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Dietary supplement

Neem Leaf 3X Concentration Ingredients & Drug Interactions

by NeemAura

Neem Leaf 3X Concentration label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Neem Leaf 3X Concentration against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Neem Leaf 3X Concentration is a dietary supplement by NeemAura with 1 active ingredient. Its ingredients are commonly taken for skin conditions, dental and gum health, antimicrobial and antiparasitic.Based on those ingredients, 1,013 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Neem leaf liquid extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Neem Leaf 3X Concentration by NeemAura

Ask about any prescription or over-the-counter medication and we check it for interactions with Neem Leaf 3X Concentration by NeemAura — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Neem Leaf 3X Concentration by NeemAura

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: neem leaf liquid extract at a 3X concentration. Neem is derived from the neem tree, and the leaf extract is what's being used here as the therapeutic component.

The liquid is formulated with vegetable glycerin, deionized water, and grain alcohol as inactive ingredients (the carriers and preservatives that make it shelf-stable and easy to dose).

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Neem's overall clinical evidence instead.

Moderate

Some clinical evidence supports Neem for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Dental plaque — rated "Possibly Effective" (Natural Medicines).
  • On file: Gingivitis — rated "Possibly Effective" (Natural Medicines).
  • On file: Lice — rated "Possibly Effective" (Natural Medicines).

The evidence supports neem leaf extract as possibly effective for gingivitis and dental plaque when used for oral health, and possibly effective against head lice. For acne and tungiasis, the evidence available isn't reliable enough to say whether it works.

If you're considering this for gingivitis or plaque, the data suggests it may help, but talk with your dentist about how it might fit into your routine.

The evidence, ingredient by ingredient Neem

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Neem leaf preparations are generally well tolerated when taken by mouth in the short term for most adults, though rigorous safety testing hasn't been done. Topically, it's also well tolerated.

However, neem oil (not the leaf extract in this product) can be toxic if swallowed, and in children, oral neem oil has caused serious problems. Rare serious effects reported with neem leaf itself include cardiac issues and kidney damage in adults.

One case showed that very high daily amounts of neem tea caused hemolysis (breakdown of red blood cells) in someone with a specific enzyme deficiency; symptoms resolved after stopping. Because neem may affect fertility and pregnancy, the safety data advises against use during pregnancy.

There isn't enough reliable information to recommend it while breastfeeding either.

Side effects, ingredient by ingredient Neem

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Neem.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 1,014 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, double-check with your pharmacist or doctor if you're on any of the following: antidiabetes medications (metformin, insulin, sulfonylureas, others) because neem can lower blood sugar; blood-pressure drugs, heart medications, or cancer treatments processed through CYP1A2, CYP3A4, CYP2C9, or CYP2C8 (your pharmacist can tell you which ones fit that category); medications that rely on P-glycoprotein transport, such as some cancer drugs and certain heart and immune medications; or immunosuppressants after transplant or for autoimmune disease.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Neem leaf extract is possibly effective for gum disease and lice, but it interacts with a large number of medications—especially those processed by your liver and kidney, blood-sugar-lowering drugs, and immune-suppressing medications. If you take any prescription drugs, diabetes medication, or immunosuppressants, check your exact medications with the tool on this page before starting.

Talk with your doctor or pharmacist about whether this product is right for you, especially if you're pregnant, breastfeeding, or have a history of heart problems or kidney disease.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 22, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Neem Leaf 3X Concentration, straight from the product label.

Brand NeemAura
Barcode (UPC) 786648070062
Net contents 1 Fluid Ounce(s); 29.57 mL
Market status On market
Date entered into DSLD May 22, 2020
DSLD ID 221380
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Children 4 or More Years of Age, Vegetarian, Adult (18 - 50 Years), Organic
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Neem Leaf 3X Concentration by NeemAura, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.166 mL
Maximum serving Sizes:
0.166 mL
Servings per container
178
UPC/BARCODE
786648070062
IngredientAmount% DV
Neem leaf liquid extract0.166 mL--

Other ingredients: Vegetable Glycerin, deionized Water, Grain Alcohol

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Neem is considered to be one of the most generally useful herbs in the world, with a history of use in the Ayurvedic tradition going back almost 5000 years. Modern scientific research is validating many of the traditional uses of this herb. Neem helps support proper immune system function and as a part of a diet to maintain healthy blood sugar levels already within the normal range.

Liquid herbal extract Azadirachta indica

Formulation

Cruelty free

No animal ingredients

No irradiated herbs

3X concentration compared to our Regular Strength

To help support the immune system and as a part of a diet to maintain healthy blood sugar levels already within the normal range

Dry herb to menstruum ratio 1:5

Certified Organic by International Certifications Services, Inc.

Cruelty Free International

Suggested/Recommended/Usage/Directions

Suggested Use: Shake well before using. As a dietary supplement take 5 drops, 1-3x per day.

Precautions

Warning: Keep out of reach of children. If you are being treated for any medical condition, taking medication, pregnant or lactating, or children under 2 years of age, consult your healthcare provider before use.

If you are being treated for any medical condition, taking medication, pregnant or lactating, or children under 2 years of age, consult your healthcare provider before use.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

USDA Organic

Made in USA

Brand IP Statement(s)

2018 Dist. by: Lotus Brands, Inc.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Neem Leaf 3X Concentration by NeemAura label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Neem Leaf 3X Concentration label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Neem Leaf 3X Concentration by NeemAura

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size0.166 mL Dosage formLiquid Servings per container178 Amounts shown are per serving.

Neem leaf liquid extract

Interacts with
1,013 drugs
0.166 mL per serving

Neem is a tree from India used for centuries in traditional medicine, especially for skin, dental, and antimicrobial purposes. Some small studies are...

Neem leaf liquid extract monograph & interactions

Other (inactive) ingredients: Vegetable Glycerin, Deionized Water, Grain Alcohol. These complete the product’s ingredient list but are not active constituents.

Interaction report

Neem Leaf 3X Concentration by NeemAura Drug Interactions

Want to check YOUR meds against Neem Leaf 3X Concentration?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,013Drugs
1,013 Moderate

Ingredients driving the most interactions

Neem leaf liquid extract 1,013

Individual Drug Interactions

The ingredients in Neem Leaf 3X Concentration interact with 1,013 drugs. Click any drug to see the details.

1 of the 1 ingredient in Neem Leaf 3X Concentration interact with drugs. Each result below shows which ingredient is responsible. Neem leaf liquid extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Neem Leaf 3X Concentration with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Neem leaf liquid extract7 drug types · 1,013 drugs

Antidiabetes Drugs

Neem might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Some clinical research shows that neem can lower blood glucose levels in adults with type 2 diabetes, including those already taking metformin.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, neem leaf extract might increase the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that neem leaf extract inhibits CYP1A2 enzymes. So far, this reaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C8 (Cyp2C8) Substrates

Theoretically, neem leaf extract might increase the levels and clinical effects of CYP2C8 substrates.
In vitro research shows that neem leaf methanol extract inhibits CYP2C8 enzymes. So far, this reaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, neem leaf extract might increase the levels and clinical effects of CYP2C9 substrates.
In vitro research shows that neem leaf methanol extract inhibits CYP2C9 enzymes. So far, this reaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, neem leaf extract might increase the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that neem leaf methanol extract inhibits CYP3A4 enzymes. So far, this reaction has not been reported in humans.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, neem might decrease the effectiveness of immunosuppressants.
Animal research suggests that neem might have immunostimulant effects.

Likelihood Possible Evidence D
P-Glycoprotein Substrates

Theoretically, neem leaf extract might increase the levels and clinical effects of P-glycoprotein substrates.
In vitro research shows that neem leaf methanol extract inhibits renal P-glycoprotein transport activity. So far, this reaction has not been reported in humans.

Likelihood Possible Evidence D
Neem leaf liquid extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Neem Leaf 3X Concentration, from the product label.

NeemAura

See all NeemAura products
Name
Lotus Brands, Inc.
Street Address
PO Box 325
City
Twin Lakes
State
WI
ZipCode
53181
Web Address
www.NeemAuraNaturals.com
Pharmacist Counseling Corner

Neem Leaf 3X Concentration by NeemAura: Common Questions

Does Neem Leaf 3X Concentration by NeemAura interact with any medications?
Yes. Based on its ingredients, Neem Leaf 3X Concentration has a known interaction with 1,013 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Neem Leaf 3X Concentration contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
No—neem is rated likely unsafe in pregnancy because it may affect fertility and the developing baby. There isn't enough safety information to recommend it while breastfeeding either. If you're pregnant, planning to become pregnant, or nursing, talk with your doctor or pharmacist before considering neem.
Does neem leaf extract actually work for acne?
The evidence available isn't reliable enough to say whether it works for acne. If you're interested in trying it for acne, talk with your dermatologist about what the data supports and whether it fits your treatment plan.
What are the most common side effects?
When taken by mouth, neem leaf extracts appear well tolerated in adults, though full safety testing hasn't been done. Applied to skin, it's also generally well tolerated, with contact dermatitis (a rash) possible in people sensitive to it. Serious effects are rare but have been reported with very high amounts or in infants and young children.
Is this safe for my child?
Neem oil can cause serious problems if swallowed by children, and we'd recommend avoiding it for that age group. This product is a leaf extract, not neem oil, and topical neem seems tolerated in children, but you should confirm with your pediatrician before giving any neem product to a child.
What is neem and why is it in this product?
Neem comes from the neem tree and has been used traditionally in Ayurvedic medicine. The leaf extract in this product is included because evidence suggests it may help with gum health, dental plaque, and lice—though the strongest evidence is for gingivitis and plaque.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Neem Leaf 3X Concentration is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Neem Leaf 3X Concentration label
Go deeper

The Full Monographs Behind Neem Leaf 3X Concentration’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Neem

Interacts with 1,013 drugs

Neem is a tree from India used for centuries in traditional medicine, especially for skin, dental, and antimicrobial purposes. Some small studies are promising for oral health and skin, but...

Read the full Neem monograph →
Sources

Sources & How We Checked

Neem Leaf 3X Concentration's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 28 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Neem 28 references
  1. Sinniah D, Baskaran G. Margosa oil poisoning as a cause of Reye's syndrome. Lancet 1981;1:487-9. PubMed
  2. Sinniah D, Baskaran G, Looi LM, Leong KL. Reye-like syndrome due to margosa oil poisoning: report of a case with postmortem findings. Am J Gastroenterol 1982;77:158-61.
  3. Sinniah R, Sinniah D, Chia LS, Baskaran G. Animal model of margosa oil ingestion with Reye-like syndrome. Pathogenesis of microvesicular fatty liver. J Pathol 1989;159:255-64. PubMed
  4. Lai SM, Lim KW, Cheng HK. Margosa oil poisoning as a cause of toxic encephalopathy. Singapore Med J 1990;31:463-5.
  5. Biswas K, Chattopadhyay I, Banerjee RK, Bandyopadhyay U. Biological activities and medicinal properties of neem (Azadirachta indica). Curr Sci 2002;82:1336-45.
  6. Upadhyay SN, Dhawan S, Garg S, Talwar GP. Immunomodulatory effects of neem (Azadirachta indica) oil. Int J Immunopharmacol 1992;14:1187-93. PubMed
  7. Ibrahim IA, Khalid SA, Omer SA, Adam SE. On the toxicology of Azadirachta indica leaves. J Ethnopharmacol 1992;35:267-73. PubMed
  8. Ali BH. Toxicology of Azadirachta indica. J Ethnopharmacol 1994;42:71-2. PubMed
  9. Boeke SJ, Boersma MG, Alink GM, et al. Safety evaluation of neem (Azadirachta indica) derived pesticides. J Ethnopharmacol 2004;94:25-41. PubMed
  10. Abdel-Ghaffar, F. and Semmler, M. Efficacy of neem seed extract shampoo on head lice of naturally infected humans in Egypt. Parasitol.Res 2007;100(2):329-332. PubMed
  11. Reutemann, P. and Ehrlich, A. Neem oil: an herbal therapy for alopecia causes dermatitis. Dermatitis 2008;19(3):E12-E15.
  12. Senanayake, M. P., Rupasinghe, S., and Dissanayake, P. V. Margosa (Kohomba) oil induced toxic encephalopathy following home remedy for intestinal worms. Ceylon Med.J 2009;54(4):140. PubMed
  13. Bhaskar, M. V., Pramod, S. J., Jeevika, M. U., Chandan, P. K., and Shetteppa, G. MR imaging findings of neem oil poisoning. AJNR Am J Neuroradiol. 2010;31(7):E60-E61.
  14. Iyyadurai, R., Surekha, V., Sathyendra, S., Paul, Wilson B., and Gopinath, K. G. Azadirachtin poisoning: a case report. Clin Toxicol.(Phila) 2010;48(8):857-858. PubMed
  15. Sinniah, D., Sinniah, R., Baskaran, G., Pathmanathan, R., Yamashita, F., and Yoshino, M. Evaluation of the possible role of glucose, carnitine, coenzyme Q10 and steroids in the treatment of Reye's syndrome using the margosa oil animal model. Acta Paediat PubMed
  16. Balakrishnan, V., Pillai, N. R., and Santhakumari, G. Ventricular fibrillation and cardiac arrest due to neem leaf poisoning. J.Assoc.Physicians India 1986;34(7):536.
  17. Sivashanmugham, R., Bhaskar, N., and Banumathi, N. Ventricular fibrillation and cardiac arrest due to neem leaf poisoning. J.Assoc.Physicians India 1984;32(7):610-611.
  18. Mukherjee, S. and Talwar, G. P. Termination of pregnancy in rodents by oral administration of praneem, a purified neem seed extract. Am J Reprod.Immunol. 1996;35(1):51-56. PubMed
  19. Talwar, G. P., Pal, R., Singh, O., Garg, S., Taluja, V., Upadhyay, S. N., Gopalan, S., Jain, V., Kaur, J., and Sehgal, S. Safety of intrauterine administration of purified neem seed oil (Praneem Vilci) in women & effect of its co-administration with the
  20. Talwar, G. P., Shah, S., Mukherjee, S., and Chabra, R. Induced termination of pregnancy by purified extracts of Azadirachta Indica (Neem): mechanisms involved. Am J Reprod.Immunol. 1997;37(6):485-491. PubMed
  21. Greenblatt DT, Banerjee P, White JM. Allergic contact dermatitis caused by neem oil. Contact Dermatitis. 2012;67(4):242-3. PubMed
  22. Page C, Hawes EM. Haemolytic anaemia after ingestion of Neem (Azadirachta indica) tea. BMJ Case Rep. 2013. pii: bcr2013200890.
  23. Braidy N, Berg J, Clement J, et al. Role of nicotinamide dinucleotide and related precursors as therapeutic targets for age-related degenerative diseases: rationale, biochemistry, pharmacokinetics, and outcomes. Antiox Redox Signal 2018.
  24. Jadhav PB. Leucoderma on the lips induced by neem (Azadirachta indica): case series. Clin Exp Dermatol. 2018;43(8):943-6.
  25. Giuggioli D, Lumetti F, Spinella A, et al. Use of Neem oil and Hypericum perforatum for treatment of calcinosis-related skin ulcers in systemic sclerosis. J Int Med Res 2019:300060519882176. Online ahead of print.
  26. Pingali U, Ali MA, Gundagani S, Nutalapati C. Evaluation of the effect of an aqueous extract of Azadirachta indica (neem) leaves and twigs on glycemic control, endothelial dysfunction and systemic inflammation in subjects with type 2 diabetes mellitus - a
  27. Amaeze O, Marques ES, Wei W, et al. Evaluation of Nigerian Medicinal Plants Extract on Human P-glycoprotein and Cytochrome P450 Enzyme Induction: Implications for Herb-drug Interaction. Curr Drug Metab. 2021;22(14):1103-1113. PubMed
  28. Amaeze O, Eng H, Horlbogen L, Varma MVS, Slitt A. Cytochrome P450 Enzyme Inhibition and Herb-Drug Interaction Potential of Medicinal Plant Extracts Used for Management of Diabetes in Nigeria. Eur J Drug Metab Pharmacokinet. 2021;46(3):437-450. PubMed

See these in context on the Neem monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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