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Dietary supplement

UNIQUE Tocotrienol Ingredients & Drug Interactions

by A.C. Grace Company

UNIQUE Tocotrienol label
See full label image
Softgel Capsule Category: Vitamin
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking UNIQUE Tocotrienol against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

UNIQUE Tocotrienol is a dietary supplement by A.C. Grace Company with 1 active ingredient. Its ingredients are commonly taken for heart and cholesterol support, antioxidant support, liver health (fatty liver).Based on those ingredients, 122 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Tocotrienols. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against UNIQUE Tocotrienol by A.C. Grace Company

Ask about any prescription or over-the-counter medication and we check it for interactions with UNIQUE Tocotrienol by A.C. Grace Company — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of UNIQUE Tocotrienol by A.C. Grace Company

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

UNIQUE Tocotrienol is a single-ingredient softgel: tocotrienols, a form of vitamin E. The capsule itself contains gelatin, glycerin, and water — standard inactive ingredients that make up the softgel shell.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: promoting cardiovascular and circulatory health.
  • We looked for evidence on: Hypercholesterolemia, Stroke, Metabolic syndrome, Diabetes, Impaired glucose tolerance (prediabetes), heart health — and 3 related terms.
  • The strongest evidence on file: Tocotrienols is rated "Possibly Effective" for Diabetes (Natural Medicines).
  • Also on file: Tocotrienols is rated "Possibly Ineffective" for Hypercholesterolemia.
  • Also on file: Tocotrienols is rated "Insufficient Reliable Evidence To Rate" for Stroke, Impaired glucose tolerance (prediabetes), Metabolic syndrome.

The evidence for tocotrienols is mixed. For blood sugar control (diabetes), the data rates it possibly effective.

For cholesterol levels, the evidence suggests it's possibly ineffective. For hair loss (alopecia areata) and breast cancer, there isn't enough reliable evidence yet to know either way.

The evidence, ingredient by ingredient Tocotrienols

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Orally, tocotrienols appear to be well tolerated — no adverse effects were reported in clinical trials. Long-term safety at supplement doses, however, isn't well established.

The safety data advises against supplemental doses during pregnancy. For breastfeeding, there isn't enough information to know either way; talk with your doctor or pharmacist before using it while nursing.

Side effects, ingredient by ingredient Tocotrienols

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Tocotrienols.
  • The most serious interaction on file is rated Minor.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 122 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take blood thinners (like warfarin) or antiplatelet drugs (like aspirin or clopidogrel), double-check this product with your pharmacist before starting — tocotrienols may increase bleeding risk, though it hasn't been seen in actual patients yet.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Only minor medication interactions are documented, and safety information is well characterized.

Tocotrienol might be worth considering if you're interested in blood sugar support, though the evidence is still being built. The main caution: if you take blood thinners or antiplatelet drugs, you'll want to check with us first.

Always mention this supplement to your pharmacist, especially if you're pregnant, breastfeeding, or on any clotting medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 10, 2014.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about UNIQUE Tocotrienol, straight from the product label.

Brand A.C. Grace Company
Barcode (UPC) 894612001063
Net contents 60 Softgel(s)
Market status On market
Date entered into DSLD Oct 10, 2014
DSLD ID 36972
Product type Vitamin
Supplement form Softgel Capsule
Dietary claims / uses Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for UNIQUE Tocotrienol by A.C. Grace Company, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
2 Softgel(s)
Servings per container
60
UPC/BARCODE
894612001063
IngredientAmount% DV
Tocotrienols125 mg--

Other ingredients: Gelatin, Glycerin, Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: One or two softgels daily with meal (preferably in evening) or as directed by physician.

Storage

Store in a cool dry place away from direct light.

General Statements

50+ YEARS OF EXCELLENCE!

Since 1962, A.C. Grace Company has specialized in providing the highest quality vitamin E products to healthcare professionals and consumers.

MADE IN U.S.A.

OPTIMUM TOCOTRIENOL COMPLEX for Maximum Health Benefits

Formulation

Devoid of any fillers, additives, colors, preservatives, soy or gluten, UNIQUE E(R) TOCOTRIENOL provides the highest ratio of delta tocotrienol to deliver maximum health benefits such as promoting cardiovascular and circulatory health, including maintenance of cholesterol levels within the normal range.

Tocopherol-Free

TOCOPHEROL FREE

FDA Statement of Identity

DIETARY SUPPLEMENT

Brand IP Statement(s)

UNIQUE E(R) TOCOTRIENOL is the purest tocopherol-free form of natural vitamin E tocotrienols at the highest concentration available derived from the Annatto Bean. Devoid of any fillers, additives, colors, preservatives, soy or gluten, UNIQUE E(R) TOCOTRIENOL provides the highest ratio of delta tocotrienol to deliver maximum health benefits such as promoting cardiovascular and circulatory health, including maintenance of cholesterol levels within the normal range.

Doctor Tested: Application-Based Science(TM)

Seals/Symbols

A.C. GRACE COMPANY

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formula

HIGH DELTA TOCOTRIENOLS

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

UNIQUE Tocotrienol by A.C. Grace Company label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

UNIQUE Tocotrienol label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in UNIQUE Tocotrienol by A.C. Grace Company

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container60 Amounts shown are per serving.

Tocotrienols

Interacts with
122 drugs
125 mg per serving Form: DeltaGOLD Tocotrienols

Tocotrienols are a less common form of vitamin E with strong antioxidant activity studied mostly for cholesterol, liver, and heart health. Early resea...

Tocotrienols monograph & interactions

Other (inactive) ingredients: Gelatin, Glycerin, Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

UNIQUE Tocotrienol by A.C. Grace Company Drug Interactions

Want to check YOUR meds against UNIQUE Tocotrienol?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
122Drugs
122 Minor

Ingredients driving the most interactions

Tocotrienols 122

Individual Drug Interactions

The ingredients in UNIQUE Tocotrienol interact with 122 drugs. Click any drug to see the details.

1 of the 1 ingredient in UNIQUE Tocotrienol interact with drugs. Each result below shows which ingredient is responsible. Tocotrienols

Each ingredient & the kinds of drugs it affects

For each ingredient in UNIQUE Tocotrienol with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Tocotrienols1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Concomitant use of tocotrienols with anticoagulant or antiplatelet agents might increase the risk of bleeding. However, this has not been reported in humans.
Taking tocotrienols orally inhibits experimentally-induced platelet aggregation in humans. Theoretically tocotrienols might increase the risk of bleeding if taken with antiplatelet or anticoagulant drugs. However, tocotrienols 400-800 mg daily have been used with aspirin and/or clopidogrel for 1 year with no clear cumulative antiplatelet effects and no reports of bleeding.

Likelihood Unlikely Evidence B
Tocotrienols full monograph & interactions
The maker

Brand information

Manufacturer and brand details for UNIQUE Tocotrienol, from the product label.

A.C. Grace Company

See all A.C. Grace Company products
Name
A.C. Grace Company
Street Address
P.O. BOX 570
City
Big Sandy
State
TX
ZipCode
75755
Phone Number
903-636-4368
Web Address
www.acgrace.com
Pharmacist Counseling Corner

UNIQUE Tocotrienol by A.C. Grace Company: Common Questions

Does UNIQUE Tocotrienol by A.C. Grace Company interact with any medications?
Yes. Based on its ingredients, UNIQUE Tocotrienol has a known interaction with 122 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
UNIQUE Tocotrienol contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is tocotrienol safe to take while pregnant?
The safety data advises against supplemental doses during pregnancy. If you're pregnant or planning to become pregnant, talk with your doctor or pharmacist before taking this product.
Can I take tocotrienol while breastfeeding?
There isn't enough information to know whether it's safe while breastfeeding. It's best to avoid supplements unless your doctor advises otherwise. Check with your pharmacist or doctor for personalized advice.
Does tocotrienol actually work for cholesterol?
The evidence suggests it's probably not effective for lowering cholesterol. If cholesterol management is your goal, ask your pharmacist about options with stronger research behind them.
What side effects has tocotrienol caused?
In clinical trials taken by mouth, no adverse effects were reported. Tocotrienols are generally well tolerated, though long-term safety at supplement doses hasn't been fully established.
Can tocotrienol help with blood sugar?
The evidence rates it possibly effective for blood sugar control. That means there's some promising research, but more studies are needed to be certain of its benefit.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if UNIQUE Tocotrienol is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

UNIQUE Tocotrienol label
Go deeper

The Full Monographs Behind UNIQUE Tocotrienol’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Tocotrienols

Interacts with 122 drugs

Tocotrienols are a less common form of vitamin E with strong antioxidant activity studied mostly for cholesterol, liver, and heart health. Early research is interesting but far from conclusi...

Read the full Tocotrienols monograph →
Sources

Sources & How We Checked

UNIQUE Tocotrienol's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Tocotrienols 4 references
  1. Mensink RP, van Houwelingen AC, Kromhout D, Hornstra G. A vitamin E concentrate rich in tocotrienols had no effect on serum lipids, lipoproteins, or platelet function in men with mildly elevated serum lipid concentrations. Am J Clin Nutr 1999;69:213-9. PubMed
  2. Baumann LS, Spencer JS. The effects of topical vitamin E on the cosmetic appearance of scars. Dermatol Surg 1999;25:311-5. PubMed
  3. Khoo TL, Halim AS, Zakaria Z, Mat Saad AZ, Wu LY, Lau HY. A prospective, randomised, double-blinded trial to study the efficacy of topical tocotrienol in the prevention of hypertrophic scars. J Plast Reconstr Aesthet Surg. 2011 Jun;64(6):e137-45. Epub 201 PubMed
  4. Slivka A, Rink C, Paoletto D, Sen CK. Platelet function in stroke/transient ischemic attack patients treated with tocotrienol. FASEB J. 2020;34(9):11838-11843. PubMed

See these in context on the Tocotrienols monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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