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Dietary supplement

Hemp Seed Oil 1000 mg Ingredients & Drug Interactions

by NusaPure

Hemp Seed Oil 1000 mg label
See full label image
Softgel Capsule Category: Fat/fatty Acid
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Hemp Seed Oil 1000 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Hemp Seed Oil 1000 mg is a dietary supplement by NusaPure with 1 active ingredient. Its ingredients are commonly taken for plant-based protein source, heart health support, skin and hair health.Based on those ingredients, 938 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Hemp seed Oil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Hemp Seed Oil 1000 mg by NusaPure

Ask about any prescription or over-the-counter medication and we check it for interactions with Hemp Seed Oil 1000 mg by NusaPure — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Hemp Seed Oil 1000 mg by NusaPure

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

NusaPure Hemp Seed Oil 1000 mg is a single-ingredient supplement: the active ingredient is hemp seed oil itself, delivered in a 1,000 mg softgel capsule. The capsule also contains D-alpha-tocopherol (vitamin E), which is an inactive ingredient used to preserve the oil.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Hemp product and its label doesn't state a use — see Hemp's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

Evidence for hemp seed oil is limited. The data we hold shows insufficient reliable evidence to rate it for constipation, atopic dermatitis (eczema), or familial hypercholesterolemia (a genetic cholesterol condition).

If you're considering this supplement for any of these uses, the research backing isn't established yet—talk with your doctor about what the current evidence shows for your situation.

The evidence, ingredient by ingredient Hemp

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Hemp seed foods in normal dietary amounts are generally well tolerated. Concentrated extracts and supplements like this one are less studied, so caution is advised.

In larger amounts, hemp seed oil appears to be well tolerated overall. Serious adverse effects are rare but have been reported: anaphylaxis and severe allergic reactions (facial swelling, breathing problems) can occur, especially on first exposure, though allergy to hemp seed itself is uncommon.

There's also a rare case report of elevated liver enzymes and hepatitis in a young child given a hemp extract at very high doses—not typical of oil supplements at recommended doses.

Side effects, ingredient by ingredient Hemp

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Hemp.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 939 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, double-check with your pharmacist or doctor if you're on estrogen or hormone therapy (Moderate interaction risk), blood pressure medication, ACE inhibitors, blood thinners, or any drug metabolized by your liver's CYP1A2 or CYP3A4 enzymes (all Minor risks). These are the drug types where hemp seed oil may interfere.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you're not taking hormone therapy, blood pressure medication, blood thinners, or drugs dependent on liver metabolism, this supplement is generally tolerated. If you do take any of those, clear it with your doctor or pharmacist first—the interaction potential is real, especially with hormone therapy.

Hemp seed oil's effectiveness for the conditions in the research isn't yet established, so manage your expectations on that front.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Hemp Seed Oil 1000 mg, straight from the product label.

Brand NusaPure
Barcode (UPC) X002ILL031
Net contents 180 Softgel(s)
Market status On market
Date entered into DSLD Mar 25, 2021
DSLD ID 246630
Product type Fat/fatty Acid
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Hemp Seed Oil 1000 mg by NusaPure, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
Servings per container
180
UPC/BARCODE
X002ILL031
IngredientAmount% DV
Calories10 Calorie(s)--
Total Fat1 Gram(s)1%
Hemp seed Oil1000 mg--

Other ingredients: Softgel Capsule, D-Alpha-Tocopherol

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: For adults, take 1 softgel 1 to 3 times daily, preferably with meals.

Precautions

Warning: If you are pregnant, nursing, or taking any medications, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur. May cause mild temporary gastro-intestinal disturbances.

Not intended for use by persons under the age of 18. Keep out of reach of children.

Allergen Information: Contains no yeast, wheat, gluten, soy, corn, milk, egg, fish or shellfish ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.

Storage

Store in cool dry place. Avoid excessive heat or moisture.

Formulation

Natural color variation may occur in this product.

GMO Free Made with non-GMO Ingredients Gluten Free FDA Registered Facility

Cold pressed Assembled in USA Natural 180,000 mg per bottle

Supports healthy skin & nails Supports healthy joints Max Strength

Allergen Information: Contains no yeast, wheat, gluten, soy, corn, milk, egg, fish or shellfish ingredients.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

Premium Quality Assembled in USA Gluten Free FDA Registered Facility

Manufactured in a cGMP Inspected Facility

Formula

Source of Omega 3,6,9

Each serving may typically have the following naturally occurring amounts of polyunsaturated fats and monounsaturated fats: Alpha-Linolenic Acid (Omega-3) 21%; Linoleic Acid and Gamma-Linolenic Acid (GLA) (Omega-6) 57%; Oleic Acid (omega-9) 13%; other (saturated) 9%

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Hemp Seed Oil 1000 mg by NusaPure label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Hemp Seed Oil 1000 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Hemp Seed Oil 1000 mg by NusaPure

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container180 Amounts shown are per serving.

Hemp seed Oil

Interacts with
938 drugs
1000 mg per serving

Hemp seeds and hemp seed oil are nutritious foods rich in protein, fiber, and healthy omega-3 and omega-6 fatty acids, and they are generally safe for...

Hemp seed Oil monograph & interactions

Other (inactive) ingredients: Softgel Capsule, D-Alpha-Tocopherol. These complete the product’s ingredient list but are not active constituents.

Interaction report

Hemp Seed Oil 1000 mg by NusaPure Drug Interactions

Want to check YOUR meds against Hemp Seed Oil 1000 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
938Drugs
41 Moderate 897 Minor

Ingredients driving the most interactions

Hemp seed Oil 938

Individual Drug Interactions

The ingredients in Hemp Seed Oil 1000 mg interact with 938 drugs. Click any drug to see the details.

1 of the 1 ingredient in Hemp Seed Oil 1000 mg interact with drugs. Each result below shows which ingredient is responsible. Hemp seed Oil

Each ingredient & the kinds of drugs it affects

For each ingredient in Hemp Seed Oil 1000 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Hemp seed Oil6 drug types · 938 drugs

Estrogens

Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
In an ovariectomized animal model, a diet containing hemp seed 1%, 2%, or 10% resulted in normalized plasma levels of 17-beta-estradiol. The mechanism of action for this effect is unclear.

Likelihood Possible Evidence D
Ace Inhibitors (Aceis)

Theoretically, consuming hemp seed protein isolate with ACE inhibitors might have additive effects and increase the risk of hypotension.
Hemp seed protein hydrolysate has shown ACE inhibitor-like effects in a hypertensive animal model. However, hempseed oil consumption does not seem to reduce blood pressure in humans. Until more is known, monitor blood pressure and potassium levels.

Likelihood Unlikely Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, hemp seed might increase the risk of bleeding when used concomitantly with anticoagulant/antiplatelet drugs.
In animal research, hemp seed at 5% of the diet inhibits platelet aggregation in vitro. However, in human research, taking hemp seed oil 2 grams daily for 12 weeks does not inhibit the aggregation of platelets in vitro.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, hemp seed protein may have additive effects with antihypertensive drugs.
In a hypertensive animal model, hemp seed protein hydrolysate reduced systolic blood pressure by a mechanism possibly involving the inhibition of renin and angiotensin converting enzyme (ACE) activities. However, there was no effect of hemp seed protein on blood pressure in normotensive animals. Furthermore, hempseed oil consumption does not seem to reduce blood pressure in humans.

Likelihood Unlikely Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, hemp might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that hemp induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that hemp induces CYP3A4 enzymes.

Likelihood Possible Evidence D
Hemp seed Oil full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Hemp Seed Oil 1000 mg, from the product label.

NusaPure

See all NusaPure products
Name
Gmax Central LLC
Street Address
4700 Millenia Boulevard, Suite 175 PMB 92909
City
Orlando
State
FL
ZipCode
32839
Pharmacist Counseling Corner

Hemp Seed Oil 1000 mg by NusaPure: Common Questions

Does Hemp Seed Oil 1000 mg by NusaPure interact with any medications?
Yes. Based on its ingredients, Hemp Seed Oil 1000 mg has a known interaction with 938 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Hemp Seed Oil 1000 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on birth control or hormone replacement therapy?
Not without checking first. Hemp seed oil has a Moderate interaction with estrogens—it may interfere with how your body processes hormone therapy, potentially making it less effective. Talk with your doctor or pharmacist about whether it's safe for you before starting.
What does hemp seed oil actually do?
The evidence we have isn't strong enough to confirm it works for constipation, eczema, or high cholesterol. The data shows insufficient reliable evidence to rate it for any of these uses. If you're considering it for one of these reasons, your doctor can talk you through what the current research actually shows.
Are there any side effects I should know about?
Hemp seed oil is generally well tolerated at typical doses. Serious side effects are rare, but allergic reactions—including anaphylaxis, facial swelling, and breathing problems—have been reported, especially on first exposure. If you have a tree nut or seed allergy history, mention it to your pharmacist.
Is this safe during pregnancy or breastfeeding?
The data on file doesn't have enough information to say either way. Talk with your doctor or pharmacist about whether it's appropriate for you during pregnancy or nursing—they can help you weigh what's known and what isn't.
Will this interfere with my blood pressure or blood thinner medication?
Possibly, but the evidence is limited. Animal research suggests hemp seed protein may lower blood pressure and affect clotting, but human studies on the oil itself are scarce. If you take either type of medication, mention this supplement to your doctor or pharmacist before starting.
What's in the capsule besides the oil?
The softgel capsule itself and D-alpha-tocopherol (vitamin E), which preserves the oil. Those are your only other ingredients—no extra fillers.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Hemp Seed Oil 1000 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Hemp Seed Oil 1000 mg label
Go deeper

The Full Monographs Behind Hemp Seed Oil 1000 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Hemp

Interacts with 938 drugs

Hemp seeds and hemp seed oil are nutritious foods rich in protein, fiber, and healthy omega-3 and omega-6 fatty acids, and they are generally safe for most people as part of the diet. While...

Read the full Hemp monograph →
Sources

Sources & How We Checked

Hemp Seed Oil 1000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 12 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Hemp 12 references
  1. Kaul N, Kreml R, Austria JA, et al. A comparison of fish oil, flaxseed oil and hempseed oil supplementation on selected parameters of cardiovascular health in healthy volunteers. J Am Coll Nutr 2008;27:51-8. PubMed
  2. Saberivand A, Karimi I, Becker LA, et al. The effects of Cannabis sativa L. seed (hempseed) in the ovariectomized rat model of menopause. Methods Find Exp Clin Pharmacol. 2010;32(7):467-73. PubMed
  3. Girgih AT, Alashi A, He R, Malomo S, Aluko RE. Preventive and treatment effects of a hemp seed (Cannabis sativa L.) meal protein hydrolysate against high blood pressure in spontaneously hypertensive rats. Eur J Nutr. 2014;53(5):1237-46. PubMed
  4. Richard MN, Ganguly R, Steigerwald SN, Al-Khalifa A, Pierce GN. Dietary hempseed reduces platelet aggregation. J Thromb Haemost. 2007;5(2):424-5. PubMed
  5. Stadtmauer G, Beyer K, Bardina L, Sicherer SH. Anaphylaxis to ingestion of hempseed (Cannabis sativa). J Allergy Clin Immunol. 2003;112(1):216-7. PubMed
  6. Del Bo' C, Deon V, Abello F, et al. Eight-week hempseed oil intervention improves the fatty acid composition of erythrocyte phospholipids and the omega-3 index, but does not affect the lipid profile in children and adolescents with primary hyperlipidemia. PubMed
  7. Alkhammash S, Tsui H, Thomson DMP. Cannabis and hemp seed allergy. J Allergy Clin Immunol Pract. 2019;7(7):2429-2430.e1. PubMed
  8. Stokes JR, Hartel R, Ford LB, Casale TB. Cannabis (hemp) positive skin tests and respiratory symptoms. Ann Allergy Asthma Immunol. 2000;85(3):238-40. PubMed
  9. Déléaval M, Burri H, Bakelants E. Harmless herbs? A case report of acquired long QT syndrome and torsades de pointes in a patient taking herbal supplements. HeartRhythm Case Rep 2022;8(5):309-12. PubMed
  10. Singh M, Sehgal M, Yacoub M, et al. Severe liver dysfunction in a toddler receiving nonprescription phytocannabinoid. J Am Pharm Assoc (2003) 2022;62(4):1438-1440. PubMed
  11. Clark E, Nilsson U, Samaran Q, Raison-Peyron N. Allergic contact dermatitis from Cannabis sativa (hemp) seed oil. Contact Dermatitis 2022;87(3):292-293.
  12. Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. PubMed

See these in context on the Hemp monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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