High (G) Hardcore Formulation Ingredients & Drug Interactions
by High T
What is this page for?
First and foremost: checking High (G) Hardcore Formulation against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
High (G) Hardcore Formulation is a dietary supplement by High T with 4 active ingredients. Its ingredients are commonly taken for memory and cognitive support, age-related cognitive decline, attention and focus (adhd).Based on those ingredients, 386 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are SerinAid(R), Mucuna Pruriens Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against High (G) Hardcore Formulation by High T
Ask about any prescription or over-the-counter medication and we check it for interactions with High (G) Hardcore Formulation by High T — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of High (G) Hardcore Formulation by High T
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This 4-ingredient product contains AlphaSize Alpha GPC, phosphatidylserine (marketed as SerinAid®), a Mucuna Pruriens extract (cowhage), and an Amino Acid Blend. The first three are the active ingredients; the others — potassium phosphate, FD&C dyes, and titanium dioxide — are inactive fillers and colorants.
Phosphatidylserine is thought to support brain cell structure and function. Cowhage is a plant extract that contains levodopa, an active compound similar to prescription Parkinson's medications.
AlphaSize Alpha GPC and the amino acid blend's specific roles are not detailed in the data we hold.
Does it work?
Insufficient evidence
For phosphatidylserine, the evidence shows it's possibly effective for age-related cognitive decline and Alzheimer's disease. For athletic performance, ADHD, general cognitive function, and dementia, the evidence is insufficient to rate it.
For cowhage, evidence is insufficient to establish effectiveness for anxiety, erythema (skin redness), high prolactin levels, muscle pain, Parkinson's disease, or rheumatoid arthritis. We hold no effectiveness data for AlphaSize Alpha GPC or the Amino Acid Blend.
How safe is it?
Well-documented data
Phosphatidylserine is generally well tolerated in studies, though long-term safety isn't fully established. The most common side effects are flatulence, nausea, headache, insomnia (especially at higher doses around 600 mg), and gastrointestinal upset at doses of 200–300 mg daily.
There isn't enough safety information to recommend use during pregnancy, and safety while breastfeeding is unknown — avoidance is recommended for both. Cowhage contains levodopa and should be used carefully with professional guidance.
Oral adverse effects are rare but include diarrhea, flatulence, dry mouth, nausea, abdominal bloating, vomiting, headaches, and insomnia (about 3% of trial participants). The safety data advises against use during pregnancy due to insufficient data and dopamine effects.
L-dopa can reduce milk supply, so avoidance is recommended while breastfeeding.
Meds to double-check
Major interaction found
Before taking this product, double-check with your pharmacist or doctor if you take monoamine oxidase inhibitors (MAOIs) for depression, methyldopa for blood pressure, levodopa for Parkinson's disease, or plan to have anesthesia — these are Major-severity interactions. Also check if you take anticholinergic drugs, cholinergic drugs, antidiabetes medications, antipsychotics, tricyclic antidepressants, or guanethidine.
The bottom line
Scorecard at a glanceFully disclosed formula with insufficient evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.
High T's formulation is built on ingredients with some evidence (phosphatidylserine for early cognitive decline) and others with insufficient evidence for their claimed uses. The real concern is its cowhage content — it carries serious drug interactions, especially with MAOIs and blood pressure or Parkinson's medications.
If you take any antidepressants, blood pressure drugs, diabetes medications, or antipsychotics, talk with your doctor or pharmacist before starting this product.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 25, 2012.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about High (G) Hardcore Formulation, straight from the product label.
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for High (G) Hardcore Formulation by High T, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| AlphaSize Alpha GPC | 300 mg | -- |
| SerinAid(R) | 125 mg | -- |
| Mucuna Pruriens Extract | 40 mg | -- |
| Amino Acid Blend | 560 mg | -- |
Other ingredients: Di Potassium Phosphate, FD&C BLUE #1, FD&C RED #40, FD&C YELLOW #6, FD&C YELLOW #5, Titanium Dioxide
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Seals/Symbols
AlphaSize(R) Alpha-Glyceryl Phosphoryl Choline
SerinAid(R) PhosPhatidylserine
GMP GOOD MANUFACTURING PRACTICE MANUFACTURED IN A GMP CERTIFIED FACILITY QUALITY GUARANTEED
Made in USA
kingfisher media
General Statements
Over 20 clinical studies support the ingredients in HighG(TM) which is designed to boost the body’s output of muscle development. Formulated to reduce muscle soreness, increase athletic stamina and capacity, support neuromuscular function during exercise, reduce fatigue, and reduce both physio and psychological stress.
ULTIMATEMUSCLE
Muscle Growth Booster
Clinically Supports: Natural Muscle Production Natural Strength Gain Energy with Ultimate Endurance
When the science of building muscle mass was clinically developed by our team; a proven, safe, and result driven outcome was achieved. Building muscle requires stacking many things; Nutrition, Training, Dedication, Trusted outcome and the right mix of supplements. Now the HighT(R) brand introduces HighG(TM); a dynamically formulated, clinically supported product designed to build muscle.
Suggested/Recommended/Usage/Directions
USAGE: Take 1 serving (4) capsules 90 minutes prior to resistance exercise. Heavy workout days; take 2 servings (8) capsules prior to work out or competitive activity for optimal performance. For non-work out days, take 2 capsules daily. As with all workouts we recommend proper hydration.
Precautions
PRECAUTIONS: Use only as directed.
Do not take this product if you are pregnant or nursing.
Consult a health care professional before use if you are allergic to any ingredients, have a serious medical condition, or use prescription medications.
For adult use only.
Brand IP Statement(s)
Alphasize(R) and SerinAid(R) are trademarks of Chemi Nutra, Inc. HighT(R) is a registered trademark of KingFisher Media, LLC
WORK HARD. PLAY HARD. RECOVER FASTER.(TM)
FDA Disclaimer Statement
These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.
FDA Statement of Identity
DIETARY SUPPLEMENT
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
High (G) Hardcore Formulation by High T label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in High (G) Hardcore Formulation by High T
These are the 4 active ingredients this product is made of. Select any to open its full monograph.
Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
AlphaSize Alpha GPC
SerinAid(R)
Interacts with219 drugs
Phosphatidylserine is a natural fat-like compound found in cell membranes, especially in the brain, and it is sold mainly to support memory and thinki...
SerinAid(R) monograph & interactionsMucuna Pruriens Extract
Interacts with193 drugs
Cowhage (Mucuna pruriens) is a tropical legume best known as a natural source of L-dopa, the compound the body turns into dopamine. It is most studied...
Mucuna Pruriens Extract monograph & interactionsAmino Acid Blend
Other (inactive) ingredients: Di Potassium Phosphate, FD&C BLUE #1, FD&C RED #40, FD&C YELLOW #6, FD&C YELLOW #5, Titanium Dioxide. These complete the product’s ingredient list but are not active constituents.
High (G) Hardcore Formulation by High T Drug Interactions
HelloPharmacist Interaction Report
High T High (G) Hardcore Formulation has documented interactions through its phosphatidylserine and cowhage extract content.
The most serious concern is cowhage's interaction with monoamine oxidase inhibitors (MAOIs) — a class of antidepressants — which carries a Major severity risk of hypertensive crisis (dangerously high blood pressure). Cowhage also carries Major-severity interactions with methyldopa (a blood pressure medication), levodopa (a Parkinson's drug), and anesthesia drugs.
Read the full breakdown — every affected drug type, severity by severity
Phosphatidylserine carries Moderate-severity interactions with anticholinergic drugs (which block acetylcholine) and cholinergic drugs (which increase acetylcholine), either reducing their effectiveness or amplifying their effects. Cowhage carries additional Moderate-severity interactions with antidiabetes drugs (low blood sugar risk), antipsychotic medications (reduced effectiveness), tricyclic antidepressants (reduced cowhage effectiveness and potential high blood pressure), anesthesia, and guanethidine (a blood pressure drug).
We could not check AlphaSize Alpha GPC or the Amino Acid Blend — we hold no interaction data for either. Altogether, these interactions span 386 individual medications.
Check your exact medications with the search tool on this page before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against High (G) Hardcore Formulation?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in High (G) Hardcore Formulation interact with 386 drugs. Click any drug to see the details.
2 of the 4 ingredients in High (G) Hardcore Formulation interact with drugs. Each result below shows which ingredient is responsible. SerinAid(R) Mucuna Pruriens Extract
AmphetamineAdensys XR-ODT, Adzenys ER, Dyanavel XR, Mydayis
How Amphetamine interacts with High (G) Hardcore Formulation — through 1 ingredient. Tap an ingredient for the detail:
Mucuna Pruriens ExtractMonoamine Oxidase Inhibitors (maois) Major
Interaction Summary
Theoretically, concomitant use of cowhage and non-selective MAOIs might increase the risk of hypertensive crisis.
Read the full Mucuna Pruriens Extract + Amphetamine interactionBenserazide, LevodopaMadopar, Prolopa
How Benserazide, Levodopa interacts with High (G) Hardcore Formulation — through 1 ingredient. Tap an ingredient for the detail:
Mucuna Pruriens ExtractLevodopa Major
Interaction Summary
Concomitant use can increase the risk of levodopa-related adverse effects.
Read the full Mucuna Pruriens Extract + Benserazide, Levodopa interactionCarbidopa, LevodopaDhivy, Rytary, Sinemet, Sinemet CR
How Carbidopa, Levodopa interacts with High (G) Hardcore Formulation — through 1 ingredient. Tap an ingredient for the detail:
Mucuna Pruriens ExtractLevodopa Major
Interaction Summary
Concomitant use can increase the risk of levodopa-related adverse effects.
Read the full Mucuna Pruriens Extract + Carbidopa, Levodopa interactionCarbidopa, Levodopa, EntacaponeStalevo
How Carbidopa, Levodopa, Entacapone interacts with High (G) Hardcore Formulation — through 1 ingredient. Tap an ingredient for the detail:
Mucuna Pruriens ExtractLevodopa Major
Interaction Summary
Concomitant use can increase the risk of levodopa-related adverse effects.
Read the full Mucuna Pruriens Extract + Carbidopa, Levodopa, Entacapone interactionChlorothiazide, MethyldopaAldochlor, Aldoclor 150, Aldoclor 250
How Chlorothiazide, Methyldopa interacts with High (G) Hardcore Formulation — through 1 ingredient. Tap an ingredient for the detail:
Mucuna Pruriens ExtractMethyldopa (aldomet) Major
Interaction Summary
Theoretically, concomitant use of cowhage and methyldopa might increase the risk of hypotension.
Read the full Mucuna Pruriens Extract + Chlorothiazide, Methyldopa interactionHydrochlorothiazide, MethyldopaAldoril 15, Aldoril 25, Aldoril D30, Methazide
How Hydrochlorothiazide, Methyldopa interacts with High (G) Hardcore Formulation — through 1 ingredient. Tap an ingredient for the detail:
Mucuna Pruriens ExtractMethyldopa (aldomet) Major
Interaction Summary
Theoretically, concomitant use of cowhage and methyldopa might increase the risk of hypotension.
Read the full Mucuna Pruriens Extract + Hydrochlorothiazide, Methyldopa interactionIsocarboxazidMarplan
How Isocarboxazid interacts with High (G) Hardcore Formulation — through 1 ingredient. Tap an ingredient for the detail:
Mucuna Pruriens ExtractMonoamine Oxidase Inhibitors (maois) Major
Interaction Summary
Theoretically, concomitant use of cowhage and non-selective MAOIs might increase the risk of hypertensive crisis.
Read the full Mucuna Pruriens Extract + Isocarboxazid interactionLevodopaInbrija, Larodopa
How Levodopa interacts with High (G) Hardcore Formulation — through 1 ingredient. Tap an ingredient for the detail:
Mucuna Pruriens ExtractLevodopa Major
Interaction Summary
Concomitant use can increase the risk of levodopa-related adverse effects.
Read the full Mucuna Pruriens Extract + Levodopa interactionLevodopa, CarbidopaDuodopa
How Levodopa, Carbidopa interacts with High (G) Hardcore Formulation — through 1 ingredient. Tap an ingredient for the detail:
Mucuna Pruriens ExtractLevodopa Major
Interaction Summary
Concomitant use can increase the risk of levodopa-related adverse effects.
Read the full Mucuna Pruriens Extract + Levodopa, Carbidopa interactionMethyldopaAldomet, Methyldopa
How Methyldopa interacts with High (G) Hardcore Formulation — through 1 ingredient. Tap an ingredient for the detail:
Mucuna Pruriens ExtractMethyldopa (aldomet) Major
Interaction Summary
Theoretically, concomitant use of cowhage and methyldopa might increase the risk of hypotension.
Read the full Mucuna Pruriens Extract + Methyldopa interactionMoclobemideManerix, Moclobemide
How Moclobemide interacts with High (G) Hardcore Formulation — through 1 ingredient. Tap an ingredient for the detail:
Mucuna Pruriens ExtractMonoamine Oxidase Inhibitors (maois) Major
Interaction Summary
Theoretically, concomitant use of cowhage and non-selective MAOIs might increase the risk of hypertensive crisis.
Read the full Mucuna Pruriens Extract + Moclobemide interactionOzanimod HydrochlorideZeposia
How Ozanimod Hydrochloride interacts with High (G) Hardcore Formulation — through 1 ingredient. Tap an ingredient for the detail:
Mucuna Pruriens ExtractMonoamine Oxidase Inhibitors (maois) Major
Interaction Summary
Theoretically, concomitant use of cowhage and non-selective MAOIs might increase the risk of hypertensive crisis.
Read the full Mucuna Pruriens Extract + Ozanimod Hydrochloride interactionPhenelzine SulfateNardil
How Phenelzine Sulfate interacts with High (G) Hardcore Formulation — through 1 ingredient. Tap an ingredient for the detail:
Mucuna Pruriens ExtractMonoamine Oxidase Inhibitors (maois) Major
Interaction Summary
Theoretically, concomitant use of cowhage and non-selective MAOIs might increase the risk of hypertensive crisis.
Read the full Mucuna Pruriens Extract + Phenelzine Sulfate interactionRasagilineAzilect
How Rasagiline interacts with High (G) Hardcore Formulation — through 1 ingredient. Tap an ingredient for the detail:
Mucuna Pruriens ExtractMonoamine Oxidase Inhibitors (maois) Major
Interaction Summary
Theoretically, concomitant use of cowhage and non-selective MAOIs might increase the risk of hypertensive crisis.
Read the full Mucuna Pruriens Extract + Rasagiline interactionSafinamide MesylateXadago
How Safinamide Mesylate interacts with High (G) Hardcore Formulation — through 1 ingredient. Tap an ingredient for the detail:
Mucuna Pruriens ExtractMonoamine Oxidase Inhibitors (maois) Major
Interaction Summary
Theoretically, concomitant use of cowhage and non-selective MAOIs might increase the risk of hypertensive crisis.
Read the full Mucuna Pruriens Extract + Safinamide Mesylate interactionSelegilineCarbex, Eldepryl, Emsam, Zelapar
How Selegiline interacts with High (G) Hardcore Formulation — through 1 ingredient. Tap an ingredient for the detail:
Mucuna Pruriens ExtractMonoamine Oxidase Inhibitors (maois) Major
Interaction Summary
Theoretically, concomitant use of cowhage and non-selective MAOIs might increase the risk of hypertensive crisis.
Read the full Mucuna Pruriens Extract + Selegiline interactionTranylcypromineParnate
How Tranylcypromine interacts with High (G) Hardcore Formulation — through 1 ingredient. Tap an ingredient for the detail:
Mucuna Pruriens ExtractMonoamine Oxidase Inhibitors (maois) Major
Interaction Summary
Theoretically, concomitant use of cowhage and non-selective MAOIs might increase the risk of hypertensive crisis.
Read the full Mucuna Pruriens Extract + Tranylcypromine interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with High (G) Hardcore Formulation — through 1 ingredient. Tap an ingredient for the detail:
Mucuna Pruriens ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, concomitant use of cowhage and antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Mucuna Pruriens Extract + Acarbose interactionAcepromazineAtravet
How Acepromazine interacts with High (G) Hardcore Formulation — through 2 ingredients. Tap an ingredient for the detail:
Mucuna Pruriens ExtractAntipsychotic Drugs Moderate
Interaction Summary
Theoretically, use of cowhage might decrease the clinical effects of antipsychotic drugs.
Read the full Mucuna Pruriens Extract + Acepromazine interactionSerinaid(r)Anticholinergic Drugs Moderate
Interaction Summary
Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Read the full Serinaid(r) + Acepromazine interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with High (G) Hardcore Formulation — through 1 ingredient. Tap an ingredient for the detail:
Serinaid(r)Anticholinergic Drugs Moderate
Interaction Summary
Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Read the full Serinaid(r) + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with High (G) Hardcore Formulation — through 1 ingredient. Tap an ingredient for the detail:
Serinaid(r)Anticholinergic Drugs Moderate
Interaction Summary
Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Read the full Serinaid(r) + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with High (G) Hardcore Formulation — through 1 ingredient. Tap an ingredient for the detail:
Serinaid(r)Anticholinergic Drugs Moderate
Interaction Summary
Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Read the full Serinaid(r) + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with High (G) Hardcore Formulation — through 1 ingredient. Tap an ingredient for the detail:
Serinaid(r)Anticholinergic Drugs Moderate
Interaction Summary
Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Read the full Serinaid(r) + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with High (G) Hardcore Formulation — through 1 ingredient. Tap an ingredient for the detail:
Serinaid(r)Anticholinergic Drugs Moderate
Interaction Summary
Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Read the full Serinaid(r) + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with High (G) Hardcore Formulation — through 1 ingredient. Tap an ingredient for the detail:
Serinaid(r)Anticholinergic Drugs Moderate
Interaction Summary
Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Read the full Serinaid(r) + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with High (G) Hardcore Formulation — through 1 ingredient. Tap an ingredient for the detail:
Serinaid(r)Anticholinergic Drugs Moderate
Interaction Summary
Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Read the full Serinaid(r) + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interacts with High (G) Hardcore Formulation — through 1 ingredient. Tap an ingredient for the detail:
Serinaid(r)Anticholinergic Drugs Moderate
Interaction Summary
Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Read the full Serinaid(r) + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG
How Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interacts with High (G) Hardcore Formulation — through 1 ingredient. Tap an ingredient for the detail:
Serinaid(r)Anticholinergic Drugs Moderate
Interaction Summary
Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Read the full Serinaid(r) + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylephrineAlka-Seltzer PLUS, Histex SR, Protid
How Acetaminophen, Chlorpheniramine, Phenylephrine interacts with High (G) Hardcore Formulation — through 1 ingredient. Tap an ingredient for the detail:
Serinaid(r)Anticholinergic Drugs Moderate
Interaction Summary
Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Read the full Serinaid(r) + Acetaminophen, Chlorpheniramine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, Phenylephrine, SalicylamideRhinogesic, Rhinogesic JR
How Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interacts with High (G) Hardcore Formulation — through 1 ingredient. Tap an ingredient for the detail:
Serinaid(r)Anticholinergic Drugs Moderate
Interaction Summary
Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Read the full Serinaid(r) + Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interactionEach ingredient & the kinds of drugs it affects
For each ingredient in High (G) Hardcore Formulation with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
SerinAid(R)
Anticholinergic Drugs
Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically interfere with the activity of anticholinergic agents.
Cholinergic Drugs
Theoretically, phosphatidylserine might have additive effects with cholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically lead to additive cholinergic effects when used with cholinergic drugs.
Mucuna Pruriens Extract
Levodopa
Concomitant use can increase the risk of levodopa-related adverse effects.
Cowhage contains levodopa. Some cowhage products have been standardized to contain 75-400 mg of levodopa per dose.
Methyldopa (Aldomet)
Theoretically, concomitant use of cowhage and methyldopa might increase the risk of hypotension.
Cowhage contains levodopa. Use of levodopa with methyldopa might cause additive hypotension. In addition, methyldopa may inhibit peripheral decarboxylation of levodopa and increase levodopa levels in the central nervous system; avoid using.
Monoamine Oxidase Inhibitors (Maois)
Theoretically, concomitant use of cowhage and non-selective MAOIs might increase the risk of hypertensive crisis.
Cowhage contains levodopa. Use of levodopa with non-selective MAOIs might cause hypertensive crisis. However, this interaction has not been reported with MAO-B selective inhibitors such as selegiline.
Anesthesia
Theoretically, concomitant use of cowhage and anesthesia might increase the risk of arrhythmias.
Cowhage contains levodopa. Use of levodopa with cyclopropane or halogenated hydrocarbon anesthesia has led to arrhythmias. Other anesthetics have not been implicated. Use other anesthetics in patients taking cowhage or tell patients to stop taking cowhage at least 2 weeks before surgery.
Antidiabetes Drugs
Theoretically, concomitant use of cowhage and antidiabetes drugs might increase the risk of hypoglycemia.
Animal research shows that cowhage might have hypoglycemic effects.
Antipsychotic Drugs
Theoretically, use of cowhage might decrease the clinical effects of antipsychotic drugs.
Cowhage contains levodopa. Use of levodopa might counteract the antidopaminergic effects of antipsychotic medications.
Guanethidine (Ismelin)
Theoretically, concomitant use of cowhage and guanethidine might increase the risk of hypotension.
Cowhage contains levodopa. Use of levodopa with guanethidine might cause additive hypotension; avoid using.
Tricyclic Antidepressants (Tcas)
Theoretically, use of TCAs might reduce the levels and clinical effects of cowhage.
Cowhage contains levodopa. Use of TCAs might reduce the absorption of levodopa. Some case reports describe patients that developed hypertension and dyskinesia when taking both levodopa and TCAs.
Brand information
Manufacturer and brand details for High (G) Hardcore Formulation, from the product label.
High (G) Hardcore Formulation by High T: Common Questions
Does High (G) Hardcore Formulation by High T interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take this if I'm on an antidepressant?
What side effects should I expect?
Is it safe to use during pregnancy?
Is it safe while breastfeeding?
Does this really work for the brain?
What is cowhage, and why is it in this product?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind High (G) Hardcore Formulation’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Phosphatidylserine
Interacts with 219 drugsPhosphatidylserine is a natural fat-like compound found in cell membranes, especially in the brain, and it is sold mainly to support memory and thinking. Some research suggests possible bene...
Read the full Phosphatidylserine monograph → Herb & supplement monographCowhage
Interacts with 193 drugsCowhage (Mucuna pruriens) is a tropical legume best known as a natural source of L-dopa, the compound the body turns into dopamine. It is most studied for Parkinson's disease symptoms and ma...
Read the full Cowhage monograph →Sources & How We Checked
High (G) Hardcore Formulation's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 21 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Phosphatidylserine 9 references
- Crook T, Petrie W, Wells C, Massari DC. Effects of phosphatidylserine in Alzheimer's disease. Psychopharmacol Bull 1992;28:61-6.
- Pepping J. Phosphatidylserine. Am J Health-Syst Pharm 1999;56:2038,2043-4.
- Kidd PM. Phosphatidylserine; Membrane nutrient for memory. A clinical and mechanistic assessment. Altern Med Rev 1996;1:70-84.
- Kim HY, Akbar M, Lau A, et al. Inhibition of neuronal apoptosis by docosahexaenoic acid (22:6n-3). Role of phosphatidylserine in antiapoptotic effect. J Biol Chem 2000;275:35215-23.. PubMed
- Zanotti A, Valzelli L, Toffano G. Chronic phosphatidylserine treatment improves spatial memory and passive avoidance in aged rats. Psychopharmacology (Berl) 1989;99:316-21.. PubMed
- Schreiber S, Kampf-Sherf O, Gorfine M, et al. An open trial of plant-source derived phosphatydilserine for treatment of age-related cognitive decline. Isr J Psychiatry Relat Sci 2000;37:302-7.
- Pepping, J. Phosphatidylserine. Am J Health Syst.Pharm. 10-15-1999;56(20):2038, 2043-2038, 2044.
- Monteverde, A., Gnemmi, P., Rossi, F., Monteverde, A., and Finali, G. C. Selegiline in the treatment of mild to moderate Alzheimer-type dementia. Clin.Ther 1990;12(4):315-322.
- Vakhapova V, Cohen T, Richter Y, Herzog Y, Kam Y, Korczyn AD. Phosphatidylserine containing omega-3 Fatty acids may improve memory abilities in nondemented elderly individuals with memory complaints: results from an open-label extension study. Dement Geri PubMed
Cowhage 12 references
- McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
- Anon. Epidemiological notes and reports: Mucuna pruriens-associated pruritus--New Jersey. MMWR Morb Mortal Wkly Rep 1985;34:732-3.
- HP-200 in Parkinson's Disease study group. An alternative medicine treatment for Parkinson's disease: Results of a multicenter clinical trial. J Alt Comp Med 1995;1:249-55. DOI
- Infante ME, Perez AM, Simao MR, et al. Outbreak of acute toxic psychosis attributed to Mucuna pruriens. Lancet 1990;336:1129. PubMed
- Vaidya AB, Rajagopalan TG, Mankodi NA, et al. Treatment of Parkinson's disease with the cowhage plant-Mucuna pruriens Bak. Neurol India 1978;26:171-6.
- Vadivel V, Janardhanan K. Nutritional and anti-nutritional composition of velvet bean: an under-utilized food legume in south India. Int J Food Sci Nutr 2000;51:279-87. PubMed
- Akhtar MS, Qureshi AQ, Iqbal J. Antidiabetic evaluation of Mucuna pruriens, Linn seeds. J Pak Med Assoc 1990;40:147-50.
- Prakash, D., Niranjan, A., and Tewari, S. K. Some nutritional properties of the seeds of three Mucuna species. Int.J.Food Sci.Nutr. 2001;52(1):79-82.
- Vadivel, V. and Janardhanan, K. Nutritional and antinutritional characteristics of seven South Indian wild legumes. Plant Foods Hum.Nutr 2005;60(2):69-75. PubMed
- Creapure (Creatine Monohydrate). Toxicological Datasheet. Degussa BioActives. Available at: https://www.fda.gov/ohrms/DOCKETS/.../95s-0316-rpt0154-54-Ref-50-vol112.pdf.
- Pulikkalpura H, Kurup R, Mathew PJ, Baby S. Levodopa in Mucuna pruriens and its degradation. Sci Rep 2015;5:11078. PubMed
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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