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Dietary supplement

Klamath AFA 2000 mg Ingredients & Drug Interactions

by SuperSmart

Klamath AFA 2000 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Klamath AFA 2000 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Klamath AFA 2000 mg is a dietary supplement by SuperSmart with 1 active ingredient. Its ingredients are commonly taken for general nutrition and energy, antioxidant support, cholesterol and metabolic health.Based on those ingredients, 509 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Klamath's Best. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Klamath AFA 2000 mg by SuperSmart

Ask about any prescription or over-the-counter medication and we check it for interactions with Klamath AFA 2000 mg by SuperSmart — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Klamath AFA 2000 mg by SuperSmart

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • “Klamath's Best” is listed as a grouped ingredient — the label gives one combined amount (2,000 mg) without saying how much of each component you get.

This product contains one active ingredient: phenethylamine, a naturally occurring compound found in the Klamath blue-green algae. The supplement delivers 2000 mg per capsule.

The inactive ingredients are hypromellose, acacia gum, and white rice flour—standard capsule binders and fillers.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Phenethylamine (pea) product and its label doesn't state a use — see Phenethylamine (pea)'s own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence we hold doesn't yet establish that phenethylamine works for athletic performance, depression, or weight management. Each of those uses is rated as having insufficient reliable evidence to rate.

The evidence, ingredient by ingredient Blue-green Algae Phenethylamine (pea)

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Phenethylamine may affect your heart rate and blood pressure, and because human safety data for supplements is limited, caution is warranted. Case reports describe anxiety, agitation, and rapid heart rate (tachycardia) in individuals taking weight-loss products that contained phenethylamine along with other stimulants like caffeine and bitter orange—though it's unclear which ingredient or combination caused those effects.

Not enough safety information exists to recommend this supplement during pregnancy or breastfeeding. Talk to your pharmacist or doctor before use if you're pregnant, planning to become pregnant, or nursing.

Side effects, ingredient by ingredient Blue-green Algae Phenethylamine (pea)

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Phenethylamine (pea).
  • The most serious interaction on file is rated Moderate.
  • For scale: 187 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Double-check this product if you take serotonergic antidepressants (SSRIs, SNRIs, tricyclics), serotonergic pain or migraine medications, or monoamine oxidase inhibitors (MAOIs) before you start. Both interactions carry Moderate severity.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Phenethylamine is a stimulant-like compound that affects serotonin and heart function. If you take an antidepressant or an MAOI, you'll need to check this product against your exact medications before starting.

Because human safety data is sparse, caution is wise—especially if you have heart or blood pressure concerns.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 24, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Klamath AFA 2000 mg, straight from the product label.

Brand SuperSmart
Barcode (UPC) 5453003823759
Net contents 120 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Jul 24, 2025
DSLD ID 332384
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Klamath AFA 2000 mg by SuperSmart, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
4 Capsule(s)
Servings per container
30
UPC/BARCODE
5453003823759
IngredientAmount% DV
Phenylethylamine10 mg--
Klamath's Best2000 mg--

Other ingredients: Hypromellose, Acacia Gum, White Rice Flour

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Klamath's Best is a registered trademark of Klamath Valley Botanicals, LLC, USA.

Formula

Klamath's Best 2000 mg per day

Each capsule contains 500 mg of Klamath's Best Blue Green Algae Powder.

FDA Statement of Identity

Dietary Supplement

Formulation

Guarantees: Vegan, non-GMO, gluten free, soy free, dairy free.

Guarantees: Vegan, non-GMO, gluten free, soy free, dairy free. No coloring, preservatives, or flavorings.

FDA Registered lab, good manufacturing practice, made in USA.

Suggested/Recommended/Usage/Directions

Directions: Adults. As a supplement, take 2 to 4 vegetarian capsules in the morning on an empty stomach.

Precautions

Cautions: Do not exceed the recommended daily dose.

Keep out of reach of children.

Consult a healthcare provider before using this product if pregnant, breastfeeding, or having health concerns.

Tamper evident: Do not use if seal under cap is broken or missing.

Storage

Store away from direct light, heat and humidity.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Klamath AFA 2000 mg by SuperSmart label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Klamath AFA 2000 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Klamath AFA 2000 mg by SuperSmart

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Klamath's Best

Interacts with
327 drugs
2000 mg per serving Form: Blue Green Algae Powder

Blue-green algae are nutrient-rich aquatic microorganisms (such as spirulina and Klamath Lake algae) taken as a supplement for energy, nutrition, and...

Klamath's Best monograph & interactions

Other (inactive) ingredients: Hypromellose, Acacia Gum, White Rice Flour. These complete the product’s ingredient list but are not active constituents.

Interaction report

Klamath AFA 2000 mg by SuperSmart Drug Interactions

Want to check YOUR meds against Klamath AFA 2000 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
509Drugs
509 Moderate

Ingredients driving the most interactions

Klamath's Best 327

Individual Drug Interactions

The ingredients in Klamath AFA 2000 mg interact with 509 drugs. Click any drug to see the details.

1 of the 1 ingredient in Klamath AFA 2000 mg interact with drugs. Each result below shows which ingredient is responsible. Klamath's Best

Each ingredient & the kinds of drugs it affects

For each ingredient in Klamath AFA 2000 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Klamath's Best3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, spirulina blue-green algae might increase the risk of bleeding if used with other anticoagulant or antiplatelet drugs. However, this is unlikely.
Spirulina blue-green algae have shown antiplatelet and anticoagulant effects in vitro. However, one preliminary study in 24 patients receiving spirulina blue-green algae 2.3 grams daily for 2 weeks showed no effect on platelet activation or measures of clotting time.

Likelihood Unlikely Evidence D
Antidiabetes Drugs

Theoretically, taking blue-green algae with antidiabetes drugs might increase the risk of hypoglycemia.
Human research shows that spirulina blue-green algae can have hypoglycemic effects in patients with diabetes, at least some of whom were using antidiabetes drugs. However, blue-green algae does not seem to improve glycated hemoglobin (HbA1c) levels in patients with diabetes. A meta-analysis of animal studies also suggests that spirulina blue-green algae have hypoglycemic effects.

Likelihood Possible Evidence B
Immunosuppressants

Theoretically, concurrent use of blue-green algae might interfere with immunosuppressive therapy.
Blue-green algae have been shown to stimulate the immune system.

Likelihood Possible Evidence D
Klamath's Best full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Klamath AFA 2000 mg, from the product label.

SuperSmart

See all SuperSmart products
Name
SuperSmart USA LLC
City
Miami
State
FL
ZipCode
33130
Phone Number
1(786) 522-3907
Web Address
us.SuperSmart.com
Pharmacist Counseling Corner

Klamath AFA 2000 mg by SuperSmart: Common Questions

Does Klamath AFA 2000 mg by SuperSmart interact with any medications?
Yes. Based on its ingredients, Klamath AFA 2000 mg has a known interaction with 509 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Klamath AFA 2000 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this work for weight loss, mood, or athletic performance?
The evidence we have isn't yet strong enough to rate phenethylamine for any of those uses. If you're interested in it for one of those reasons, talk it over with your pharmacist or doctor first.
Can I take this if I'm on an antidepressant?
That depends on which antidepressant you're taking. Serotonergic drugs—like SSRIs and SNRIs—may theoretically have more side effects when combined with phenethylamine. Use the drug checker on this page with your exact medication, or ask your pharmacist to verify it's safe for you.
I take an MAOI. Is this safe?
No. The interaction is Moderate severity because MAOIs block the enzyme that normally breaks down phenethylamine, which can amplify its stimulant effects. You should not combine them without explicit guidance from your prescriber.
What side effects might I experience?
Case reports mention anxiety, agitation, and rapid heart rate in people taking weight-loss products containing phenethylamine along with caffeine and other stimulants—though it's not certain which ingredient caused the effect. Phenethylamine can also affect your heart rate and blood pressure.
Is this safe during pregnancy or breastfeeding?
There isn't enough safety information to recommend it during either. Talk to your doctor or pharmacist for personalized advice if you're pregnant, planning pregnancy, or nursing.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Klamath AFA 2000 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Klamath AFA 2000 mg label
Go deeper

The Full Monographs Behind Klamath AFA 2000 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Blue-green Algae

Interacts with 327 drugs

Blue-green algae are nutrient-rich aquatic microorganisms (such as spirulina and Klamath Lake algae) taken as a supplement for energy, nutrition, and general wellness. Evidence for most heal...

Read the full Blue-green Algae monograph → Herb & supplement monograph

Phenethylamine (pea)

Interacts with 187 drugs

Phenethylamine (PEA) is a natural compound made in the body and found in foods like chocolate; supplements are marketed for mood, focus, and energy. Reliable human research on the supplement...

Read the full Phenethylamine (pea) monograph →
Sources

Sources & How We Checked

Klamath AFA 2000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 31 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Phenethylamine (pea) 9 references
  1. Singhal AB, Caviness VS, Begleiter AF, et al. Cerebral vasoconstriction and stroke after use of serotonergic drugs. Neurology 2002;58:130-3. PubMed
  2. Sabelli H, Fink P, Fawcett J, et al. Sustained antidepressant effect of PEA replacement. J Neuropsychiatry Clin Neurosci. 1996;8(2):168-71.
  3. Xie Z, Miller G. Beta-phenylehtylamine alters monoamine transporter function via trace amine-associated receptor 1: implication for modulatory roles of trace amines in brain. J Pharmacol Exp Ther. 2008;325(2):617-28.
  4. Lukasik-Glebocka M, Sommerfeld K, Tezyk A, et al. [Acute poisoning with weight-loss dietary supplement falsely suggesting the use of amphetamine]. Przegl Lek. 2013;70(10):880-3.
  5. Nakamura M, Ishii A, Nakahara D. Characterization of beta-phenyltheylamine-induced monoamine release in rat nucleus accumbens: a microdialysis study. Eur J Pharmacol. 1998;349(2-3):163-9.
  6. Bailey B, Philips S, Boulton A. In vivo release of endogenous dopamine, 5-hydroxytryptamine and some of their metabolites from rat caudate nucleus by phenylethylamine. Neurochem Res. 1987;12(2):173-8. PubMed
  7. Mantegazza P, Riva M. Amphetamine-like activity of beta-phenethylamine after a monoamine oxidase inhibitor in vivo. Journal of Pharmacy and Pharmacology. 1963;151(1):472-8.
  8. Grimsby J, Toth M, Chen K, et al. Increased stress response and beta-phenylethylamine in MAOB-deficient mice. Nat Genet. 1997;17(2):206-10.
  9. Lindemann L, Hoener MC. A renaissance in trace amines inspired by a novel GPCR family. Trends Pharmacol Sci. 2005;26(5):274-81. PubMed

See these in context on the Phenethylamine (pea) monograph →

Blue-green Algae 22 references
  1. Jensen GS, Ginsberg DJ, Huerta P, et al. Consumption of Aphanizomenon flos-aquae has rapid effects on the circulation and function of immune cells in humans. A novel approach to nutritional mobilization of the immune system. JANA 2000;2:50-6.
  2. Iwasa M, Yamamoto M, Tanaka Y, et al. Spirulina-associated hepatotoxicity. Am J Gastroenterol 2002;97:3212-13. PubMed
  3. Hayashi O, Katoh T, Okuwaki Y. Enhancement of antibody production in mice by dietary Spirulina platensis. J Nutr Sci Vitaminol (Tokyo) 1994;40:431-41.. PubMed
  4. Vitale S, Miller NR, Mejico LJ, et al. A randomized, placebo-controlled, crossover clinical trial of super blue-green algae in patients with essential blepharospasm or Meige syndrome. Am J Ophthalmol 2004;138:18-32. PubMed
  5. Mani UV, Desai S, Iyer U. Studies on the long-term effect of spirulina supplementation on serum lipid profile and glycated proteins in NIDDM patients. J Nutraceut 2000;2(3):25-32. DOI
  6. Chiu HF, Yang SP, Kuo YL, et al. Mechanisms involved in the antiplatelet effect of C-phycocyanin. Br J Nutr 2006;95:435-40. PubMed
  7. Hsiao G, Chou PH, Shen MY, et al. C-phycocyanin, a very potent and novel platelet aggregation inhibitor from Spirulina platensis. J Agric Food Chem 2005;53:7734-40.
  8. Katz M, Levine AA, Kol-Degani H, Kav-Venaki L. A compound herbal preparation (CHP) in the treatment of children with ADHD: a randomized controlled trial. J Atten Disord 2010;14:281-91. PubMed
  9. Madhyastha, H. K., Radha, K. S., Sugiki, M., Omura, S., and Maruyama, M. Purification of c-phycocyanin from Spirulina fusiformis and its effect on the induction of urokinase-type plasminogen activator from calf pulmonary endothelial cells. Phytomedicine PubMed
  10. Mazokopakis, E. E., Karefilakis, C. M., Tsartsalis, A. N., Milkas, A. N., and Ganotakis, E. S. Acute rhabdomyolysis caused by Spirulina (Arthrospira platensis). Phytomedicine. 2008;15(6-7):525-527. PubMed
  11. Halidou, Doudou M., Degbey, H., Daouda, H., Leveque, A., Donnen, P., Hennart, P., and Dramaix-Wilmet, M. [The effect of spiruline during nutritional rehabilitation: systematic review]. Rev.Epidemiol.Sante Publique 2008;56(6):425-431.
  12. Konno, T., Umeda, Y., Umeda, M., Kawachi, I., Oyake, M., and Fujita, N. [A case of inflammatory myopathy with widely skin rash following use of supplements containing Spirulina]. Rinsho Shinkeigaku 2011;51(5):330-333. PubMed
  13. Le TM, Knulst AC, Röckmann H. Anaphylaxis to Spirulina confirmed by skin prick test with ingredients of Spirulina tablets. Food Chem Toxicol 2014;74:309-10. PubMed
  14. Rzymski P, Niedzielski P, Kaczmarek N, Jurczak T, Klimaszyk P. The multidisciplinary approach to safety and toxicity assessment of microalgae-based food supplements following clinical cases of poisoning. Harmful Algae 2015;46:34-42. DOI
  15. Petrus M, Culerrier R, Campistron M, et al. First case report of anaphylaxis to spirulin: identification of phycocyanin as responsible allergen. Allergy 2010;65(7):924-5. PubMed
  16. Marles RJ, Barrett ML, Barnes J, et al. United States Pharmacopeia safety evaluation of spirulina. Crit Rev Food Sci Nutr 2011;51(7):593-604. PubMed
  17. Majdoub H, Ben Mansour M, Chaubet F, et al. Anticoagulant activity of a sulfated polysaccharide from the green alga Arthrospira platensis. Biochim Biophys Acta 2009;1790(10):1377-81. PubMed
  18. Cha BG, Kwak HW, Park AR, et al. Structural characteristics and biological performance of silk fibroin nanofiber containing microalgae spirulina extract. Biopolymers 2014;101(4):307-18. PubMed
  19. Jensen GS, Drapeau C, Lenninger M, Benson KF. Clinical safety of a high dose of phycocyanin-enriched aqueous extract from Arthrospira (Spirulina) platensis: results from a randomized, double-Blind, placebo-controlled study with a focus on anticoagulant ac
  20. Hamedifard Z, Milajerdi A, Reiner Z, Taghizadeh M, Kolahdooz F, Asemi Z. The effects of spirulina on glycemic control and serum lipoproteins in patients with metabolic syndrome and related disorders: A systematic review and meta-analysis of randomized con
  21. Moradi S, Zobeiri M, Feizi A, Clark CCT, Entezari MH. The effects of spirulina (Arthrospira platensis) supplementation on anthropometric indices, blood pressure, sleep quality, mental health, fatigue status and quality of life in patients with ulcerative
  22. Ghanbari F, Amerizadeh A, Behshood P, Moradi S, Asgary S. Effect of microalgae arthrospira on biomarkers of glycemic control and glucose metabolism: a systematic Review and meta-analysis. Curr Probl Cardiol 2022;47(10):100942. PubMed

See these in context on the Blue-green Algae monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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