Oxycodone

62 interactions 5 explained in plain English
Also sold as: Oxaydo Oxycontin Roxicodone Roxybond Xtampza
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Lacosamide Injection Palonosetron Injection Ketoconazole Topical Buprenorphine Diazepam Nasal Spray Midazolam Nasal Spray
59 Major 3 Moderate
All (62) Major (59) Moderate (3)

Major

Oxycodone Lefamulin Xenleta Increased sensitive CYP3A4 substrate exposure and an increased risk of sensitive CYP3A4 substrate-related toxicities associated wi... Details Oxycodone Lenacapavir Injection Sunlenca Increased CYP3A substrate exposure and an increased risk of CYP3A substrate-mediated adverse reactions Details Oxycodone Lenacapavir Oral Sunlenca Increased CYP3A substrate exposure and an increased risk of CYP3A substrate-mediated adverse reactions Details Oxycodone Letermovir Injection Prevymis Increased oxyCODONE exposure Details Oxycodone Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Oxycodone Linezolid Injection Zyvox An increased risk of serotonin syndrome or opioid-related toxicity Details Oxycodone Lithium Carbonate Lithobid Increased risk of serotonin syndrome Details Oxycodone Metoclopramide Injection Gimoti Increased risk of CNS depression Details Oxycodone Metoclopramide Nasal Spray Gimoti Increased risk of CNS depression Details Oxycodone Midazolam Nasal Spray Nayzilam An increased risk of respiratory depression, profound sedation, coma and death Details Oxycodone Midazolam Injection Nayzilam An increased risk of respiratory depression, profound sedation, coma and death Details Oxycodone Mitapivat Aqvesme Reduced CYP3A substrate exposure Details Oxycodone Morphine Injection Astramorph® PF Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Oxycodone Nafcillin Injection Unipen® Injection Reduced oxyCODONE exposure Details Oxycodone Nalbuphine Injection Nubain® Reduced analgesic effect or precipitation of withdrawal symptoms, and an increased risk of serotonin syndrome Details Oxycodone Nevirapine Viramune Reduced oxyCODONE exposure Details Oxycodone Octreotide Bynfezia Increased exposure of CYP3A4 substrates with narrow therapeutic index Details Oxycodone Octreotide Injection Bynfezia Increased exposure of CYP3A4 substrates with narrow therapeutic index Details Oxycodone Palonosetron Injection Aloxi® Increased risk of serotonin syndrome Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.