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Dietary supplement

L-Glutamine 500 mg Ingredients & Drug Interactions

by Spring Valley

Tablet Or Pill Category: Amino Acid/protein
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

L-Glutamine 500 mg is a dietary supplement by Spring Valley with 1 active ingredient. Its ingredients are commonly taken for muscle recovery and sports performance, gut health and 'leaky gut', recovery from severe illness or injury.Based on those ingredients, 50 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L-Glutamine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of L-Glutamine 500 mg by Spring Valley

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This supplement contains one active ingredient: L-glutamine, 500 mg per tablet. L-glutamine is an amino acid—one of the building blocks your body uses to make proteins.

The remaining ingredients are inert fillers and binders like cellulose, dicalcium phosphate, and magnesium stearate that hold the tablet together and help your body absorb it.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Glutamine's overall clinical evidence instead.

Strong

Strong clinical evidence supports Glutamine for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Sickle cell disease — rated "Effective" (Natural Medicines).
  • On file: HIV/AIDS-related wasting — rated "Possibly Effective" (Natural Medicines).
  • On file: Critical illness (trauma) — rated "Possibly Effective" (Natural Medicines).
  • On file: Postoperative recovery — rated "Possibly Effective" (Natural Medicines).
  • On file: Pancreatitis — rated "Possibly Effective" (Natural Medicines).

The evidence shows L-glutamine is effective for sickle cell disease. It's rated possibly effective for HIV/AIDS-related wasting, recovery after surgery, and critical illness from trauma.

Outside of those uses, the effectiveness data we hold doesn't cover other conditions people might take it for—that doesn't mean it doesn't work for them, just that we don't have established ratings on file.

The evidence, ingredient by ingredient Glutamine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-glutamine is generally well tolerated in healthy adults. The most common side effects from oral doses are gastrointestinal: belching, bloating, constipation, diarrhea, flatulence, nausea, and vomiting.

Headache and musculoskeletal pain have also been reported. If you have kidney or liver disease, use it only under your doctor's supervision.

Two cases of mania or hypomania have been reported in people with bipolar disorder taking higher doses (up to 4 grams daily), so that's worth discussing with your healthcare provider if that applies to you.

Side effects, ingredient by ingredient Glutamine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Glutamine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: seizure medications.
  • For scale: 50 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take anticonvulsants (seizure medications), double-check with your doctor or pharmacist before starting this product—glutamine theoretically might reduce their effectiveness, though this hasn't yet been reported in actual patients. No other medication interactions are documented in our data for the active ingredient we could check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with strong clinical evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

L-glutamine is well tolerated and effective for sickle cell disease if that's why you're considering it. If you take anticonvulsants, check with your doctor or pharmacist first.

People with kidney or liver disease should only use it under medical supervision. Your pharmacist can review your exact medications against this product before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 24, 2012.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about L-Glutamine 500 mg, straight from the product label.

Brand Spring Valley
Barcode (UPC) 681131111911
Net contents 100 Tablet(s)
Market status On market
Date entered into DSLD Aug 24, 2012
DSLD ID 12129
Product type Amino Acid/protein
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for L-Glutamine 500 mg by Spring Valley, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
2 Tablet(s)
UPC/BARCODE
681131111911
IngredientAmount% DV
L-Glutamine500 mg--

Other ingredients: Cellulose, Dicalcium Phosphate, Hypromellose, Croscarmellose, Silica, Vegetable Magnesium Stearate, Cellulose Coating

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

WARNING: If you are pregnant, nursing or taking any medications, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

KEEP OUT OF THE REACH OF CHILDREN.

FOR YOUR PROTECTION, DO NOT USE IF SEAL UNDER CAP IS BROKEN OR MISSING.

Storage

KEEP IN A DRY PLACE, TIGHTLY CLOSED AND AVOID EXCESSIVE HEAT.

General Statements

UNCONDITIONALLY GUARANTEED BY REFUND OR REPLACEMENT

VITAMIN #1 BRAND

AMINO ACID MUSCLE FUEL* L-Glutamine is one of 20 amino acids, the building blocks of protein.* Increasingly popular among bodybuilders, Glutamine is the most highly concentrated amino acid in muscle and can serve an an energy precursor.*

FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formulation

No Gluten, No Yeast, No Wheat, No Milk or Milk Derivatives, No Lactose, No Sugar, No Preservatives, No Soy, No Artificial Color, No Artificial Flavor, No Sodium (less than 5 mg per serving).

Suggested/Recommended/Usage/Directions

SUGGESTED USE: For adults, take one (1) to two (2) tablets one to four times daily, preferably with a meal. As a reminder, discuss the supplements and medications you take with your health care providers.

FDA Statement of Identity

Dietary Supplement

General

Item No. 3042 B3040W 01A

See for yourself

L-Glutamine 500 mg by Spring Valley label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in L-Glutamine 500 mg by Spring Valley

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.

L-Glutamine

Interacts with
50 drugs
500 mg per serving

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle c...

L-Glutamine monograph & interactions

Other (inactive) ingredients: Cellulose, Dicalcium Phosphate, Hypromellose, Croscarmellose, Silica, Vegetable Magnesium Stearate, Cellulose Coating. These complete the product’s ingredient list but are not active constituents.

Interaction report

L-Glutamine 500 mg by Spring Valley Drug Interactions

Want to check YOUR meds against L-Glutamine 500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
50Drugs
50 Moderate

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in L-Glutamine 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

L-Glutamine1 drug type · 50 drugs

Anticonvulsants

Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Glutamine is metabolized to the excitatory neurotransmitter glutamate. Glutamate might have antagonistic effects with anticonvulsant drugs. However, this interaction has not yet been reported in humans.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for L-Glutamine 500 mg, from the product label.

Spring Valley

See all Spring Valley products
Name
US Nutrition, Inc.
City
Bohemia
State
NY
ZipCode
11716-2510
Pharmacist Counseling Corner

L-Glutamine 500 mg by Spring Valley: Common Questions

Does L-Glutamine 500 mg by Spring Valley interact with any medications?
Yes. Based on its ingredients, L-Glutamine 500 mg has a known interaction with 50 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
L-Glutamine 500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is L-glutamine safe if I'm pregnant?
Yes, L-glutamine is rated likely safe in pregnancy. If you're pregnant and considering it, you can feel confident on the safety side—just check with your doctor about whether it's right for your individual situation.
What are the side effects?
Most side effects are digestive: belching, bloating, constipation, diarrhea, flatulence, nausea, and vomiting. Headache and muscle pain have been reported less often. These tend to happen at higher doses.
Does L-glutamine actually work?
It's proven effective for sickle cell disease. It's possibly effective for HIV/AIDS-related wasting, recovery after surgery, and critical illness. For other uses, we don't have evidence data on file—talk with your doctor about whether it might help your particular situation.
Can I take this if I have kidney or liver disease?
Not without medical supervision. If you have either condition, check with your doctor or pharmacist before taking this supplement.
Is it safe if I'm breastfeeding?
There isn't enough safety data to know. Talk with your doctor or pharmacist before taking supplemental glutamine while nursing.
What is L-glutamine?
It's an amino acid—one of the building blocks your body uses to make and repair proteins. Your body makes some on its own, and you also get it from protein-rich foods.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if L-Glutamine 500 mg is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

L-Glutamine 500 mg label
Go deeper

The Full Monographs Behind L-Glutamine 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Sources

Sources & How We Checked

L-Glutamine 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glutamine 11 references
  1. Miller AL. Therapeutic considerations of L-glutamine: a review of the literature. Altern Med Rev 1999;4:239-48..
  2. Bozzetti F, Biganzoli L, Gavazzi C, et al. Glutamine supplementation in cancer patients receiving chemotherapy: a double-blind randomized study. Nutrition 1997;13:748-51.. PubMed
  3. Mebane AH. L-Glutamine and mania. Am J Psychiatry 984;141:1302-3.
  4. Meldrum BS. Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr 2000;130:1007S-15S.. PubMed
  5. Garlick PJ. Assessment of the safety of glutamine and other amino acids. J Nutr 2001;131:2556S-61S.. PubMed
  6. Chapman AG. Glutamate and epilepsy. J Nutr 2000;130:1043S-5S.. PubMed
  7. Ziegler TR. Glutamine supplementation in cancer patients receiving bone marrow transplantation and high dose chemotherapy. J Nutr 2001;131:2578S-84S.. PubMed
  8. Laviano A, Molfino A, Lacaria MT, Canelli A, De Leo S, Preziosa I, Rossi Fanelli F. Glutamine supplementation favors weight loss in nondieting obese female patients. A pilot study. Eur J Clin Nutr. 2014 Nov;68(11):1264-6. PubMed
  9. Endari (l-glutamine) [package insert]. Torrance, CA: Emmaus Medical,Inc; 2017.
  10. Niihara Y, Miller ST, Kanter J, et al. A Phase 3 Trial of l-Glutamine in Sickle Cell Disease. N Engl J Med 2018;379(3):226-35. doi: 10.1056/NEJMoa1715971.
  11. Ogden HB, Child RB, Fallowfield JL, et al. Gastrointestinal Tolerance of Low, Medium and High Dose Acute Oral l-Glutamine Supplementation in Healthy Adults: A Pilot Study. Nutrients. 2020;12(10):2953. PubMed

See these in context on the Glutamine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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