotoxic effects.
Read the full Dolichos Lobatus + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with GRP-HD — through 1 ingredient. Tap an ingredient for the detail:
Dolichos LobatusCaffeine, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking kudzu with caffeine might increase levels of caffeine.
Read the full Dolichos Lobatus + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with GRP-HD — through 1 ingredient. Tap an ingredient for the detail:
Dolichos LobatusHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive hepatotoxic effects.
Read the full Dolichos Lobatus + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with GRP-HD — through 1 ingredient. Tap an ingredient for the detail:
Dolichos LobatusHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive hepatotoxic effects.
Read the full Dolichos Lobatus + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with GRP-HD — through 1 ingredient. Tap an ingredient for the detail:
Dolichos LobatusHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive hepatotoxic effects.
Read the full Dolichos Lobatus + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with GRP-HD — through 1 ingredient. Tap an ingredient for the detail:
Dolichos LobatusHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive hepatotoxic effects.
Read the full Dolichos Lobatus + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with GRP-HD — through 1 ingredient. Tap an ingredient for the detail:
Dolichos LobatusHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive hepatotoxic effects.
Read the full Dolichos Lobatus + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in GRP-HD with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Dolichos lobatus
Anticoagulant/Antiplatelet Drugs
Theoretically, kudzu may increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Kudzu isoflavones are reported to have antiplatelet activity.
Caffeine
Theoretically, taking kudzu with caffeine might increase levels of caffeine.
In healthy males injected with the kudzu constituent puerarin, caffeine clearance and metabolism is inhibited. This effect has been attributed to inhibition of cytochrome P450 1A2 (CYP1A2) enzyme, which is involved in caffeine metabolism. It is unclear if taking kudzu orally would have this same effect.
Estrogens
Theoretically, kudzu might alter the effects of estrogen therapy.
Some research suggests that kudzu has estrogenic effects. This may enhance or inhibit the effects of estrogen therapy.
Hepatotoxic Drugs
Theoretically, concomitant use might have additive hepatotoxic effects.
There is some concern that kudzu can adversely affect the liver.
Methotrexate (Trexall, Others)
Theoretically, taking kudzu with methotrexate might increase the risk of methotrexate toxicity.
Preclinical research suggests that kudzu extract greatly reduces the elimination and increases the toxicity of methotrexate. Kudzu might inhibit organic anion transporters (OATs) that are responsible for hepatobiliary and renal excretion of anions, similar to the interaction between methotrexate and non-steroidal anti-inflammatory drugs (NSAIDs).
Tamoxifen (Nolvadex)
Theoretically, kudzu might interfere with tamoxifen activity.
Some research suggests that kudzu may have estrogenic effects.
Antidiabetes Drugs
Theoretically, taking kudzu with antidiabetes drugs might increase the risk of hypoglycemia.
Kudzu might lower blood glucose levels and have additive effects in patients treated with antidiabetic agents. The dose of diabetes medications might need to be adjusted.
Yellow Centiyane
Antihypertensive Drugs
Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.
In vitro research shows that gentian can cause vasodilation and lower blood pressure.
Brand information
Manufacturer and brand details for GRP-HD, from the product label.
GRP-HD by Image Sports: Common Questions
Does GRP-HD by Image Sports interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Does gentian in this product lower blood pressure?
What stomach side effects might I get from GRP-HD?
Is it safe to take GRP-HD while pregnant?
Can I breastfeed while taking this product?
Does this product work for building muscle or improving athletic performance?
What are the inactive ingredients, and is this product free of fillers?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if GRP-HD is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind GRP-HD’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Gentian
Interacts with 172 drugsGentian is a very bitter root traditionally used to stimulate appetite and ease mild digestive complaints, often as part of "bitters" before meals. The evidence is mostly traditional and pre...
Read the full Gentian monograph → Herb & supplement monographKudzu
Interacts with 584 drugsKudzu is a fast-growing vine whose root has long been used in traditional Chinese medicine and is now studied mostly for reducing alcohol intake. Early research is promising for cutting back...
Read the full Kudzu monograph →Sources & How We Checked
GRP-HD's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 26 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Gentian 5 references
- Neubauer N, Marz RW. Placebo-controlled, randomized, double-blind, clincal trial with Sinupret sugar coated tablets on the basis of a therapy with antibiotics and decongestant nasal drops in acute sinusitis. Phytomedicine 1994;1:177-81.
- Marz RW, Ismail C, Popp MA. Action profile and efficacy of a herbal combination preparation for the treatment of sinusitis. Wien Med Wochenschr 1999;149:202-8.
- Uncini Manganelli RE, Chericoni S, Baragatti B. Ethnopharmacobotany in Tuscany: plants used as antihypertensives. Fitoterapia 2000;71:S95-100. PubMed
- Baragatti B, Calderone V, Testai L, et al. Vasodilator activity of crude methanolic extract of Gentiana kokiana Perr. et Song. (Gentianaceae). J Ethnopharmacol 2002;79:369-72. PubMed
- Sanatani M, Younus J, Stitt L, et al. Tolerability of the combination of ginger (Zingiber officinalis), gentian (Gentiana lutea) and turmeric (Curcuma longa) in patients with cancer-associated anorexia. J Complement Integr Med. 2015;12(1):57-60.
Kudzu 21 references
- Woo J, Lau E, Ho SC, et al. Comparison of Pueraria lobata with hormone replacement therapy in treating the adverse health consequences of menopause. Menopause 2003;10:352-61. PubMed
- Akita H, Sowa J, Makiura M, et al. Maculopapular drug eruption due to the Japanese herbal medicine Kakkonto (kudzu or arrowroot decoction). Contact Dermatitis 2003;48:348-9. PubMed
- Luo ZR, Zheng B. [Effect of Puerarin on platelet activating factors CD63 and CD62P, plasminogen activator inhibitor and C-reactive protein in patients with unstable angia pectoris]. Zhongguo Zhong Xi Yi Jie He Za Zhi 2001;21:31-3 .
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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