Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

TUDCA+ Ingredients & Drug Interactions

by EA Enhanced

TUDCA+ label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking TUDCA+ against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

TUDCA+ is a dietary supplement by EA Enhanced with 2 active ingredients. Its ingredients are commonly taken for liver support, digestive complaints, asthma and breathing problems.Based on those ingredients, 207 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Picorhiza kurroa Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against TUDCA+ by EA Enhanced

Ask about any prescription or over-the-counter medication and we check it for interactions with TUDCA+ by EA Enhanced — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of TUDCA+ by EA Enhanced

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

TUDCA+ contains two active ingredients: Tudca and Picrorhiza kurroa Extract. Tudca is a bile acid derivative thought to support liver and digestive function.

Picrorhiza kurroa Extract is derived from a plant used in traditional medicine, believed to have anti-inflammatory and immune-supporting properties. The capsules also contain inactive ingredients — rice flour, silicon dioxide, calcium stearate, and gelatin — that serve as fillers and binders.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Picrorhiza's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Liver health, digestion, and neurological support.
  • We looked for evidence on: Hepatitis, Digestive health, Bile acid metabolism, Neuroprotection.
  • The closest evidence on file: Picrorhiza is rated "Insufficient Reliable Evidence To Rate" for Hepatitis (Natural Medicines).

Evidence for Picrorhiza kurroa is mixed. It's possibly effective for vitiligo.

For asthma, the data suggests it's possibly ineffective. For chronic obstructive pulmonary disease (COPD), hepatitis, and other conditions, we don't have enough reliable evidence to rate its effectiveness.

No effectiveness data are on file for Tudca in our records.

The evidence, ingredient by ingredient Picrorhiza

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Picrorhiza is generally used in traditional medicine, but human safety data are limited, so use with care. Reported side effects from oral use include vomiting, rash, anorexia (loss of appetite), diarrhea, itching, and dizziness.

There isn't enough safety information to recommend Picrorhiza during pregnancy or while breastfeeding — talk with your doctor or pharmacist about whether this product is right for you if you're pregnant, nursing, or planning to become pregnant. No safety data for Tudca are on file.

Side effects, ingredient by ingredient Picrorhiza

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Picrorhiza.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 207 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking TUDCA+, double-check if you're on immunosuppressant drugs (like cyclosporine or tacrolimus for transplant or autoimmune disease) or diabetes medications (including insulin or oral blood-sugar-lowering drugs) — Picrorhiza may interfere with both. No interaction data exist for Tudca in our records.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This product may help with certain conditions, but the evidence is strongest for vitiligo and weaker for others. If you take immunosuppressants or diabetes medications, check with your pharmacist before starting — the Picrorhiza component could interfere with how those drugs work.

Given the limited human safety data, talk with your doctor if you have liver disease, are pregnant, or are breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 23, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about TUDCA+, straight from the product label.

Brand EA Enhanced
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Jan 23, 2025
DSLD ID 321441
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for TUDCA+ by EA Enhanced, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
60
IngredientAmount% DV
Tudca255 mg--
Picorhiza kurroa Extract45 mg--

Other ingredients: Rice Flour, Silicon Dioxide, Calcium Stearate, Gelatin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: Take 1-2 capsules daily with or without food.

For best results stack with liver, kidney & heart support

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General Statements

Hardcore formulas using clinical dosages backed by superhuman results

Seals/Symbols

Made in USA GMP Quality Good Manufacturing Practice Certification

FDA Statement of Identity

Dietary Supplement

Formulation

Liver health Supports digestion Neurological benefits

Precautions

Caution: Do not exceed recommended dosage.

Pregnant or nursing women, children under 18 and individuals with known medical conditions should consult a doctor before taking this or any dietary supplement.

Pregnant or nursing women, children under 18 and individuals with known medical conditions should consult a doctor before taking this or any dietary supplement. Keep out of reach of children and don't use if safety seal is damaged or missing.

Storage

Store in a cool, dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

TUDCA+ by EA Enhanced label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

TUDCA+ label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in TUDCA+ by EA Enhanced

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Tudca

255 mg per serving

Picorhiza kurroa Extract

Interacts with
207 drugs
45 mg per serving Form: Kutkins

Picrorhiza (Picrorhiza kurroa) is a bitter Himalayan herb used in Ayurvedic medicine, mainly for liver and digestive complaints. Early lab and small h...

Picorhiza kurroa Extract monograph & interactions

Other (inactive) ingredients: Rice Flour, Silicon Dioxide, Calcium Stearate, Gelatin. These complete the product’s ingredient list but are not active constituents.

Interaction report

TUDCA+ by EA Enhanced Drug Interactions

Want to check YOUR meds against TUDCA+?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
207Drugs
207 Moderate

Ingredients driving the most interactions

Picorhiza kurroa Extract 207

Individual Drug Interactions

The ingredients in TUDCA+ interact with 207 drugs. Click any drug to see the details.

1 of the 2 ingredients in TUDCA+ interact with drugs. Each result below shows which ingredient is responsible. Picorhiza kurroa Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in TUDCA+ with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Picorhiza kurroa Extract2 drug types · 207 drugs

Antidiabetes Drugs

Evidence from animal research suggests that an extract of picrorhiza can reduce fasting and non-fasting blood sugar levels. Theoretically, picrorhiza might have additive effects with antidiabetes drugs and increase the risk of hypoglycemia. Monitor blood glucose levels closely. Dose adjustments might be necessary. Some antidiabetes drugs include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), and others.

Likelihood Possible Evidence D
Immunosuppressants

Picrorhiza seems to have immunostimulating activity. Theoretically, picrorhiza may interfere with immunosuppressant therapy. Immunosuppressant drugs include azathioprine (Imuran), basiliximab (Simulect), cyclosporine (Neoral, Sandimmune), daclizumab (Zenapax), muromonab-CD3 (OKT3, Orthoclone OKT3), mycophenolate (CellCept), tacrolimus (FK506, Prograf), sirolimus (Rapamune), prednisone (Deltasone, Orasone), and other corticosteroids (glucocorticoids).

Likelihood Possible Evidence D
Picorhiza kurroa Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for TUDCA+, from the product label.

EA Enhanced

See all EA Enhanced products
Name
Enhanced Labs
Street Address
P.O. Box 255671
City
Sacramento
State
CA
ZipCode
95865
Web Address
getenhanced.shop
Pharmacist Counseling Corner

TUDCA+ by EA Enhanced: Common Questions

Does TUDCA+ by EA Enhanced interact with any medications?
Yes. Based on its ingredients, TUDCA+ has a known interaction with 207 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
TUDCA+ contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What does Picrorhiza kurroa do?
Picrorhiza kurroa is a plant extract used in traditional medicine and thought to have anti-inflammatory and immune-supporting properties. In our data, it's possibly effective for vitiligo, but evidence for other uses like asthma or hepatitis is weak or limited.
What are the side effects?
Picrorhiza may cause vomiting, diarrhea, loss of appetite, rash, itching, or dizziness. These effects aren't common, but they can happen. If you notice any of these, stop taking it and talk with your pharmacist.
Can I take this if I'm pregnant or breastfeeding?
There isn't enough safety information for Picrorhiza during pregnancy or breastfeeding. The data advise against use. Talk with your doctor or pharmacist before taking it if you're pregnant, nursing, or planning to become pregnant — they can give you personalized advice.
Why does it matter that this product has 202 medication interactions?
Most of those interactions involve Picrorhiza and medications in two big categories: immunosuppressants and diabetes drugs. That number reflects all the different drug names in those categories, not that every person takes all of them. Use the checker on this page to see if your specific medications are affected.
What's Tudca?
Tudca is a bile acid derivative thought to support liver and digestive function. We don't hold effectiveness or interaction data for it in our records, so we can't tell you how well it works or how it affects medications.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

TUDCA+ label
Go deeper

The Full Monographs Behind TUDCA+’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Picrorhiza

Interacts with 207 drugs

Picrorhiza (Picrorhiza kurroa) is a bitter Himalayan herb used in Ayurvedic medicine, mainly for liver and digestive complaints. Early lab and small human studies suggest possible liver-prot...

Read the full Picrorhiza monograph →
Sources

Sources & How We Checked

TUDCA+'s label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 7 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Picrorhiza 7 references
  1. Sharma ML, Rao CS, Duda PL. Immunostimulatory activity of Picrorhiza kurroa leaf extract. J Ethnopharmacol 1994;41:185-92. PubMed
  2. Bedi KL, Zutshi U, Chopra CL, Amla V. Picrorhiza kurroa, an ayurvedic herb, may potentiate photochemotherapy in vitiligo. J Ethnopharmacol 1989;27:347-52. PubMed
  3. Vaidya AB, Antarkar DS, Doshi JC, et al. Picrorhiza kurroa (Kutaki) Royle ex Benth as a hepatoprotective agent--experimental & clinical studies. J Postgrad Med 1996;42:105-8.
  4. Baruah CC, Gupta PP, Nath A, et al. Anti-allergic and anti-anaphylactic activity of picroliv--a standardised iridoid glycoside fraction of Picrorhiza kurroa. Pharmacol Res 1998;38:487-92.
  5. Doshi VB, Shetye VM, Mahashur AA, Kamat SR. Picrorrhiza kurroa in bronchial asthma. J Postgrad Med 1983;29:89-95.
  6. Joy, K. L. and Kuttan, R. Anti-diabetic activity of Picrorrhiza kurroa extract. J Ethnopharmacol 11-1-1999;67(2):143-148. PubMed
  7. Brockwell C, Ampikaipakan S, Sexton DW, Price D, Freeman D, Thomas M, Ali M, Wilson AM. Adjunctive treatment with oral AKL1, a botanical nutraceutical, in chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis 2014;9:715-21. PubMed

See these in context on the Picrorhiza monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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