One More Rep Hurricane Orange Ingredients & Drug Interactions
by BPI Sports
What is this page for?
First and foremost: checking One More Rep Hurricane Orange against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
One More Rep Hurricane Orange is a dietary supplement by BPI Sports with 12 active ingredients. Its ingredients are commonly taken for exercise performance, muscle soreness and fatigue, blood flow and circulation.Based on those ingredients, 1,437 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Yohimbe (bark) extract, Beet, Niacin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against One More Rep Hurricane Orange by BPI Sports
Ask about any prescription or over-the-counter medication and we check it for interactions with One More Rep Hurricane Orange by BPI Sports — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of One More Rep Hurricane Orange by BPI Sports
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Partial disclosure
One More Rep Hurricane Orange contains 12 active ingredients formulated as a pre-workout blend. L-citrulline and L-carnitine L-tartrate support blood flow and workout performance.
Caffeine anhydrous and theobromine (from cocoa) provide stimulant energy for alertness and focus. N-acetyl-L-cysteine supports recovery and muscle function.
Niacin aids energy metabolism. Phosphatidylcholine supports cell membrane health.
Beet provides dietary nitrates for circulation. Yohimbe bark extract is included as a stimulant component.
Himalayan pink salt and sodium provide electrolytes. Trimethylglycine is added as a methyl donor.
The product also contains inactive ingredients including maltodextrin, natural and artificial flavors, citric acid, silica, malic acid, sucralose, and acesulfame K.
Does it work?
Strong evidence
The evidence for this product's ingredients is mixed. Caffeine is likely effective for mental alertness and athletic performance.
L-citrulline is possibly effective for athletic performance but possibly ineffective for muscle loss (sarcopenia). Beet is possibly effective for athletic performance and exercise-related muscle soreness.
L-carnitine is possibly effective for high cholesterol and heart failure. Niacin is likely effective for a deficiency disease (pellagra) and possibly effective for certain cholesterol problems.
Cocoa (theobromine) is possibly effective for heart disease. For other uses in this product—including cardiovascular disease, heart failure, and diabetes—the evidence we hold is either insufficient or not established.
N-acetyl-L-cysteine, phosphatidylcholine, and yohimbe lack effectiveness data in our system for most athletic or energy-support claims.
How safe is it?
Well-documented data
Caffeine anhydrous is generally well tolerated in moderate amounts but can cause anxiety, insomnia, tremors, nausea, and rarely, stroke at high doses. L-citrulline is generally well tolerated but can cause gastrointestinal discomfort and heartburn.
N-acetyl-L-cysteine is generally well tolerated at typical doses but can cause diarrhea, dry mouth, heartburn, nausea, and vomiting. L-carnitine may cause abdominal cramps, diarrhea, nausea, and a fishy body odor, and rare seizures at high doses.
Theobromine (cocoa) is generally well tolerated but can cause constipation, nausea, headaches, and rarely, fast heart rate. Niacin commonly causes flushing and gastrointestinal upset (up to 70% of users experience flushing), and can rarely cause liver problems at high doses.
Phosphatidylcholine is generally well tolerated but high doses can cause bloating, diarrhea, nausea, and altered taste. Beet may cause red or black stools (harmless) but rarely hypocalcemia or kidney damage in very large amounts.
Yohimbe can cause anxiety, agitation, sweating, flushing, headache, high blood pressure, fast heart rate, tremor, and nausea; it is considered unsafe in pregnancy and breastfeeding. Sodium in large amounts is linked to high blood pressure and kidney strain.
Meds to double-check
Major interaction found
Before taking this product, check with your doctor or pharmacist if you take any of these: ephedrine or other stimulants (Major severity risk); blood pressure medications (Moderate severity, multiple ingredients); blood thinners like warfarin or acenocoumarol (Moderate severity); nitroglycerin (Major severity, from N-acetyl-L-cysteine); antidepressants—especially SSRIs, tricyclic antidepressants, or MAOIs (Moderate severity from yohimbe and caffeine); diabetes medications (Moderate severity from niacin); seizure medications like carbamazepine or phenobarbital (Moderate severity from caffeine); thyroid hormone replacement (Moderate severity from L-carnitine); statins (Moderate severity from niacin); quinolone antibiotics (Moderate severity from caffeine); or gout medications like allopurinol (Moderate severity from niacin).
The bottom line
Scorecard at a glancePartially disclosed formula with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.
This pre-workout is built around caffeine and stimulant ingredients—it's designed to boost energy and athletic output. If you take any blood pressure medication, blood thinner, antidepressant, diabetes drug, thyroid replacement, seizure medication, or statin, or if you take an MAOI for mood or any stimulant medication, you need to run your full medication list against the interaction checker on this page before starting.
The combination of caffeine, cocoa, and yohimbe creates significant stimulant load; stop and talk to your doctor immediately if you feel chest pain, severe headache, tremor, or unusual anxiety. Talk it over with your own doctor or pharmacist before adding this to your routine, especially if you have heart disease, high blood pressure, or anxiety.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 10 of 12 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 25, 2018.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about One More Rep Hurricane Orange, straight from the product label.
| Brand | BPI Sports |
|---|---|
| Barcode (UPC) | 810516030480 |
| Net contents | 8.8 oz.; 250 Gram(s) |
| Market status | On market |
| Date entered into DSLD | Apr 25, 2018 |
| DSLD ID | 174937 |
| Product type | Other Combinations |
| Supplement form | Powder |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for One More Rep Hurricane Orange by BPI Sports, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| L-Citrulline | 3 Gram(s) | -- |
| Caffeine Anhydrous | 0 NP | -- |
| Theobromine | 0 NP | -- |
| Phosphatidylcholine | 0 NP | -- |
| N-Acetyl-L-Cysteine | 500 mg | -- |
| Himalayan Pink Salt | 0 NP | -- |
| L-Carnitine L-Tartrate | 1 Gram(s) | -- |
| Sodium | 128 mg | 5% |
| Trimethylglycine | 500 mg | -- |
| Niacin | 30 mg | 150% |
| Beet | 500 mg | -- |
| One More Rep Energy Blend (Combination) | 454 mg | -- |
| Yohimbe (bark) extract | 0 NP | -- |
Other ingredients: Maltodextrin, Natural and Artificial flavors, Citric Acid, Silica, Malic Acid, Sucralose, Acesulfame K
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
Power Series
L-carnitine L-tartrate helps transfer fatty acids into the mitochondria of cells for energy production, which may play an important role in muscle building, fat burning and performance.
N-acetyl cysteine is a potent antioxidant that may have a beneficial effect on exercise performance.
To report an adverse event or for more information call: 954.926.0900 (tel)
Facebook/ BPIOnLine Instagram @ BPI_Sports
When combined with a proper exercise and nutrition regimen. Statements based on early-stage independent 3rd party in vivo and/or in vitro model scientific research data findings for individual ingredients.
Energy
Natural and artificial flavors
New!
25 servings
Push harder, train longer.
Brand IP Statement(s)
One More Rep is our Premier Pre-Workout, designed to promote Focus, energy, pump, performance, strength and recovery.
BeBetter. BeStronger. BPI.
Legendary 1.M.R Performance!
Formula
One More Rep includes Beetroot powder and L-Citrulline to support muscle pump and fullness.
L-Citrulline L-Carnitine Beet root powder
Caffeine warning: The recommended serving of this product contains approximately as much caffeine as three cups of coffee.
Caution: One More Rep contains the B vitamin niacin. Niacin may cause temporary flushing, tingling, skin reddening, and sensations of heat, especially if taken on an empty stomach. This is a common reaction.
Seals/Symbols
Made in the USA with domestic and international ingredients.
General
Rev. 01-001-ONE002 12/17
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Suggested/Recommended/Usage/Directions
Take 1 scoop blended into 8oz water before workout
Please read entire label before use. Suggested Use: Use on training days only. Take one (1) serving (1 scoop) approximately 15-30 minutes prior to training, blended into 6-8 ounces of cold water or beverage, or as suggested by a qualified healthcare practitioner.
Do not exceed recommended dose. Do not take for more than eight (8) consecutive weeks.
FDA Statement of Identity
Dietary Supplement
Precautions
Important Note(s): Do not exceed one (1) serving (1 scoop) per training day. Avoid eating food or drinking a protein shake within an hour after consuming One More Rep. To avoid sleeplessness, do not take within four (4) hours of bedtime. Taking One More Rep with food, or on a full stomach, may diminish its effects.
Warnings: Not intended for use by persons under age 18.
Get the consent of a licensed physician before using this product, especially if you are taking medication, have a medical condition, you are pregnant, nursing or thinking about becoming pregnant.
Discontinue use two weeks prior to surgery.
Keep this product and all supplements out of the reach of children.
Do not consume caffeine, or combine with synephrine, including but not limited to coffee, tea, soda and other dietary supplements or medications containing phenylephrine or caffeine.
Too much caffeine may cause nervousness, irritability, sleeplessness, and occasionally rapid heartbeat. Discontinue use if you experience dizziness, severe headache, rapid heartbeat or shortness of breath.
Caution: One More Rep contains the B vitamin niacin. Niacin may cause temporary flushing, tingling, skin reddening, and sensations of heat, especially if taken on an empty stomach. This is a common reaction.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
One More Rep Hurricane Orange by BPI Sports label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in One More Rep Hurricane Orange by BPI Sports
These are the 12 active ingredients this product is made of. Select any to open its full monograph.
Serving size10 Gram(s) Dosage formPowder Servings per container25 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
L-Citrulline
Interacts with178 drugs
L-citrulline is an amino acid that the body turns into L-arginine to help make nitric oxide, which relaxes blood vessels and may improve blood flow. I...
L-Citrulline monograph & interactionsN-Acetyl-L-Cysteine
Interacts with294 drugs
N-acetyl cysteine (NAC) is a supplement form of the amino acid cysteine and a building block for the antioxidant glutathione. It has well-established...
N-Acetyl-L-Cysteine monograph & interactionsL-Carnitine L-Tartrate
Interacts with19 drugs
L-carnitine is a compound your body makes naturally and also gets from foods like meat. It helps cells turn fat into energy, and supplements are most...
L-Carnitine L-Tartrate monograph & interactionsSodium
Interacts with205 drugs
Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...
Sodium monograph & interactionsTrimethylglycine
Niacin
Interacts with727 drugs
Niacin (vitamin B3) is an essential nutrient your body needs for energy and metabolism, and deficiency is uncommon in most developed countries. Prescr...
Niacin monograph & interactionsBeet
Interacts with861 drugs
Beet, especially beetroot juice, is a nitrate-rich food that may modestly lower blood pressure and slightly improve exercise performance in some peopl...
Beet monograph & interactionsOne More Rep Energy Blend (Combination)
- › Caffeine Anhydrous
- › Theobromine
- › Phosphatidylcholine
- › Himalayan Pink Salt
- › Yohimbe (bark) extract
Other (inactive) ingredients: Maltodextrin, Natural and Artificial flavors, Citric Acid, Silica, Malic Acid, Sucralose, Acesulfame K. These complete the product’s ingredient list but are not active constituents.
One More Rep Hurricane Orange by BPI Sports Drug Interactions
HelloPharmacist Interaction Report
One More Rep Hurricane Orange by BPI Sports contains several ingredients with documented interactions: L-citrulline, caffeine anhydrous, theobromine (from cocoa), N-acetyl-L-cysteine, L-carnitine L-tartrate, sodium, niacin, beet, and yohimbe bark extract.
The most serious interaction is between caffeine anhydrous and ephedrine—a Major severity interaction that can increase the risk of life-threatening stimulant effects including hypertension, heart attack, stroke, and seizures.
Read the full breakdown — every affected drug type, severity by severity
Caffeine anhydrous also interacts with several drug types at Moderate severity: pentobarbital and carbamazepine (which may reduce seizure control), dipyridamole (interfering with cardiac stress testing), clozapine (raising its levels and side effects), cimetidine (increasing caffeine levels), quinolone antibiotics (increasing caffeine levels), and phenobarbital (reducing its anticonvulsant activity). Theobromine (cocoa) shares similar interactions with caffeine because it's a related stimulant compound.
L-citrulline and N-acetyl-L-cysteine interact with blood pressure medications at Moderate severity. N-acetyl-L-cysteine also has a Major interaction with nitroglycerin—it can cause severe low blood pressure and severe headaches.
Additionally, N-acetyl-L-cysteine may increase bleeding risk with anticoagulants or blood thinners, and may interfere with chloroquine's antimalarial effects. L-carnitine may enhance blood thinners like warfarin and acenocoumarol, and may reduce thyroid medication effectiveness.
Sodium can reduce blood pressure medication effectiveness and may worsen heart strain. Niacin interacts with blood pressure drugs, diabetes medications, statins, and gout medications at Moderate severity.
Yohimbe bark extract has a Major interaction with MAOIs (mood medications), and Moderate interactions with blood pressure drugs and stimulant medications. Beet contains compounds that may affect drugs metabolized by liver enzymes.
Phosphatidylcholine and Himalayan pink salt were also checked or could not be checked, but no interactions are documented in our data for phosphatidylcholine. We could not check Himalayan pink salt and trimethylglycine.
Altogether, these interactions span 1,438 individual medications.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against One More Rep Hurricane Orange?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in One More Rep Hurricane Orange interact with 1,437 drugs. Click any drug to see the details.
9 of the 12 ingredients in One More Rep Hurricane Orange interact with drugs. Each result below shows which ingredient is responsible. Yohimbe (bark) extract Beet Niacin Theobromine Caffeine Anhydrous N-Acetyl-L-Cysteine Sodium L-Citrulline L-Carnitine L-Tartrate
Aminophylline, Amobarbital, EphedrineAmesec
How Aminophylline, Amobarbital, Ephedrine interacts with One More Rep Hurricane Orange — through 3 ingredients. Tap an ingredient for the detail:
Caffeine AnhydrousEphedrine, Stimulant Drugs Major
Interaction Summary
Theoretically, concomitant use might increase the risk for stimulant adverse effects.
Read the full Caffeine Anhydrous + Aminophylline, Amobarbital, Ephedrine interactionTheobromineEphedrine, Stimulant Drugs Moderate
Interaction Summary
Theoretically, concomitant use might increase the risk for stimulant adverse effects.
Read the full Theobromine + Aminophylline, Amobarbital, Ephedrine interactionYohimbe (bark) ExtractStimulant Drugs Moderate
Interaction Summary
Theoretically, taking yohimbe with stimulant drugs can have additive effects.
Read the full Yohimbe (bark) Extract + Aminophylline, Amobarbital, Ephedrine interactionAmphetamineAdensys XR-ODT, Adzenys ER, Dyanavel XR, Mydayis
How Amphetamine interacts with One More Rep Hurricane Orange — through 3 ingredients. Tap an ingredient for the detail:
Yohimbe (bark) ExtractStimulant Drugs, Monoamine Oxidase Inhibitors (maois) +1 Major
Interaction Summary
Theoretically, taking yohimbe with stimulant drugs can have additive effects.
Read the full Yohimbe (bark) Extract + Amphetamine interactionTheobromineStimulant Drugs, Monoamine Oxidase Inhibitors (maois) Moderate
Interaction Summary
Theoretically, concomitant use might increase stimulant adverse effects.
Read the full Theobromine + Amphetamine interactionCaffeine AnhydrousStimulant Drugs, Monoamine Oxidase Inhibitors (maois) Moderate
Interaction Summary
Theoretically, concomitant use might increase stimulant adverse effects.
Read the full Caffeine Anhydrous + Amphetamine interactionCarbetapentane Tannate, Chlorpheniramine Tannate, Ephedrine Tannate, Phenylephrine TannateQuadratuss, Ry Tuss, Rynatuss, Tri Tannate Plus
How Carbetapentane Tannate, Chlorpheniramine Tannate, Ephedrine Tannate, Phenylephrine Tannate interacts with One More Rep Hurricane Orange — through 4 ingredients. Tap an ingredient for the detail:
Caffeine AnhydrousEphedrine, Stimulant Drugs Major
Interaction Summary
Theoretically, concomitant use might increase the risk for stimulant adverse effects.
Read the full Caffeine Anhydrous + Carbetapentane Tannate, Chlorpheniramine Tannate, Ephedrine Tannate, Phenylephrine Tannate interactionBeetCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, beet might increase the levels of CYP3A4 substrates.
Read the full Beet + Carbetapentane Tannate, Chlorpheniramine Tannate, Ephedrine Tannate, Phenylephrine Tannate interactionTheobromineStimulant Drugs, Ephedrine Moderate
Interaction Summary
Theoretically, concomitant use might increase stimulant adverse effects.
Read the full Theobromine + Carbetapentane Tannate, Chlorpheniramine Tannate, Ephedrine Tannate, Phenylephrine Tannate interactionYohimbe (bark) ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Stimulant Drugs +1 Moderate
Interaction Summary
Theoretically, yohimbe might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Yohimbe (bark) Extract + Carbetapentane Tannate, Chlorpheniramine Tannate, Ephedrine Tannate, Phenylephrine Tannate interactionDyphylline, Ephedrine, Guaifenesin, PhenobarbitalLufyllin-EPG
How Dyphylline, Ephedrine, Guaifenesin, Phenobarbital interacts with One More Rep Hurricane Orange — through 3 ingredients. Tap an ingredient for the detail:
Caffeine AnhydrousStimulant Drugs, Phenobarbital (luminal) +1 Major
Interaction Summary
Theoretically, concomitant use might increase stimulant adverse effects.
Read the full Caffeine Anhydrous + Dyphylline, Ephedrine, Guaifenesin, Phenobarbital interactionTheobromineStimulant Drugs, Phenobarbital (luminal) +1 Moderate
Interaction Summary
Theoretically, concomitant use might increase stimulant adverse effects.
Read the full Theobromine + Dyphylline, Ephedrine, Guaifenesin, Phenobarbital interactionYohimbe (bark) ExtractStimulant Drugs Moderate
Interaction Summary
Theoretically, taking yohimbe with stimulant drugs can have additive effects.
Read the full Yohimbe (bark) Extract + Dyphylline, Ephedrine, Guaifenesin, Phenobarbital interactionEphedrine, Guaifenesin (otc Drug)Ephedrine Formula 400, Ephedrine Plus Tabs
How Ephedrine, Guaifenesin (otc Drug) interacts with One More Rep Hurricane Orange — through 3 ingredients. Tap an ingredient for the detail:
Caffeine AnhydrousEphedrine, Stimulant Drugs Major
Interaction Summary
Theoretically, concomitant use might increase the risk for stimulant adverse effects.
Read the full Caffeine Anhydrous + Ephedrine, Guaifenesin (otc Drug) interactionTheobromineStimulant Drugs, Ephedrine Moderate
Interaction Summary
Theoretically, concomitant use might increase stimulant adverse effects.
Read the full Theobromine + Ephedrine, Guaifenesin (otc Drug) interactionYohimbe (bark) ExtractStimulant Drugs Moderate
Interaction Summary
Theoretically, taking yohimbe with stimulant drugs can have additive effects.
Read the full Yohimbe (bark) Extract + Ephedrine, Guaifenesin (otc Drug) interactionEphedrine, Guaifenesin, Phenobarbital, TheophyllineMudrane GG
How Ephedrine, Guaifenesin, Phenobarbital, Theophylline interacts with One More Rep Hurricane Orange — through 4 ingredients. Tap an ingredient for the detail:
Caffeine AnhydrousStimulant Drugs, Theophylline +2 Major
Interaction Summary
Theoretically, concomitant use might increase stimulant adverse effects.
Read the full Caffeine Anhydrous + Ephedrine, Guaifenesin, Phenobarbital, Theophylline interactionYohimbe (bark) ExtractStimulant Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, taking yohimbe with stimulant drugs can have additive effects.
Read the full Yohimbe (bark) Extract + Ephedrine, Guaifenesin, Phenobarbital, Theophylline interactionTheobrominePhenobarbital (luminal), Ephedrine +2 Moderate
Interaction Summary
Theoretically, cocoa might reduce the effects of phenobarbital and increase the risk for convulsions.
Read the full Theobromine + Ephedrine, Guaifenesin, Phenobarbital, Theophylline interactionBeetCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, beet might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Beet + Ephedrine, Guaifenesin, Phenobarbital, Theophylline interactionEphedrine, Hydroxyzine, TheophyllineAmi Rax, Marax
How Ephedrine, Hydroxyzine, Theophylline interacts with One More Rep Hurricane Orange — through 4 ingredients. Tap an ingredient for the detail:
Caffeine AnhydrousTheophylline, Ephedrine +1 Major
Interaction Summary
Theoretically, caffeine might increase the levels and adverse effects of theophylline.
Read the full Caffeine Anhydrous + Ephedrine, Hydroxyzine, Theophylline interactionYohimbe (bark) ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Stimulant Drugs Moderate
Interaction Summary
Theoretically, yohimbe might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Yohimbe (bark) Extract + Ephedrine, Hydroxyzine, Theophylline interactionTheobromineStimulant Drugs, Theophylline +1 Moderate
Interaction Summary
Theoretically, concomitant use might increase stimulant adverse effects.
Read the full Theobromine + Ephedrine, Hydroxyzine, Theophylline interactionBeetCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, beet might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Beet + Ephedrine, Hydroxyzine, Theophylline interactionEphedrine, Phenobarbital, Potassium Iodide, TheophyllineMudrane, Quadrinal
How Ephedrine, Phenobarbital, Potassium Iodide, Theophylline interacts with One More Rep Hurricane Orange — through 3 ingredients. Tap an ingredient for the detail:
Caffeine AnhydrousStimulant Drugs, Theophylline +2 Major
Interaction Summary
Theoretically, concomitant use might increase stimulant adverse effects.
Read the full Caffeine Anhydrous + Ephedrine, Phenobarbital, Potassium Iodide, Theophylline interactionTheobrominePhenobarbital (luminal), Ephedrine +2 Moderate
Interaction Summary
Theoretically, cocoa might reduce the effects of phenobarbital and increase the risk for convulsions.
Read the full Theobromine + Ephedrine, Phenobarbital, Potassium Iodide, Theophylline interactionYohimbe (bark) ExtractStimulant Drugs Moderate
Interaction Summary
Theoretically, taking yohimbe with stimulant drugs can have additive effects.
Read the full Yohimbe (bark) Extract + Ephedrine, Phenobarbital, Potassium Iodide, Theophylline interactionEphedrine, Phenobarbital, TheophyllineTedral
How Ephedrine, Phenobarbital, Theophylline interacts with One More Rep Hurricane Orange — through 3 ingredients. Tap an ingredient for the detail:
Caffeine AnhydrousTheophylline, Phenobarbital (luminal) +2 Major
Interaction Summary
Theoretically, caffeine might increase the levels and adverse effects of theophylline.
Read the full Caffeine Anhydrous + Ephedrine, Phenobarbital, Theophylline interactionYohimbe (bark) ExtractStimulant Drugs Moderate
Interaction Summary
Theoretically, taking yohimbe with stimulant drugs can have additive effects.
Read the full Yohimbe (bark) Extract + Ephedrine, Phenobarbital, Theophylline interactionTheobromineStimulant Drugs, Theophylline +2 Moderate
Interaction Summary
Theoretically, concomitant use might increase stimulant adverse effects.
Read the full Theobromine + Ephedrine, Phenobarbital, Theophylline interactionIsocarboxazidMarplan
How Isocarboxazid interacts with One More Rep Hurricane Orange — through 3 ingredients. Tap an ingredient for the detail:
Yohimbe (bark) ExtractMonoamine Oxidase Inhibitors (maois) Major
Interaction Summary
Concomitant use of MAOIs with yohimbe can result in additive effects.
Read the full Yohimbe (bark) Extract + Isocarboxazid interactionTheobromineMonoamine Oxidase Inhibitors (maois) Moderate
Interaction Summary
Theoretically, concomitant use might increase the risk of a hypertensive crisis.
Read the full Theobromine + Isocarboxazid interactionCaffeine AnhydrousMonoamine Oxidase Inhibitors (maois) Moderate
Interaction Summary
Theoretically, concomitant use might increase the risk of a hypertensive crisis.
Read the full Caffeine Anhydrous + Isocarboxazid interactionMoclobemideManerix, Moclobemide
How Moclobemide interacts with One More Rep Hurricane Orange — through 3 ingredients. Tap an ingredient for the detail:
Yohimbe (bark) ExtractCytochrome P450 2d6 (cyp2d6) Inhibitors, Monoamine Oxidase Inhibitors (maois) Major
Interaction Summary
CYP2D6 inhibitors may increase the levels and adverse effects of yohimbine, a constituent of yohimbe.
Read the full Yohimbe (bark) Extract + Moclobemide interactionTheobromineMonoamine Oxidase Inhibitors (maois) Moderate
Interaction Summary
Theoretically, concomitant use might increase the risk of a hypertensive crisis.
Read the full Theobromine + Moclobemide interactionCaffeine AnhydrousMonoamine Oxidase Inhibitors (maois) Moderate
Interaction Summary
Theoretically, concomitant use might increase the risk of a hypertensive crisis.
Read the full Caffeine Anhydrous + Moclobemide interactionNitroglycerinGonitro, Nitro Time, Nitro-Bid, Nitrocine Timecaps, Nitrogard, Nitrogard SR +7 more
How Nitroglycerin interacts with One More Rep Hurricane Orange — through 1 ingredient. Tap an ingredient for the detail:
N-acetyl-l-cysteineNitroglycerin Major
Interaction Summary
N-acetyl cysteine can increase the risk for hypotension and headaches when taken with intravenous or transdermal nitroglycerin.
Read the full N-acetyl-l-cysteine + Nitroglycerin interactionOzanimod HydrochlorideZeposia
How Ozanimod Hydrochloride interacts with One More Rep Hurricane Orange — through 4 ingredients. Tap an ingredient for the detail:
Yohimbe (bark) ExtractMonoamine Oxidase Inhibitors (maois) Major
Interaction Summary
Concomitant use of MAOIs with yohimbe can result in additive effects.
Read the full Yohimbe (bark) Extract + Ozanimod Hydrochloride interactionTheobromineMonoamine Oxidase Inhibitors (maois) Moderate
Interaction Summary
Theoretically, concomitant use might increase the risk of a hypertensive crisis.
Read the full Theobromine + Ozanimod Hydrochloride interactionNiacinHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.
Read the full Niacin + Ozanimod Hydrochloride interactionCaffeine AnhydrousMonoamine Oxidase Inhibitors (maois) Moderate
Interaction Summary
Theoretically, concomitant use might increase the risk of a hypertensive crisis.
Read the full Caffeine Anhydrous + Ozanimod Hydrochloride interactionPhenelzine SulfateNardil
How Phenelzine Sulfate interacts with One More Rep Hurricane Orange — through 3 ingredients. Tap an ingredient for the detail:
Yohimbe (bark) ExtractMonoamine Oxidase Inhibitors (maois) Major
Interaction Summary
Concomitant use of MAOIs with yohimbe can result in additive effects.
Read the full Yohimbe (bark) Extract + Phenelzine Sulfate interactionTheobromineMonoamine Oxidase Inhibitors (maois) Moderate
Interaction Summary
Theoretically, concomitant use might increase the risk of a hypertensive crisis.
Read the full Theobromine + Phenelzine Sulfate interactionCaffeine AnhydrousMonoamine Oxidase Inhibitors (maois) Moderate
Interaction Summary
Theoretically, concomitant use might increase the risk of a hypertensive crisis.
Read the full Caffeine Anhydrous + Phenelzine Sulfate interactionRasagilineAzilect
How Rasagiline interacts with One More Rep Hurricane Orange — through 4 ingredients. Tap an ingredient for the detail:
Yohimbe (bark) ExtractMonoamine Oxidase Inhibitors (maois), Cytochrome P450 1a2 (cyp1a2) Substrates Major
Interaction Summary
Concomitant use of MAOIs with yohimbe can result in additive effects.
Read the full Yohimbe (bark) Extract + Rasagiline interactionCaffeine AnhydrousMonoamine Oxidase Inhibitors (maois) Moderate
Interaction Summary
Theoretically, concomitant use might increase the risk of a hypertensive crisis.
Read the full Caffeine Anhydrous + Rasagiline interactionTheobromineMonoamine Oxidase Inhibitors (maois) Moderate
Interaction Summary
Theoretically, concomitant use might increase the risk of a hypertensive crisis.
Read the full Theobromine + Rasagiline interactionBeetCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, beet might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Beet + Rasagiline interactionSafinamide MesylateXadago
How Safinamide Mesylate interacts with One More Rep Hurricane Orange — through 3 ingredients. Tap an ingredient for the detail:
Yohimbe (bark) ExtractMonoamine Oxidase Inhibitors (maois) Major
Interaction Summary
Concomitant use of MAOIs with yohimbe can result in additive effects.
Read the full Yohimbe (bark) Extract + Safinamide Mesylate interactionCaffeine AnhydrousMonoamine Oxidase Inhibitors (maois) Moderate
Interaction Summary
Theoretically, concomitant use might increase the risk of a hypertensive crisis.
Read the full Caffeine Anhydrous + Safinamide Mesylate interactionTheobromineMonoamine Oxidase Inhibitors (maois) Moderate
Interaction Summary
Theoretically, concomitant use might increase the risk of a hypertensive crisis.
Read the full Theobromine + Safinamide Mesylate interactionSelegilineCarbex, Eldepryl, Emsam, Zelapar
How Selegiline interacts with One More Rep Hurricane Orange — through 3 ingredients. Tap an ingredient for the detail:
Yohimbe (bark) ExtractMonoamine Oxidase Inhibitors (maois) Major
Interaction Summary
Concomitant use of MAOIs with yohimbe can result in additive effects.
Read the full Yohimbe (bark) Extract + Selegiline interactionTheobromineMonoamine Oxidase Inhibitors (maois) Moderate
Interaction Summary
Theoretically, concomitant use might increase the risk of a hypertensive crisis.
Read the full Theobromine + Selegiline interactionCaffeine AnhydrousMonoamine Oxidase Inhibitors (maois) Moderate
Interaction Summary
Theoretically, concomitant use might increase the risk of a hypertensive crisis.
Read the full Caffeine Anhydrous + Selegiline interactionTranylcypromineParnate
How Tranylcypromine interacts with One More Rep Hurricane Orange — through 3 ingredients. Tap an ingredient for the detail:
Yohimbe (bark) ExtractMonoamine Oxidase Inhibitors (maois) Major
Interaction Summary
Concomitant use of MAOIs with yohimbe can result in additive effects.
Read the full Yohimbe (bark) Extract + Tranylcypromine interactionCaffeine AnhydrousMonoamine Oxidase Inhibitors (maois) Moderate
Interaction Summary
Theoretically, concomitant use might increase the risk of a hypertensive crisis.
Read the full Caffeine Anhydrous + Tranylcypromine interactionTheobromineMonoamine Oxidase Inhibitors (maois) Moderate
Interaction Summary
Theoretically, concomitant use might increase the risk of a hypertensive crisis.
Read the full Theobromine + Tranylcypromine interaction6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with One More Rep Hurricane Orange — through 1 ingredient. Tap an ingredient for the detail:
NiacinHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.
Read the full Niacin + 6-mercaptopurine interactionAdo-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with One More Rep Hurricane Orange — through 2 ingredients. Tap an ingredient for the detail:
BeetCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, beet might increase the levels of CYP3A4 substrates.
Read the full Beet + Ado-trastuzumab Emtansine interactionYohimbe (bark) ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, yohimbe might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Yohimbe (bark) Extract + Ado-trastuzumab Emtansine interactionAbacavir Sulfate, Dolutegravir, LamivudineTriumeq
How Abacavir Sulfate, Dolutegravir, Lamivudine interacts with One More Rep Hurricane Orange — through 1 ingredient. Tap an ingredient for the detail:
NiacinHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.
Read the full Niacin + Abacavir Sulfate, Dolutegravir, Lamivudine interactionAbacavir, LamivudineEpzicom
How Abacavir, Lamivudine interacts with One More Rep Hurricane Orange — through 1 ingredient. Tap an ingredient for the detail:
NiacinHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.
Read the full Niacin + Abacavir, Lamivudine interactionAbametapirXeglyze
How Abametapir interacts with One More Rep Hurricane Orange — through 3 ingredients. Tap an ingredient for the detail:
Yohimbe (bark) ExtractCytochrome P450 3a4 (cyp3a4) Inhibitors Moderate
Interaction Summary
Theoretically, CYP3A4 inhibitors might increase the levels and adverse effects of yohimbine, a constituent of yohimbe bark.
Read the full Yohimbe (bark) Extract + Abametapir interactionTheobromineCytochrome P450 1a2 (cyp1a2) Inhibitors Moderate
Interaction Summary
Theoretically, concomitant use might increase the levels and adverse effects of caffeine.
Read the full Theobromine + Abametapir interactionCaffeine AnhydrousCytochrome P450 1a2 (cyp1a2) Inhibitors Minor
Interaction Summary
Theoretically, concomitant use might increase the levels and adverse effects of caffeine.
Read the full Caffeine Anhydrous + Abametapir interactionAbciximabReoPro
How Abciximab interacts with One More Rep Hurricane Orange — through 5 ingredients. Tap an ingredient for the detail:
TheobromineAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cocoa may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Theobromine + Abciximab interactionNiacinAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, niacin may have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Niacin + Abciximab interactionN-acetyl-l-cysteineAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, N-acetyl cysteine might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full N-acetyl-l-cysteine + Abciximab interactionCaffeine AnhydrousAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, caffeine may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Caffeine Anhydrous + Abciximab interactionYohimbe (bark) ExtractAnticoagulant/antiplatelet Drugs Minor
Interaction Summary
Theoretically, combining yohimbe bark with antiplatelet or anticoagulant drugs might have additive effects; however, this has not been reported in clinical research.
Read the full Yohimbe (bark) Extract + Abciximab interactionAbemaciclibVerzenio
How Abemaciclib interacts with One More Rep Hurricane Orange — through 2 ingredients. Tap an ingredient for the detail:
BeetCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, beet might increase the levels of CYP3A4 substrates.
Read the full Beet + Abemaciclib interactionYohimbe (bark) ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, yohimbe might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Yohimbe (bark) Extract + Abemaciclib interactionAbiraterone
How Abiraterone interacts with One More Rep Hurricane Orange — through 5 ingredients. Tap an ingredient for the detail:
BeetCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, beet might increase the levels of CYP3A4 substrates.
Read the full Beet + Abiraterone interactionYohimbe (bark) ExtractCytochrome P450 3a4 (cyp3a4) Inhibitors, Cytochrome P450 2d6 (cyp2d6) Inhibitors +1 Moderate
Interaction Summary
Theoretically, CYP3A4 inhibitors might increase the levels and adverse effects of yohimbine, a constituent of yohimbe bark.
Read the full Yohimbe (bark) Extract + Abiraterone interactionNiacinHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.
Read the full Niacin + Abiraterone interactionTheobromineCytochrome P450 1a2 (cyp1a2) Inhibitors Moderate
Interaction Summary
Theoretically, concomitant use might increase the levels and adverse effects of caffeine.
Read the full Theobromine + Abiraterone interactionCaffeine AnhydrousCytochrome P450 1a2 (cyp1a2) Inhibitors Minor
Interaction Summary
Theoretically, concomitant use might increase the levels and adverse effects of caffeine.
Read the full Caffeine Anhydrous + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with One More Rep Hurricane Orange — through 3 ingredients. Tap an ingredient for the detail:
Yohimbe (bark) ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Inhibitors Moderate
Interaction Summary
Theoretically, yohimbe might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Yohimbe (bark) Extract + Abiraterone Acetate interactionBeetCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, beet might increase the levels of CYP3A4 substrates.
Read the full Beet + Abiraterone Acetate interactionNiacinHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.
Read the full Niacin + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with One More Rep Hurricane Orange — through 5 ingredients. Tap an ingredient for the detail:
NiacinAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, niacin may have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Niacin + Abrocitinib interactionTheobromineAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cocoa may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Theobromine + Abrocitinib interactionCaffeine AnhydrousAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, caffeine may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Caffeine Anhydrous + Abrocitinib interactionN-acetyl-l-cysteineAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, N-acetyl cysteine might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full N-acetyl-l-cysteine + Abrocitinib interactionYohimbe (bark) ExtractAnticoagulant/antiplatelet Drugs Minor
Interaction Summary
Theoretically, combining yohimbe bark with antiplatelet or anticoagulant drugs might have additive effects; however, this has not been reported in clinical research.
Read the full Yohimbe (bark) Extract + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with One More Rep Hurricane Orange — through 2 ingredients. Tap an ingredient for the detail:
BeetCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, beet might increase the levels of CYP3A4 substrates.
Read the full Beet + Acalabrutinib interactionYohimbe (bark) ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, yohimbe might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Yohimbe (bark) Extract + Acalabrutinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with One More Rep Hurricane Orange — through 2 ingredients. Tap an ingredient for the detail:
NiacinHepatotoxic Drugs, Antidiabetes Drugs Moderate
Interaction Summary
Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.
Read the full Niacin + Acarbose interactionCaffeine AnhydrousAntidiabetes Drugs Minor
Interaction Summary
Theoretically, taking caffeine with antidiabetes drugs might interfere with blood glucose control.
Read the full Caffeine Anhydrous + Acarbose interactionEach ingredient & the kinds of drugs it affects
For each ingredient in One More Rep Hurricane Orange with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Yohimbe (bark) extract
Monoamine Oxidase Inhibitors (Maois)
Concomitant use of MAOIs with yohimbe can result in additive effects.
Yohimbine, a constituent of yohimbe, has MAO inhibitory effects. At high doses, yohimbine is a non-selective inhibitor of MAO.
Antihypertensive Drugs
Theoretically, yohimbe might reduce the effects of antihypertensive drugs.
Yohimbine, a constituent of yohimbe, is an alpha-2 adrenoceptor antagonist and has been reported to increase blood pressure in clinical research. Theoretically, concomitant use of yohimbe and antihypertensive drugs can interfere with blood pressure control.
Clonidine (Catapres)
Theoretically, yohimbe might precipitate clonidine withdrawal.
Chronic clonidine use can downregulate alpha-2 adrenoreceptors. Animal research and one human case report suggest that concomitant administration of yohimbine, an alpha-2 adrenoceptor antagonist, may precipitate clonidine withdrawal and lead to sympathomimetic toxicity, including hypertensive crisis.
Cytochrome P450 2D6 (Cyp2D6) Inhibitors
CYP2D6 inhibitors may increase the levels and adverse effects of yohimbine, a constituent of yohimbe.
In vitro and clinical research shows that the yohimbe bark constituent, yohimbine, is metabolized by CYP2D6 isoenzymes. Paroxetine, a cytochrome P450 (CYP) 2D6 inhibitor, increases the maximum serum concentration of yohimbine and reduces the clearance of yohimbine compared to yohimbine alone in patients who are extensive CYP2D6 metabolizers..
Cytochrome P450 2D6 (Cyp2D6) Substrates
Theoretically, yohimbe might increase the levels and adverse effects of CYP2D6 substrates.
In vitro research suggests that yohimbine, a constituent of yohimbe bark, inhibits CYP2D6 enzyme activity.
Cytochrome P450 3A4 (Cyp3A4) Inhibitors
Theoretically, CYP3A4 inhibitors might increase the levels and adverse effects of yohimbine, a constituent of yohimbe bark.
In vitro and clinical research shows that the yohimbe bark constituent, yohimbine, is metabolized by CYP3A4 enzymes. Theoretically, drugs that inhibit CYP3A4 might increase the levels and adverse effects of yohimbine.
Paroxetine (Paxil)
Paroxetine decreases the clearance of yohimbine and may increase its effects.
Paroxetine, a cytochrome P450 (CYP) 2D6 inhibitor, increases the maximum serum concentration of yohimbine by about 350% and reduces the clearance of yohimbine by about 80% compared to yohimbine alone in patients who are extensive CYP2D6 metabolizers. No significant changes in pharmacokinetic parameters of yohimbine were observed with coadministration of paroxetine in patients who are poor CYP2D6 metabolizers.
Phenothiazines
Theoretically, using yohimbine with phenothiazines might have additive effects.
Yohimbine, a constituent of yohimbe, has alpha-2 adrenergic antagonist effects. Theoretically, combining it with phenothiazines can cause additive alpha-2 adrenergic antagonism.
Stimulant Drugs
Theoretically, taking yohimbe with stimulant drugs can have additive effects.
Yohimbine, a constituent of yohimbe, has sympathomimetic effects and increases blood pressure in a dose-dependent manner. Theoretically, taking yohimbe with stimulant drugs can have additive stimulant and hypertensive effects.
Tricyclic Antidepressants (Tcas)
Theoretically, taking yohimbe with TCAs can increase adverse effects.
A small clinical study in patients taking TCAs for at least 4 weeks shows that receiving doses of intravenous yohimbine 2.5-20 mg daily for up to 7 days precipitates severe anxiety, agitation, and tremor. The effects of yohimbe bark itself are unclear; oral yohimbe bark contains 0.6% to 1.38% yohimbine, but it is unclear how much is absorbed.
Anticoagulant/Antiplatelet Drugs
Theoretically, combining yohimbe bark with antiplatelet or anticoagulant drugs might have additive effects; however, this has not been reported in clinical research.
Research in healthy adults shows that taking yohimbine, a constituent of yohimbe bark, in doses of 8 mg or more, seems to inhibit platelet aggregation in vitro by binding to the alpha-2 adrenoceptor. The effects of yohimbe bark itself are unclear; yohimbe bark contains 0.6% to 1.38% yohimbine, but it is unclear how much is absorbed.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, yohimbe might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that yohimbe extract induces CYP1A2 enzymes.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, yohimbe might decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that yohimbe extract induces CYP3A4 enzymes.
Beet
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, beet might increase the levels of CYP3A4 substrates.
In vitro research suggests that betanin, the major pigment in beet, competitively inhibits CYP3A4 in a dose-dependent manner similarly to strong CYP3A4 inhibitor ketoconazole.
Antihypertensive Drugs
Beet and beetroot contain nitrates, which can cause vasodilation, potentially leading to lower blood pressure. However, a study published in the European Journal of Clinical Nutrition using concentrated beetroot juice found no significant impact on blood pressure or heart rate in different age groups. Other small clinical studies suggest that while beet consumption might transiently lower blood pressure due to vessel dilation, there's no consistent evidence of a lasting effect. Overall, the theoretical risk of reduced blood pressure due to beet's nitrate content exists, but studies generally indicate a low and temporary impact rather than a sustained decrease.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, beet might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research suggests that beet induces CYP1A2 enzymes.
Niacin
Alcohol (Ethanol)
Concomitant use of alcohol and niacin might increase the risk of flushing and hepatotoxicity.
Alcohol can exacerbate the flushing and pruritus associated with niacin. Large doses of niacin might also exacerbate liver dysfunction associated with chronic alcohol use. A case report describes delirium and lactic acidosis in a patient taking niacin 3 grams daily who ingested 1 liter of wine. Advise patients to avoid large amounts of alcohol while taking niacin.
Allopurinol (Zyloprim)
Theoretically, niacin might antagonize the therapeutic effects of uricosurics such as allopurinol.
Large doses of niacin can reduce urinary excretion of uric acid, potentially resulting in hyperuricemia. Doses of uricosurics such as allopurinol might need to be increased to maintain control of gout in patients who start taking niacin. People who have frequent attacks of gout despite uricosuric therapy should avoid niacin.
Anticoagulant/Antiplatelet Drugs
Theoretically, niacin may have additive effects when used with anticoagulant or antiplatelet drugs.
Several cases of clotting factor synthesis deficiency and coagulopathy have been reported in patients taking sustained-release niacin. Also, thrombocytopenia has been reported in patients treated with niacin or niacin plus lovastatin.
Antidiabetes Drugs
Niacin can increase blood glucose levels and may diminish the effects of antidiabetes drugs.
Niacin impairs glucose tolerance in a dose-dependent manner, probably by causing or aggravating insulin resistance and increasing hepatic production of glucose. In diabetes patients, niacin 4.5 grams daily for 5 weeks can increase plasma glucose by an average of 16% and glycated hemoglobin (HbA1c) by 21%. However, lower doses of 1.5 grams daily or less appear to have minimal effects on blood glucose. In some patients, glucose levels increase when niacin is started, but then return to baseline when a stable dose is reached. Up to 35% of patients with diabetes may need adjustments in hypoglycemic therapy when niacin is added.
Antihypertensive Drugs
Theoretically, niacin may increase the risk of hypotension when used with antihypertensive drugs.
The vasodilating effects of niacin can cause hypotension. Furthermore, some clinical evidence suggests that a one-hour infusion of niacin can reduce systolic, diastolic, and mean blood pressure in hypertensive patients. This effect is not observed in normotensive patients.
Bile Acid Sequestrants
Bile acid sequestrants can bind niacin and decrease absorption. Separate administration by 4-6 hours to avoid an interaction.
In vitro studies show that colestipol (Colestid) binds about 98% of available niacin and cholestyramine (Questran) binds 10% to 30%.
Gemfibrozil (Lopid)
Theoretically, concomitant use of niacin and gemfibrozil might increase the risk of myopathy in some patients.
A case of myopathy from concomitant use of niacin and gemfibrozil has been reported. Niacin alone has also been associated with cases of myopathy. Using gemfibrozil with niacin might further increase the risk of developing myopathy.
Hepatotoxic Drugs
Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.
Niacin has been associated with cases of liver toxicity, especially when used in pharmacologic doses. Sustained-release niacin preparations appear to be associated with a higher risk of hepatotoxicity than immediate-release niacin.
Hmg-Coa Reductase Inhibitors ("Statins")
Theoretically, concomitant use of niacin and statins might increase the risk of myopathy and rhabdomyolysis in some patients.
Some case reports have raised concerns that niacin might increase the risk of myopathy and rhabdomyolysis when combined with statins. However, a significantly increased risk of myopathy has not been demonstrated in clinical trials, including those using an FDA-approved combination of lovastatin and niacin (Advicor).
Probenecid (Benemid)
Theoretically, niacin might antagonize the therapeutic effects of uricosurics such as probenecid.
Large doses of niacin reduce urinary excretion of uric acid, potentially causing hyperuricemia. Doses of uricosurics such as probenecid might need to be increased to maintain control of gout in patients who start taking niacin. People who have frequent attacks of gout despite uricosuric therapy should avoid niacin.
Sulfinpyrazone (Anturane)
Theoretically, niacin might antagonize the therapeutic effects of uricosurics such as sulfinpyrazone.
Large doses of niacin reduce urinary excretion of uric acid, potentially causing hyperuricemia. Doses of uricosurics such as sulfinpyrazone might need to be increased to maintain control of gout in patients who start taking niacin. People who have frequent attacks of gout despite uricosuric therapy should avoid niacin.
Thyroid Hormone
Theoretically, niacin might antagonize the therapeutic effects of thyroid hormones.
Clinical research and case reports suggests that taking niacin can reduce serum levels of thyroxine-binding globulin by up to 25% and moderately reduce levels of thyroxine (T4). Patients taking thyroid hormone for hypothyroidism might need dose adjustments when using niacin.
Transdermal Nicotine (Nicoderm)
Theoretically, concomitant use of niacin and transdermal nicotine might increase the risk of flushing and dizziness.
Niacin and nicotine can both cause flushing and dizziness.
Warfarin (Coumadin)
There is limited evidence that niacin may increase the anticoagulant effects of warfarin.
In a case report, a patient on warfarin developed an elevated international normalized ratio (INR) of 3.9 after taking niacin for two weeks. The patient's INR was previously stable, ranging between 2 and 3 in recent months, and no other medication changes were identified. The elevated INR returned to therapeutic range within 4 days following the discontinuation of niacin.
Aspirin
Large doses of aspirin might alter the clearance of niacin.
Aspirin is often used with niacin to reduce niacin-induced flushing. Doses of 80-975 mg aspirin have been used, but 325 mg appears to be optimal. Aspirin also seems to reduce the clearance of niacin by competing for glycine conjugation. Taking aspirin 1 gram seems to reduce niacin clearance by 45%. This is probably a dose-related effect and not clinically significant with the more common aspirin dose of 325 mg.
Theobromine
Ace Inhibitors (Aceis)
Theoretically, taking cocoa with ACEIs might increase the risk of adverse effects.
Human research shows that dark chocolate can inhibit ACE. Additionally, prolonged angioedema in an elderly patient on an ACE inhibitor was precipitated with intake of diabetic chocolate.
Adenosine (Adenocard)
Theoretically, cocoa might decrease the vasodilatory effects of adenosine and interfere with its use prior to stress testing.
Cocoa contains caffeine. Caffeine is a competitive inhibitor of adenosine at the cellular level. However, caffeine does not seem to affect supplemental adenosine because high interstitial levels of adenosine overcome the antagonistic effects of caffeine. It is recommended that methylxanthines and methylxanthine-containing products be stopped 24 hours prior to pharmacological stress tests. However, methylxanthines appear more likely to interfere with dipyridamole than adenosine-induced stress testing.
Alcohol (Ethanol)
Theoretically, concomitant use might increase levels and adverse effects of caffeine.
Cocoa contains caffeine. Alcohol reduces caffeine metabolism. Concomitant use of alcohol can increase caffeine serum concentrations and the risk of caffeine adverse effects.
Anticoagulant/Antiplatelet Drugs
Theoretically, cocoa may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Clinical research shows that intake of cocoa can inhibit platelet adhesion, aggregation, and activity and increase aspirin-induced bleeding time. For patients on dual antiplatelet therapy, cocoa may enhance the inhibitory effect of clopidogrel, but not aspirin, on platelet aggregation.
Antihypertensive Drugs
Theoretically, taking cocoa with antihypertensive drugs might increase the risk of hypotension.
Clinical research shows that cocoa can modestly decrease blood pressure in hypertensive and normotensive patients.
Beta-Adrenergic Agonists
Theoretically, large amounts of cocoa might increase the cardiac inotropic effects of beta-agonists.
Cocoa contains caffeine. Theoretically, large amounts of caffeine might increase cardiac inotropic effects of beta-agonists. A case of atrial fibrillation associated with consumption of large quantities of chocolate in a patient with chronic albuterol inhalation abuse has also been reported.
Cytochrome P450 1A2 (Cyp1A2) Inhibitors
Theoretically, concomitant use might increase the levels and adverse effects of caffeine.
Cocoa contains caffeine. Caffeine is metabolized by cytochrome P450 1A2 (CYP1A2),. Theoretically, drugs that inhibit CYP1A2 may decrease the clearance rate of caffeine from cocoa and increase caffeine levels.
Dipyridamole (Persantine)
Theoretically, cocoa might decrease the vasodilatory effects of dipyridamole and interfere with its use prior to stress testing.
Cocoa contains caffeine. Caffeine may inhibit dipyridamole-induced vasodilation. It is recommended that methylxanthines and methylxanthine-containing products be stopped 24 hours prior to pharmacological stress tests. Methylxanthines appear more likely to interfere with dipyridamole than adenosine-induced stress testing.
Disulfiram (Antabuse)
Theoretically, disulfiram might increase the risk of adverse effects from caffeine.
Cocoa contains caffeine. In human research, disulfiram decreases the rate of caffeine clearance.
Diuretic Drugs
Theoretically, using cocoa with diuretic drugs might increase the risk of hypokalemia.
Cocoa contains caffeine. In excessive amounts, caffeine can reduce potassium levels due to stimulation of the sodium-potassium pump. Diuretics can also cause lower potassium levels.
Ephedrine
Theoretically, concomitant use might increase the risk for stimulant adverse effects.
Cocoa contains caffeine. There is evidence that using ephedrine with caffeine might increase the risk of serious life-threatening or debilitating adverse effects such as hypertension, myocardial infarction, stroke, seizures, and death.
Estrogens
Theoretically, estrogens might increase the levels and adverse effects of caffeine.
Cocoa contains caffeine. Estrogen inhibits caffeine metabolism.
Flutamide (Eulexin)
Theoretically, cocoa might increase the levels and adverse effects of flutamide.
Cocoa contains caffeine. In vitro evidence suggests that caffeine can inhibit the metabolism of flutamide.
Fluvoxamine (Luvox)
Theoretically, fluvoxamine might increase the levels and adverse effects of caffeine.
Cocoa contains caffeine. Fluvoxamine reduces caffeine metabolism.
Lithium
Theoretically, abrupt cocoa withdrawal might increase the levels and adverse effects of lithium.
Cocoa contains caffeine. There are two case reports of lithium tremor that worsened upon abrupt coffee withdrawal.
Monoamine Oxidase Inhibitors (Maois)
Theoretically, concomitant use might increase the risk of a hypertensive crisis.
Cocoa contains caffeine. Large amounts of caffeine with MAOIs might precipitate a hypertensive crisis.
Nicotine
Theoretically, concomitant use might increase the risk of hypertension.
Cocoa contains caffeine. Concomitant use of caffeine and nicotine has been shown to have additive cardiovascular effects, including increased heart rate and blood pressure. Blood pressure was increased by 10.8/12.4 mmHg when the agents were used concomitantly.
Pentobarbital (Nembutal)
Theoretically, cocoa might decrease the effects of pentobarbital.
Cocoa contains caffeine. Caffeine might negate the hypnotic effects of pentobarbital.
Phenobarbital (Luminal)
Theoretically, cocoa might reduce the effects of phenobarbital and increase the risk for convulsions.
Cocoa contains caffeine. Animal research suggests that caffeine can decrease the anticonvulsant activity of phenobarbital. The exact mechanism of this interaction is unclear.
Phenylpropanolamine
Theoretically, phenylpropanolamine might increase the risk of hypertension, as well as the levels and adverse effects of caffeine.
Cocoa contains caffeine. Concomitant use of phenylpropanolamine and caffeine might cause an additive increase in blood pressure. Phenylpropanolamine also seems to increase caffeine serum levels.
Phenytoin (Dilantin)
Theoretically, cocoa might reduce the effects of phenytoin and increase the risk for convulsions.
Cocoa contains caffeine. Animal research suggests that caffeine can decrease the anticonvulsant activity of phenytoin. The effect does not seem to be related to the seizure threshold-lowering effects of caffeine. However, the exact mechanism of this interaction is unclear.
Quinolone Antibiotics
Theoretically, quinolone antibiotics might increase the levels and adverse effects of caffeine.
Cocoa contains caffeine. Quinolones (also referred to as fluoroquinolones) decrease caffeine clearance.
Riluzole (Rilutek)
Theoretically, concomitant use might increase the levels and adverse effects of both caffeine and riluzole.
Cocoa contains caffeine. Caffeine and riluzole are both metabolized by cytochrome P450 1A2, and concomitant use might reduce metabolism of one or both agents.
Stimulant Drugs
Theoretically, concomitant use might increase stimulant adverse effects.
Cocoa contains caffeine. Concomitant use might increase the risk of stimulant adverse effects.
Theophylline
Theoretically, cocoa might increase the levels and adverse effects of theophylline.
Cocoa contains caffeine. Large amounts of caffeine might inhibit theophylline metabolism. Caffeine decreases theophylline clearance 23% to 29%.
Caffeine Anhydrous
Ephedrine
Theoretically, concomitant use might increase the risk for stimulant adverse effects.
Use of ephedrine with caffeine can increase the risk of stimulatory adverse effects. There is evidence that using ephedrine with caffeine might increase the risk of serious life-threatening or debilitating adverse effects such as hypertension, myocardial infarction, stroke, seizures, and death.
Adenosine (Adenocard)
Theoretically, caffeine might decrease the vasodilatory effects of adenosine and interfere with its use prior to stress testing.
Some evidence shows that caffeine is a competitive inhibitor of adenosine and can reduce the vasodilatory effects of adenosine in humans. However, other research shows that caffeine does not seem to affect supplemental adenosine because high interstitial levels of adenosine overcome the antagonistic effects of caffeine. It is recommended that methylxanthines and methylxanthine-containing products be stopped 24 hours prior to pharmacological stress tests. However, methylxanthines appear more likely to interfere with dipyridamole (Persantine) than adenosine-induced stress testing.
Anticoagulant/Antiplatelet Drugs
Theoretically, caffeine may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Caffeine is reported to have antiplatelet activity. Theoretically, it might increase the risk of bleeding when used concomitantly with these agents; however, this interaction has not been reported in humans.
Beta-Adrenergic Agonists
Theoretically, large amounts of caffeine might increase the cardiac inotropic effects of beta-agonists.
Carbamazepine (Tegretol)
Theoretically, caffeine might reduce the effects of carbamazepine and increase the risk for convulsions.
Animal research suggests that taking caffeine can lower the anticonvulsant effects of carbamazepine and can induce seizures when taken in doses above 400 mg/kg. Human research has shown that taking caffeine 300 mg in three divided doses along with carbamazepine 200 mg reduces the bioavailability of carbamazepine by 32% and prolongs the plasma half-life of carbamazepine 2-fold in healthy individuals.
Cimetidine (Tagamet)
Theoretically, cimetidine might increase the levels and adverse effects of caffeine.
Cimetidine decreases the rate of caffeine clearance by 31% to 42%.
Clozapine (Clozaril)
Caffeine might increase the levels and adverse effects of clozapine and acutely exacerbate psychotic symptoms.
Caffeine might increase the effects and toxicity of clozapine. Caffeine doses of 400-1000 mg per day inhibit clozapine metabolism. Clozapine is metabolized by cytochrome P450 1A2 (CYP1A2). Although researchers speculate that caffeine might inhibit CYP1A2, there is no reliable evidence that caffeine affects CYP1A2. There is also speculation that genetic factors might make some patients more sensitive to an interaction between clozapine and caffeine. In one case report, severe, life-threatening clozapine toxicity and multiorgan system failure occurred in a patient with schizophrenia stabilized on clozapine who consumed caffeine 600 mg daily.
Dipyridamole (Persantine)
Theoretically, caffeine might decrease the vasodilatory effects of dipyridamole and interfere with its use prior to stress testing.
Caffeine inhibits dipyridamole-induced vasodilation. It is recommended that methylxanthines and methylxanthine-containing products be stopped 24 hours prior to pharmacological stress tests. Methylxanthines appear more likely to interfere with dipyridamole (Persantine) than adenosine-induced stress testing.
Disulfiram (Antabuse)
Theoretically, disulfiram use might increase the levels and adverse effects of caffeine.
Disulfiram decreases the rate of caffeine clearance.
Diuretic Drugs
Theoretically, using caffeine with diuretic drugs might increase the risk of hypokalemia.
Caffeine, especially in excessive amounts, can reduce potassium levels due to stimulation of the sodium-potassium pump. Diuretics can also cause lower potassium levels.
Estrogens
Theoretically, estrogens might increase the levels and adverse effects of caffeine.
Estrogen inhibits caffeine metabolism.
Ethosuximide (Zarontin)
Theoretically, caffeine might reduce the effects of ethosuximide and increase the risk for convulsions.
Animal research suggests that caffeine 92.4 mg/kg can decrease the anticonvulsant activity of ethosuximide. However, this effect has not been reported in humans.
Felbamate (Felbatol)
Theoretically, caffeine might reduce the effects of felbamate and increase the risk for convulsions.
Animal research suggests that a high dose of caffeine 161.7 mg/kg can decreases the anticonvulsant activity of felbamate. However, this effect has not been reported in humans.
Flutamide (Eulexin)
Theoretically, caffeine might increase the levels and adverse effects of flutamide.
In vitro evidence suggests that caffeine can inhibit the metabolism of flutamide. However, this effect has not been reported in humans.
Fluvoxamine (Luvox)
Theoretically, fluvoxamine might increase the levels and adverse effects of caffeine.
Fluvoxamine reduces caffeine metabolism.
Lithium
Abrupt caffeine withdrawal might increase the levels and adverse effects of lithium.
Caffeine has diuretic activity. When abruptly discontinued, caffeine may alter the clearance of lithium. There are two case reports of lithium tremor that worsened upon abrupt coffee withdrawal and 6 case reports of elevated serum lithium levels after reducing or eliminating caffeine intake. In one case, a male with schizoaffective disorder stabilized on lithium had an elevated lithium level after reducing his caffeine intake by 87%. At a later date, he increased his caffeine intake by 6-fold, resulting in a subtherapeutic lithium level and a recurrence of psychiatric symptoms.
Monoamine Oxidase Inhibitors (Maois)
Theoretically, concomitant use might increase the risk of a hypertensive crisis.
Caffeine has been shown to inhibit monoamine oxidase (MAO) A and B in laboratory studies. Concomitant intake of large amounts of caffeine with MAOIs might precipitate a hypertensive crisis. In a case report, a patient that consumed 10-12 cups of caffeinated coffee and took the MAOI tranylcypromine presented with severe hypertension. Hypertension was resolved after the patient switched to drinking decaffeinated coffee.
Nicotine
Theoretically, concomitant use might increase the risk of hypertension.
Concomitant use of caffeine and nicotine has been shown to have additive cardiovascular effects, including increased heart rate and blood pressure. Blood pressure was increased by 10.8/12.4 mmHg when the agents were used concomitantly.
Pentobarbital (Nembutal)
Theoretically, caffeine might decrease the effects of pentobarbital.
Caffeine might negate the hypnotic effects of pentobarbital.
Phenobarbital (Luminal)
Theoretically, caffeine might reduce the effects of phenobarbital and increase the risk for convulsions.
Animal research suggests that caffeine can decrease the anticonvulsant activity of phenobarbital. However, the exact mechanism of this interaction is unclear.
Phenylpropanolamine
Theoretically, phenylpropanolamine might increase the risk of hypertension, as well as the levels and adverse effects of caffeine.
Concomitant use of phenylpropanolamine and caffeine might cause an additive increase in blood pressure. Phenylpropanolamine also seems to increase caffeine serum levels.
Phenytoin (Dilantin)
Theoretically, caffeine might reduce the effects of phenytoin and increase the risk for convulsions.
Animal research suggests that caffeine can decrease the anticonvulsant activity of phenytoin. The effect does not seem to be related to the seizure threshold-lowering effects of caffeine. However, the exact mechanism of this interaction is unclear.
Pioglitazone (Actos)
Theoretically, caffeine might increase the levels and clinical effects of pioglitazone.
Animal research suggests that caffeine can modestly increase the maximum concentration, area under the curve, and half-life of pioglitazone, and also reduce its clearance. This increased the antidiabetic effects of pioglitazone. However, the exact mechanism of this interaction is unclear.
Quinolone Antibiotics
Theoretically, quinolone antibiotics might increase the levels and adverse effects of caffeine.
Quinolones (also called fluoroquinolones) can decrease caffeine clearance by inhibiting cytochrome P450 1A2 (CYP1A2) enzyme.
Riluzole (Rilutek)
Theoretically, concomitant use might increase the levels and adverse effects of both caffeine and riluzole.
Caffeine and riluzole are both metabolized by cytochrome P450 1A2 (CYP1A2), and concomitant use might reduce the metabolism of one or both agents.
N-Acetyl-L-Cysteine
Nitroglycerin
N-acetyl cysteine can increase the risk for hypotension and headaches when taken with intravenous or transdermal nitroglycerin.
Clinical research shows that concomitant administration of N-acetyl cysteine and intravenous or transdermal nitroglycerin can cause severe hypotension and intolerable headaches. Furthermore, in vitro research suggests that N-acetyl cysteine increases the anticoagulant activity of nitroglycerin.
Activated Charcoal
N-acetyl cysteine might reduce the effects of activated charcoal, while activated charcoal might reduce the absorption of N-acetyl cysteine.
N-acetyl cysteine appears to reduce the capacity of activated charcoal to adsorb acetaminophen and salicylic acid. Conversely, although clinical research suggests that although activated charcoal can reduce the absorption of N-acetyl cysteine by up to 40%, it does not seem to reduce its clinical effects. Other clinical evidence suggests that activated charcoal does not affect the absorption of N-acetyl cysteine.
Anticoagulant/Antiplatelet Drugs
Theoretically, N-acetyl cysteine might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Clinical research suggests that intravenous N-acetyl cysteine decreases prothrombin time, prolongs coagulation time, decreases platelet aggregation, and increases blood loss in surgical patients. Furthermore, in vitro research suggests that N-acetyl cysteine increases the anticoagulant activity of nitroglycerin.
Antihypertensive Drugs
Theoretically, N-acetyl cysteine might increase the risk of hypotension when taken with antihypertensive drugs.
Animal research suggests that N-acetyl cysteine potentiates the hypotensive effects of the angiotensin-converting enzyme inhibitors (ACEIs) captopril and enalaprilat. Theoretically, combining N-acetyl cysteine with other antihypertensive drugs might increase the risk of hypotension.
Chloroquine (Aralen)
Theoretically, N-acetyl cysteine might interfere with the antimalarial effects of chloroquine.
Animal research suggests that N-acetyl cysteine might reduce the antimalarial effects of chloroquine by increasing cellular levels of glutathione.
Sodium
Antihypertensive Drugs
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.
Corticosteroids
Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.
Didanosine (Videx)
Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.
Lithium
Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.
Sodium Phosphates
Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.
Sodium-Containing Drugs
Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.
Tolvaptan (Samsca)
Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.
L-Citrulline
Antihypertensive Drugs
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. However, a meta-analysis of 5 small clinical studies suggests that taking L-citrulline 3-6 grams daily for 1-8 weeks does not lower blood pressure when compared with control.
Phosphodiesterase-5 Inhibitors
Theoretically, concurrent use of phosphodiesterase-5 (PDE-5) inhibitors and L-citrulline might result in additive vasodilation.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. Theoretically, taking L-arginine with PDE-5 inhibitors might have additive vasodilatory and hypotensive effects. However, in studies evaluating the combined use of L-arginine and sildenafil for erectile dysfunction, hypotension was not reported.
L-Carnitine L-Tartrate
Acenocoumarol (Sintrom)
Theoretically, L-carnitine might increase the anticoagulant effects of acenocoumarol.
L-carnitine might enhance the anticoagulant effects of acenocoumarol, an oral anticoagulant similar to warfarin, but shorter-acting. There are at least two case reports of INR elevation with concomitant use. In one case, a 33-year-old male with a previously stable INR had an elevated INR of 4.65 after L-carnitine was started and continued for 10 weeks. INR normalized after discontinuation of the L-carnitine-containing product.
Thyroid Hormone
Theoretically, L-carnitine might decrease the effectiveness of thyroid hormone replacement.
L-carnitine appears to act as a peripheral thyroid hormone antagonist by inhibiting entry of thyroid hormone into the nucleus of cells. Taking L-carnitine also seems to diminish some of the symptoms of hyperthyroidism.
Warfarin (Coumadin)
Theoretically, L-carnitine might increase the anticoagulant effects of warfarin.
L-carnitine might increase the anticoagulant effects of acenocoumarol, a shorter-acting oral anticoagulant similar to warfarin. There is not enough information to know whether this interaction occurs with L-carnitine and warfarin.
Brand information
Manufacturer and brand details for One More Rep Hurricane Orange, from the product label.
BPI Sports
See all BPI Sports products- Name
- BPI Sports
- Street Address
- 3149 SW 42nd St. Suite 200
- City
- Hollywood
- State
- FL
- ZipCode
- 33312
- Phone Number
- 954.926.0900
- Web Address
- www.bpisports.com
One More Rep Hurricane Orange by BPI Sports: Common Questions
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The Full Monographs Behind One More Rep Hurricane Orange’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
L-citrulline
Interacts with 178 drugsL-citrulline is an amino acid that the body turns into L-arginine to help make nitric oxide, which relaxes blood vessels and may improve blood flow. It is popular for exercise performance an...
Read the full L-citrulline monograph → Herb & supplement monographN-acetyl Cysteine (nac)
Interacts with 294 drugsN-acetyl cysteine (NAC) is a supplement form of the amino acid cysteine and a building block for the antioxidant glutathione. It has well-established prescription uses for acetaminophen over...
Read the full N-acetyl Cysteine (nac) monograph → Herb & supplement monographL-carnitine
Interacts with 19 drugsL-carnitine is a compound your body makes naturally and also gets from foods like meat. It helps cells turn fat into energy, and supplements are most clearly useful for people with a true ca...
Read the full L-carnitine monograph → Herb & supplement monographSodium
Interacts with 205 drugsSodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...
Read the full Sodium monograph → Herb & supplement monographNiacin
Interacts with 727 drugsNiacin (vitamin B3) is an essential nutrient your body needs for energy and metabolism, and deficiency is uncommon in most developed countries. Prescription-strength niacin has been used to...
Read the full Niacin monograph → Herb & supplement monographBeet
Interacts with 861 drugsBeet, especially beetroot juice, is a nitrate-rich food that may modestly lower blood pressure and slightly improve exercise performance in some people. It is generally safe as a food, but s...
Read the full Beet monograph → Herb & supplement monographCaffeine
Interacts with 655 drugsCaffeine is a natural stimulant found in coffee, tea, and many other plants and products. In moderate amounts it can boost alertness and reduce tiredness for most healthy adults, but too muc...
Read the full Caffeine monograph → Herb & supplement monographCocoa
Interacts with 661 drugsCocoa is rich in plant compounds called flavanols that may modestly support blood vessel function and blood pressure, but most chocolate products are high in sugar, fat, and calories, which...
Read the full Cocoa monograph → Herb & supplement monographPhosphatidylcholine
Phosphatidylcholine is a phospholipid that is part of every cell membrane and a source of choline. People take it for liver, brain, and gut health, but solid human evidence is limited for mo...
Read the full Phosphatidylcholine monograph → Herb & supplement monographYohimbe
Interacts with 1,125 drugsYohimbe is a West African tree bark that contains yohimbine, a compound mainly promoted for erectile dysfunction and as an aphrodisiac. A prescription form of yohimbine has some evidence for...
Read the full Yohimbe monograph →Sources & How We Checked
One More Rep Hurricane Orange's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 689 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
L-citrulline 8 references
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- Romero MJ, Platt DH, Caldwell RB, Caldwell RW. Therapeutic use of citrulline in cardiovascular disease. Cardiovasc Drug Rev 2006;24:275-90. PubMed
- Balderas-Munoz K, Castillo-Martínez L, Orea-Tejeda A, et al. Improvement of ventricular function in systolic heart failure patients with oral L-citrulline supplementation. Cardiol J 2012;19:612-7. PubMed
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- Xu Z, Liu C, Liu S, Zhou Z. Comparison of efficacy and safety of daily oral L-arginine and PDE5Is alone or combination in treating erectile dysfunction: A systematic review and meta-analysis of randomised controlled trials. Andrologia. 2021:e14007. PubMed
Caffeine 236 references
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- Brown NJ, Ryder D, Branch RA. A pharmacodynamic interaction between caffeine and phenylpropanolamine. Clin Pharmacol Ther 1991;50:363-71. PubMed
- Sanderink GJ, Bournique B, Stevens J, et al. Involvement of human CYP1A isoenzymes in the metabolism and drug interactions of riluzole in vitro. Pharmacol Exp Ther 1997;282:1465-72. DOI
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- Aqel RA, Zoghbi GJ, Trimm JR, et al. Effect of caffeine administered intravenously on intracoronary-administered adenosine-induced coronary hemodynamics in patients with coronary artery disease. Am J Cardiol 2004;93:343-6. PubMed
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See these in context on the N-acetyl Cysteine (nac) monograph →
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