Andiroba - Xifaxan (Rifaximin) Interaction
Herbal: Andiroba
Also Known As: Carapa guianensis, Andiroba Oil, Andiroba-Saruba, Andiroba-Saruva, Bastard Mahogany, Brazilian Mahogany, Caoba Bastarda, Caobilla, Carapa, Carapa Rouge, Carapinha, Cedro Macho, Crabwood, Najesí, Nandiroba, Requia
Drug: Rifaximin
Brand names:
Xifaxan
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 25, 2025
Interaction Details
There were no interactions found between Rifaximin and Andiroba. This does not mean the potential for an interaction does not exist, however. There is often a lack of studies and data surrounding traditional medicine, especially concerning drug interactions, so it is important to always consult your provider before making any changes to your medication regimen.
Andiroba Overview
Carapa guianensis, commonly known as Andiroba, is a tropical tree native to the Amazon rainforest, valued for various parts, including its bark, leaves, fruit oil, and seed oil. These parts contain bioactive compounds such as limonoids, triterpenes, coumarins, and flavonoids. The seed oil, rich in oleic and palmitic acids, also contains bitter substances like limonoids or meliacins, such as gedunin and andirobin. Andiroba is believed to possess medicinal properties, including potential anticonvulsant effects of fatty acid amides found in its oil, which may modulate GABA-A receptors. The oil's anti-inflammatory properties are attributed to its limonoid and triterpene content. It also demonstrates anti-plasmodial effects against parasites, primarily due to gedunin and its derivatives. Moreover, Andiroba leaves are used in the treatment of skin conditions such as ulcers and wounds, with research indicating that the leaf extract can accelerate wound healing and epithelialization, potentially through the augmentation of hydroxyproline concentrations.
Rifaximin Overview
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Rifaximin 200-mg tablets are used to treat traveler's diarrhea caused by certain bacteria in adults and children at least 12 years of age. Rifaximin 550-mg tablets are used to prevent episodes of hepatic encephalopathy (changes in thinking, behavior, and personality caused by a build-up of toxins in the brain in people who have liver disease) in adults who have liver disease and to treat irritable bowel syndrome (with diarrhea) in adults. Rifaximin is in a class of medications called antibiotics. Rifaximin treats traveler's diarrhea and irritable bowel syndrome by stopping the growth of the bacteria that cause diarrhea. Rifaximin treats hepatic encephalopathy by stopping the growth of bacteria that produce toxins and that may worsen liver disease. Rifaximin will not work to treat traveler's diarrhea that is bloody or occurs with fever.
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Antibiotics such as rifaximin will not work for colds, flu, or other viral infections. Taking antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment.
Andiroba - More Interactions
Andiroba interacts with 50 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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