Eszopiclone

24 interactions 3 explained in plain English
Also sold as: Lunesta
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Fentanyl Transdermal Patch Abametapir Buprenorphine Nalbuphine Injection Morphine Injection Ketoconazole Topical
23 Major 1 Moderate
All (24) Major (23) Moderate (1)

Major

Eszopiclone Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of respiratory and CNS depression Details Eszopiclone Abametapir Explained Increased exposure of CYP3A4 substrate Details Eszopiclone Buprenorphine Belbuca Explained An increased risk of respiratory depression and CNS depression Details Eszopiclone Butorphanol Injection Butorphic Increased risk of respiratory and CNS depression Details Eszopiclone Butorphanol Nasal Spray Stadol® NS Increased risk of respiratory and CNS depression Details Eszopiclone Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Eszopiclone Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Eszopiclone Diazepam Nasal Spray Valtoco Increased risk of CNS depression Details Eszopiclone Diazepam Rectal Diastat Increased risk of CNS depression Details Eszopiclone Esketamine Nasal Spray Spravato Increased risk of sedation Details Eszopiclone Fentanyl Transdermal Patch Duragesic® Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Eszopiclone Hydromorphone Injection Dilaudid Increased risk of respiratory and CNS depression Details Eszopiclone Hydromorphone Rectal available generically Increased risk of respiratory and CNS depression Details Eszopiclone Ketoconazole Topical Extina® Foam Increased plasma concentrations of eszopiclone Details Eszopiclone Lacosamide Injection Motpoly An increased risk of CNS depression Details Eszopiclone Letermovir Injection Prevymis Increased CYP3A substrate exposure Details Eszopiclone Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Eszopiclone Metoclopramide Injection Gimoti Increased risk of CNS depression Details Eszopiclone Metoclopramide Nasal Spray Gimoti Increased risk of CNS depression Details Eszopiclone Midazolam Nasal Spray Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Eszopiclone Midazolam Injection Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Eszopiclone Morphine Injection Astramorph® PF Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Eszopiclone Nalbuphine Injection Nubain® Increased risk of respiratory and CNS depression Details

Moderate

Eszopiclone Clonidine Transdermal Patch Catapres An increased risk of sedation and somnolence Details

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