Ritonavir

174 interactions 11 explained in plain English
Also sold as: Norvir
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Contraindicated

Ritonavir Colchicine Colcrys Explained Increased colchicine exposure and an increased risk of colchicine toxicity Details Ritonavir Simvastatin Flolipid Explained Increased simvastatin exposure and an increased risk of myopathy or rhabdomyolysis Details Ritonavir Atorvastatin Atorvaliq Increased atorvastatin exposure and an increased risk of myopathy, including rhabdomyolysis Details Ritonavir Alfuzosin UroXatral An increase in alfuzosin exposure Details Ritonavir Dihydroergotamine Injection DHE-45® Injection Increased ergot derivatives exposure and an increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Ritonavir Dihydroergotamine Nasal Spray Migranal Increased ergot derivatives exposure and an increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Ritonavir Everolimus Afinitor Increased everolimus exposure and an increased risk of immunosuppressant-related adverse effects Details Ritonavir Finerenone Kerendia Increased finerenone exposure and an increased risk of finerenone-related adverse effects Details Ritonavir Flecainide Tambocor® Increased flecainide exposure and an increased risk of cardiac arrhythmias Details Ritonavir Ivabradine Corlanor Increased ivabradine exposure, an increased risk of ivabradine-related adverse effects and an increased risk of QT prolongation Details Ritonavir Ketoconazole Topical Extina® Foam Increased ketoconazole exposure, an increased nirmatrelvir/ritonavir exposure and an increased risk for QT interval prolongation Details Ritonavir Levonorgestrel After banger An increased risk of ALT elevation, reduced progestin exposure and reduced efficacy of contraceptive Details Ritonavir Levonorgestrel Intrauterine System Kyleena An increased risk of ALT elevation, reduced progestin exposure and reduced efficacy of contraceptive Details Ritonavir Lovastatin Altocor® Increased lovastatin exposure and an increased risk of lovastatin-related adverse effects, such as an increased risk of myopathy o... Details Ritonavir Lurasidone Latuda Increased lurasidone exposure Details Ritonavir Methylergonovine Methergine Increased ergot derivatives exposure and an increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Ritonavir Midazolam Nasal Spray Nayzilam An increased risk of extreme sedation and respiratory depression Details Ritonavir Midazolam Injection Nayzilam An increased risk of extreme sedation and respiratory depression Details Ritonavir Naloxegol Movantik Increased naloxegol exposure and an increased risk of naloxegol-related adverse effects Details Ritonavir Nimodipine Nimotop Increased serum nimodipine concentrations Details

Major

Ritonavir Acetaminophen And Codeine Capital® & Codeine Explained Increased codeine and morphine exposure Details Ritonavir Omeprazole Gastrobim Explained Decreased omeprazole exposure Details Ritonavir Sertraline Explained Increased sertraline exposure and an increased risk of QT interval prolongation Details Ritonavir Buprenorphine Belbuca Explained An increased risk of QT interval prolongation, increased buprenorphine exposure and an increased risk of buprenorphine-related adv... Details Ritonavir Relugolix Orgovyx Explained Increased relugolix exposure and an increased risk of QT interval prolongation Details Ritonavir Acalabrutinib Calquence Increased acalabrutinib exposure Details Ritonavir Ado-Trastuzumab Emtansine Injection KADCYLA Increased exposure of cytotoxic component DM1 (maytansine derivative) and risk of toxicity Details Ritonavir Aliskiren Tekturna Increased aliskiren exposure Details Ritonavir Alpelisib Piqray Increased alpelisib exposure and an increased risk of alpelisib-related adverse effects and toxicity Details Ritonavir Amisulpride Injection Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Ritonavir Apixaban Eliquis Explained Increased apixaban exposure and an increased risk of bleeding Details Ritonavir Arsenic Trioxide Trisenox Increased risk of QT-interval prolongation and torsade de pointes Details Ritonavir Aripiprazole Injection Abilify Increased ARIPiprazole exposure and an increased risk of QT interval prolongation Details Ritonavir Arsenic Trioxide Injection Trisenox Increased risk of QT-interval prolongation and torsade de pointes Details Ritonavir Asciminib Scemblix Increased asciminib exposure and an increased risk of asciminib-related adverse effects Details Ritonavir Asenapine Transdermal Patch Secuado Increased risk of QT interval prolongation Details Ritonavir Atogepant Qulipta Altered atogepant exposure Details Ritonavir Atovaquone Mepron Decreased atovaquone serum concentrations Details Ritonavir Avapritinib Ayvakit Increased avapritinib exposure and increased incidence and severity of adverse reactions Details Ritonavir Azathioprine Azasan An increased risk of hepatotoxicity Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.