Major interaction on record — check this product against your medications before combining. Based on 10 of 11 ingredients. Check your meds →
Dietary supplement

Mr Hyde Intense Energy Pre Workout Fruit Punch Ingredients & Drug Interactions

by PS ProSupps

Mr Hyde Intense Energy Pre Workout Fruit Punch label
See full label image
Powder Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Mr Hyde Intense Energy Pre Workout Fruit Punch against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Mr Hyde Intense Energy Pre Workout Fruit Punch is a dietary supplement by PS ProSupps with 11 active ingredients. Its ingredients are commonly taken for mental alertness and reducing fatigue, improving athletic performance, headache and migraine relief.Based on those ingredients, 1,443 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Citrus aurantium fruit extract, Caffeine Matrix, Noble Orchid (Dendrobium nobile) stem extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Mr Hyde Intense Energy Pre Workout Fruit Punch by PS ProSupps

Ask about any prescription or over-the-counter medication and we check it for interactions with Mr Hyde Intense Energy Pre Workout Fruit Punch by PS ProSupps — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Mr Hyde Intense Energy Pre Workout Fruit Punch by PS ProSupps

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 13 of its 13 active ingredients.
  • “Caffeine Matrix” is a proprietary blend — the label gives one combined amount (419 mg) without saying how much of each component you get.
  • “Strength Matrix” is a proprietary blend — the label gives one combined amount (5 Gram(s)) without saying how much of each component you get.
  • “Intensity Matrix” is a proprietary blend — the label gives one combined amount (300 mg) without saying how much of each component you get.

Mr Hyde Intense Energy contains 13 active ingredients formulated as a pre-workout supplement. The product includes three sources of caffeine — Caffeine Anhydrous, Caffeine Citrate, and Infinergy (a delayed-release form) — which work to boost alertness and athletic performance.

It also contains beta-alanine (CarnoSyn brand), creatine nitrate, L-citrulline aspartate, and agmatine sulfate, all aimed at supporting muscle performance and blood flow during exercise. Additional active ingredients are octopamine HCl and N-methyl L-tyramine HCl (stimulant-type compounds), picamilon (Pikatropin), dendrobium nobile stem extract, and bitter orange fruit extract.

The inactive ingredients are natural and artificial flavoring, soluble corn fiber, malic acid, calcium silicate, sucralose, silicon dioxide, and colorants.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: intense energy for pre-workout performance.
  • We looked for evidence on: Athletic performance, Fatigue, Mental alertness, Muscle strength, Exercise-induced muscle soreness, endurance — and 3 related terms.
  • The strongest evidence on file: Caffeine is rated "Likely Effective" for Athletic performance (Natural Medicines).
  • Also on file: Caffeine is rated "Likely Effective" for Mental alertness.
  • Also on file: Creatine is rated "Possibly Effective" for Athletic performance, Muscle strength.

Caffeine in this product is shown to be effective for mental alertness and likely effective for athletic performance, based on clinical evidence. Beta-alanine (CarnoSyn) is possibly effective for athletic and physical performance but has insufficient evidence for cognitive function or other claimed uses.

Creatine nitrate is possibly effective for muscle strength and athletic performance but possibly ineffective for bone health (osteopenia) and Huntington disease. L-citrulline aspartate is possibly effective for athletic performance.

For octopamine, agmatine, N-methyl L-tyramine, picamilon, and dendrobium, the evidence we hold does not establish their effectiveness — either there is insufficient reliable evidence or effectiveness is not rated in our data.

The evidence, ingredient by ingredient Caffeine Beta-alanine Creatine L-citrulline Agmatine Octopamine N-methyltyramine Picamilon

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 8 of the 10 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 10 of 10.
  • General safety write-ups exist for 10 of 10.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Caffeine is generally well tolerated in moderate amounts for healthy adults, but high doses can cause serious side effects. Common side effects include anxiety, insomnia, headache, nausea, tremors, and restlessness; in rare cases, stroke has been reported.

Caffeine passes small amounts into breast milk and may affect the baby; high intake in pregnancy carries potential risks, so ask your doctor about safe limits. Beta-alanine is generally well tolerated but commonly causes a harmless pins-and-needles tingling feeling (paresthesia) and skin flushing, usually starting on the scalp within 20 minutes and lasting about an hour.

Safety during pregnancy and breastfeeding has not been established for beta-alanine, so it's best avoided. Creatine is generally well tolerated but may cause dehydration, diarrhea, muscle cramps, and water retention; those with kidney disease should be careful.

Avoid creatine in pregnancy and while breastfeeding due to lack of safety data. Octopamine has limited safety data and Health Canada limits it to 50 mg daily maximum due to stimulant-related cardiovascular concerns; case reports describe heart attack with chronic use of multi-ingredient supplements containing it.

N-methyl L-tyramine, agmatine, L-citrulline, picamilon, and dendrobium all have limited human safety data. Bitter orange contains stimulant compounds and can raise blood pressure and heart rate, especially with caffeine; serious adverse effects including heart attack, stroke, and seizure have been rarely reported.

None of these ingredients are established as safe during pregnancy or breastfeeding.

Side effects, ingredient by ingredient Caffeine Beta-alanine Creatine L-citrulline Agmatine Octopamine N-methyltyramine Picamilon

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 8 of the 10 matched ingredients can interact with medications — Bitter Orange, Caffeine, L-citrulline, Dendrobium, Agmatine, among others.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; seizure medications; diabetes medications; heart-rhythm medications; lithium.
  • For scale: 1,444 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take ephedrine or any ephedrine-containing products (Major risk — life-threatening stimulant effects possible), MAOIs or antidepressants like phenelzine or tranylcypromine (Major risk — dangerous blood pressure spike), or the sedative midazolam (Major risk — excessive sedation). Also discuss it if you use blood pressure medications, diabetes medications, heart rhythm or heart rate medications, sleeping pills (barbiturates), anticonvulsants (seizure medications), antipsychotics like clozapine, quinolone antibiotics, cimetidine, dipyridamole (cardiac stress-test medication), erectile dysfunction drugs, or any medications broken down by the liver.

No interactions are documented for L-Leucine among the ingredients we could check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This is a high-stimulant pre-workout designed for serious athletes willing to accept stimulant side effects like jitteriness and insomnia. If you take any blood pressure, heart, brain, diabetes, or anxiety medications, or any MAOIs, you need to check this product against your exact prescriptions with your doctor or pharmacist first — the interaction risks are real and potentially serious.

Pregnant and nursing women should avoid it. Even if you're not on medications, the heavy caffeine load plus multiple stimulant compounds means it's not suitable for anyone sensitive to caffeine, those with heart conditions, or adolescents.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 12 of 13 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 24, 2015.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Mr Hyde Intense Energy Pre Workout Fruit Punch, straight from the product label.

Brand PS ProSupps
Barcode (UPC) 682055406237
Net contents 8.1 oz.; 231 Gram(s)
Market status On market
Date entered into DSLD Jul 24, 2015
DSLD ID 47973
Product type Other Combinations
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Mr Hyde Intense Energy Pre Workout Fruit Punch by PS ProSupps, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
7.7 Gram(s)
Maximum serving Sizes:
7.7 Gram(s)
Servings per container
30
UPC/BARCODE
682055406237
IngredientAmount% DV
L-Leucine500 mg--
Caffeine Anhydrous300 mg--
CarnoSyn2.5 Gram(s)--
Octopamine HCl15 mg--
Caffeine Citrate50 mg--
Creatine Nitrate1 Gram(s)--
N-Methyl L-Tyramine HCl200 mg--
Caffeine Matrix419 mg--
Strength Matrix5 Gram(s)--
L-Citrulline Aspartate500 mg--
Agmatine Sulfate500 mg--
Pikatropin50 mg--
Infinergy69 mg--
Intensity Matrix300 mg--
Noble Orchid (Dendrobium nobile) stem extract5 mg--
Citrus aurantium fruit extract30 mg--

Other ingredients: Natural & Artificial flavor, soluble Corn Fiber, Malic Acid, Calcium Silicate, Sucralose, Silicon Dioxide, FD&C Red #40, FD&C Red Lake #40, Soy Lecithin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

WARNING: NOT FOR USE BY INDIVIDUALS UNDER THE AGE OF 18 YEARS.

DO NOT USE IF PREGNANT OR NURSING.

CONSULT A PHYSICIAN OR LICENSED QUALIFIED HEALTH CARE PROFESSIONAL BEFORE USING THIS PRODUCT IF YOU HAVE, OR HAVE A FAMILY HISTORY OF HEART DISEASE, THYROID DISEASE, DIABETES, HIGH BLOOD PRESSURE, DEPRESSION OR OTHER PSYCHIATRIC CONDITION, GLAUCOMA, DIFFICULTY IN URINATING, PROSTATE ENLARGEMENT, OR SEIZURE DISORDER. DO NOT EXCEED RECOMMENDED SERVING. EXCEEDING RECOMMENDED SERVING MAY CAUSE ADVERSE HEALTH EFFECTS. DISCONTINUE USE AND CALL A PHYSICIAN OR LICENSED QUALIFIED HEALTH CARE PROFESSIONAL IMMEDIATELY IF YOU EXPERIENCE RAPID HEARTBEAT, DIZZINESS, SEVERE HEADACHE, SHORTNESS OF BREATH OR OTHER SIMILAR SYMPTOMS. INDIVIDUALS WHO ARE SENSITIVE TO THE EFFECTS OF CAFFEINE OR HAVE A MEDICAL CONDITION SHOULD CONSULT A LICENSED HEALTH CARE PROFESSIONAL BEFORE CONSUMING THIS PRODUCT. DO NOT USE THIS PRODUCT IF YOU ARE MORE THAN 15 POUNDS OVERWEIGHT. THE CONSUMER ASSUMES TOTAL LIABILITY IF THIS PRODUCT IS USED IN A MANNER INCONSISTENT WITH LABEL GUIDELINES. DO NOT USE FOR WEIGHT REDUCTION. THIS PRODUCT IS INTENDED FOR USE BY HEALTHY INDIVIDUALS ONLY.

KEEP OUT OF REACH OF CHILDREN.

TOO MUCH CAFFEINE MAY CAUSE NERVOUSNESS, IRRITABILITY, SLEEPLESSNESS AND OCCASIONALLY RAPID HEARTBEAT.

MANUFACTURED IN A FACILITY THAT PROCESSES MILK, EGG, SOY, WHEAT, AND SHELLFISH.

Contains Soy Lecithin.

DO NOT CONSUME MRHYDE(TM) WITHIN 4 HOURS PRIOR TO BEDTIME. DO NOT TAKE ANY OTHER PRODUCTS THAT CONTAIN CAFFEINE OR ANY OTHER STIMULANTS WHILE TAKING HYDE(TM).

*WARNING: MRHYDE(TM) IS FOR ADVANCED EXERCISE AND SUPPLEMENT USERS ONLY. DO NOT EXCEED ONE SCOOP PRIOR TO EXERCISE UNDER ANY CIRCUMSTANCES.

General Statements

PLEASE REFER TO ADDITIONAL *WARNING.

INTENSE ENERGY PRE WORKOUT+

30 SERVINGS

NATURAL AND ARTIFICIAL FLAVOR

MANUFACTURED IN A cGMP FACILITY

INTL

FDA Disclaimer Statement

THESE STATEMENTS HAVE NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION. THIS PRODUCT IS NOT INTENDED TO DIAGNOSE, TREAT, CURE OR PREVENT ANY DISEASE.

Seals/Symbols

prosupps(R) RESULTS . . . PERIOD!+

PS(R)

AGMAPURE(R) Natural Agmatine sulfate

CarnoSyn(R) Carnosine Synthesizer

CERTIFIED cGMP

NO3T(R) NITRATE TECHNOLOGY NO3-T.COM/PATENTS

GLUTEN-FREE

{AMERICAN FLAG} MADE IN USA

Formula

POTENT COMBINATION OF HIGH-POWERED THERMOGENIC COMPOUNDS+ > L-CITRULLINE AND LEUCINE TO PREVENT MUSCLE CATABOLISM+ >THREE STAGE ENERGY BLEND +

Contains Soy Lecithin.

LOADED WITH L-LEUCINE, EXPLOSIVE STIMULANT BLENDS AND THE NOVEL PUMP AGENT AGMATINE SULFATE, HYDE(TM) WILL SHATTER WEIGHT-TRAINING PLATEAUS. +

FDA Statement of Identity

DIETARY SUPPLEMENT

Formulation

Contains 0% Juice.

GLUTEN-FREE

Suggested/Recommended/Usage/Directions

SUGGESTED USE: AS A DIETARY SUPPLEMENT, MIX 1 SCOOP OF MRHYDE(TM) WITH 8 OZ OF COLD WATER. CONSUME 15 TO 30 MINUTES BEFORE EXERCISE.

Brand IP Statement(s)

“THE DESCRIPTION OF MRHYDE(TM) AS AN ALMOST PREHUMAN CREATURE AND HIS ACTIONS THAT OCCUR WITHOUT THOUGHT, SUGGESTS THAT HYDE(TM) IS MORE ANIMAL THAN MAN” - SIR ROBERT STEVENSON, AUTHOR “DR JEKYLL AND MR HYDE”

FROM THE TRAINING JOURNAL OF THE LATE IFBB PRO ART ATWOOD COMES THE MOST EXTREME AND EFFECTIVE PRE-WORKOUT ON THE MARKET: PROSUPPS(R) MRHYDE(R). MRHYDE(TM) GIVES YOU A SERIOUS KICK IN THE A**!

CarnoSyn(R) trademark and patents owned by Natural Alternatives Internationsl, Inc., www.carnosyn.com.

NO3T(R) is a Trademark of ThermoLife International & protected by US Patent Numbers 7,777,074 - 8,466,187 8,455,531 - 8,178,572 8,183,288

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Mr Hyde Intense Energy Pre Workout Fruit Punch by PS ProSupps label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Mr Hyde Intense Energy Pre Workout Fruit Punch label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Mr Hyde Intense Energy Pre Workout Fruit Punch by PS ProSupps

These are the 11 active ingredients this product is made of. Select any to open its full monograph.

Serving size7.7 Gram(s) Dosage formPowder Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Caffeine Matrix

Interacts with
655 drugs
419 mg per serving

Caffeine is a natural stimulant found in coffee, tea, and many other plants and products. In moderate amounts it can boost alertness and reduce tiredn...

Caffeine Matrix monograph & interactions

Strength Matrix

5 Gram(s) per serving

Other (inactive) ingredients: Natural & Artificial flavor, Soluble Corn Fiber, Malic Acid, Calcium Silicate, Sucralose, Silicon Dioxide, FD&C Red #40, FD&C Red Lake #40, Soy Lecithin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Mr Hyde Intense Energy Pre Workout Fruit Punch by PS ProSupps Drug Interactions

Want to check YOUR meds against Mr Hyde Intense Energy Pre Workout Fruit Punch?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,443Drugs
18 Major 1,386 Moderate 39 Minor

Ingredients driving the most interactions

Citrus aurantium fruit extract 957
Caffeine Matrix 655
Noble Orchid (Dendrobium nobile) stem extract 609
Octopamine HCl 352
N-Methyl L-Tyramine HCl 344

Individual Drug Interactions

The ingredients in Mr Hyde Intense Energy Pre Workout Fruit Punch interact with 1,443 drugs. Click any drug to see the details.

8 of the 11 ingredients in Mr Hyde Intense Energy Pre Workout Fruit Punch interact with drugs. Each result below shows which ingredient is responsible. Citrus aurantium fruit extract Caffeine Matrix Noble Orchid (Dendrobium nobile) stem extract Octopamine HCl N-Methyl L-Tyramine HCl Agmatine Sulfate L-Citrulline Aspartate Pikatropin

Each ingredient & the kinds of drugs it affects

For each ingredient in Mr Hyde Intense Energy Pre Workout Fruit Punch with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Citrus aurantium fruit extract13 drug types · 957 drugs

Midazolam (Versed)

Bitter orange might increase blood levels of midazolam.
One small clinical study shows that bitter orange juice can increase midazolam levels, likely through inhibition of cytochrome P450 3A4 (CYP3A4). Theoretically, bitter orange might increase the risk of midazolam-related adverse effects.

Likelihood Probable Evidence B
Monoamine Oxidase Inhibitors (Maois)

Theoretically, taking MAOIs with synephrine-containing bitter orange preparations might increase the hypertensive effects of synephrine, potentially leading to hypertensive crisis.
Bitter orange contains tyramine, octopamine, and synephrine, which are MAO substrates.

Likelihood Probable Evidence D
Antidiabetes Drugs

Theoretically, bitter orange might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Some clinical research shows that drinking a tea containing bitter orange and Indian snakeroot reduces fasting and postprandial glucose levels in patients with type 2 diabetes who are using antidiabetes drugs. However, it is unclear if these effects are due to bitter orange, Indian snakeroot, or the combination. An animal study also shows that p-synephrine in combination with gliclazide , a sulfonylurea, causes an additional 20% to 44% decrease in glucose levels when compared with gliclazide alone.

Likelihood Possible Evidence B
Caffeine

Bitter orange might increase blood pressure and heart rate when taken with caffeine.
Small clinical studies show that taking bitter orange in combination with caffeine can increase blood pressure and heart rate in otherwise healthy normotensive adults. Theoretically, this might increase the risk of serious cardiovascular adverse effects.

Likelihood Possible Evidence B
Colchicine

Bitter orange might affect colchicine levels.
Colchicine is a substrate of P-glycoprotein and cytochrome P450 3A4 (CYP3A4). Bitter orange has been reported to inhibit CYP3A4 and increase levels of CYP3A4 substrates. However, one small clinical study in healthy adults shows that drinking bitter orange juice 240 mL twice daily for 4 days and taking a single dose of colchicine 0.6 mg on the 4th day decreases colchicine peak serum levels by 24%, time to peak serum level by 1 hour, and overall exposure to colchicine by 20%. The clinical significance of this finding is unclear.

Likelihood Possible Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Bitter orange might increase levels of drugs metabolized by CYP3A4.
Small clinical studies suggest that single or multiple doses of freshly squeezed bitter orange juice 200-240 mL can inhibit CYP3A4 metabolism of drugs, causing increased drug levels and potentially increasing the risk of adverse effects. However, the extent of the effect of bitter orange on CYP3A4-mediated drug interactions is unknown. Some evidence suggests that bitter orange selectively inhibits intestinal CYP3A4, but not hepatic CYP3A4. Its effect on P-glycoprotein, which strongly overlaps with CYP3A4 interactions, is unclear. One small clinical study shows that drinking 8 ounces of freshly squeezed bitter orange juice has no effect on cyclosporine, which seems to be more dependent on hepatic CYP3A4 and P-glycoprotein than intestinal CYP3A4.

Likelihood Possible Evidence B
Dextromethorphan (Robitussin Dm, Others)

Bitter orange might increase blood levels of dextromethorphan.
One small clinical study shows that bitter orange juice increases dextromethorphan levels, likely through cytochrome P450 3A4 (CYP3A4) inhibition. Theoretically, bitter orange might increase the risk for dextromethorphan-related adverse effects.

Likelihood Possible Evidence B
Felodipine (Plendil)

Bitter orange might increase blood levels of felodipine.
One small clinical study shows that bitter orange juice increases felodipine levels, likely through cytochrome P450 3A4 (CYP3A4) inhibition. Theoretically, bitter orange might increase the risk for felodipine-related adverse effects.

Likelihood Probable Evidence B
Indinavir (Crixivan)

Bitter orange might increase blood levels of indinavir.
One small clinical study shows that bitter orange juice slightly increases indinavir levels, but this effect is likely to be clinically insignificant. Bitter orange selectively inhibits intestinal cytochrome P450 3A4 (CYP3A4); however, the metabolism of indinavir seems to be more dependent on hepatic CYP3A4. The effect of bitter orange on other protease inhibitors has not been studied.

Likelihood Possible Evidence B
Qt Interval-Prolonging Drugs

Theoretically, bitter orange might have an additive effect when combined with drugs that prolong the QT interval, potentially increasing the risk of ventricular arrhythmias.
One case report suggests that taking bitter orange in combination with other stimulants such as caffeine might prolong the QT interval in some patients.

Likelihood Possible Evidence D
Sildenafil (Viagra)

Bitter orange juice might increase blood levels of sildenafil.
A small clinical study in healthy adult males shows that drinking freshly squeezed bitter orange juice 250 mL daily for 3 days and taking a single dose of sildenafil 50 mg on the 3rd day increases the peak plasma concentration of sildenafil by 18% and the overall exposure to sildenafil by 44%. Theoretically, this may be due to inhibition of cytochrome P450 3A4 by bitter orange.

Likelihood Probable Evidence B
Stimulant Drugs

Theoretically, bitter orange might increase the risk of hypertension and adverse cardiovascular effects when taken with stimulant drugs.
Bitter orange appears to have stimulant effects.

Likelihood Possible Evidence B
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, bitter orange might increase levels of drug metabolized by CYP2D6.
In vitro research shows that octopamine, a constituent of bitter orange, weakly inhibits CYP2D6 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Citrus aurantium fruit extract full monograph & interactions

Caffeine Matrix41 drug types · 655 drugs

Ephedrine

Theoretically, concomitant use might increase the risk for stimulant adverse effects.
Use of ephedrine with caffeine can increase the risk of stimulatory adverse effects. There is evidence that using ephedrine with caffeine might increase the risk of serious life-threatening or debilitating adverse effects such as hypertension, myocardial infarction, stroke, seizures, and death.

Likelihood Probable Evidence D
Adenosine (Adenocard)

Theoretically, caffeine might decrease the vasodilatory effects of adenosine and interfere with its use prior to stress testing.
Some evidence shows that caffeine is a competitive inhibitor of adenosine and can reduce the vasodilatory effects of adenosine in humans. However, other research shows that caffeine does not seem to affect supplemental adenosine because high interstitial levels of adenosine overcome the antagonistic effects of caffeine. It is recommended that methylxanthines and methylxanthine-containing products be stopped 24 hours prior to pharmacological stress tests. However, methylxanthines appear more likely to interfere with dipyridamole (Persantine) than adenosine-induced stress testing.

Likelihood Possible Evidence B
Anticoagulant/Antiplatelet Drugs

Theoretically, caffeine may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Caffeine is reported to have antiplatelet activity. Theoretically, it might increase the risk of bleeding when used concomitantly with these agents; however, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Beta-Adrenergic Agonists

Theoretically, large amounts of caffeine might increase the cardiac inotropic effects of beta-agonists.

Likelihood Probable Evidence D
Carbamazepine (Tegretol)

Theoretically, caffeine might reduce the effects of carbamazepine and increase the risk for convulsions.
Animal research suggests that taking caffeine can lower the anticonvulsant effects of carbamazepine and can induce seizures when taken in doses above 400 mg/kg. Human research has shown that taking caffeine 300 mg in three divided doses along with carbamazepine 200 mg reduces the bioavailability of carbamazepine by 32% and prolongs the plasma half-life of carbamazepine 2-fold in healthy individuals.

Likelihood Possible Evidence D
Cimetidine (Tagamet)

Theoretically, cimetidine might increase the levels and adverse effects of caffeine.
Cimetidine decreases the rate of caffeine clearance by 31% to 42%.

Likelihood Likely Evidence B
Clozapine (Clozaril)

Caffeine might increase the levels and adverse effects of clozapine and acutely exacerbate psychotic symptoms.
Caffeine might increase the effects and toxicity of clozapine. Caffeine doses of 400-1000 mg per day inhibit clozapine metabolism. Clozapine is metabolized by cytochrome P450 1A2 (CYP1A2). Although researchers speculate that caffeine might inhibit CYP1A2, there is no reliable evidence that caffeine affects CYP1A2. There is also speculation that genetic factors might make some patients more sensitive to an interaction between clozapine and caffeine. In one case report, severe, life-threatening clozapine toxicity and multiorgan system failure occurred in a patient with schizophrenia stabilized on clozapine who consumed caffeine 600 mg daily.

Likelihood Possible Evidence B
Dipyridamole (Persantine)

Theoretically, caffeine might decrease the vasodilatory effects of dipyridamole and interfere with its use prior to stress testing.
Caffeine inhibits dipyridamole-induced vasodilation. It is recommended that methylxanthines and methylxanthine-containing products be stopped 24 hours prior to pharmacological stress tests. Methylxanthines appear more likely to interfere with dipyridamole (Persantine) than adenosine-induced stress testing.

Likelihood Probable Evidence B
Disulfiram (Antabuse)

Theoretically, disulfiram use might increase the levels and adverse effects of caffeine.
Disulfiram decreases the rate of caffeine clearance.

Likelihood Probable Evidence B
Diuretic Drugs

Theoretically, using caffeine with diuretic drugs might increase the risk of hypokalemia.
Caffeine, especially in excessive amounts, can reduce potassium levels due to stimulation of the sodium-potassium pump. Diuretics can also cause lower potassium levels.

Likelihood Possible Evidence D
Estrogens

Theoretically, estrogens might increase the levels and adverse effects of caffeine.
Estrogen inhibits caffeine metabolism.

Likelihood Probable Evidence B
Ethosuximide (Zarontin)

Theoretically, caffeine might reduce the effects of ethosuximide and increase the risk for convulsions.
Animal research suggests that caffeine 92.4 mg/kg can decrease the anticonvulsant activity of ethosuximide. However, this effect has not been reported in humans.

Likelihood Possible Evidence D
Felbamate (Felbatol)

Theoretically, caffeine might reduce the effects of felbamate and increase the risk for convulsions.
Animal research suggests that a high dose of caffeine 161.7 mg/kg can decreases the anticonvulsant activity of felbamate. However, this effect has not been reported in humans.

Likelihood Possible Evidence D
Flutamide (Eulexin)

Theoretically, caffeine might increase the levels and adverse effects of flutamide.
In vitro evidence suggests that caffeine can inhibit the metabolism of flutamide. However, this effect has not been reported in humans.

Likelihood Probable Evidence D
Fluvoxamine (Luvox)

Theoretically, fluvoxamine might increase the levels and adverse effects of caffeine.
Fluvoxamine reduces caffeine metabolism.

Likelihood Probable Evidence D
Lithium

Abrupt caffeine withdrawal might increase the levels and adverse effects of lithium.
Caffeine has diuretic activity. When abruptly discontinued, caffeine may alter the clearance of lithium. There are two case reports of lithium tremor that worsened upon abrupt coffee withdrawal and 6 case reports of elevated serum lithium levels after reducing or eliminating caffeine intake. In one case, a male with schizoaffective disorder stabilized on lithium had an elevated lithium level after reducing his caffeine intake by 87%. At a later date, he increased his caffeine intake by 6-fold, resulting in a subtherapeutic lithium level and a recurrence of psychiatric symptoms.

Likelihood Probable Evidence D
Monoamine Oxidase Inhibitors (Maois)

Theoretically, concomitant use might increase the risk of a hypertensive crisis.
Caffeine has been shown to inhibit monoamine oxidase (MAO) A and B in laboratory studies. Concomitant intake of large amounts of caffeine with MAOIs might precipitate a hypertensive crisis. In a case report, a patient that consumed 10-12 cups of caffeinated coffee and took the MAOI tranylcypromine presented with severe hypertension. Hypertension was resolved after the patient switched to drinking decaffeinated coffee.

Likelihood Possible Evidence D
Nicotine

Theoretically, concomitant use might increase the risk of hypertension.
Concomitant use of caffeine and nicotine has been shown to have additive cardiovascular effects, including increased heart rate and blood pressure. Blood pressure was increased by 10.8/12.4 mmHg when the agents were used concomitantly.

Likelihood Probable Evidence B
Pentobarbital (Nembutal)

Theoretically, caffeine might decrease the effects of pentobarbital.
Caffeine might negate the hypnotic effects of pentobarbital.

Likelihood Possible Evidence B
Phenobarbital (Luminal)

Theoretically, caffeine might reduce the effects of phenobarbital and increase the risk for convulsions.
Animal research suggests that caffeine can decrease the anticonvulsant activity of phenobarbital. However, the exact mechanism of this interaction is unclear.

Likelihood Possible Evidence D
Phenylpropanolamine

Theoretically, phenylpropanolamine might increase the risk of hypertension, as well as the levels and adverse effects of caffeine.
Concomitant use of phenylpropanolamine and caffeine might cause an additive increase in blood pressure. Phenylpropanolamine also seems to increase caffeine serum levels.

Likelihood Probable Evidence B
Phenytoin (Dilantin)

Theoretically, caffeine might reduce the effects of phenytoin and increase the risk for convulsions.
Animal research suggests that caffeine can decrease the anticonvulsant activity of phenytoin. The effect does not seem to be related to the seizure threshold-lowering effects of caffeine. However, the exact mechanism of this interaction is unclear.

Likelihood Possible Evidence D
Pioglitazone (Actos)

Theoretically, caffeine might increase the levels and clinical effects of pioglitazone.
Animal research suggests that caffeine can modestly increase the maximum concentration, area under the curve, and half-life of pioglitazone, and also reduce its clearance. This increased the antidiabetic effects of pioglitazone. However, the exact mechanism of this interaction is unclear.

Likelihood Possible Evidence D
Quinolone Antibiotics

Theoretically, quinolone antibiotics might increase the levels and adverse effects of caffeine.
Quinolones (also called fluoroquinolones) can decrease caffeine clearance by inhibiting cytochrome P450 1A2 (CYP1A2) enzyme.

Likelihood Probable Evidence B
Riluzole (Rilutek)

Theoretically, concomitant use might increase the levels and adverse effects of both caffeine and riluzole.
Caffeine and riluzole are both metabolized by cytochrome P450 1A2 (CYP1A2), and concomitant use might reduce the metabolism of one or both agents.

Likelihood Possible Evidence D
Caffeine Matrix full monograph & all 41 interactions

Noble Orchid (Dendrobium nobile) stem extract3 drug types · 609 drugs

Anticonvulsants

The dendrobium constituent dendrobine is reported to have convulsant effects. Theoretically, combining dendrobium with anticonvulsant drugs might decrease drug effectiveness and increase the risk of seizure. Some anticonvulsant drugs include phenobarbital, primidone (Mysoline), valproic acid (Depakene), gabapentin (Neurontin), carbamazepine (Tegretol), phenytoin (Dilantin), and others.

Likelihood Possible Evidence D
Seizure Threshold Lowering Drugs

The dendrobium constituent dendrobine is reported to have convulsant effects. Theoretically, combining dendrobium with pro-convulsant drugs might increase the risk of seizure. Some drugs that lower the seizure threshold include anesthetics (propofol, others), antiarrhythmics (mexiletine), antibiotics (amphotericin, penicillin, cephalosporins, imipenem), antidepressants (bupropion, others), antihistamines (cyproheptadine, others), immunosuppressants (cyclosporine), narcotics (fentanyl, others), stimulants (methylphenidate), theophylline, and others.

Likelihood Possible Evidence D
Antihypertensive Drugs

The dendrobium constituent dendrobine is reported to have hypotensive effects. Theoretically, combining dendrobium with antihypertensive drugs might increase the risk of hypotension; use with caution.

Likelihood Possible Evidence D
Noble Orchid (Dendrobium nobile) stem extract full monograph & interactions

Octopamine HCl3 drug types · 352 drugs

Antihypertensive Drugs

In humans, octopamine 450-600 mg daily increases blood pressure in hypotensive patients. However, evidence from animal research suggests that octopamine can lower blood pressure. Theoretically, concomitant use of octopamine and antihypertensive drugs might potentiate and/or reduce the activity of antihypertensive drugs.
Some antihypertensive drugs include captopril (Capoten), enalapril (Vasotec), losartan (Cozaar), valsartan (Diovan), diltiazem (Cardizem), Amlodipine (Norvasc), hydrochlorothiazide (HydroDiuril), furosemide (Lasix), and many others.

Likelihood Possible Evidence B
Monoamine Oxidase Inhibitors (Maois)

Octopamine is metabolized by monoamine oxidase. Theoretically, concurrent use of MAOIs with octopamine might increase the effects and side effects of octopamine. Tell patients taking MAOIs to avoid using octopamine. Some MAOIs include phenelzine (Nardil), tranylcypromine (Parnate), and others.

Likelihood Possible Evidence D
Stimulant Drugs

Octopamine is thought to have stimulant effects. Theoretically, taking octopamine with other stimulant drugs might increase the risk of hypertension and adverse cardiovascular effects.
Some stimulant drugs include amphetamine, caffeine, diethylpropion (Tenuate), methylphenidate, phentermine (Ionamin), pseudoephedrine (Sudafed, others), and many others.

Likelihood Possible Evidence D
Octopamine HCl full monograph & interactions

N-Methyl L-Tyramine HCl2 drug types · 344 drugs

Antihypertensive Drugs

In animal research, N-methyltyramine increased blood pressure. This has not been shown in humans. Theoretically, concomitant use of N-methyltyramine and antihypertensive drugs might reduce the effects of antihypertensive drugs.
Some antihypertensive drugs include captopril (Capoten), enalapril (Vasotec), losartan (Cozaar), valsartan (Diovan), diltiazem (Cardizem), Amlodipine (Norvasc), hydrochlorothiazide (HydroDiuril), furosemide (Lasix), and many others.

Likelihood Possible Evidence D
Stimulant Drugs

N-methyltyramine is thought to have stimulant effects. However, this has not been shown in humans and laboratory research does not support the proposed stimulant effects of N-methyltyramine. Theoretically, taking N-methyltyramine with other stimulant drugs might increase the risk of hypertension and adverse cardiovascular effects. Until more is known, avoid taking N-methyltyramine with stimulant drugs.
Some stimulant drugs include amphetamine, caffeine, diethylpropion (Tenuate), methylphenidate, phentermine (Ionamin), pseudoephedrine (Sudafed, others), and many others.

Likelihood Possible Evidence D
N-Methyl L-Tyramine HCl full monograph & interactions

Agmatine Sulfate2 drug types · 258 drugs

Antidiabetes Drugs

Theoretically, agmatine might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal and in vitro research suggest that agmatine has mild hypoglycemic effects.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, agmatine might increase the risk of hypotension when taken with antihypertensive drugs.
Animal research suggests that agmatine can modestly decrease heart rate and blood pressure.

Likelihood Possible Evidence D
Agmatine Sulfate full monograph & interactions

L-Citrulline Aspartate2 drug types · 178 drugs

Antihypertensive Drugs

Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. However, a meta-analysis of 5 small clinical studies suggests that taking L-citrulline 3-6 grams daily for 1-8 weeks does not lower blood pressure when compared with control.

Likelihood Possible Evidence B
Phosphodiesterase-5 Inhibitors

Theoretically, concurrent use of phosphodiesterase-5 (PDE-5) inhibitors and L-citrulline might result in additive vasodilation.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. Theoretically, taking L-arginine with PDE-5 inhibitors might have additive vasodilatory and hypotensive effects. However, in studies evaluating the combined use of L-arginine and sildenafil for erectile dysfunction, hypotension was not reported.

Likelihood Possible Evidence D
L-Citrulline Aspartate full monograph & interactions

Pikatropin1 drug type · 3 drugs

Niacin

Picamilon is broken down into gamma-aminobutyric acid (GABA) and niacin after oral administration. Concomitant use with niacin might cause additive effects and adverse effects. However, this interaction is only theoretical and has not been documented in humans.

Likelihood Possible Evidence D
Pikatropin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Mr Hyde Intense Energy Pre Workout Fruit Punch, from the product label.

PS ProSupps

See all PS ProSupps products
Name
PROSUPPS USA, LLC.
Street Address
601 Century Pkwy. Ste. 300
City
Allen
State
TX
ZipCode
75013
Web Address
www.prosupps.com
Pharmacist Counseling Corner

Mr Hyde Intense Energy Pre Workout Fruit Punch by PS ProSupps: Common Questions

Does Mr Hyde Intense Energy Pre Workout Fruit Punch by PS ProSupps interact with any medications?
Yes. Based on its ingredients, Mr Hyde Intense Energy Pre Workout Fruit Punch has a known interaction with 1,443 medications, including 18 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Mr Hyde Intense Energy Pre Workout Fruit Punch contains 11 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this give me the tingling sensation I've heard about in pre-workouts?
Yes, likely. The beta-alanine (CarnoSyn) in this product commonly causes a harmless pins-and-needles feeling called paresthesia, usually starting on your scalp within 20 minutes of taking it and lasting about an hour. The intensity depends on the dose — it's mild at low doses and more noticeable at higher ones.
How much caffeine is actually in this?
The product facts we have don't specify the exact total amount of caffeine per serving, though it contains three caffeine sources: Caffeine Anhydrous, Caffeine Citrate, and Infinergy. We'd recommend checking the label or contacting the manufacturer for the precise dose, especially if you're sensitive to caffeine or take other caffeine-containing products.
Is this safe if I have high blood pressure?
No, not without talking to your doctor first. This product contains multiple stimulant ingredients — caffeine, octopamine, bitter orange, and others — all of which can raise blood pressure. If you have hypertension or take blood pressure medications, you need to discuss this with your healthcare provider before using it.
Can I take this while pregnant or breastfeeding?
The safety data advises against it. Caffeine has possible safety concerns in pregnancy at high doses, and beta-alanine, creatine, octopamine, agmatine, L-citrulline, picamilon, dendrobium, and bitter orange all lack sufficient safety information for pregnancy or breastfeeding. Talk with your doctor or pharmacist for personalized advice.
What are the common side effects I might notice?
From caffeine, expect possible anxiety, insomnia, headache, nausea, tremors, or restlessness — especially if you're not used to high caffeine doses. Beta-alanine typically causes harmless tingling and flushing. Creatine may cause dehydration, diarrhea, or water retention. Gastrointestinal upset (heartburn, stomach discomfort) is possible from L-citrulline or agmatine.
Why is this product more complicated than other pre-workouts?
It combines multiple active ingredients — three different caffeine sources plus octopamine, bitter orange, agmatine, and others — all with stimulant or blood-vessel-affecting effects. That means more interactions with more medications and a higher overall stimulant load, which is why it needs careful vetting if you take any prescriptions.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Mr Hyde Intense Energy Pre Workout Fruit Punch is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Mr Hyde Intense Energy Pre Workout Fruit Punch label
Go deeper

The Full Monographs Behind Mr Hyde Intense Energy Pre Workout Fruit Punch’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Caffeine

Interacts with 655 drugs

Caffeine is a natural stimulant found in coffee, tea, and many other plants and products. In moderate amounts it can boost alertness and reduce tiredness for most healthy adults, but too muc...

Read the full Caffeine monograph → Herb & supplement monograph

Beta-alanine

Beta-alanine is an amino acid taken mostly by athletes to raise muscle carnosine, which may help buffer acid and reduce fatigue during short, high-intensity exercise. The evidence is moderat...

Read the full Beta-alanine monograph → Herb & supplement monograph

Creatine

Creatine is one of the most studied sports supplements, with solid evidence that it can boost strength and performance during short, high-intensity activities like weightlifting and sprintin...

Read the full Creatine monograph → Herb & supplement monograph

L-citrulline

Interacts with 178 drugs

L-citrulline is an amino acid that the body turns into L-arginine to help make nitric oxide, which relaxes blood vessels and may improve blood flow. It is popular for exercise performance an...

Read the full L-citrulline monograph → Herb & supplement monograph

Agmatine

Interacts with 258 drugs

Agmatine is a compound your body makes from the amino acid arginine, and it is sold mainly as a workout and 'pump' supplement. Human evidence for most of its claimed benefits is limited and...

Read the full Agmatine monograph → Herb & supplement monograph

Octopamine

Interacts with 352 drugs

Octopamine is a stimulant-like compound found in small amounts in some plants (such as bitter orange) and made naturally in the body. It is marketed mostly in weight-loss and sports suppleme...

Read the full Octopamine monograph → Herb & supplement monograph

N-methyltyramine

Interacts with 344 drugs

N-methyltyramine is a natural compound related to tyramine that is found in bitter orange, barley, and other plants, and it is often added to weight-loss and pre-workout supplements. Solid h...

Read the full N-methyltyramine monograph → Herb & supplement monograph

Picamilon

Interacts with 3 drugs

Picamilon is a synthetic compound made by joining niacin (vitamin B3) and GABA, originally developed in the former Soviet Union as a prescription drug. It is sold in some countries as a supp...

Read the full Picamilon monograph → Herb & supplement monograph

Dendrobium

Interacts with 609 drugs

Dendrobium is a group of orchids long used in traditional Chinese medicine, often to moisten the body and as a general tonic. Human evidence for its modern health claims is very limited, so...

Read the full Dendrobium monograph → Herb & supplement monograph

Bitter Orange

Interacts with 957 drugs

Bitter orange is a citrus fruit whose extracts contain synephrine, a mild stimulant often added to weight-loss and energy supplements. Evidence that it works for weight loss or performance i...

Read the full Bitter Orange monograph →
Sources

Sources & How We Checked

Mr Hyde Intense Energy Pre Workout Fruit Punch's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 407 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Caffeine 236 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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