Major interaction on record — check this product against your medications before combining. Based on 2 of 4 ingredients. Check your meds →
Dietary supplement

High (G) Hardcore Formulation Ingredients & Drug Interactions

by High T

Capsule Category: Other Combinations
Most serious interaction: Major
The interaction bottom line Most serious interaction: Major

High (G) Hardcore Formulation is a dietary supplement by High T with 4 active ingredients. Its ingredients are commonly taken for memory and cognitive support, age-related cognitive decline, attention and focus (adhd).Based on those ingredients, 386 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are SerinAid(R), Mucuna Pruriens Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of High (G) Hardcore Formulation by High T

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This 4-ingredient product contains AlphaSize Alpha GPC, phosphatidylserine (marketed as SerinAid®), a Mucuna Pruriens extract (cowhage), and an Amino Acid Blend. The first three are the active ingredients; the others — potassium phosphate, FD&C dyes, and titanium dioxide — are inactive fillers and colorants.

Phosphatidylserine is thought to support brain cell structure and function. Cowhage is a plant extract that contains levodopa, an active compound similar to prescription Parkinson's medications.

AlphaSize Alpha GPC and the amino acid blend's specific roles are not detailed in the data we hold.

Does it work?

Insufficient evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Insufficient

There isn't enough reliable clinical evidence to rate this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: boost muscle development, reduce soreness, increase athletic stamina.
  • We looked for evidence on: Athletic performance, Exercise-induced muscle soreness, Muscle strength, Endurance capacity, Neuromuscular function.
  • The closest evidence on file: Phosphatidylserine is rated "Insufficient Reliable Evidence To Rate" for Athletic performance (Natural Medicines).
  • Also on file: Phosphatidylserine is rated "Insufficient Reliable Evidence To Rate" for Exercise-induced muscle soreness.

For phosphatidylserine, the evidence shows it's possibly effective for age-related cognitive decline and Alzheimer's disease. For athletic performance, ADHD, general cognitive function, and dementia, the evidence is insufficient to rate it.

For cowhage, evidence is insufficient to establish effectiveness for anxiety, erythema (skin redness), high prolactin levels, muscle pain, Parkinson's disease, or rheumatoid arthritis. We hold no effectiveness data for AlphaSize Alpha GPC or the Amino Acid Blend.

The evidence, ingredient by ingredient Phosphatidylserine Cowhage

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Phosphatidylserine is generally well tolerated in studies, though long-term safety isn't fully established. The most common side effects are flatulence, nausea, headache, insomnia (especially at higher doses around 600 mg), and gastrointestinal upset at doses of 200–300 mg daily.

There isn't enough safety information to recommend use during pregnancy, and safety while breastfeeding is unknown — avoidance is recommended for both. Cowhage contains levodopa and should be used carefully with professional guidance.

Oral adverse effects are rare but include diarrhea, flatulence, dry mouth, nausea, abdominal bloating, vomiting, headaches, and insomnia (about 3% of trial participants). The safety data advises against use during pregnancy due to insufficient data and dopamine effects.

L-dopa can reduce milk supply, so avoidance is recommended while breastfeeding.

Side effects, ingredient by ingredient Phosphatidylserine Cowhage

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Phosphatidylserine, Cowhage.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: diabetes medications; Parkinson's medications.
  • For scale: 386 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your pharmacist or doctor if you take monoamine oxidase inhibitors (MAOIs) for depression, methyldopa for blood pressure, levodopa for Parkinson's disease, or plan to have anesthesia — these are Major-severity interactions. Also check if you take anticholinergic drugs, cholinergic drugs, antidiabetes medications, antipsychotics, tricyclic antidepressants, or guanethidine.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with insufficient evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

High T's formulation is built on ingredients with some evidence (phosphatidylserine for early cognitive decline) and others with insufficient evidence for their claimed uses. The real concern is its cowhage content — it carries serious drug interactions, especially with MAOIs and blood pressure or Parkinson's medications.

If you take any antidepressants, blood pressure drugs, diabetes medications, or antipsychotics, talk with your doctor or pharmacist before starting this product.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 25, 2012.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about High (G) Hardcore Formulation, straight from the product label.

Brand High T
Net contents 120 Capsule(s)
Market status On market
Date entered into DSLD Oct 25, 2012
DSLD ID 12467
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for High (G) Hardcore Formulation by High T, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
8 Capsule(s)
Servings per container
30
IngredientAmount% DV
AlphaSize Alpha GPC300 mg--
SerinAid(R)125 mg--
Mucuna Pruriens Extract40 mg--
Amino Acid Blend560 mg--

Other ingredients: Di Potassium Phosphate, FD&C BLUE #1, FD&C RED #40, FD&C YELLOW #6, FD&C YELLOW #5, Titanium Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Seals/Symbols

AlphaSize(R) Alpha-Glyceryl Phosphoryl Choline

SerinAid(R) PhosPhatidylserine

GMP GOOD MANUFACTURING PRACTICE MANUFACTURED IN A GMP CERTIFIED FACILITY QUALITY GUARANTEED

Made in USA

kingfisher media

General Statements

Over 20 clinical studies support the ingredients in HighG(TM) which is designed to boost the body’s output of muscle development. Formulated to reduce muscle soreness, increase athletic stamina and capacity, support neuromuscular function during exercise, reduce fatigue, and reduce both physio and psychological stress.

ULTIMATEMUSCLE

Muscle Growth Booster

Clinically Supports: Natural Muscle Production Natural Strength Gain Energy with Ultimate Endurance

When the science of building muscle mass was clinically developed by our team; a proven, safe, and result driven outcome was achieved. Building muscle requires stacking many things; Nutrition, Training, Dedication, Trusted outcome and the right mix of supplements. Now the HighT(R) brand introduces HighG(TM); a dynamically formulated, clinically supported product designed to build muscle.

Suggested/Recommended/Usage/Directions

USAGE: Take 1 serving (4) capsules 90 minutes prior to resistance exercise. Heavy workout days; take 2 servings (8) capsules prior to work out or competitive activity for optimal performance. For non-work out days, take 2 capsules daily. As with all workouts we recommend proper hydration.

Precautions

PRECAUTIONS: Use only as directed.

Do not take this product if you are pregnant or nursing.

Consult a health care professional before use if you are allergic to any ingredients, have a serious medical condition, or use prescription medications.

For adult use only.

Brand IP Statement(s)

Alphasize(R) and SerinAid(R) are trademarks of Chemi Nutra, Inc. HighT(R) is a registered trademark of KingFisher Media, LLC

WORK HARD. PLAY HARD. RECOVER FASTER.(TM)

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

DIETARY SUPPLEMENT

See for yourself

High (G) Hardcore Formulation by High T label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in High (G) Hardcore Formulation by High T

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

AlphaSize Alpha GPC

300 mg per serving

SerinAid(R)

Interacts with
219 drugs
125 mg per serving

Phosphatidylserine is a natural fat-like compound found in cell membranes, especially in the brain, and it is sold mainly to support memory and thinki...

SerinAid(R) monograph & interactions

Mucuna Pruriens Extract

Interacts with
193 drugs
40 mg per serving Form: L-Dopa

Cowhage (Mucuna pruriens) is a tropical legume best known as a natural source of L-dopa, the compound the body turns into dopamine. It is most studied...

Mucuna Pruriens Extract monograph & interactions

Amino Acid Blend

560 mg per serving Form: Arginine Alpha-Ketoglutarate, L-Arginine, L-Citrulline, L-Glutamine, L-Isoleucine, L-Leucine

Other (inactive) ingredients: Di Potassium Phosphate, FD&C BLUE #1, FD&C RED #40, FD&C YELLOW #6, FD&C YELLOW #5, Titanium Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

High (G) Hardcore Formulation by High T Drug Interactions

Want to check YOUR meds against High (G) Hardcore Formulation?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
386Drugs
17 Major 369 Moderate

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in High (G) Hardcore Formulation with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

SerinAid(R)2 drug types · 219 drugs

Anticholinergic Drugs

Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically interfere with the activity of anticholinergic agents.

Likelihood Possible Evidence B
Cholinergic Drugs

Theoretically, phosphatidylserine might have additive effects with cholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically lead to additive cholinergic effects when used with cholinergic drugs.

Likelihood Possible Evidence B

Mucuna Pruriens Extract8 drug types · 193 drugs

Levodopa

Concomitant use can increase the risk of levodopa-related adverse effects.
Cowhage contains levodopa. Some cowhage products have been standardized to contain 75-400 mg of levodopa per dose.

Likelihood Likely Evidence D
Methyldopa (Aldomet)

Theoretically, concomitant use of cowhage and methyldopa might increase the risk of hypotension.
Cowhage contains levodopa. Use of levodopa with methyldopa might cause additive hypotension. In addition, methyldopa may inhibit peripheral decarboxylation of levodopa and increase levodopa levels in the central nervous system; avoid using.

Likelihood Probable Evidence D
Monoamine Oxidase Inhibitors (Maois)

Theoretically, concomitant use of cowhage and non-selective MAOIs might increase the risk of hypertensive crisis.
Cowhage contains levodopa. Use of levodopa with non-selective MAOIs might cause hypertensive crisis. However, this interaction has not been reported with MAO-B selective inhibitors such as selegiline.

Likelihood Probable Evidence D
Anesthesia

Theoretically, concomitant use of cowhage and anesthesia might increase the risk of arrhythmias.
Cowhage contains levodopa. Use of levodopa with cyclopropane or halogenated hydrocarbon anesthesia has led to arrhythmias. Other anesthetics have not been implicated. Use other anesthetics in patients taking cowhage or tell patients to stop taking cowhage at least 2 weeks before surgery.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, concomitant use of cowhage and antidiabetes drugs might increase the risk of hypoglycemia.
Animal research shows that cowhage might have hypoglycemic effects.

Likelihood Possible Evidence D
Antipsychotic Drugs

Theoretically, use of cowhage might decrease the clinical effects of antipsychotic drugs.
Cowhage contains levodopa. Use of levodopa might counteract the antidopaminergic effects of antipsychotic medications.

Likelihood Possible Evidence D
Guanethidine (Ismelin)

Theoretically, concomitant use of cowhage and guanethidine might increase the risk of hypotension.
Cowhage contains levodopa. Use of levodopa with guanethidine might cause additive hypotension; avoid using.

Likelihood Probable Evidence D
Tricyclic Antidepressants (Tcas)

Theoretically, use of TCAs might reduce the levels and clinical effects of cowhage.
Cowhage contains levodopa. Use of TCAs might reduce the absorption of levodopa. Some case reports describe patients that developed hypertension and dyskinesia when taking both levodopa and TCAs.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for High (G) Hardcore Formulation, from the product label.

High T

See all High T products
Phone Number
1-877-902-7743
Web Address
www.HighTProducts.com
Pharmacist Counseling Corner

High (G) Hardcore Formulation by High T: Common Questions

Does High (G) Hardcore Formulation by High T interact with any medications?
Yes. Based on its ingredients, High (G) Hardcore Formulation has a known interaction with 386 medications, including 17 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
High (G) Hardcore Formulation contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on an antidepressant?
It depends on which one. If you take an MAOI (a type of older antidepressant), this product is not safe — cowhage can cause a dangerous spike in blood pressure when combined with MAOIs. Talk with your doctor or pharmacist about your specific medication before starting.
What side effects should I expect?
The most common are flatulence, nausea, headache, insomnia, and stomach upset. Insomnia is more likely if you take a higher dose of the phosphatidylserine component (around 600 mg). A small number of trial participants using cowhage reported insomnia as well.
Is it safe to use during pregnancy?
No — there isn't enough safety data for phosphatidylserine during pregnancy, and cowhage is best avoided due to insufficient data and its dopamine effects. Talk with your doctor if you're pregnant or planning pregnancy.
Is it safe while breastfeeding?
Safety data for phosphatidylserine while breastfeeding is unknown, so avoidance is recommended. Cowhage contains L-dopa, which can reduce milk supply, so it should also be avoided. Check with your doctor or pharmacist for personalized advice.
Does this really work for the brain?
Phosphatidylserine is possibly effective for age-related cognitive decline and Alzheimer's disease based on available evidence. For ADHD, general cognitive function, and dementia, the evidence isn't strong enough to rate it. Cowhage's effectiveness for any condition we have data on hasn't been established.
What is cowhage, and why is it in this product?
Cowhage is a plant extract that contains levodopa, a compound similar to Parkinson's medications — it's included for its potential effects on dopamine. Because it's drug-like, it needs to be used carefully and checked against your other medications.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

High (G) Hardcore Formulation label
Sources

Sources & How We Checked

High (G) Hardcore Formulation's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 21 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Phosphatidylserine 9 references
  1. Crook T, Petrie W, Wells C, Massari DC. Effects of phosphatidylserine in Alzheimer's disease. Psychopharmacol Bull 1992;28:61-6.
  2. Pepping J. Phosphatidylserine. Am J Health-Syst Pharm 1999;56:2038,2043-4.
  3. Kidd PM. Phosphatidylserine; Membrane nutrient for memory. A clinical and mechanistic assessment. Altern Med Rev 1996;1:70-84.
  4. Kim HY, Akbar M, Lau A, et al. Inhibition of neuronal apoptosis by docosahexaenoic acid (22:6n-3). Role of phosphatidylserine in antiapoptotic effect. J Biol Chem 2000;275:35215-23.. PubMed
  5. Zanotti A, Valzelli L, Toffano G. Chronic phosphatidylserine treatment improves spatial memory and passive avoidance in aged rats. Psychopharmacology (Berl) 1989;99:316-21.. PubMed
  6. Schreiber S, Kampf-Sherf O, Gorfine M, et al. An open trial of plant-source derived phosphatydilserine for treatment of age-related cognitive decline. Isr J Psychiatry Relat Sci 2000;37:302-7.
  7. Pepping, J. Phosphatidylserine. Am J Health Syst.Pharm. 10-15-1999;56(20):2038, 2043-2038, 2044.
  8. Monteverde, A., Gnemmi, P., Rossi, F., Monteverde, A., and Finali, G. C. Selegiline in the treatment of mild to moderate Alzheimer-type dementia. Clin.Ther 1990;12(4):315-322.
  9. Vakhapova V, Cohen T, Richter Y, Herzog Y, Kam Y, Korczyn AD. Phosphatidylserine containing omega-3 Fatty acids may improve memory abilities in nondemented elderly individuals with memory complaints: results from an open-label extension study. Dement Geri PubMed

See these in context on the Phosphatidylserine monograph →

Cowhage 12 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  3. Anon. Epidemiological notes and reports: Mucuna pruriens-associated pruritus--New Jersey. MMWR Morb Mortal Wkly Rep 1985;34:732-3.
  4. HP-200 in Parkinson's Disease study group. An alternative medicine treatment for Parkinson's disease: Results of a multicenter clinical trial. J Alt Comp Med 1995;1:249-55. DOI
  5. Infante ME, Perez AM, Simao MR, et al. Outbreak of acute toxic psychosis attributed to Mucuna pruriens. Lancet 1990;336:1129. PubMed
  6. Vaidya AB, Rajagopalan TG, Mankodi NA, et al. Treatment of Parkinson's disease with the cowhage plant-Mucuna pruriens Bak. Neurol India 1978;26:171-6.
  7. Vadivel V, Janardhanan K. Nutritional and anti-nutritional composition of velvet bean: an under-utilized food legume in south India. Int J Food Sci Nutr 2000;51:279-87. PubMed
  8. Akhtar MS, Qureshi AQ, Iqbal J. Antidiabetic evaluation of Mucuna pruriens, Linn seeds. J Pak Med Assoc 1990;40:147-50.
  9. Prakash, D., Niranjan, A., and Tewari, S. K. Some nutritional properties of the seeds of three Mucuna species. Int.J.Food Sci.Nutr. 2001;52(1):79-82.
  10. Vadivel, V. and Janardhanan, K. Nutritional and antinutritional characteristics of seven South Indian wild legumes. Plant Foods Hum.Nutr 2005;60(2):69-75. PubMed
  11. Creapure (Creatine Monohydrate). Toxicological Datasheet. Degussa BioActives. Available at: https://www.fda.gov/ohrms/DOCKETS/.../95s-0316-rpt0154-54-Ref-50-vol112.pdf.
  12. Pulikkalpura H, Kurup R, Mathew PJ, Baby S. Levodopa in Mucuna pruriens and its degradation. Sci Rep 2015;5:11078. PubMed

See these in context on the Cowhage monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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