Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Renaltrex Ingredients & Drug Interactions

by Global Healing Center

Renaltrex label
See full label image
Liquid Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Renaltrex against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Renaltrex is a dietary supplement by Global Healing Center with 7 active ingredients. Its ingredients are commonly taken for general wellness and energy, gut health, antioxidant support.Based on those ingredients, 2,211 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are organic Marshmallow, wildcrafted Chanca Piedra, organic Uva Ursi. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Renaltrex by Global Healing Center

Ask about any prescription or over-the-counter medication and we check it for interactions with Renaltrex by Global Healing Center — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Renaltrex by Global Healing Center

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 7 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (14.80 mL) without saying how much of each component you get.

Renaltrex contains seven active ingredients in a proprietary blend: fulvic acid, organic horsetail, organic uva ursi, organic marshmallow, wildcrafted hydrangea, wildcrafted chanca piedra, and organic goldenrod. These botanicals are commonly used in traditional remedies for kidney and urinary support.

The product is delivered as a liquid in vegetable glycerin and purified water.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: kidney cleanse and urinary tract health.
  • We looked for evidence on: Kidney stones (nephrolithiasis), Urinary tract infections (UTIs), Bladder health, Renal function, Mild diuretic support.
  • The strongest evidence on file: Chanca Piedra is rated "Possibly Effective" for Kidney stones (nephrolithiasis) (Natural Medicines).
  • Also on file: Uva Ursi is rated "Possibly Ineffective" for Urinary tract infections (UTIs).
  • Also on file: Goldenrod is rated "Insufficient Reliable Evidence To Rate" for Kidney stones (nephrolithiasis), Urinary tract infections (UTIs).

The evidence we hold does not establish that any of these ingredients are effective for their traditional uses. Fulvic acid, horsetail, and marshmallow all carry ratings of insufficient reliable evidence for conditions like respiratory infections, eczema, and fatigue.

Uva ursi is rated possibly ineffective for urinary tract infections. Chanca piedra shows possibly effective evidence only for kidney stones; it is rated likely ineffective for hepatitis B.

Hydrangea and goldenrod have no effectiveness ratings on file. If you're considering this product for a specific health concern, talk with your doctor or pharmacist about what the evidence actually shows.

The evidence, ingredient by ingredient Fulvic Acid Horsetail Uva Ursi Marshmallow Hydrangea Chanca Piedra Goldenrod

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 6 of the 7 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 6 of 7.
  • General safety write-ups exist for 7 of 7.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Short-term use of these ingredients appears generally well tolerated in people without other health conditions, but human safety data are limited across all of them. Fulvic acid may cause diarrhea, headache, or sore throat; horsetail may cause abdominal bloating, increased bowel movements, or nausea; uva ursi may cause nausea, vomiting, diarrhea, or stomach upset, especially at high doses; chanca piedra may cause abdominal pain, nausea, or vomiting; hydrangea may cause gastroenteritis, dizziness, or chest tightness.

Horsetail contains thiaminase, which can lead to thiamine (vitamin B1) deficiency with prolonged use, though Canadian products are required to be tested for this. Goldenrod may rarely cause allergic contact dermatitis.

There is not enough data to confirm safety during pregnancy or breastfeeding for any of these ingredients — the data advises against use in both situations.

Side effects, ingredient by ingredient Fulvic Acid Horsetail Uva Ursi Marshmallow Hydrangea Chanca Piedra Goldenrod

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 7 of the 7 matched ingredients can interact with medications — Goldenrod, Uva Ursi, Chanca Piedra, Hydrangea, Marshmallow, among others.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; lithium.
  • For scale: 2,212 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Renaltrex, double-check with your own doctor or pharmacist if you take blood thinners or antiplatelet drugs (moderate risk), lithium (moderate risk), diuretics (water pills, moderate risk), thyroid hormone (moderate risk), immunosuppressants (moderate risk), or HIV antiretrovirals (moderate risk). Also confirm if you take diabetes medications, any drugs processed through liver enzymes, or oral medications taken at the same time as this supplement.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Renaltrex is a liquid herbal blend with ingredients traditionally used for kidney support, but we don't have evidence establishing they work for that purpose. Because the product interacts significantly with blood thinners, lithium, diuretics, HIV medications, thyroid drugs, and many others metabolized by your liver, you should check your exact medications with the tool on this page before taking it.

If you use any blood pressure, heart, psychiatric, diabetes, or immune-suppressing medication, talk with your own doctor or pharmacist first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 7 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 24, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Renaltrex, straight from the product label.

Brand Global Healing Center
Barcode (UPC) 718122406159
Net contents 2 fl. Oz.; 59.2 mL
Market status On market
Date entered into DSLD Jul 24, 2019
DSLD ID 204382
Product type Other Combinations
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Renaltrex by Global Healing Center, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.5 oz.
Maximum serving Sizes:
0.5 oz.
Servings per container
4
UPC/BARCODE
718122406159
IngredientAmount% DV
Proprietary Blend14.8 mL--
Fulvic Acid0 NP--
organic Horsetail0 NP--
organic Uva Ursi0 NP--
organic Marshmallow0 NP--
wildcrafted Hydrangea0 NP--
wildcrafted Chanca Piedra0 NP--
organic Goldenrod0 NP--

Other ingredients: USP Kosher certified Vegetable Glycerin, purified Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use Initial use: Start with 1 gallon of distilled water. Pour out 5 ounces. Add the following to the gallon: 1 bottle of Renaltrex, 1 ounce of Organic Raw Apple Cider Vinegar, and the juice of 1 organic lemon. Shake and refrigerate. Drink an 8-oz. glass 4 times daily for 4 days on an empty stomach. Regular use: Mix 2 full droppers with 4 ounces purified water and drink before breakfast 2 to 3 times weekly.

Precautions

Warning: Keep out of reach of children.

Consult your healthcare provider before taking if you are pregnant or nursing, or have any other medical concerns.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General Statements

Since 1998

Kidney cleanse Spagyrex formula

FDA Statement of Identity

All Natural Dietary Supplement

Seals/Symbols

GMO Free

Vegan

Made in the USA

Gluten Free

No Animal Testing

Formulation

GMO Free

Vegan

Gluten Free

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Renaltrex by Global Healing Center label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Renaltrex label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Renaltrex by Global Healing Center

These are the 7 active ingredients this product is made of. Select any to open its full monograph.

Serving size0.5 oz. Dosage formLiquid Servings per container4 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Other (inactive) ingredients: USP Kosher certified Vegetable Glycerin, Purified Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Renaltrex by Global Healing Center Drug Interactions

Want to check YOUR meds against Renaltrex?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2,211Drugs
1,120 Moderate 1,091 Minor

Ingredients driving the most interactions

organic Marshmallow 2,040
wildcrafted Chanca Piedra 1,020
organic Uva Ursi 803
Fulvic Acid 257
organic Horsetail 188

Individual Drug Interactions

The ingredients in Renaltrex interact with 2,211 drugs. Click any drug to see the details.

7 of the 7 ingredients in Renaltrex interact with drugs. Each result below shows which ingredient is responsible. organic Marshmallow wildcrafted Chanca Piedra organic Uva Ursi Fulvic Acid organic Horsetail organic Goldenrod wildcrafted Hydrangea

Each ingredient & the kinds of drugs it affects

For each ingredient in Renaltrex with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

organic Marshmallow3 drug types · 2,040 drugs

Lithium

Theoretically, due to potential diuretic effects, marshmallow might reduce excretion and increase levels of lithium.
Marshmallow is thought to have diuretic properties. To avoid lithium toxicity, the dose of lithium might need to be decreased when used with marshmallow.

Likelihood Probable Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, marshmallow flower might have antiplatelet effects.
Animal research suggests that marshmallow flower extract has antiplatelet effects. However, the root and leaf of marshmallow, not the flower, are the plant parts most commonly found in dietary supplements. Theoretically, use of marshmallow flower with anticoagulant/antiplatelet drugs can have additive effects, and might increase the risk for bleeding in some patients.

Likelihood Unlikely Evidence D
Oral Drugs

Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Marshmallow contains mucilage which can affect oral drug absorption. To avoid changes in absorption, take marshmallow 30-60 minutes after oral medications.

Likelihood Possible Evidence D
organic Marshmallow full monograph & interactions

wildcrafted Chanca Piedra8 drug types · 1,020 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, chanca piedra might increase the risk of bleeding when used concomitantly with anticoagulant/antiplatelet drugs.
In vitro research suggests that methyl brevifolincarboxylate, a constituent isolated from chanca piedra, can inhibit platelet aggregation. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, chanca piedra might reduce the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that chanca piedra extract increases CYP1A2 activity. Theoretically, chanca piedra might increase metabolism of CYP1A2 substrates and lower serum concentrations. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, use of chanca piedra might increase the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that chanca piedra extract inhibits CYP3A4. Theoretically, chanca piedra might increase the levels of CYP3A4 substrates. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, concomitant use of chanca piedra with diuretics might increase diuresis.
Some preliminary clinical research in adults with hypertension shows that chanca piedra has diuretic properties. However, higher quality research in adults with kidney stones shows taking chanca piedra does not increase urine volume when compared with placebo. Until more is known, use cautiously in patients taking diuretic drugs.

Likelihood Possible Evidence D
Lithium

Theoretically, chanca piedra might reduce excretion and increase levels of lithium.
Some preliminary clinical research in adults with hypertension shows that chanca piedra has diuretic properties. However, higher quality research in adults with kidney stones shows that taking chanca piedra does not increase urine volume when compared with placebo. Until more is known, use cautiously in patients taking lithium. The dose of lithium might need to be decreased.

Likelihood Possible Evidence D
Norepinephrine (Levophed)

Theoretically, chanca piedra may reduce the effects of norepinephrine.
Animal research suggests that methyl brevifolincarboxylate, a constituent isolated from chanca piedra, can reverse blood vessel contraction caused by norepinephrine.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, concomitant use with antidiabetes drugs might affect glucose control and increase the risk of hypoglycemia.
Animal research suggests that chanca piedra can have hypoglycemic effects. However, a small clinical study in adults with diabetes shows that chanca piedra extract 25 grams orally daily for 1 week does not lower fasting or postprandial blood glucose levels.

Likelihood Unlikely Evidence D
Antihypertensive Drugs

Theoretically, concomitant use of chanca piedra with antihypertensive drugs might have additive blood pressure lowering effects.
Animal research suggests that chanca piedra can decrease blood pressure. However, this effect was not observed in most hypertensive patients treated with chanca piedra for 10 days.

Likelihood Unlikely Evidence D
wildcrafted Chanca Piedra full monograph & interactions

organic Uva Ursi6 drug types · 803 drugs

Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, uva ursi may decrease the metabolism of CYP2C19 substrates.
In vitro, uva ursi appears to inhibit cytochrome CYP2C19. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, uva ursi may decrease the metabolism of CYP3A4 substrates.
In vitro, uva ursi appears to inhibit CYP3A4. This effect has not been reported in humans.

Likelihood Possible Evidence D
Glucuronidated Drugs

Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.
In vitro, uva ursi extract appears to strongly inhibit UDP-glucuronosyltransferase (UGT) 1A1 (UGT1A1). However, uva ursi extract does not appear to inhibit UGT1A1 in animal models. This effect has not been reported in humans.

Likelihood Possible Evidence D
Lithium

Theoretically, uva ursi may increase lithium levels, necessitating a decrease in dose.
Uva ursi may have diuretic properties. Diuretics may increase lithium reabsorption with sodium in the proximal tubule of the kidney. Theoretically, uva ursi might reduce excretion and increase levels of lithium.

Likelihood Probable Evidence D
Urinary Acidifying Agents

Effects of uva ursi in the urinary tract may be reduced by urinary acidifying agents.
Uva ursi seems to work best in alkaline urine. Theoretically, taking uva ursi with medications known to acidify the urine may decrease any effects of uva ursi on the urinary tract.

Likelihood Possible Evidence D
P-Glycoprotein Substrates

Theoretically, uva ursi may alter the levels of drugs transported by P-glycoprotein.
In vitro, uva ursi appears to inhibit the multi-drug transporter protein, P-glycoprotein. This effect has not been reported in humans.

Likelihood Possible Evidence D
organic Uva Ursi full monograph & interactions

Fulvic Acid3 drug types · 257 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, taking fulvic acid may decrease the effectiveness of anticoagulant and antiplatelet drugs.
In vitro evidence shows that fulvic acid, formed from the oxidation and polymerization of protocatechuic acid, can shorten prothrombin time in human plasma, increasing the risk of clot formation.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, taking fulvic acid might decrease the effects of immunosuppressive therapy.
Animal research shows that fulvic acid stimulates immune function.

Likelihood Possible Evidence D
Thyroid Hormone

Theoretically, taking fulvic acid with thyroid hormone therapy might interfere with the ability to normalize thyroid function.
Animal research shows that fulvic acid increases the plasma level of thyroid-stimulating hormone (TSH) and decreases the thyroxine (T4):triiodothyronine (T3) ratio.

Likelihood Possible Evidence D
Fulvic Acid full monograph & interactions

organic Horsetail5 drug types · 188 drugs

Antidiabetes Drugs

Theoretically, taking horsetail with antidiabetes drugs might increase the risk of hypoglycemia.
Equisetum myriochaetum has demonstrated hypoglycemic activity in clinical research. In an animal diabetic model, Equisetum giganteum had hypoglycemic effects. It is unclear whether other horsetail species have hypoglycemic effects.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, taking horsetail with diuretic drugs might increase potassium loss and the risk of hypokalemia.
Laboratory research shows that various species of horsetail have diuretic properties. Due to its diuretic effects, there has been concern that taking horsetail along with potassium-depleting diuretics might increase the risk for hypokalemia. However, pharmacokinetic research in humans shows that taking horsetail 900 mg daily for 4 days does not affect urinary excretion of electrolytes, including potassium and sodium, despite having a diuretic effect similar to taking hydrochlorothiazide 25 mg daily. It is unclear if taking horsetail for a longer duration would affect electrolyte levels. Until more is known, use with caution.

Likelihood Possible Evidence D
Efavirenz (Sustiva)

Theoretically, horsetail might decrease the levels and clinical effects of efavirenz.
In two case reports, patients were found to have detectable viral loads when taking horsetail-containing supplements along with an antiretroviral regimen that included efavirenz. In one case, the antiretroviral regimen included zidovudine, lamivudine, and efavirenz; in the other case, the regimen consisted of emtricitabine, tenofovir disoproxil fumarate, and efavirenz. One month after discontinuing horsetail, the viral loads became undetectable in both cases. The exact mechanism of this interaction is unknown. It is also unclear if this interaction is specific to efavirenz or if it is related to various components of antiretroviral therapy.

Likelihood Possible Evidence D
Lithium

Theoretically, horsetail might increase the levels and adverse effects of lithium.
Animal research suggests that horsetail has diuretic properties. Theoretically, due to these potential diuretic effects, horsetail might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Possible Evidence D
Nucleoside Reverse Transcriptase Inhibitors (Nrtis)

Theoretically, horsetail might decrease the levels and clinical effects of NRTIs.
In two case reports, patients were found to have detectable viral loads when taking horsetail-containing supplements along with an antiretroviral therapy. In one case, the antiretroviral regimen included zidovudine, lamivudine, and efavirenz; in the other case, the regimen consisted of emtricitabine, tenofovir disoproxil fumarate, and efavirenz. One month after discontinuing the supplement, the viral loads became undetectable in both cases. The exact mechanism of these interactions is unknown. It is also unclear if these interactions are specific to NRTIs or if they are related to various components of antiretroviral therapy.

Likelihood Possible Evidence D
organic Horsetail full monograph & interactions

organic Goldenrod1 drug type · 75 drugs

Diuretic Drugs

Theoretically, goldenrod might increase the effects and adverse effects of diuretic drugs.
In vitro and animal research suggests that goldenrod has diuretic effects.

Likelihood Possible Evidence D
organic Goldenrod full monograph & interactions

wildcrafted Hydrangea1 drug type · 1 drug

Lithium

Hydrangea is thought to have diuretic properties. Theoretically, due to these potential diuretic effects, hydrangea might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
wildcrafted Hydrangea full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Renaltrex, from the product label.

Global Healing Center

See all Global Healing Center products
Name
Global Healing Center, LP.
City
Houston
State
Texas
ZipCode
77018
Phone Number
1.800.476.0016
Web Address
www.globalhealingcenter.com
Pharmacist Counseling Corner

Renaltrex by Global Healing Center: Common Questions

Does Renaltrex by Global Healing Center interact with any medications?
Yes. Based on its ingredients, Renaltrex has a known interaction with 2,211 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Renaltrex contains 7 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Renaltrex if I'm pregnant or breastfeeding?
The safety data advises against use during pregnancy and breastfeeding for all the active ingredients in this product. There isn't enough information to know if it's safe for you or your baby. Talk with your doctor or pharmacist before taking it if you're pregnant, planning to become pregnant, or nursing.
What are the most common side effects I might notice?
The most common reported side effects are gastrointestinal: diarrhea, nausea, vomiting, abdominal pain or bloating, and stomach upset. Some people have also reported headache or sore throat. If these bother you, stop taking it and let your doctor or pharmacist know.
Does this product actually work for kidney stones?
Chanca piedra, one ingredient in this blend, is rated possibly effective for kidney stones — that's the strongest evidence we have for any ingredient here. The other ingredients lack established evidence for their traditional uses. If you're dealing with kidney stones, your doctor can discuss what actually works.
What is fulvic acid and why is it in here?
Fulvic acid is an organic compound formed from soil decomposition. It's included in this product for its traditional use in herbal medicine, though the evidence we hold doesn't establish it works for the conditions it's used for. It does interact with blood thinners, immune drugs, and thyroid medications, so that's worth checking before you start.
Should I take Renaltrex at a different time than my other medications?
Marshmallow's mucilage can reduce how well your body absorbs other oral medications taken at the same time. If you do take this product, separate it from your other drugs by 30–60 minutes. But first, check your exact medications with the tool on this page — some may not mix with these ingredients at all.
Can Renaltrex affect how much lithium I need?
Yes. Horsetail, uva ursi, marshmallow, hydrangea, and chanca piedra all have potential diuretic effects that may reduce lithium excretion and raise its levels in your blood. If you take lithium, you must talk with your doctor or pharmacist before using this product — your dose might need to be adjusted.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Renaltrex label
Go deeper

The Full Monographs Behind Renaltrex’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Fulvic Acid

Interacts with 257 drugs

Fulvic acid is a natural compound formed when plants and microbes break down in soil, and it is sold as a supplement for energy, gut, and overall wellness. Human research is very limited, so...

Read the full Fulvic Acid monograph → Herb & supplement monograph

Horsetail

Interacts with 188 drugs

Horsetail is a traditional herb most often used as a mild diuretic and for hair, nail, and bone support, but high-quality human evidence is limited. It can cause thiamine (vitamin B1) loss w...

Read the full Horsetail monograph → Herb & supplement monograph

Uva Ursi

Interacts with 803 drugs

Uva ursi is a traditional herb used mainly for urinary tract infections, and its leaves contain a compound called arbutin that may have antimicrobial effects in the urine. Evidence in people...

Read the full Uva Ursi monograph → Herb & supplement monograph

Marshmallow

Interacts with 2,040 drugs

Marshmallow root is a traditional herb rich in soothing, gel-like fibers called mucilage, which is why it has long been used for coughs, sore throats, and stomach irritation. Evidence for th...

Read the full Marshmallow monograph → Herb & supplement monograph

Hydrangea

Interacts with 1 drug

Hydrangea root has a long history in folk medicine, mainly for urinary and kidney stone complaints, but there is very little modern human research to confirm it works for any condition. Beca...

Read the full Hydrangea monograph → Herb & supplement monograph

Chanca Piedra

Interacts with 1,020 drugs

Chanca piedra is a tropical herb traditionally used as a 'stone breaker' for kidney and gallstones, and for liver and urinary health. Human evidence for these uses is limited and mostly smal...

Read the full Chanca Piedra monograph → Herb & supplement monograph

Goldenrod

Interacts with 75 drugs

Goldenrod is a flowering plant traditionally used as an herbal diuretic and for urinary tract health. Human evidence is limited, and while it is generally well tolerated, people with certain...

Read the full Goldenrod monograph →
Sources

Sources & How We Checked

Renaltrex's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 55 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Fulvic Acid 3 references
  1. Lu, FJ. Arsenic as a promoter in the effect of humic substances on plasma prothrombin time in vitro. Thromb Res 6-15-1990;58(6):537-541. PubMed
  2. Vucskits, AV, Hullar, I, Bersenyi, A, Andrasofszky, E, Kulcsar, M, Szabo, J. Effect of fulvic and humic acids on performance, immune response and thyroid function in rats. J Anim Physiol Anim Nutr (Berl) 2010;94(6):721-728. PubMed
  3. Gandy JJ, Meeding JP, Snyman JR, et al. Phase 1 clinical study of the acute and subacute safety and proof-of-concept efficacy of carbohydrate-derived fulvic acid. Clin Pharmacol. 2012;4:7-11. PubMed

See these in context on the Fulvic Acid monograph →

Horsetail 14 references
  1. Sudan BJ. Seborrhoeic dermatitis induced by nicotine of horsetails (Equisetum arvense L.). Contact Dermatitis 1985;13:201-2.
  2. Perez Gutierrez RM, Laguna GY, Walkowski A. Diuretic activity of Mexican equisetum. J Ethnopharmacol 1985;14:269-72. PubMed
  3. Lemus I, Garcia R, Erazo S, et al. Diuretic activity of an Equisetum bogotense tea (Platero herb): evaluation in healthy volunteers. J Ethnopharmacol 1996;54:55-8. PubMed
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See these in context on the Horsetail monograph →

Uva Ursi 8 references
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Marshmallow 5 references
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See these in context on the Marshmallow monograph →

Hydrangea 1 reference
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See these in context on the Hydrangea monograph →

Chanca Piedra 18 references
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  5. Nishiura, J. L., Campos, A. H., Boim, M. A., Heilberg, I. P., and Schor, N. Phyllanthus niruri normalizes elevated urinary calcium levels in calcium stone forming (CSF) patients. Urol.Res 2004;32(5):362-366. PubMed
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Goldenrod 6 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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