Oxycodone
62 interactions 5 explained in plain English
Also sold as:
Oxaydo
Oxycontin
Roxicodone
Roxybond
Xtampza
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Most serious with:
Lacosamide Injection
Palonosetron Injection
Ketoconazole Topical
Buprenorphine
Diazepam Nasal Spray
Midazolam Nasal Spray
Major
Oxycodone Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Oxycodone Amitriptyline Elavil Explained Increased risk of paralytic ileus and an increased risk of serotonin syndrome Details Oxycodone Sertraline Explained Increased oxyCODONE exposure and an increased risk of serotonin syndrome Details Oxycodone Buprenorphine Belbuca Explained Reduced analgesic effect or precipitation of withdrawal symptoms, and an increased risk of serotonin syndrome Details Oxycodone Trospium / Xanomeline Cobenfy Explained An increased risk of paralytic ileus Details Oxycodone Aripiprazole Injection Abilify Increased risk of respiratory and CNS depression Details Oxycodone Asciminib Scemblix Increased CYP3A4 exposure and an increased risk of CYP3A4-related adverse reactions Details Oxycodone Asenapine Transdermal Patch Secuado Increased risk of respiratory and CNS depression Details Oxycodone Abiraterone Abirtega Increased oxyCODONE exposure Details Oxycodone Aclidinium Oral Inhalation Tudorza An increased risk of paralytic ileus Details Oxycodone Atropine Ophthalmic Atropine Care 1% An increased risk of paralytic ileus Details Oxycodone Butorphanol Injection Butorphic Reduced analgesic effect or precipitation of withdrawal symptoms, and an increased risk of serotonin syndrome Details Oxycodone Butorphanol Nasal Spray Stadol® NS Reduced analgesic effect or precipitation of withdrawal symptoms, and an increased risk of serotonin syndrome Details Oxycodone Cetirizine Injection Aller-Tec An increased risk of respiratory depression, profound sedation, coma and death Details Oxycodone Cetirizine Ophthalmic Zerviate An increased risk of respiratory depression, profound sedation, coma and death Details Oxycodone Clopidogrel Plavix Reduced efficacy of clopidogrel Details Oxycodone Cyclopentolate Ophthalmic Akpentolate® An increased risk of paralytic ileus Details Oxycodone Cyclosporine Injection Atopica Increased oxyCODONE exposure Details Oxycodone Cyclosporine Ophthalmic Cequa Increased oxyCODONE exposure Details Oxycodone Dexamethasone Injection Decadron Reduced oxyCODONE exposure Details Oxycodone Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Reduced oxyCODONE exposure Details Oxycodone Diazepam Nasal Spray Valtoco An increased risk of respiratory depression, profound sedation, coma and death Details Oxycodone Diazepam Rectal Diastat An increased risk of respiratory depression, profound sedation, coma and death Details Oxycodone Diphenhydramine Injection Banophen Increased risk of paralytic ileus and increased risk of respiratory and CNS depression Details Oxycodone Diphenhydramine Topical Afterbite with Antihistamine Increased risk of paralytic ileus and increased risk of respiratory and CNS depression Details Oxycodone Dolasetron Anzemet Increased risk of serotonin syndrome Details Oxycodone Dolasetron Injection Anzemet Increased risk of serotonin syndrome Details Oxycodone Enasidenib Idhifa Reduced CYP3A substrate exposure and reduced efficacy of CYP3A substrate Details Oxycodone Esketamine Nasal Spray Spravato An increased risk of respiratory depression, profound sedation, coma and death Details Oxycodone Fentanyl Transdermal Patch Duragesic® Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Oxycodone Glycopyrronium Topical Cuvposa® An increased risk of paralytic ileus Details Oxycodone Granisetron Transdermal Patch Sancuso Increased risk of serotonin syndrome Details Oxycodone Granisetron Injection Granisol Increased risk of serotonin syndrome Details Oxycodone Hydromorphone Injection Dilaudid Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Oxycodone Hydromorphone Rectal available generically Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Oxycodone Ipratropium Nasal Spray Atrovent Nasal Spray® An increased risk of paralytic ileus Details Oxycodone Ipratropium Oral Inhalation Atrovent® HFA An increased risk of paralytic ileus Details Oxycodone Ketoconazole Topical Extina® Foam Increased oxyCODONE exposure Details Oxycodone Lacosamide Injection Motpoly An increased risk of CNS depression Details Oxycodone Lanreotide Injection Somatuline Altered exposure to CYP3A4 substrate DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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