Protriptyline
106 interactions 6 explained in plain English
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Most serious with:
Metoclopramide Injection
Metoclopramide Nasal Spray
Linezolid Injection
Butorphanol Injection
Alfuzosin
Palonosetron Injection
Contraindicated
Protriptyline Linezolid Injection Zyvox An increased risk of serotonin syndrome Details Protriptyline Metoclopramide Injection Gimoti An increased risk of extrapyramidal reactions and neuroleptic malignant syndrome Details Protriptyline Metoclopramide Nasal Spray Gimoti An increased risk of extrapyramidal reactions and neuroleptic malignant syndrome DetailsMajor
Protriptyline Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of paralytic ileus; increased risk of serotonin syndrome Details Protriptyline Amitriptyline Elavil Explained An increased risk of QT interval prolongation Details Protriptyline Sertraline Explained Increased risk of serotonin syndrome and an increased risk of QT interval prolongation Details Protriptyline Albuterol Oral Inhalation Accuneb® Explained An increased risk of cardiovascular system effects Details Protriptyline Buprenorphine Belbuca Explained An increased risk of QT interval prolongation, an increased risk of serotonin syndrome and an increased risk of paralytic ileus Details Protriptyline Relugolix Orgovyx Explained Increased risk of QT interval prolongation Details Protriptyline Amisulpride Injection Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Protriptyline Arsenic Trioxide Trisenox An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Protriptyline Aripiprazole Injection Abilify An increased risk of QT interval prolongation Details Protriptyline Arsenic Trioxide Injection Trisenox An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Protriptyline Asenapine Transdermal Patch Secuado Increased risk of QT interval prolongation Details Protriptyline Aspirin Acuprin® An increased risk of bleeding Details Protriptyline Aspirin Rectal Aspirin An increased risk of bleeding Details Protriptyline Azithromycin AzaSite An increased risk of QT interval prolongation and torsade de pointes Details Protriptyline Alfuzosin UroXatral An increased risk of QT interval prolongation Details Protriptyline Anagrelide Agrylin Increased risk of QT interval prolongation Details Protriptyline Bedaquiline Sirturo Increased risk of QT interval prolongation Details Protriptyline Bromfenac Ophthalmic Bromday® An increased risk of bleeding Details Protriptyline Butorphanol Injection Butorphic Increased risk of serotonin syndrome; increased risk of respiratory and CNS depression Details Protriptyline Butorphanol Nasal Spray Stadol® NS Increased risk of serotonin syndrome; increased risk of respiratory and CNS depression Details Protriptyline Chloroquine Aralen® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Protriptyline Clonidine Transdermal Patch Catapres Reduced antihypertensive effects and may counteract the hypotensive effects of cloNIDine Details Protriptyline Dasatinib Phyrago An increased risk of QT interval prolongation Details Protriptyline Degarelix Injection Firmagon Increased risk of QT interval prolongation Details Protriptyline Deutetrabenazine Austedo An increased risk of QT interval prolongation Details Protriptyline Diclofenac Ophthalmic Voltaren® Eye Drops An increased risk of bleeding Details Protriptyline Diclofenac Topical (Actinic Keratosis) Pennsaid An increased risk of bleeding Details Protriptyline Diclofenac Topical (Arthritis Pain) Pennsaid® An increased risk of bleeding Details Protriptyline Diclofenac Transdermal Patch Flector An increased risk of bleeding Details Protriptyline Disopyramide Norpace An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Protriptyline Dofetilide Tikosyn An increased risk of QT interval prolongation Details Protriptyline Dolasetron Anzemet Increased risk of serotonin syndrome and QT-interval prolongation Details Protriptyline Dolasetron Injection Anzemet Increased risk of serotonin syndrome and QT-interval prolongation Details Protriptyline Encorafenib Braftovi Increased risk of QT interval prolongation Details Protriptyline Entrectinib Rozlytrek An increased risk of QT interval prolongation Details Protriptyline Etodolac Lodine An increased risk of bleeding Details Protriptyline Fenoprofen Fenopron An increased risk of bleeding DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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