Cannabidiol (cbd) + Belladonna Extract, Phenobarbital
Belladonna Extract, Phenobarbital brand name: Belap.
Belladonna Extract, Phenobarbital falls into 4 drug categories that Cannabidiol (cbd) can interact with; the most serious is rated moderate. Theoretically, cannabidiol might have additive effects if used with other CNS depressants.
Read the full interaction reportCannabidiol (cbd) and Belladonna Extract, Phenobarbital
These two interact in 4 distinct ways. Each one is explained separately below.
Why Are There 4 Interactions?
Cannabidiol (cbd) interacts with whole categories of medication. Belladonna Extract, Phenobarbital falls into 4 of those categories, so it can interact with Cannabidiol (cbd) in 4 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).
CNS DEPRESSANTS
1 of 4Why this applies to Belladonna Extract, Phenobarbital
Belladonna Extract, Phenobarbital falls under CNS DEPRESSANTS — the group Cannabidiol (cbd) interacts with.
Preliminary clinical research, case reports, and animal studies suggest that high dose cannabidiol has sedative and hypnotic effects. Theoretically, concomitant use of cannabidiol with drugs with sedative and anesthetic properties may cause additive therapeutic and adverse effects.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
The piece of your Belap to keep an eye on here is the phenobarbital, a barbiturate that calms the nervous system. CBD can have its own mild sedating effect, so layering the two together may add up. In plain terms, you could feel more drowsy, foggy, dizzy, or unsteady than you would from the medicine alone, and that can make driving or moving around the house riskier.
I'll be honest that this concern is mostly theoretical, drawn from how these things behave rather than strong human studies, and it tends to matter more with higher CBD doses. Phenobarbital is a long-acting drug with a narrow safe range, so even small shifts deserve respect. Please loop in your pharmacist or doctor before combining them.
- Carlini EA, Cunha JM. Hypnotic and antiepileptic effects of cannabidiol. J Clin Pharmacol 1981;21(8-9 Suppl):417S-27S. PubMed
- Monti JM. Hypnoticlike effects of cannabidiol in the rat. Psychopharmacology (Berl) 1977;55(3):263-5. PubMed
- Pickens JT. Sedative activity of cannabis in relation to its delta'-trans-tetrahydrocannabinol and cannabidiol content. Br J Pharmacol 1981;72(4):649-56.
- Perez-Vilar S, Karami S, Long K, Leishear K. Cannabidiol exposures in the United States, National Poison Data System, July 2014-June 2021. Clin Toxicol (Phila) 2022. PubMed
CYTOCHROME P450 2C19 (CYP2C19) INDUCERS
2 of 4Belladonna Extract, Phenobarbital also falls under CYTOCHROME P450 2C19 (CYP2C19) INDUCERS.
Cannabidiol is a substrate of CYP2C19 enzymes. Theoretically, drugs that induce CYP2C19 enzymes might decrease the levels and effects of cannabidiol.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here's the thing to notice with this pair: it's the phenobarbital in your Belap that may affect your CBD, not the other way around. Phenobarbital is a strong revver-upper of liver enzymes, including the one called CYP2C19 that helps process CBD. So over time, phenobarbital can speed up how fast your body clears CBD, which may leave you with lower CBD levels and a weaker effect than you'd expect.
This is a theoretical concern based on how the drugs behave, not something proven in studies, so I wouldn't lose sleep over it. Your phenobarbital itself shouldn't become less effective. Still, if you're using CBD for a real reason and feel it isn't working, mention it to your pharmacist or doctor before changing anything.
- Epidiolex (cannabidiol) prescribing information. Greenwich Biosciences, Inc., Carlsbad, CA, 2019. Available at: https://www.epidiolex.com/sites/default/files/EPIDIOLEX_Full_Prescribing_Information.pdf (accessed 5/9/2019)
CYTOCHROME P450 3A4 (CYP3A4) INDUCERS
3 of 4Belladonna Extract, Phenobarbital also falls under CYTOCHROME P450 3A4 (CYP3A4) INDUCERS.
Cannabidiol is a substrate of CYP3A4 enzymes. Theoretically, drugs that induce CYP3A4 enzymes might reduce the levels and effects of cannabidiol.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here's the key thing to know: this interaction works on the CBD, not the other way around. Phenobarbital is a well-known liver enzyme booster (it speeds up the CYP3A4 system). Since your body clears CBD using that same pathway, taking phenobarbital could make your body break CBD down faster, leaving less of it around. In plain terms, your CBD may simply not work as well as you'd expect.
I'll be honest, this is a theoretical concern based on how these drugs behave, not something proven in real patients, so I don't want to alarm you. Phenobarbital is also a serious medicine you should never adjust on your own. Before adding CBD, please run it by your pharmacist or doctor so they can keep an eye on things.
- Epidiolex (cannabidiol) prescribing information. Greenwich Biosciences, Inc., Carlsbad, CA, 2019. Available at: https://www.epidiolex.com/sites/default/files/EPIDIOLEX_Full_Prescribing_Information.pdf (accessed 5/9/2019)
CYTOCHROME P450 2B6 (CYP2B6) SUBSTRATES
4 of 4Belladonna Extract, Phenobarbital also falls under CYTOCHROME P450 2B6 (CYP2B6) SUBSTRATES.
In vitro research shows that cannabidiol inhibits CYP2B6. However, this interaction has yet to be reported in humans. Until more is known, use with caution. Theoretically, concomitant use of cannabidiol with CYP2B6 substrates might increase the risk for adverse effects from these substrates.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here's the thing to know about combining CBD with Belap (which contains phenobarbital). The phenobarbital part is partly broken down by a liver enzyme called CYP2B6, and lab studies suggest CBD can slow that enzyme down. In theory, that could let phenobarbital build up a bit more than usual, nudging up its sedating side effects like extra drowsiness, grogginess, dizziness, or feeling unsteady on your feet.
I want to be honest with you: this is a theoretical concern based on test-tube research, not something that has actually been documented in people. Still, phenobarbital is a sensitive medicine where small shifts can matter, so I'd loop in your pharmacist or doctor before adding any CBD product, and don't change your dose on your own.
- Yamaori S, Maeda C, Yamamoto I, Watanabe K. Differential inhibition of human cytochrome P450 2A6 and 2B6 by major phytocannabinoids. Forensic Toxicol 2011;29:117-24. DOI
- Nasrin S, Watson CJW, Perez-Paramo YX, Lazarus P. Cannabinoid Metabolites as Inhibitors of Major Hepatic CYP450 Enzymes, with Implications for Cannabis-Drug Interactions. Drug Metab Dispos 2021;49(12):1070-1080. PubMed
What These Ratings Mean
Every interaction above is graded three ways — here’s the key to each label.
Clinically significant. Avoid the combination, or use only under close professional supervision.
Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.
Generally not serious. Be aware of it and mention it to your pharmacist.
- LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
- ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
- UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
- AHigh-quality meta-analysis (quantitative systematic review).
- BCase-control study.
- CConsensus.
- DAnecdotal evidence.
These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.
Cannabidiol (cbd) Also Interacts With Other Medications
Cannabidiol (cbd) has 1,050 moderate known drug interactions in our database — the Belladonna Extract, Phenobarbital one above is among them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Cannabidiol (cbd)
We haven’t checked that one against Cannabidiol (cbd) yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Cannabidiol (cbd). Pick one to open its full report.
See Every Supplement That Interacts With Belladonna Extract, Phenobarbital
This page covers Cannabidiol (cbd) only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Belladonna Extract, Phenobarbital page lists 164 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Henbane (major).
By severity: 10 major · 134 moderate · 20 minor.
From our pharmacist’s overview on the Belladonna Extract, Phenobarbital page
“Belap pairs belladonna, a drying antispasmodic, with phenobarbital, a barbiturate that sedates the brain, and its supplement list calls for genuine care. Ten of the 164 documented interactions rate major, and most of the danger is sedation piled on sedation.”
Reviewed by 2 · Jul 18, 2026
Where Cannabidiol (cbd) and Belladonna Extract, Phenobarbital Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#427 of 1,452 supplements looked up here in the last 7 days
#565 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
About Cannabidiol (cbd)
What is Cannabidiol (cbd)?
- Anxiety and stress
- Sleep problems
- Chronic pain
- Certain seizure disorders
- Inflammation
CBD is a compound from the cannabis (hemp) plant that does not cause a 'high.' It has strong evidence only for certain rare seizure disorders (as a prescription drug), while most other popular uses are still backed by limited or early research. Product quality varies a lot, so talk with your pharmacist or doctor before using it, especially if you take other medicines.
Other Drugs & Cannabidiol (cbd)
Browse every other medication we’ve checked against Cannabidiol (cbd) — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
1,050 interactions
- Diclofenac Sodium ›
- Diltiazem ›
- Theophylline ›
- Nifedipine ›
- Ibuprofen ›
- Metronidazole ›
- Diphenhydramine ›
- Hydrocortisone ›
- Naproxen ›
- Erythromycin ›
- Estradiol ›
- Propranolol ›
- Lidocaine ›
- Norethindrone ›
- Testosterone ›
- Verapamil ›
- Levonorgestrel ›
- Prednisone ›
- Quinidine ›
- Cyclosporine ›
- Dexamethasone ›
- Flurazepam ›
- Glyburide ›
- Triazolam ›
- Zopiclone ›
- Bupropion ›
- Ciprofloxacin ›
- Colchicine ›
- Fentanyl ›
- Flurbiprofen ›
- Isotretinoin ›
- Orphenadrine ›
- Oxybutynin ›
- Oxycodone ›
- Phenytoin ›
- Prednisolone ›
- Tacrolimus ›
- Temazepam ›
- Apomorphine ›
- Budesonide ›
- Carbamazepine ›
- Clindamycin ›
- Dextromethorphan ›
- Diclofenac Potassium ›
- Doxorubicin ›
- Fluticasone ›
- Formoterol ›
- Indomethacin ›
- Miconazole ›
- Morphine Sulfate ›
- Nitrazepam ›
- Trimipramine ›
- Acetaminophen ›
- Amphetamine ›
- Buprenorphine ›
- Conjugated Estrogens ›
- Diazepam ›
- Everolimus ›
- Griseofulvin ›
- Ivabradine ›
Showing 60 of 1,050 moderate interactions — see all 1,050 on the Cannabidiol (cbd) page.
No interaction 1,779 drugs checked — show the list
We also checked Cannabidiol (cbd) against these medications and found no known interaction in our sources. Open any page to confirm.
- Levothyroxine ›
- Methylphenidate ›
- Ivermectin ›
- Aspirin ›
- Rosuvastatin ›
- Tirzepatide ›
- Docusate ›
- Hydroxyurea ›
- Valacyclovir ›
- Metformin ›
- Sumatriptan ›
- Semaglutide ›
- Levothyroxine, Liothyronine ›
- Methotrexate ›
- Amoxicillin ›
- Lisinopril ›
- Azithromycin ›
- Doxycycline ›
- Acyclovir ›
- Methylene Blue ›
- Candesartan Cilexetil ›
- Amoxicillin, Clavulanate Potassium ›
- Acetylsalicylic Acid ›
- Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate ›
- Insulin Degludec, Liraglutide ›
- Aluminum Hydroxide, Aspirin, Magnesium Hydroxide ›
- Ezetimibe ›
- Cephalexin ›
- Cyclopentolate ›
- Atenolol, Chlorthalidone ›
- Avatrombopag Maleate ›
- Thyroid Hormone ›
- Carbidopa, Levodopa ›
- Bendroflumethiazide, Rauwolfia Serpentina ›
- Mannitol ›
- Levodopa ›
- Enalapril Maleate ›
- Canagliflozin, Metformin ›
- Aspirin, Butalbital ›
- Acarbose ›
- Spironolactone ›
- Ceftolozane Sulfate, Tazobactam Sodium ›
- Alginic Acid, Aluminum Hydroxide ›
- Mitomycin ›
- Atenolol ›
- Charcoal (otc Drug) ›
- Efgartigimod Alfa-fcab ›
- Levothyroxine Sodium ›
- Magnesium Hydroxide (otc Drug) ›
- Hydrocortisone, Clioquinol, Pramoxine ›
- Daunorubicin, Cytarabine ›
- Atropine Methyl Nitrate, Digestive Enzymes ›
- Peginterferon Alfa-2a, Ribavirin ›
- Aminolevulinic Acid Hydrochloride ›
- Articaine, Epinephrine ›
- Alpha-1 Proteinase Inhibitor ›
- Minoxidil ›
- Sodium Bicarbonate (otc Drug) ›
- Cytomegalovirus Immune Globulin ›
- Saxagliptin, Metformin Xr ›
Showing the 60 most looked-up of 1,779 medications checked with no known interaction — see the full Cannabidiol (cbd) list.
Sources & How We Checked
Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference for vitamins, herbs and supplements — the basis for our interaction data.
- MedlinePlus, U.S. National Library of Medicine — NIH consumer drug information, used for the medication overviews.
- NIH Dietary Supplement Label Database (DSLD) — Official supplement product labels.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Belladonna Extract, Phenobarbital Is Linked to Lower Levels of 7 Nutrients
Natural Medicines records Belladonna Extract, Phenobarbital as a medicine that can lower these. This is not an interaction with Cannabidiol (cbd) — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Belladonna Extract, Phenobarbital nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Cannabidiol (cbd) and Belladonna Extract, Phenobarbital Together: Common Questions
Can you take Cannabidiol (cbd) with Belladonna Extract, Phenobarbital?
Why are there 4 interactions listed for Cannabidiol (cbd) and Belladonna Extract, Phenobarbital?
How serious is the Cannabidiol (cbd) and Belladonna Extract, Phenobarbital interaction?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.