Celecoxib
104 interactions 6 explained in plain English
Also sold as:
Celebrex
Elyxyb
Vyscoxa
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Most serious with:
Ketorolac
Ketorolac Nasal Spray
Ketorolac Ophthalmic
Ketorolac Injection
Meloxicam Injection
Aspirin
Contraindicated
Celecoxib Ketorolac Acular Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Celecoxib Ketorolac Injection Acular Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Celecoxib Ketorolac Nasal Spray Sprix Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Celecoxib Ketorolac Ophthalmic Acular Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) DetailsMajor
Celecoxib Acetaminophen And Codeine Capital® & Codeine Explained Increased CYP2D6 substrate exposure and an increased risk of CYP2D6 substrate-related adverse effects Details Celecoxib Amitriptyline Elavil Explained An increased risk of bleeding Details Celecoxib Sertraline Explained An increased risk of bleeding Details Celecoxib Apixaban Eliquis Explained An increased risk of bleeding Details Celecoxib Aripiprazole Injection Abilify Increased CYP2D6 substrate exposure and an increased risk of CYP2D6 substrate-related adverse effects Details Celecoxib Aspirin Acuprin® An increased risk of bleeding, decreased renal function, and an increased risk of gastrointestinal adverse events Details Celecoxib Aspirin Rectal Aspirin An increased risk of bleeding, decreased renal function, and an increased risk of gastrointestinal adverse events Details Celecoxib Betrixaban Bevyxxa® An increased risk of bleeding Details Celecoxib Anagrelide Agrylin An increased risk of bleeding Details Celecoxib Bromfenac Ophthalmic Bromday® Increased risk of bleeding Details Celecoxib Budesonide Entocort Increased risk of gastrointestinal ulcer or bleeding Details Celecoxib Budesonide Nasal Spray Rhinocort Increased risk of gastrointestinal ulcer or bleeding Details Celecoxib Budesonide Oral Inhalation Pulmicort Increased risk of gastrointestinal ulcer or bleeding Details Celecoxib Capecitabine Xeloda Increased celecoxib exposure and an increased risk of celecoxib-related adverse effects Details Celecoxib Clopidogrel Plavix An increased risk of bleeding Details Celecoxib Cyclosporine Injection Atopica An increased risk of cycloSPORINE nephrotoxicity Details Celecoxib Cyclosporine Ophthalmic Cequa An increased risk of cycloSPORINE nephrotoxicity Details Celecoxib Dabigatran Pradaxa® An increased risk of bleeding Details Celecoxib Dabigatran Etexilate An increased risk of bleeding Details Celecoxib Dalteparin Injection Fragmin An increased risk of bleeding Details Celecoxib Deflazacort Emflaza Increased risk of gastrointestinal ulcer or bleeding Details Celecoxib Deutetrabenazine Austedo Increased CYP2D6 substrate exposure and an increased risk of CYP2D6 substrate-related adverse effects Details Celecoxib Dexamethasone Injection Decadron Increased risk of gastrointestinal ulcer or bleeding Details Celecoxib Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Increased risk of gastrointestinal ulcer or bleeding Details Celecoxib Digoxin Cardoxin® Increased digoxin exposure and prolonged half-life of digoxin Details Celecoxib Dipyridamole Permole® An increased risk of bleeding Details Celecoxib Doxorubicin Adriamycin Increased CYP2D6 substrate exposure and an increased risk of CYP2D6 substrate-related adverse effects Details Celecoxib Edoxaban Savaysa An increased risk of bleeding Details Celecoxib Emtricitabine Emtriva Increased emtricitabine exposure and an increased risk of emtricitabine-related adverse effects Details Celecoxib Enoxaparin Lovenox An increased risk of bleeding Details Celecoxib Enoxaparin Injection Lovenox An increased risk of bleeding Details Celecoxib Epoprostenol Flolan An increased risk of bleeding Details Celecoxib Etodolac Lodine An increased risk of GI toxicity and an increased risk of bleeding Details Celecoxib Fenoprofen Fenopron An increased risk of GI toxicity and an increased risk of bleeding Details Celecoxib Flecainide Tambocor® Increased CYP2D6 substrate exposure and an increased risk of CYP2D6 substrate-related adverse effects Details Celecoxib Fluorouracil Adrucil Increased celecoxib exposure and an increased risk of celecoxib-related adverse effects DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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