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Dietary supplement

Natural Appetite Control Ingredients & Drug Interactions

by Life Extension

Natural Appetite Control label
See full label image
Softgel Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Natural Appetite Control against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Natural Appetite Control is a dietary supplement by Life Extension with 1 active ingredient. Its ingredients are commonly taken for appetite control and weight management, heart and cholesterol health, general nutrition and energy.Based on those ingredients, 172 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Korean Pine nut seed Oil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Natural Appetite Control by Life Extension

Ask about any prescription or over-the-counter medication and we check it for interactions with Natural Appetite Control by Life Extension — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Natural Appetite Control by Life Extension

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This supplement contains one active ingredient: Korean pine nut seed oil. It's derived from the seeds of the Korean pine tree and is the sole component designed to address appetite control.

The softgel capsule also contains inactive ingredients—gelatin, glycerin, purified water, and annatto color—which serve as the capsule shell and base.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: appetite control and weight management.
  • We looked for evidence on: Appetite suppression, Hunger control, Weight management, Obesity.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

The evidence for Korean pine nut oil isn't established in the data we hold. Studies have rated its effectiveness for dyslipidemia (abnormal cholesterol levels) as insufficient reliable evidence, meaning we don't have enough quality research to say whether it works.

We found no effectiveness information on file regarding appetite control specifically.

The evidence, ingredient by ingredient Korean Pine

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 0 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Pine nuts and pine nut oil used as food are generally well tolerated, but concentrated supplements like this one are far less studied. Our safety notes caution that while food amounts are fine, the safety of concentrated supplements remains unknown, so use caution if you decide to take it.

No adverse effects were reported in our data. Pregnancy and lactation data is not on file for this ingredient, so talk with your doctor or pharmacist before using it if you're pregnant or breastfeeding.

Side effects, ingredient by ingredient Korean Pine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Korean Pine.
  • The most serious interaction on file is rated Moderate.
  • For scale: 172 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take any medication to lower blood pressure—whether prescription or over-the-counter—check it in the search tool on this page. Altogether, these interactions span 170 individual medications.

Korean pine nut seed oil may add to the blood pressure-lowering effect and cause your blood pressure to drop too low.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and some safety-information gaps remain.

If you're looking for an appetite-control supplement with minimal ingredient complexity, this single-ingredient product may appeal to you. However, the evidence for its effectiveness isn't established, and the safety profile for concentrated supplements isn't well studied.

Anyone taking blood pressure medication should check their exact drugs with the tool below. Talk to your pharmacist if you have questions about whether it's right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 24, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Natural Appetite Control, straight from the product label.

Brand Life Extension
Barcode (UPC) 737870891093
Net contents 90 Softgel(s)
Market status On market
Date entered into DSLD Jun 24, 2016
DSLD ID 62056
Product type Botanical
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Natural Appetite Control by Life Extension, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Softgel(s)
Maximum serving Sizes:
3 Softgel(s)
Servings per container
30
UPC/BARCODE
737870891093
IngredientAmount% DV
Calories30 Calorie(s)--
Calories from Fat30 Calorie(s)--
Saturated Fat0 Gram(s)--
Cholesterol0 mg--
Total Fat3 Gram(s)5%
Trans Fat0 Gram(s)--
Korean Pine nut seed Oil3000 mg--

Other ingredients: Gelatin, Glycerin, purified Water, Annatto color

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Scan for product info

Promotes sensible eating and food intake–naturally

To report a serious adverse event or obtain product information, contact 1-866-280-2852.

Suggested/Recommended/Usage/Directions

Read the entire label and follow the directions carefully prior to use. Directions: To reduce meal size, take three (3) softgels 30-60 minutes before the meal with the highest caloric content, or as recommended by a healthcare practitioner. To reduce snacking, you can take three (3) softgels between meals. Do not exceed six (6) softgels daily. The best time to use this product may be in the evening to reduce food intake before bedtime. This supplement should be taken in conjunction with a healthy diet and regular exercise program. Results may vary.

Formula

Korean pine nuts contain the highest concentration of pinolenic acid, which helps to suppress appetite by stimulating the appetite controlling hormones cholecystokinin (CCK) and glucagon-like peptide 1 (GLP-1) in the gastrointestinal tract.

Contains tree nuts (pine).

Formulation

Natural Appetite Control is a stimulant-free method for controlling appetite and excess hunger that can hamper the ability to sustain a long-term weight management program.

Stimulant free

Precautions

Warnings: - Keep out of reach of children.

- Do not exceed recommended dose. - Do not purchase if outer seal is broken or damaged.

- When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

Contains tree nuts (pine).

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General

Q00891E

FDA Statement of Identity

Dietary Supplement

Storage

Store tightly closed in a cool, dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Natural Appetite Control by Life Extension label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Natural Appetite Control label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Natural Appetite Control by Life Extension

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size3 Softgel(s) Dosage formSoftgel Capsule Servings per container30 Amounts shown are per serving.

Korean Pine nut seed Oil

Interacts with
172 drugs
3000 mg per serving Form: Pinolenic Acid

Korean Pine is best known as the source of edible pine nuts and pine nut oil, which are nutritious foods rich in healthy fats. While some early resear...

Korean Pine nut seed Oil monograph & interactions

Other (inactive) ingredients: Gelatin, Glycerin, Purified Water, Annatto color. These complete the product’s ingredient list but are not active constituents.

Interaction report

Natural Appetite Control by Life Extension Drug Interactions

Want to check YOUR meds against Natural Appetite Control?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
172Drugs
172 Moderate

Ingredients driving the most interactions

Korean Pine nut seed Oil 172

Individual Drug Interactions

The ingredients in Natural Appetite Control interact with 172 drugs. Click any drug to see the details.

1 of the 1 ingredient in Natural Appetite Control interact with drugs. Each result below shows which ingredient is responsible. Korean Pine nut seed Oil

Each ingredient & the kinds of drugs it affects

For each ingredient in Natural Appetite Control with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Korean Pine nut seed Oil1 drug type · 172 drugs

Antihypertensive Drugs

Animal research shows that Korean pine nut oil reduces blood pressure in spontaneously hypertensive rats. Theoretically, Korean pine may increase the risk of hypotension when used in combination with drugs that lower blood pressure.

Likelihood Possible Evidence D
Korean Pine nut seed Oil full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Natural Appetite Control, from the product label.

Life Extension

See all Life Extension products
Name
Quality Supplements and Vitamins, Inc.
City
Ft. Lauderdale
State
FL
ZipCode
33309
Phone Number
866-280-2852
Web Address
www.lef.org
Pharmacist Counseling Corner

Natural Appetite Control by Life Extension: Common Questions

Does Natural Appetite Control by Life Extension interact with any medications?
Yes. Based on its ingredients, Natural Appetite Control has a known interaction with 172 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Natural Appetite Control contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this actually help with appetite control?
We don't have effectiveness data on file for appetite control specifically. The ingredient has been studied for cholesterol levels, but not with enough quality research to say whether it works for that either.
Is Korean pine nut oil safe?
When eaten as food, pine nuts and their oil are generally well tolerated. But this is a concentrated supplement, and concentrated extracts haven't been studied much, so safety is uncertain. Use caution, and talk to your pharmacist if you have concerns.
Can I take this if I'm pregnant or breastfeeding?
We don't have pregnancy or lactation safety data on file for Korean pine nut oil. Talk with your doctor or pharmacist—they can give you personalized advice based on your health history.
What are the inactive ingredients?
The softgel capsule contains gelatin, glycerin, purified water, and annatto color. These are the shell and base—not the active ingredient.
Will this interact with my blood pressure medicine?
Possibly. Animal research suggests Korean pine nut oil lowers blood pressure, so combining it with blood pressure medication could make your pressure drop too low. Use the medication search tool on this page to check your exact drug, and talk to your pharmacist before starting.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Natural Appetite Control is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Natural Appetite Control label
Go deeper

The Full Monographs Behind Natural Appetite Control’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Korean Pine

Interacts with 172 drugs

Korean Pine is best known as the source of edible pine nuts and pine nut oil, which are nutritious foods rich in healthy fats. While some early research looks at pine nut oil for appetite an...

Read the full Korean Pine monograph →
Sources

Sources & How We Checked

Natural Appetite Control's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 2 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Korean Pine 2 references
  1. Sugano M, Ikeda I, Wakamatsu K, Oka T. Influence of Korean pine (Pinus koraiensis)-seed oil containing cis-5,cis-9,cis-12-octadecatrienoic acid on polyunsaturated fatty acid metabolism, eicosanoid production and blood pressure of rats. Br J Nutr 1994;72(5
  2. Lee H, Kim H, Choue R, Lim H. Evaluation of the Effects of Pinus koraiensis Needle Extracts on Serum Lipid and Oxidative Stress in Adults with Borderline Dyslipidemia: A Randomized, Double-Blind, and Placebo-Controlled Clinical Trial. Evid Based Complemen

See these in context on the Korean Pine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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