Drug & supplement interaction

1,3-dmaa + Aspirin, Butalbital, Caffeine, Codeine Phosphate

Aspirin, Butalbital, Caffeine, Codeine Phosphate brand name: Fiorinal w/ Codeine.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Aspirin, Butalbital, Caffeine, Codeine Phosphate falls into 2 drug categories that 1,3-dmaa can interact with; the most serious is rated moderate. 1,3-DMAA strongly inhibits cytochrome P450 2D6 (CYP2D6) enzymes in vitro.

Read the full interaction report
SeverityModerate
LikelihoodPossible
Interactions2
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

1,3-dmaa and Aspirin, Butalbital, Caffeine, Codeine Phosphate

These two interact in 2 distinct ways. Each one is explained separately below.

Why Are There 2 Interactions?

1,3-dmaa interacts with whole categories of medication. Aspirin, Butalbital, Caffeine, Codeine Phosphate falls into 2 of those categories, so it can interact with 1,3-dmaa in 2 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).

Moderate

CYTOCHROME P450 2D6 (CYP2D6) SUBSTRATES

1 of 2

Why this applies to Aspirin, Butalbital, Caffeine, Codeine Phosphate

Aspirin, Butalbital, Caffeine, Codeine Phosphate falls under CYTOCHROME P450 2D6 (CYP2D6) SUBSTRATES — the group 1,3-dmaa interacts with.

1,3-DMAA strongly inhibits cytochrome P450 2D6 (CYP2D6) enzymes in vitro. Theoretically, 1,3-DMAA can increase levels of CYP2D6 substrates. Some of drugs that are CYP2D6 substrates include amitriptyline (Elavil), clozapine (Clozaril), codeine, desipramine (Norpramin), donepezil (Aricept), fentanyl (Duragesic), flecainide (Tambocor), fluoxetine (Prozac), meperidine (Demerol), methadone (Dolophine), metoprolol (Lopressor, Toprol XL), olanzapine (Zyprexa), ondansetron (Zofran), tramadol (Ultram), trazodone (Desyrel), and others.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the wrinkle with Fiorinal with Codeine: the codeine part is a prodrug. Your body has to switch it on using an enzyme called CYP2D6, turning it into morphine, which is what actually relieves pain. Lab studies suggest 1,3-DMAA blocks that same enzyme. If that happens in people, less codeine gets converted, so you may get weaker pain relief from this medicine rather than more.

On top of that, DMAA is a banned, risky stimulant, and stacking it with the caffeine and butalbital in this combo could really push your heart rate and blood pressure. This interaction rests only on test-tube data, but the bigger issue is that DMAA itself is unsafe. Please run this by your pharmacist or doctor before mixing them.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Liu Y, Santillo MF. Cytochrome P450 2D6 and 3A4 enzyme inhibition by amine stimulants in dietary supplements. Drug Test Anal. 2016;8(3-4):307-10. PubMed
Moderate

STIMULANT DRUGS

2 of 2

Aspirin, Butalbital, Caffeine, Codeine Phosphate also falls under STIMULANT DRUGS.

1,3-DMAA is thought to have stimulant effects. There is concern that taking 1,3-DMAA with stimulant drugs might increase the risk of adverse cardiovascular effects. Some preliminary research shows that taking 1,3-DMAA 50 mg daily in combination with caffeine 250 mg daily does not increase respiratory rate, blood pressure, or other cardiovascular outcomes compared to taking caffeine alone in healthy men. However, a number of cardiovascular side effects have been reported for patients taking 1,3-DMAA in combination with other stimulants including caffeine. Theoretically, combining 1,3-DMAA with stimulant drugs might increase the risk of adverse cardiovascular effects. Some stimulant drugs include amphetamine, caffeine, diethylpropion (Tenuate), methylphenidate, phentermine (Ionamin), pseudoephedrine (Sudafed, others), and many others.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the thing with Fiorinal with Codeine: it already contains caffeine, which is a stimulant in its own right. DMAA is also a powerful stimulant that revs up your fight-or-flight system, raising blood pressure and speeding up your heart. Stacking it on top of the caffeine in this medication could pile those effects together, and I'd worry about a racing or pounding heartbeat, jitteriness, a spike in blood pressure, or chest discomfort.

To be fair, this concern is mostly theoretical, based on how these stimulants work rather than strong studies in people. But DMAA has been linked to real heart problems and is banned by the FDA, so I'd steer clear of it entirely. Please check with your pharmacist or doctor before combining anything with this medication.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Adverse Event Report. Jack3d. Natural MedWatch, May 28, 2011.
  2. Smith TB, Staub BA, Natarajan GM, et al. Acute myocardial infarction associated with dietary supplements containing 1,3-dimethylamylamine and Citrus aurantium. Tex Heart Inst J 2014;41(1):70-2. PubMed
  3. Armstrong M. Atrial Fibrillation with Rapid Ventricular Response following use of Dietary Supplement Containing 1,3 Dimethylamylamine and Caffeine. J Spec Oper Med. 2012 Winter;12(4):1-4. PubMed
  4. Bloomer RJ, Farney TM, Harvey IC, Alleman RJ. Safety profile of caffeine and 1,3-dimethylamylamine supplementation in healthy men. Hum Exp Toxicol. 2013 Nov;32(11):1126-36. PubMed
  5. Brown JA, Buckley NA. Toxicity from bodybuilding supplements and recreational use of products containing 1,3-dimethylamylamine. Med J Aust. 2013 May 6;198(8):414-5. PubMed
  6. Dolan SB, Gatch MB. Abuse liability of the dietary supplement dimethylamylamine. Drug Alcohol Depend. 2015 Jan 1;146:97-102. PubMed
  7. Forrester M. Exposures to 1,3-dimethylamylamine-containing products reported to Texas poison centers. Hum Exp Toxicol. 2013 Jan;32(1):18-23. PubMed
  8. Van Hout MC, Hearne E. "Plant or poison": A netnographic study of recreational use of 1,3-dimethylamylamine (DMAA). Int J Drug Policy. 2015 Dec;26(12):1279-81. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

1,3-dmaa Also Interacts With Other Medications

1,3-dmaa has 320 moderate known drug interactions in our database — the Aspirin, Butalbital, Caffeine, Codeine Phosphate one above is among them. If you take anything else, check it against the full list below.

Moderate 320 No known interaction 2,510 (incl. Aspirin, Butalbital, Caffeine, Codeine Phosphate)
Taking anything else?

Check Another of Your Medications Against 1,3-dmaa

Covers the 2,830 medications we’ve checked against 1,3-dmaa. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Aspirin, Butalbital, Caffeine, Codeine Phosphate

This page covers 1,3-dmaa only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Aspirin, Butalbital, Caffeine, Codeine Phosphate page lists 398 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Asarabacca (major), Beer (major) and Danshen (major).

By severity: 17 major · 334 moderate · 47 minor.

From our pharmacist’s overview on the Aspirin, Butalbital, Caffeine, Codeine Phosphate page

“Fiorinal with Codeine packs four active drugs into one capsule, and I would treat its supplement list with genuine wariness rather than a quick skim. The aspirin component is why roughly half of the 398 ingredients on file raise bleeding risk, while the codeine and butalbital explain a second large cluster that deepens sedation, someti…”

Reviewed by 2 · Jul 18, 2026

Open the Aspirin, Butalbital, Caffeine, Codeine Phosphate interaction page

One more smart check

Taking 1,3-dmaa as Part of a Dietary Supplement Product? Check It for Interactions

We hold 94 real supplement products containing 1,3-dmaa, each one broken down to its full ingredient list — and combination products often carry several ingredients besides 1,3-dmaa. Your product may carry other ingredients that interact with Aspirin, Butalbital, Caffeine, Codeine Phosphate too, on top of 1,3-dmaa — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where 1,3-dmaa and Aspirin, Butalbital, Caffeine, Codeine Phosphate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement 1,3-dmaa
Top half

#417 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Aspirin, Butalbital, Caffeine, Codeine Phosphate
Steady interest

#1,700 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About 1,3-dmaa

What is 1,3-dmaa?

1,3-dmaa
  • Energy and stimulation
  • Pre-workout performance
  • Weight loss
  • Appetite suppression
  • Focus and concentration

DMAA (1,3-dimethylamylamine) is a synthetic stimulant that was sold in pre-workout and weight-loss supplements but has been linked to serious harm, including high blood pressure, heart problems, strokes, and deaths. The U.S. FDA and regulators in many countries have declared it illegal and unsafe in dietary supplements, so it should be avoided.

Read the full 1,3-dmaa monograph & all interactions
Keep checking

Other Drugs & 1,3-dmaa

Browse every other medication we’ve checked against 1,3-dmaa — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
320Moderate
0Minor
2,509No known interaction
320 Moderate 2,509 No interaction
Moderate

320 interactions

Showing 60 of 320 moderate interactions — see all 320 on the 1,3-dmaa page.

No interaction 2,509 drugs checked — show the list

We also checked 1,3-dmaa against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,509 medications checked with no known interaction — see the full 1,3-dmaa list.

See the full 1,3-dmaa interactions page
See every supplement checked against Aspirin, Butalbital, Caffeine, Codeine Phosphate, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
1,3-dmaa monograph › Uses, safety, and every drug interaction in one place Aspirin, Butalbital, Caffeine, Codeine Phosphate supplement interactions › Every supplement checked against Aspirin, Butalbital, Caffeine, Codeine Phosphate, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking 1,3-dmaa and Aspirin, Butalbital, Caffeine, Codeine Phosphate Together: Common Questions

Can you take 1,3-dmaa with Aspirin, Butalbital, Caffeine, Codeine Phosphate?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
Why are there 2 interactions listed for 1,3-dmaa and Aspirin, Butalbital, Caffeine, Codeine Phosphate?
Aspirin, Butalbital, Caffeine, Codeine Phosphate belongs to more than one drug category, and 1,3-dmaa interacts with each of those categories a little differently. We list every one so nothing is missed — your overall risk is driven by the most serious of them.
How serious is the 1,3-dmaa and Aspirin, Butalbital, Caffeine, Codeine Phosphate interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.