Protriptyline

106 interactions 6 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Metoclopramide Injection Metoclopramide Nasal Spray Linezolid Injection Butorphanol Injection Alfuzosin Palonosetron Injection
3 Contraindicated 97 Major 3 Moderate 3 Minor
All (106) Contraindicated (3) Major (97) Moderate (3) Minor (3)

Major

Protriptyline Metronidazole Topical MetroCream® An increased risk of QT interval prolongation Details Protriptyline Metronidazole Vaginal MetroGel® Vaginal An increased risk of QT interval prolongation Details Protriptyline Morphine Injection Astramorph® PF Increased risk of urinary retention, severe constipation, paralytic ileus and an increased risk of serotonin syndrome Details Protriptyline Moxifloxacin Avelox Increased risk of QT interval prolongation Details Protriptyline Moxifloxacin Injection Avelox Increased risk of QT interval prolongation Details Protriptyline Moxifloxacin Ophthalmic Moxeza® Increased risk of QT interval prolongation Details Protriptyline Nabumetone Relafen An increased risk of bleeding Details Protriptyline Nalbuphine Injection Nubain® Increased risk of serotonin syndrome and an increased risk of paralytic ileus Details Protriptyline Naproxen Aleve An increased risk of bleeding Details Protriptyline Octreotide Bynfezia An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Protriptyline Octreotide Injection Bynfezia An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Protriptyline Ofloxacin Floxin® An increased risk of QT interval prolongation Details Protriptyline Ofloxacin Ophthalmic Ocuflox An increased risk of QT interval prolongation Details Protriptyline Ofloxacin Otic Floxin® Otic An increased risk of QT interval prolongation Details Protriptyline Olodaterol Oral Inhalation Striverdi An increased risk of QT interval prolongation, an increased risk of ventricular arrhythmias and potentiated cardiovascular effects Details Protriptyline Oxaliplatin Injection Eloxatin® Increased risk of QT-interval prolongation Details Protriptyline Palonosetron Injection Aloxi® An increased risk of serotonin syndrome Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.