Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

MenoComplete Ingredients & Drug Interactions

by Terry Naturally

MenoComplete label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking MenoComplete against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

MenoComplete is a dietary supplement by Terry Naturally with 3 active ingredients. Its ingredients are commonly taken for sleep problems and insomnia, anxiety and restlessness, menopausal symptoms.Based on those ingredients, 1,267 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Pomegranate (Punica granatum) fruit extract, patented Hops (Humulus lupulus L.) cone extract, Black Cohosh (Cimicifuga racemosa) root and rhizome extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against MenoComplete by Terry Naturally

Ask about any prescription or over-the-counter medication and we check it for interactions with MenoComplete by Terry Naturally — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of MenoComplete by Terry Naturally

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 20, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 3 active ingredients.
  • “Proprietary Complex” is a proprietary blend — the label gives one combined amount (560 mg) without saying how much of each component you get.

MenoComplete has 3 active ingredients. The patented hops cone extract is a standardized preparation meant to address menopausal symptoms.

Pomegranate fruit extract and black cohosh root and rhizome extract round out the formula. The product also contains inactive ingredients—cellulose powder, vegetable cellulose capsules (the capsule shell itself), silicon dioxide, and vegetable source magnesium stearate—that serve as filler, flow agents, and binder.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Complete menopause support including hot flashes and sleep.
  • We looked for evidence on: Menopausal symptoms, Insomnia, Anxiety, Cardiovascular disease (CVD), Hypertension, Osteoporosis — and 3 related terms.
  • The strongest evidence on file: Pomegranate is rated "Possibly Effective" for Hypertension (Natural Medicines).
  • Also on file: Black Cohosh is rated "Possibly Effective" for Menopausal symptoms.
  • Also on file: Pomegranate is rated "Insufficient Reliable Evidence To Rate" for Menopausal symptoms.

For black cohosh, there is possibly effective evidence for menopausal symptoms—the main reason this ingredient is used in menopause support formulas. Pomegranate is possibly effective for high blood pressure, though it's marked as possibly ineffective for cholesterol and blood sugar problems.

The hops extract's effectiveness for menopausal symptoms, anxiety, sleep, attention, digestive upset, or sexual function has insufficient reliable evidence in our data—meaning the evidence base is too limited to establish a clear benefit.

The evidence, ingredient by ingredient Hops Pomegranate Black Cohosh

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Black cohosh and hops are generally well tolerated short-term, but long-term safety isn't well studied for either. Black cohosh carries a rare but documented concern for liver damage, so medical guidance before use is wise.

Pomegranate fruit and juice are generally safe in normal food amounts, but the concentrated extract in this supplement means you should use caution. The most common side effects with pomegranate extract are diarrhea and gas; hops may cause drowsiness.

Black cohosh may cause headache, dizziness, tiredness, breast tenderness, or rash. During pregnancy, black cohosh is considered possibly unsafe due to insufficient safety data and possible effects on the uterus; hops also has not enough safety information and should be avoided.

For breastfeeding, safety data is not established for black cohosh and hops, so both should be avoided. Pomegranate is rated possibly safe in pregnancy and lactation.

Side effects, ingredient by ingredient Hops Pomegranate Black Cohosh

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Pomegranate, Hops, Black Cohosh.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 1,268 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking MenoComplete, check with your doctor or pharmacist if you take serotonergic antidepressants or anti-anxiety drugs (black cohosh raises the risk of serotonin syndrome), CNS depressants like sedatives (hops may add sedation), blood pressure medications or ACE inhibitors (pomegranate may lower blood pressure further), blood thinners like warfarin (pomegranate may increase bleeding risk), CYP2D6-metabolized drugs such as some antidepressants and pain relievers (both pomegranate and black cohosh), statins like atorvastatin and rosuvastatin (black cohosh and pomegranate respectively carry documented concerns), or hormone therapies including estrogen replacement (hops and black cohosh may interfere). No interactions are documented for the inactive ingredients we could check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

MenoComplete may help with menopausal symptoms through its black cohosh content, which has some evidence of benefit. However, because all three ingredients interact with a wide range of medications—especially blood pressure drugs, antidepressants, blood thinners, and statins—this is not a product to start without checking your full medication list first.

If you're pregnant, breastfeeding, or take any prescription drugs, talk with your doctor or pharmacist before using it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 22, 2015.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about MenoComplete, straight from the product label.

Brand Terry Naturally
Barcode (UPC) 367703305062
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Oct 22, 2015
DSLD ID 51804
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Menopause, Seniors/Mature (>50 Years) - Women ONLY, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for MenoComplete by Terry Naturally, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
367703305062
IngredientAmount% DV
Proprietary Complex560 mg--
patented Hops (Humulus lupulus L.) cone extract0 NP--
Pomegranate (Punica granatum) fruit extract0 NP--
Black Cohosh (Cimicifuga racemosa) root and rhizome extract0 NP--

Other ingredients: Cellulose powder, Vegetable Cellulose Capsules, Silicon Dioxide, Vegetable Source Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

UNCONDITIONALLY GUARANTEED COMPLETE MENOPAUSE SUPPORT: - Supports breast health - Reduces hot flashes - Promotes natural, restful sleep - Supports heart health - Improves mood and decreases irritability - Supports healthy bone re-mineralization - Supports healthy weight management*

In conjunction with a healthy diet and exercise plan

For Your Good Health Terry

Suggested/Recommended/Usage/Directions

Recommendations: 2 capsules daily.

For optimal menopause relief we also recommend Terry Naturally Tri-Iodine

FDA Disclaimer Statement

THESE STATEMENTS HAVE NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION. THIS PRODUCT IS NOT INTENDED TO DIAGNOSE, TREAT, CURE OR PREVENT ANY DISEASE.

General

JC 34 91 + 3(5,6)EP L30506.07

Formula

Multi-Symptom Menopause Relief*

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

V VEGAN

Terry Naturally EuroPharma

Formulation

No sugar, soy, yeast, wheat, gluten, corn, dairy products, artificial flavoring, artificial coloring, or artificial preservatives.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

MenoComplete by Terry Naturally label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

MenoComplete label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in MenoComplete by Terry Naturally

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Other (inactive) ingredients: Cellulose powder, Vegetable Cellulose Capsules, Silicon Dioxide, Vegetable Source Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

MenoComplete by Terry Naturally Drug Interactions

Want to check YOUR meds against MenoComplete?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,267Drugs
921 Moderate 346 Minor

Ingredients driving the most interactions

Pomegranate (Punica granatum) fruit extract 922
patented Hops (Humulus lupulus L.) cone extract 863
Black Cohosh (Cimicifuga racemosa) root and rhizome extract 652

Individual Drug Interactions

The ingredients in MenoComplete interact with 1,267 drugs. Click any drug to see the details.

3 of the 3 ingredients in MenoComplete interact with drugs. Each result below shows which ingredient is responsible. Pomegranate (Punica granatum) fruit extract patented Hops (Humulus lupulus L.) cone extract Black Cohosh (Cimicifuga racemosa) root and rhizome extract

Each ingredient & the kinds of drugs it affects

For each ingredient in MenoComplete with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Pomegranate (Punica granatum) fruit extract9 drug types · 922 drugs

Ace Inhibitors (Aceis)

Theoretically, taking pomegranate with ACEIs might increase the risk of adverse effects.
Pomegranate juice is thought to have ACE inhibitor-like effects.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, taking pomegranate with antihypertensive drugs might increase the risk of hypotension.
Consuming pomegranate juice can modestly lower blood pressure.

Likelihood Possible Evidence B
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
In vitro, pomegranate juice inhibits CYP2D6. However, the clinical significance of this potential interaction in humans is not known.

Likelihood Possible Evidence D
Rosuvastatin (Crestor)

Theoretically, taking pomegranate with rosuvastatin might increase the risk of adverse effects.
In one case, a patient taking rosuvastatin 5 mg every other day in combination with ezetimibe 10 mg daily developed rhabdomyolysis after drinking pomegranate juice 200 mL twice weekly for 3 weeks. This patient had a history of elevated creatine kinase levels while not receiving any statin treatment. This suggests a possible underlying myopathy and predisposition to rhabdomyolysis.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, pomegranate might increase warfarin levels and increase the risk of bleeding. Also, discontinuing regular consumption of pomegranate juice might decrease warfarin levels.
In one case report, a patient had a stable, therapeutic bleeding time, as measured by international normalized ratio (INR), while taking warfarin in combination with pomegranate juice 2-3 times per week. The patient became subtherapeutic within about 10 days after discontinuing pomegranate juice, which required a warfarin dose increase. In another case report, a patient with a stable INR for over one year presented with an INR of 14. The patient noted no changes to medications or diet but did report consuming around 3 liters of pomegranate juice over the previous week. The patient's INR stabilized upon moderation of pomegranate juice consumption. The mechanism of this potential interaction is unclear.

Likelihood Possible Evidence D
Carbamazepine (Tegretol)

Theoretically, taking pomegranate with carbamazepine might increase the risk of adverse effects, although research suggests this interaction is unlikely to be clinically significant.
Animal research shows that pomegranate juice may inhibit cytochrome P450 3A4 (CYP3A4) metabolism of carbamazepine and increase levels of carbamazepine by 1.5 times without prolonging the elimination half-life. This suggests that pomegranate juice inhibits intestinal CYP3A4, but might not inhibit hepatic CYP3A4. However, some human research suggests that pomegranate does not significantly inhibit CYP3A4 drug metabolism in humans.

Likelihood Unlikely Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, pomegranate might increase levels of drugs metabolized by CYP2C9.
Some animal and in vitro research shows that pomegranate juice inhibits intestinal, but not hepatic, CYP2C9 isoenzyme activity. However, clinical research shows that neither pomegranate juice nor pomegranate extract have a significant effect on CYP2C9 activity in humans.

Likelihood Unlikely Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to be clinically significant.
Pomegranate contains several polyphenols that have individually been shown to inhibit CYP3A4. However, there is contradictory evidence about the effect of whole pomegranate juice on CYP3A4 activity. In vitro, pomegranate juice significantly inhibits the CYP3A4 enzyme, with comparable inhibition to grapefruit juice. In an animal model, pomegranate juice inhibits CYP3A4 metabolism of carbamazepine and increases levels of carbamazepine by 1.5 times; however, in human volunteers, drinking a single glass of pomegranate juice 240 mL or taking 200 mL daily for 2 weeks does not significantly affect levels of the CYP3A4 substrate midazolam after oral or intravenous administration. Another study in healthy volunteers shows that consuming pomegranate juice 300 mL three times daily for three days also does not significantly affect levels of simvastatin, a CYP3A4 substrate This suggests that pomegranate is unlikely to significantly affect levels of CYP3A4 substrates in humans.

Likelihood Unlikely Evidence B
Tolbutamide (Orinase)

Theoretically, pomegranate might increase levels of tolbutamide, although research suggests this interaction is unlikely to be clinically significant.
Animal research shows that pomegranate juice inhibits the cytochrome P450 2C9 (CYP2C9) metabolism of tolbutamide. Pomegranate juice increased tolbutamide levels by 1.2 times without prolonging the elimination half-life. This suggests that pomegranate juice inhibits intestinal CYP2C9, but might not inhibit hepatic CYP2C9. Despite this evidence, clinical research shows that neither pomegranate juice nor pomegranate extract have a significant effect on CYP2C9 activity in humans. This interaction does not appear to be clinically significant in humans.

Likelihood Unlikely Evidence D
Pomegranate (Punica granatum) fruit extract full monograph & interactions

patented Hops (Humulus lupulus L.) cone extract4 drug types · 863 drugs

Cns Depressants

Theoretically, concomitant use of hops with sedative drugs might cause additive sedation.
Some animal research shows that hops has sedative effects.

Likelihood Possible Evidence D
Estrogens

Theoretically, concomitant use of large amounts of hops might interfere with hormone replacement therapy due to competition for estrogen receptors.
In vitro research suggests that certain hops constituents can competitively bind to estrogen receptors. However, most hops extracts contain very small amounts of these constituents.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Hops extract does not seem to affect the metabolism of CYP1A2 substrates.
In vitro research suggests that flavonoid constituents of hops inhibit CYP1A2 enzyme activity. However, a pharmacokinetic study in healthy postmenopausal patients shows that taking a standardized extract of spent hops containing prenylated phenols, as 59.5 mg twice daily for 2 weeks, does not affect levels of caffeine, a CYP1A2 probe substrate.

Likelihood Unlikely Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, hops extract might alter metabolism of CYP3A4 substrates; however, this effect may not be clinically significant.
Animal research suggests that specific constituents of hops, called lupulones, can induce hepatic CYP3A4 enzyme activity. However, a pharmacokinetic study in healthy postmenopausal patients with normal metabolism shows that taking a standardized extract of spent hops containing prenylated phenols, as 59.5 mg twice daily for 2 weeks, decreases the concentration of alprazolam, a CYP3A4 probe substrate, by 7.6%. This reduction is unlikely to be clinically relevant.

Likelihood Possible Evidence D
patented Hops (Humulus lupulus L.) cone extract full monograph & interactions

Black Cohosh (Cimicifuga racemosa) root and rhizome extract7 drug types · 652 drugs

Atorvastatin (Lipitor)

Taking black cohosh with atorvastatin might increase the risk for elevated liver function tests.
In one case report, a patient taking atorvastatin (Lipitor) developed significantly elevated liver function enzymes after starting black cohosh 100 mg four times daily. Liver enzymes returned to normal when black cohosh was discontinued. It is unclear whether the elevated liver enzymes were due to black cohosh itself or an interaction between atorvastatin and black cohosh.

Likelihood Possible Evidence D
Cisplatin (Platinol-Aq)

Theoretically, black cohosh may reduce the clinical effects of cisplatin.
Animal research suggests that black cohosh might decrease the cytotoxic effect of cisplatin on breast cancer cells.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Some research suggests that black cohosh might inhibit CYP2D6, but there is conflicting evidence.
Some clinical research suggests that black cohosh might modestly inhibit CYP2D6 and increase levels of drugs metabolized by this enzyme. However, contradictory clinical research shows a specific black cohosh product (Remifemin, Enzymatic Therapy) 40 mg twice daily does not significantly inhibit metabolism of a CYP2D6 substrate in healthy study volunteers. Until more is known, use black cohosh cautiously in patients taking drugs metabolized by CYP2D6.

Likelihood Possible Evidence B
Estrogens

Theoretically, black cohosh may alter the effects of estrogen therapy.
Some research suggests that black cohosh has estrogenic effects. This may enhance or inhibit the effects of estrogen therapy.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, taking black cohosh with hepatotoxic drugs may increase the risk of liver damage.
There is concern that black cohosh might be linked to cases of liver failure and autoimmune hepatitis.

Likelihood Possible Evidence D
Serotonergic Drugs

Combining serotonergic drugs with black cohosh might cause additive serotonergic effects.
Black cohosh might increase the risk of serotonin syndrome when combined with other serotonergic drugs. Black cohosh acts as an agonist at several serotonin receptor subtypes and might interact with other serotonergic medications. In one case, a 55-year-old female who had been on stable treatment with sertraline 50 mg and duloxetine 60 mg daily developed serotonin syndrome after taking black cohosh extract 40 mg daily for 3 days.

Likelihood Possible Evidence D
Organic Anion-Transporting Polypeptide Substrates (Oatp)

Black cohosh may inhibit one form of OATP, OATP2B1, which could reduce the bioavailability and clinical effects of OATP2B1 substrates.
In vitro research shows that black cohosh modestly inhibits OATP2B1. OATPs are expressed in the small intestine and liver and are responsible for the uptake of drugs and other compounds into the body. Inhibition of OATP may reduce the bioavailability of oral drugs that are substrates of OATP.

Likelihood Possible Evidence D
Black Cohosh (Cimicifuga racemosa) root and rhizome extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for MenoComplete, from the product label.

Terry Naturally

See all Terry Naturally products
Name
EuroPharma, Inc.
City
Green Bay
State
WI
ZipCode
54311
Phone Number
(866) 807-2731
Web Address
www.EuroPharmaUSA.com
Pharmacist Counseling Corner

MenoComplete by Terry Naturally: Common Questions

Does MenoComplete by Terry Naturally interact with any medications?
Yes. Based on its ingredients, MenoComplete has a known interaction with 1,267 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
MenoComplete contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take MenoComplete if I'm on an antidepressant?
Not without checking first. Black cohosh in this product can interact with serotonergic antidepressants and raise the risk of serotonin syndrome. Talk with your doctor or pharmacist about your specific antidepressant before starting MenoComplete.
What are the side effects of MenoComplete?
Black cohosh may cause headache, dizziness, tiredness, breast tenderness, or rash. Hops may cause drowsiness. Pomegranate commonly causes diarrhea and gas, especially at higher doses. Most people tolerate these ingredients well at typical doses, but long-term safety isn't well studied.
Is MenoComplete safe during pregnancy or breastfeeding?
No. Black cohosh and hops should be avoided in pregnancy and while breastfeeding due to insufficient safety data. Pomegranate is rated possibly safe, but because the other two ingredients are not, it's best to skip this product if you're pregnant or nursing and talk with your doctor.
Does MenoComplete actually work for hot flashes?
Black cohosh, one of the three active ingredients, is possibly effective for menopausal symptoms like hot flashes. The hops and pomegranate don't have strong evidence for that use in our data.
Can I take MenoComplete with blood pressure medication?
Possibly not safely. Pomegranate can lower blood pressure, so combining it with blood pressure drugs might cause it to drop too far. Hops may also interact with certain blood pressure medications. Check with your doctor or pharmacist before use.
What's in MenoComplete besides the active ingredients?
The capsule contains cellulose powder, silicon dioxide, and magnesium stearate—common inactive ingredients that help hold the supplement together and fill out the capsule. The capsule shell itself is made of vegetable cellulose.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

MenoComplete label
Go deeper

The Full Monographs Behind MenoComplete’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Hops

Interacts with 863 drugs

Hops are most often used for sleep and mild anxiety, frequently combined with valerian, but the human evidence is limited and not very strong. They are generally well tolerated when used sho...

Read the full Hops monograph → Herb & supplement monograph

Pomegranate

Interacts with 922 drugs

Pomegranate is a nutrient-rich fruit that is high in antioxidants and is widely enjoyed as food and juice. Early research suggests it may support heart health and blood pressure, but the evi...

Read the full Pomegranate monograph → Herb & supplement monograph

Black Cohosh

Interacts with 652 drugs

Black cohosh is a North American plant most often used to ease menopause symptoms like hot flashes, but the research is mixed and far from settled. It is generally well tolerated for short-t...

Read the full Black Cohosh monograph →
Sources

Sources & How We Checked

MenoComplete's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 110 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Hops 15 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  3. Zava DT, Dollbaum CM, Blen M. Estrogen and progestin bioactivity of foods, herbs, and spices. Proc Soc Exp Biol Med 1998;217:369-78. PubMed
  4. Milligan SR, Kalita JC, Heyerick A, et al. Identification of a potent phytoestrogen in hops (Humulus lupulus L.) and beer. J Clin Endocrinol Metab 1999;84:2249-52.. PubMed
  5. Milligan SR, Kalita JC, Pocock V, et al. The endocrine activities of 8-prenylnaringenin and related hop (Humulus lupulus L.) flavonoids. J Clin Endocrinol Metab 2000;85:4912-5.. DOI
  6. Henderson MC, Miranda CL, Stevens JF, et al. In vitro inhibition of human P450 enzymes by prenylated flavonoids from hops, Humulus lupulus. Xenobiotica 2000;30:235-51.. PubMed
  7. Mannering, G. J., Shoeman, J. A., and Deloria, L. B. Identification of the antibiotic hops component, colupulone, as an inducer of hepatic cytochrome P-4503A in the mouse. Drug Metab Dispos 1992;20(2):142-147. DOI
  8. Skorska, C., Mackiewicz, B., Gora, A., Golec, M., and Dutkiewicz, J. Health effects of inhalation exposure to organic dust in hops farmers. Ann.Univ Mariae.Curie Sklodowska [Med] 2003;58(1):459-465.
  9. Schiller, H., Forster, A., Vonhoff, C., Hegger, M., Biller, A., and Winterhoff, H. Sedating effects of Humulus lupulus L. extracts. Phytomedicine. 2006;13(8):535-541. PubMed
  10. van Hunsel, F. P. and Kampschoer, P. [Postmenopausal bleeding and dietary supplements: a possible causal relationship with hop- and soy-containing preparations]. Ned.Tijdschr.Geneeskd. 2012;156(41):A5095.
  11. Fenselau, C. and Talalay, P. Is oestrogenic activity present in hops? Food Cosmet.Toxicol. 1973;11(4):597-602. PubMed
  12. Godnic-Cvar, J., Zuskin, E., Mustajbegovic, J., Schachter, E. N., Kanceljak, B., Macan, J., Ilic, Z., and Ebling, Z. Respiratory and immunological findings in brewery workers. Am J Ind Med 1999;35(1):68-75. DOI
  13. Lee KM, Jung JS, Song DK, and et al. Effects of Humulus lupulus extract on the central nervous system in mice. Planta Med 1993;59(Suppl):A691.
  14. Assessment report on Humulus lupulus L., flos. European Medicines Agency, 2014. Available at: https://www.ema.europa.eu/en/documents/herbal-report/final-assessment-report-humulus-lupulus-l-flos_en.pdf. Accessed September 29, 2021.
  15. van Breemen RB, Chen L, Tonsing-Carter A, et al. Pharmacokinetic Interactions of a Hop Dietary Supplement with Drug Metabolism in Perimenopausal and Postmenopausal Women. J Agric Food Chem. 2020;68(18):5212-5220. PubMed

See these in context on the Hops monograph →

Pomegranate 27 references
  1. Igea JM, Cuesta J, Cuevas M, et al. Adverse reaction to pomegranate ingestion. Allergy 1991;46:472-4. DOI
  2. Gaig P, Bartolome B, Lleonart R, et al. Allergy to pomegranate (Punica granatum). Allergy 1999;54:287-8.
  3. Aviram M, Dornfeld L. Pomegranate juice consumption inhibits serum angiotensin converting enzyme activity and reduces systolic blood pressure. Atherosclerosis 2001;158:195-8. PubMed
  4. Valsecchi R, Reseghetti A, Leghissa P, et al. Immediate contact hypersensitivity to pomegranate. Contact Dermatitis 1998;38:44-5. PubMed
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See these in context on the Pomegranate monograph →

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See these in context on the Black Cohosh monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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