Fludrocortisone

17 interactions
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 11, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Desmopressin Nasal Ofloxacin Moxifloxacin Moxifloxacin Injection Moxifloxacin Ophthalmic Levofloxacin Injection
1 Contraindicated 13 Major 3 Moderate
All (17) Contraindicated (1) Major (13) Moderate (3)

Contraindicated

Fludrocortisone Desmopressin Nasal Concentraid® Increased risk of severe hyponatremia Details

Major

Fludrocortisone Aspirin Acuprin® An increased risk of salicylism subsequent to withdrawal of corticosteroids Details Fludrocortisone Aspirin Rectal Aspirin An increased risk of salicylism subsequent to withdrawal of corticosteroids Details Fludrocortisone Besifloxacin Ophthalmic Besivance An increased risk of tendon rupture Details Fludrocortisone Gatifloxacin Ophthalmic Zymar® An increased risk of tendon rupture Details Fludrocortisone Gemifloxacin Factive An increased risk of tendon rupture Details Fludrocortisone Levofloxacin Levaquin An increased risk of tendon rupture Details Fludrocortisone Levofloxacin Injection Levaquin An increased risk of tendon rupture Details Fludrocortisone Moxifloxacin Avelox An increased risk of tendon rupture Details Fludrocortisone Moxifloxacin Injection Avelox An increased risk of tendon rupture Details Fludrocortisone Moxifloxacin Ophthalmic Moxeza® An increased risk of tendon rupture Details Fludrocortisone Ofloxacin Floxin® An increased risk of tendon rupture Details Fludrocortisone Ofloxacin Ophthalmic Ocuflox An increased risk of tendon rupture Details Fludrocortisone Ofloxacin Otic Floxin® Otic An increased risk of tendon rupture Details

Moderate

Fludrocortisone Furosemide Injection Disal Hypokalemia Details Fludrocortisone Metformin Fortamet® An increased risk of hyperglycemia and potential loss of glycemic control Details Fludrocortisone Olodaterol Oral Inhalation Striverdi An increased risk of hypokalemia Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.