Protriptyline

106 interactions 6 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Protriptyline Flurbiprofen Ophthalmic Ocufen An increased risk of bleeding Details Protriptyline Foscarnet Injection Foscavir An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Protriptyline Fostemsavir Rukobia Increased risk of torsade de pointes Details Protriptyline Gatifloxacin Ophthalmic Zymar® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Protriptyline Gemifloxacin Factive An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Protriptyline Glasdegib Daurismo Increased risk of QT interval prolongation Details Protriptyline Glucagon Injection Baqsimi Increased risk of gastrointestinal side effects Details Protriptyline Glucagon Injection / Solution Baqsimi Increased risk of gastrointestinal side effects Details Protriptyline Glucagon Nasal Powder Baqsimi Increased risk of gastrointestinal side effects Details Protriptyline Glycopyrronium Topical Cuvposa® An increased risk of anticholinergic side effects Details Protriptyline Goserelin Implant Zoladex Increased risk of QT interval prolongation Details Protriptyline Granisetron Transdermal Patch Sancuso Increased risk of serotonin syndrome and QT-interval prolongation Details Protriptyline Granisetron Injection Granisol Increased risk of serotonin syndrome and QT-interval prolongation Details Protriptyline Histrelin Implant Supprelin Increased risk of QT interval prolongation Details Protriptyline Hydromorphone Injection Dilaudid Increased risk of paralytic ileus and an increased risk of serotonin syndrome Details Protriptyline Hydromorphone Rectal available generically Increased risk of paralytic ileus and an increased risk of serotonin syndrome Details Protriptyline Hydroxychloroquine Plaquenil An increased risk of seizures and an increased risk of QT interval prolongation Details Protriptyline Ibuprofen Addaprin An increased risk of bleeding Details Protriptyline Inotuzumab Ozogamicin Injection Besponsa Increased risk of QT interval prolongation Details Protriptyline Isradipine DynaCirc® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Protriptyline Ivabradine Corlanor Increased risk of QT prolongation Details Protriptyline Ketoconazole Topical Extina® Foam Increased risk of QT interval prolongation Details Protriptyline Ketoprofen Actron® An increased risk of bleeding Details Protriptyline Ketorolac Acular An increased risk of bleeding Details Protriptyline Ketorolac Injection Acular An increased risk of bleeding Details Protriptyline Ketorolac Nasal Spray Sprix An increased risk of bleeding Details Protriptyline Ketorolac Ophthalmic Acular An increased risk of bleeding Details Protriptyline Lefamulin Xenleta Increased risk of QT interval prolongation Details Protriptyline Lenvatinib Lenvima Increased risk of QT-interval prolongation Details Protriptyline Levofloxacin Levaquin Increased risk of QT interval prolongation Details Protriptyline Levofloxacin Injection Levaquin Increased risk of QT interval prolongation Details Protriptyline Lithium Carbonate Lithobid Increased risk of serotonin syndrome Details Protriptyline Loperamide Diamode An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Protriptyline Meclofenamate Meclodium® An increased risk of bleeding Details Protriptyline Mefenamic Acid Ponstel® An increased risk of bleeding Details Protriptyline Mefloquine Lariam® An increased risk of QT interval prolongation Details Protriptyline Meloxicam Alloxate An increased risk of bleeding Details Protriptyline Meloxicam Injection Alloxate An increased risk of bleeding Details Protriptyline Metronidazole Flagyl An increased risk of QT interval prolongation Details Protriptyline Metronidazole Injection Flagyl An increased risk of QT interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.