Interactions on record — worth a quick check against your medications. Based on 2 of 4 ingredients. Check your meds →
Dietary supplement

Natadrol Ingredients & Drug Interactions

by LG Sciences

Natadrol label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Natadrol against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Natadrol is a dietary supplement by LG Sciences with 4 active ingredients. Its ingredients are commonly taken for immune support, fever, blood sugar support.Based on those ingredients, 612 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Androgenic Fraction, Anabolic Factor. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Natadrol by LG Sciences

Ask about any prescription or over-the-counter medication and we check it for interactions with Natadrol by LG Sciences — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Natadrol by LG Sciences

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 5 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label doesn't break down how much of each component you get.
  • “pSARM CoFactors” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.
  • “Androgenic Fraction” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.

Natadrol contains five active ingredients delivered as proprietary blends and complexes: Curculigo Orchioides, pSARM CoFactors, Hibiscus Rosa-Sinensis, Nata-D Complex, Tinospora Cordifolia, and Cissus Quadrangularis (alongside an Androgenic Fraction and Anabolic Factor). The product also contains inactive ingredients — microcrystalline cellulose (a binder), magnesium stearate (a lubricant), and colorants (FD&C Blue #1, FD&C Red #40, and titanium dioxide).

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Moderate

Some clinical evidence supports its ingredients for:

  • Diabetes via Tinospora Cordifolia Possibly Effective
  • Obesity via Cissus Quadrangularis Possibly Effective
Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Diabetes — rated "Possibly Effective" (Tinospora Cordifolia) (Natural Medicines).
  • On file: Obesity — rated "Possibly Effective" (Cissus Quadrangularis) (Natural Medicines).

Evidence for Natadrol's active ingredients is mixed. Tinospora Cordifolia is possibly effective for type 2 diabetes based on clinical research showing it can lower fasting blood glucose.

Cissus Quadrangularis is possibly effective for obesity. For the other uses these ingredients are traditionally claimed to support — hay fever, asthma, athletic performance, cancer, and hepatitis (for Tinospora Cordifolia) and high cholesterol, bone loss, and epilepsy (for Cissus Quadrangularis) — the evidence is insufficient to establish whether they work.

We hold no effectiveness data for the other ingredients in this product.

The evidence, ingredient by ingredient Tinospora Cordifolia Cissus Quadrangularis

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

When taken by mouth, both Tinospora Cordifolia and Cissus Quadrangularis are generally well tolerated in the short term. Tinospora Cordifolia most commonly causes headache and nasal pain, though liver injury has been reported rarely but seriously — case reports document autoimmune hepatitis, acute hepatitis, worsening chronic liver disease, and acute liver failure in 49 patients after 42–90 days of use, with 2 requiring transplant and 4 deaths.

Cissus Quadrangularis may cause headache, insomnia, flatulence, diarrhea, gastritis, or dry mouth at rates similar to placebo, and long-term safety isn't well studied. Safety has not been established in pregnancy for either ingredient — avoid this product if you're pregnant.

There isn't enough reliable safety data to use it while breastfeeding either.

Side effects, ingredient by ingredient Tinospora Cordifolia Cissus Quadrangularis

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Tinospora Cordifolia, Cissus Quadrangularis.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 612 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Natadrol, check with your doctor or pharmacist if you take antidiabetes medications (risk of low blood sugar is Moderate). Also confirm any drugs processed by your liver's CYP2D6, CYP2C19, CYP1A2, or CYP2C9 systems, immunosuppressants, or any medication that could be affected by increased blood levels.

Use the search tool on this page to verify your exact drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Natadrol may be considered by those looking to support blood sugar or weight management, but it carries a moderate risk of increasing blood sugar medications' effects and altering how your liver processes several other drug types. If you take any medications — especially for diabetes, blood pressure, depression, or immunosuppression — talk with your doctor or pharmacist before starting.

Avoid this product if you're pregnant or breastfeeding, and be aware of rare but serious liver injury reports with Tinospora Cordifolia.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2014.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Natadrol, straight from the product label.

Brand LG Sciences
Net contents 120 Capsule(s)
Market status On market
Date entered into DSLD Jun 25, 2014
DSLD ID 34361
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Natadrol by LG Sciences, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
4 Capsule(s)
Maximum serving Sizes:
6 Capsule(s)
Servings per container
120
IngredientAmount% DV
Proprietary Blend0 NP--
Curculigo Orchioides0 NP--
pSARM CoFactors0 NP--
Hibiscus Rosa-Sinensis0 NP--
Nata-D Complex550 mg--
Androgenic Fraction0 NP--
Tinospora Cordifolia0 NP--
Anabolic Factor0 NP--
Cissus Quadrangularis0 NP--

Other ingredients: Microcrystallline Cellulose, Magnesium Stearate, FD&C Blue Dye #1, FD&C Red Dye #40, Titanium Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Discontinue two weeks prior to surgery, do not exceed recommended dosage.

Do not take if you are pregnant or nursing.

WARNING: KEEP OUT OF REACH OF CHILDREN Product use should be strictly limited to healthy adults above the age of 18.

ALLERGEN WARNING: Made in a facility that also processes egg, dairy, soy, peanut, tree nuts, fish, crustaceans/shellfish, wheat, and barley products.

Discontinue use if there are any side affects.

Always consult your health care professional before use especially if you are taking any prescriptions drugs, beginning any new diet and exercise program, or have any health concerns or pre-existing conditions.

Do not use this product if you are at risk for heart disease, high blood pressure, heart, kidney, thyroid, psychiatric disease, difficulty in urinating, prostate, enlargement, anxiety, depression, seizure disorder or stroke.

General Statements

Product efficacy depends on proper diet and exercise.

Extracted From: whole plant, leaf, flower and whole plant respectively

Formulation

NON-STEROIDAL ANDROGEN

FDA Statement of Identity

DIETARY SUPPLEMENT

Suggested/Recommended/Usage/Directions

RECOMMENDATIONS: As a dietary supplement take 4-6 capsules per day in divided doses with your meals. Use for a 4-8 week program.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Natadrol by LG Sciences label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Natadrol label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Natadrol by LG Sciences

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size4 Capsule(s) Dosage formCapsule Servings per container120 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

0 NP per serving

Other (inactive) ingredients: Microcrystallline Cellulose, Magnesium Stearate, FD&C Blue Dye #1, FD&C Red Dye #40, Titanium Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Natadrol by LG Sciences Drug Interactions

Want to check YOUR meds against Natadrol?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
612Drugs
612 Moderate

Ingredients driving the most interactions

Androgenic Fraction 612
Anabolic Factor 86

Individual Drug Interactions

The ingredients in Natadrol interact with 612 drugs. Click any drug to see the details.

2 of the 4 ingredients in Natadrol interact with drugs. Each result below shows which ingredient is responsible. Androgenic Fraction Anabolic Factor

Each ingredient & the kinds of drugs it affects

For each ingredient in Natadrol with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Androgenic Fraction6 drug types · 612 drugs

Antidiabetes Drugs

Theoretically, Tinospora cordifolia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Clinical research in adults with type 2 diabetes shows that Tinospora cordifolia can reduce fasting blood glucose and glycated hemoglobin. Additionally, animal research shows that Tinospora cordifolia has hypoglycemic effects.

Likelihood Possible Evidence A
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP1A2.
In vitro research shows that Tinospora cordifolia extract inhibits CYP1A2 at high concentrations. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP2C19.
In vitro research shows that Tinospora cordifolia extract inhibits CYP2C19 at high concentrations. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP2C9.
In vitro research shows that Tinospora cordifolia extract inhibits CYP2C9. Animal research shows that Tinospora cordifolia extract 400 mg/kg twice daily for 14 days reduces the clearance and increases plasma levels of glyburide, a CYP2C9 substrate. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP2D6.
In vitro research shows that Tinospora cordifolia extract inhibits CYP2D6 at high concentrations. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, Tinospora cordifolia might reduce the effectiveness of immunosuppressants.
In vitro and animal research shows that Tinospora cordifolia has immunostimulant effects.

Likelihood Possible Evidence D
Androgenic Fraction full monograph & interactions

Anabolic Factor1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, Cissus quadrangularis might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Small clinical studies suggest that Cissus quadrangularis might reduce fasting blood glucose in individuals with overweight or obesity.

Likelihood Possible Evidence D
Anabolic Factor full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Natadrol, from the product label.

LG Sciences

See all LG Sciences products
Name
LG Sciences
Pharmacist Counseling Corner

Natadrol by LG Sciences: Common Questions

Does Natadrol by LG Sciences interact with any medications?
Yes. Based on its ingredients, Natadrol has a known interaction with 612 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Natadrol contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does Tinospora Cordifolia in this product really lower blood sugar?
Clinical research in adults with type 2 diabetes shows Tinospora Cordifolia can reduce fasting blood glucose and glycated hemoglobin, so it's rated possibly effective for diabetes. If you have diabetes or prediabetes, talk with your doctor before adding this product — especially if you're on diabetes medications, since it may increase their effect and lower your blood sugar too much.
What are the common side effects?
Tinospora Cordifolia most commonly causes headache and nasal pain. Cissus Quadrangularis may cause headache, insomnia, flatulence, diarrhea, gastritis, or dry mouth — though these occurred at rates similar to placebo in studies. Both are generally well tolerated by mouth, but rare liver injury has been reported with Tinospora Cordifolia, so stop and contact your doctor if you develop jaundice, dark urine, or upper right abdominal pain.
Can I take this while pregnant or breastfeeding?
No — safety has not been established in pregnancy, so it should be avoided. There also isn't enough reliable safety data to use it while breastfeeding. Talk with your doctor or pharmacist if you're planning to become pregnant or are nursing.
What is Cissus Quadrangularis supposed to do?
Cissus Quadrangularis is rated possibly effective for obesity based on small clinical studies suggesting it may reduce fasting blood glucose in people with overweight or obesity. For other uses like high cholesterol, bone loss, and epilepsy, the evidence is insufficient to know whether it works.
What ingredients in Natadrol are we unsure about?
We hold no interaction or safety data for Curculigo Orchioides, Hibiscus Rosa-Sinensis, and Nata-D Complex, so we cannot assess whether they interact with medications or what their side effects may be. Your pharmacist or doctor can help you weigh the unknowns against what you're hoping to achieve.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Natadrol label
Go deeper

The Full Monographs Behind Natadrol’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Tinospora Cordifolia

Interacts with 612 drugs

Tinospora cordifolia, known as Guduchi or Giloy in Ayurvedic medicine, is a climbing plant traditionally used to support immunity and treat fevers. Early laboratory and small human studies s...

Read the full Tinospora Cordifolia monograph → Herb & supplement monograph

Cissus Quadrangularis

Interacts with 86 drugs

Cissus quadrangularis is a traditional vine used mainly for bone health, joint pain, and weight management. Most of the supporting evidence comes from animal studies and a small number of hu...

Read the full Cissus Quadrangularis monograph →
Sources

Sources & How We Checked

Natadrol's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 21 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Tinospora Cordifolia 16 references
  1. Stanely Mainzen Prince P, Menon VP. Hypoglycaemic and hypolipidaemic action of alcohol extract of Tinospora cordifolia roots in chemical induced diabetes in rats. Phytother Res 2003;17:410-3.
  2. Grover JK, Vats V, Rathi SS. Anti-hyperglycemic effect of Eugenia jambolana and Tinospora cordifolia in experimental diabetes and their effects on key metabolic enzymes involved in carbohydrate metabolism. J Ethnopharmacol 2000;73:461-70. PubMed
  3. Manjrekar PN, Jolly CI, Narayanan S. Comparative studies of the immunomodulatory activity of Tinospora cordifolia and Tinospora sinensis. Fitoterapia 2000;71:254-7. PubMed
  4. Prince PS, Menon VP. Antioxidant activity of Tinospora cordifolia roots in experimental diabetes. J Ethnopharmacol 1999;65:277-81. PubMed
  5. Stanely Mainzen Prince P, Menon VP, Gunasekaran G. Hypolipidaemic action of Tinospora cordifolia roots in alloxan diabetic rats. J Ethnopharmacol 1999;64:53-7. PubMed
  6. Badar VA, Thawani VR, Wakode PT, et al. Efficacy of Tinospora cordifolia in allergic rhinitis. J Ethnopharmacol 2005;96:445-9. PubMed
  7. Kapil A, Sharma S. Immunopotentiating compounds from Tinospora cordifolia. J Ethnopharmacol 1997;58:89-95. PubMed
  8. Nair PK, Rodriguez S, Ramachandran R, et al. Immune stimulating properties of a novel polysaccharide from the medicinal plant Tinospora cordifolia. Int Immunopharmacol 2004;4:1645-59. PubMed
  9. Castillo AL, Osi MO, Ramos JD, De Francia JL, Dujunco MU, Quilala PF. Efficacy and safety of Tinospora cordifolia lotion in Sarcoptes scabiei var hominis-infected pediatric patients: A single blind, randomized controlled trial. J Pharmacol Pharmacother. 2 PubMed
  10. Sahu R, Ahmed T, Sangana R, Punde R, Subudhi BB. Effect of Tinospora cordifolia aqua-alcoholic extract on pharmacokinetic of glibenclamide in rat: an herb-drug interaction study. J Pharm Biomed Anal. 2018;151:310-6. doi: 10.1016/j.jpba.2018.01.010. PubMed
  11. Patial V, Katoch S, Chhimwal J, Singh PP, Suresh PS, Padwad Y. Tinospora cordifolia activates PPAR? pathway and mitigates glomerular and tubular cell injury in diabetic kidney disease. Phytomedicine 2021;91:153663. PubMed
  12. Kulkarni AV, Hanchanale P, Prakash V, et al. Tinospora Cordifolia (Giloy)-Induced Liver Injury During the COVID-19 Pandemic-Multicenter Nationwide Study From India. Hepatol Commun 2022;6(6):1289-1300. PubMed
  13. Nagral A, Adhyaru K, Rudra OS, Gharat A, Bhandare S. Herbal Immune Booster-Induced Liver Injury in the COVID-19 Pandemic - A Case Series. J Clin Exp Hepatol. 2021;11(6):732-738. PubMed
  14. Chattopadhyay K, Wang H, Kaur J, et al. Effectiveness and Safety of Ayurvedic Medicines in Type 2 Diabetes Mellitus Management: A Systematic Review and Meta-Analysis. Front Pharmacol. 2022;13:821810. Published 2022 Jun 8. PubMed
  15. Nnamani I, Tolu-Akinnawo O, Dufera RR, Akintunde A, Maliakkal B. Tinospora cordifolia (Guduchi/Giloy)-Induced Liver Injury: A Case Review. Cureus 2023;15(5):e39793. PubMed
  16. May K, Jeitler M, Murthy V, Stapelfeldt E, Kessler CS. A Case Report of Acute Hepatitis Involving the Medicinal Herb Tinospora cordifolia Along with Other Variables. J Integr Complement Med 2023;29(5):327-333.

See these in context on the Tinospora Cordifolia monograph →

Cissus Quadrangularis 5 references
  1. Oben J, Kuate D, Agbor G, et al. The use of a Cissus quadrangularis formulation in the management of weight loss and metabolic syndrome. Lipids Health Dis 2006, 5:24.
  2. Oben JE, Ngondi JL, Momo CN, et al. The use of Cissus quadrangularis/Irvingia gabonensis combination in the management of weight loss: a double-blind placebo-controlled study. Lipids Health Dis 2008;7:12.
  3. Panpimanmas, S., Sithipongsri, S., Sukdanon, C., and Manmee, C. Experimental comparative study of the efficacy and side effects of Cissus quadrangularis L. (Vitaceae) to Daflon (Servier) and placebo in the treatment of acute hemorrhoids. J Med Assoc.Thai
  4. Nash R, Azantsa B, Kuate D, Singh H, Oben J. The use of a stem and leaf aqueous extract of Cissus quadrangularis (CQR-300) to reduce body fat and other components of metabolic syndrome in overweight participants. J Altern Complement Med. 2019;25(1):98-106
  5. Benjawan S, Nimitphong H, Tragulpiankit P, Musigavong O, Prathanturarug S, Pathomwichaiwat T. The effect of Cissus quadrangularis L. on delaying bone loss in postmenopausal women with osteopenia: A randomized placebo-controlled trial. Phytomedicine 2022;1 PubMed

See these in context on the Cissus Quadrangularis monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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