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Dietary supplement

Trim Cafe Ingredients & Drug Interactions

by TLS Weight Loss Solution

Trim Cafe label
See full label image
Powder Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Oct 7, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Trim Cafe against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Trim Cafe is a dietary supplement by TLS Weight Loss Solution with 1 active ingredient. Its ingredients are commonly taken for weight loss, appetite control, cholesterol support.Based on those ingredients, 94 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are GoTrim (IGOB131). Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Trim Cafe by TLS Weight Loss Solution

Ask about any prescription or over-the-counter medication and we check it for interactions with Trim Cafe by TLS Weight Loss Solution — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Trim Cafe by TLS Weight Loss Solution

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 17, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Trim Cafe is a single-ingredient powder: Irvingia gabonensis (GoTrim), a plant extract also known as African mango seed extract. The powder also contains Colombian Arabica coffee as an inactive ingredient for flavor and consistency.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Irvingia Gabonensis's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: thermogenic slimming supplement.
  • We looked for evidence on: Obesity, Metabolic syndrome, Diabetes, Hypercholesterolemia, Weight management, Thermogenesis — and 2 related terms.
  • The closest evidence on file: Irvingia Gabonensis is rated "Insufficient Reliable Evidence To Rate" for Diabetes (Natural Medicines).
  • Also on file: Irvingia Gabonensis is rated "Insufficient Reliable Evidence To Rate" for Hypercholesterolemia, Obesity, Metabolic syndrome.

The evidence for Irvingia gabonensis isn't established in the data we hold. Studies have looked at its potential for weight loss, cholesterol, blood sugar control, and metabolic syndrome, but the evidence is insufficient to rate how well it actually works for any of these uses.

The evidence, ingredient by ingredient Irvingia Gabonensis

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Irvingia gabonensis is generally well tolerated in the short term, but long-term safety and product quality haven't been well studied. The most common side effects reported are flatulence, headache, insomnia, and nausea.

One rare case of liver inflammation (hepatitis) has been reported after starting the supplement, so if you develop yellowing of the skin, abdominal pain, or unusual tiredness, stop and contact your doctor. During pregnancy, the safety data advises against use.

There isn't enough information to know whether it's safe while breastfeeding — talk with your doctor or pharmacist for personalized guidance.

Side effects, ingredient by ingredient Irvingia Gabonensis

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Irvingia Gabonensis.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 94 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Trim Cafe, double-check your medications with your doctor or pharmacist if you take antidiabetes drugs (risk of low blood sugar) or testosterone products (risk of additive effects). No interactions are documented for other common medication types, but confirm your specific drugs first.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Trim Cafe is a single-ingredient weight-loss product whose effectiveness for its intended use isn't well established. If you take antidiabetes medication or testosterone, you should discuss this product with your doctor or pharmacist before starting — the interactions could affect how those drugs work or your blood sugar levels.

For everyone else, check your exact medications using the tool on this page.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Trim Cafe, straight from the product label.

Brand TLS Weight Loss Solution
Net contents 15 Stick Pack(s); 1.75 Ounce(s); 50 Gram(s)
Market status On market
Date entered into DSLD Oct 24, 2023
DSLD ID 298787
Product type Botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Trim Cafe by TLS Weight Loss Solution, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3.3 Gram(s)
Maximum serving Sizes:
3.3 Gram(s)
Servings per container
15
IngredientAmount% DV
GoTrim (IGOB131)300 mg--

Other ingredients: Colombian Arabica Coffee Powder

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Gluten Free

A thermogenic slimming supplement

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

XTLS Weight Loss Solution

General Statements

15 - 0.1164 oz (3.3 g) stickpacks

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Trim Cafe by TLS Weight Loss Solution label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Trim Cafe label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Trim Cafe by TLS Weight Loss Solution

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size3.3 Gram(s) Dosage formPowder Servings per container15 Amounts shown are per serving.

GoTrim (IGOB131)

Interacts with
94 drugs
300 mg per serving Form: African Mango Seed Extract

Irvingia gabonensis (African mango) is a seed extract marketed mainly for weight loss and metabolic health. A few small studies suggest possible benef...

GoTrim (IGOB131) monograph & interactions

Other (inactive) ingredients: Colombian Arabica Coffee Powder. These complete the product’s ingredient list but are not active constituents.

Interaction report

Trim Cafe by TLS Weight Loss Solution Drug Interactions

Want to check YOUR meds against Trim Cafe?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
94Drugs
94 Moderate

Ingredients driving the most interactions

GoTrim (IGOB131) 94

Individual Drug Interactions

The ingredients in Trim Cafe interact with 94 drugs. Click any drug to see the details.

1 of the 1 ingredient in Trim Cafe interact with drugs. Each result below shows which ingredient is responsible. GoTrim (IGOB131)

Each ingredient & the kinds of drugs it affects

For each ingredient in Trim Cafe with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

GoTrim (IGOB131)2 drug types · 94 drugs

Antidiabetes Drugs

Theoretically, taking Irvingia gabonensis with antidiabetes drugs might increase the risk of hypoglycemia in some patients.
Human research shows that Irvingia gabonensis decreases blood sugar in diabetic patients being treated with antidiabetes agents. Monitor blood glucose levels closely. Dose adjustments might be necessary.

Likelihood Possible Evidence B
Testosterone

Theoretically, taking Irvingia gabonensis with testosterone products drugs might cause additive effects in some patients.
Animal research suggests that Irvingia gabonensis increases testosterone levels. The mechanism of action is unclear. Until more is known, advise patients taking testosterone to avoid using or use Irvingia gabonensis cautiously.

Likelihood Possible Evidence D
GoTrim (IGOB131) full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Trim Cafe, from the product label.

TLS Weight Loss Solution

See all TLS Weight Loss Solution products
Name
Market America, Inc.
Street Address
1302 Pleasant Ridge Road
City
Greensboro
State
NC
ZipCode
27409
Pharmacist Counseling Corner

Trim Cafe by TLS Weight Loss Solution: Common Questions

Does Trim Cafe by TLS Weight Loss Solution interact with any medications?
Yes. Based on its ingredients, Trim Cafe has a known interaction with 94 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Trim Cafe contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take if I'm pregnant or breastfeeding?
The safety data advises against use during pregnancy. During breastfeeding, there isn't enough information to know either way — talk with your doctor or pharmacist for personalized advice.
What side effects might I experience?
The most common ones reported are flatulence, headache, insomnia, and nausea. One rare case of liver inflammation has been reported, so if you develop yellowing of the skin, abdominal pain, or unusual tiredness, stop and contact your doctor.
Does it actually work for weight loss?
The evidence isn't established in the data we hold. Studies have looked at it, but there isn't enough reliable research to say how well it works.
Why is there coffee powder in a weight-loss product?
The Colombian Arabica coffee powder is an inactive ingredient — it's there for flavor and to help mix the powder. It's not part of the active formula.
How long has this been studied?
Short-term studies exist, but long-term safety and how consistent the product quality is haven't been well established. That's why talking with your doctor before starting is a good idea.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Trim Cafe label
Go deeper

The Full Monographs Behind Trim Cafe’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Irvingia Gabonensis

Interacts with 94 drugs

Irvingia gabonensis (African mango) is a seed extract marketed mainly for weight loss and metabolic health. A few small studies suggest possible benefits, but the research is limited and low...

Read the full Irvingia Gabonensis monograph →
Sources

Sources & How We Checked

Trim Cafe's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 7 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Irvingia Gabonensis 7 references
  1. Oben JE, Ngondi JL, Momo CN, et al. The use of Cissus quadrangularis/Irvingia gabonensis combination in the management of weight loss: a double-blind placebo-controlled study. Lipids Health Dis 2008;7:12.
  2. Ngondi JL, Etoundi BC, Nyangono CB, et al. IGOB131, a novel seed extract of the West African plant Irvingia gabonensis, significantly reduces body weight and improves metabolic parameters in overweight humans in a randomized double-blind placebo controll
  3. Adamson, I., Okafor, C., and Abu-Bakare, A. A supplement of Dikanut (Irvingia gabonesis) improves treatment of type II diabetics. West Afr.J.Med. 1990;9(2):108-115.
  4. Adamson, I., Okafor, C., and Abu-Bakare, A. Erythrocyte membrane ATPases in diabetes: effect of dikanut (Irvingia gabonensis). Enzyme 1986;36(3):212-215. PubMed
  5. Wolfe OA, Ijeoma UF. Effects of aqueous extracts of Irvingia gabonensis seeds on the hormonal parameters of male guinea pigs. Asian Pacific Journal of Tropical Medicine. 2010;3(3):200-204. DOI
  6. Kilinçalp S, Basar O, Coban S, Yüksel I. Irvingia gabonensis (African mango): innocent magic formula? Acta Gastroenterol Belg 2014;77(1):75-6.
  7. Nonsa-Ard R, Aneknan P, Tong-Un T, Honsawek S, Leelayuwat N. Effects of Irvingia gabonensis Extract on Metabolism, Antioxidants, Adipocytokines, Telomere Length, and Aerobic Capacity in Overweight/Obese Individuals. Nutrients 2022;14(21):4646. PubMed

See these in context on the Irvingia Gabonensis monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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