Drug & supplement interaction

Chrysin + Toremifene Citrate

Toremifene Citrate brand name: Fareston.

Minor Interaction
Medically reviewed by · Updated September 2026
The bottom line Minor

Chrysin has a minor interaction with Toremifene Citrate. Theoretically, chrysin might increase the clearance of drugs that are UGT1A1 substrates, thereby reducing their effectiveness.

Read the full interaction report
SeverityMinor
LikelihoodUnlikely
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Chrysin and Toremifene Citrate

Here is the interaction we found between these two, with the evidence behind it.

Minor

GLUCURONIDATED DRUGS

Why this applies to Toremifene Citrate

Toremifene Citrate falls under GLUCURONIDATED DRUGS — the group Chrysin interacts with.

Theoretically, chrysin might increase the clearance of drugs that are UGT1A1 substrates, thereby reducing their effectiveness.
In vitro research suggests that chrysin might induce UDP-glucuronosyltransferase 1A1 (UGT1A1).
Severity Minor Likelihood Unlikely Evidence D

Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist for toremifene (Fareston). Your body partly clears this medicine by attaching a sugar molecule to it through an enzyme system called UGT1A1. In test-tube studies, chrysin seems to speed up that enzyme. In theory, that could push toremifene out of your system a little faster, which might make it slightly less effective at blocking estrogen in breast tissue.

I want to be straight with you, though: this is a theoretical, lab-only finding, and chrysin is very poorly absorbed when taken by mouth, so a real-world effect is unlikely. Still, toremifene is treating something serious, so I wouldn't gamble on it. Please run any chrysin use by your oncologist or pharmacist first.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Galijatovic A, Walle UK, Walle T. Induction of UDP-glucuronosyltransferase by the flavonoids chrysin and quercetin in Caco-2 cells. Pharm Res 2000;17:21-6.
  2. Walle T, Otake Y, Galijatovic A, et al. Induction of UDP-glucuronosyltransferase UGT1A1 by the flavonoid chrysin in the human hepatoma cell line hep G2. Drug Metab Dispos 2000;28:1077-82. DOI
  3. Galijatovic A, Otake Y, Walle UK, Walle T. Induction of UDP-glucuronosyltransferase UGT1A1 by the flavonoid chrysin in Caco-2 cells--potential role in carcinogen bioinactivation. Pharm Res 2001;18:374-9. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Chrysin Also Interacts With Other Medications

Chrysin has 179 moderate, 178 minor known drug interactions in our database — the Toremifene Citrate one above is one of them. If you take anything else, check it against the full list below.

Moderate 179 Minor 178 No known interaction 2,473 (incl. Toremifene Citrate)
Taking anything else?

Check Another of Your Medications Against Chrysin

Covers the 2,830 medications we’ve checked against Chrysin. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Toremifene Citrate

This page covers Chrysin only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Toremifene Citrate page lists 143 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

By severity: 3 major · 101 moderate · 39 minor.

From our pharmacist’s overview on the Toremifene Citrate page

“Toremifene (Fareston) treats hormone receptor positive breast cancer, and I'd want you to be genuinely careful with supplements while you're on it. Of the 143 flagged ingredients, 121 can change how your liver clears toremifene through an enzyme called CYP3A4, so your blood level of the drug can drift up or down.”

Reviewed by 2 · Jul 18, 2026

Open the Toremifene Citrate interaction page

One more smart check

Taking Chrysin as Part of a Dietary Supplement Product? Check It for Interactions

We hold 272 real supplement products containing Chrysin, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Chrysin. Your product may carry other ingredients that interact with Toremifene Citrate too, on top of Chrysin — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Chrysin and Toremifene Citrate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Chrysin
Top 25%

#306 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Toremifene Citrate
Steady interest

#1,445 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Chrysin

What is Chrysin?

  • Bodybuilding and testosterone support
  • Anxiety and stress
  • Anti-inflammatory
  • Antioxidant support
  • Prostate health

Chrysin is a plant flavonoid sold mainly as a bodybuilding supplement claimed to raise testosterone or block estrogen, but human studies have not shown these benefits, largely because the body absorbs very little of it. Evidence for its other proposed uses is mostly limited to laboratory and animal research, so its real-world value is unclear. Talk with your pharmacist or doctor before using it.

Read the full Chrysin monograph & all interactions
Medication

About Toremifene

What Is Toremifene Used For?

Brand name: Fareston

Toremifene citrate tablets — sold as Fareston and under the generic name toremifene citrate — are used to treat metastatic breast cancer (breast cancer that has spread to other parts of the body) in postmenopausal women. It is specifically approved for tumors that test positive for estrogen receptors, or for tumors where the receptor status is not known.

See full Toremifene drug information
Keep checking

Other Drugs & Chrysin

Browse every other medication we’ve checked against Chrysin — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
179Moderate
178Minor
2,472No known interaction
179 Moderate 178 Minor 2,472 No interaction
Moderate

179 interactions

Showing 60 of 179 moderate interactions — see all 179 on the Chrysin page.

Minor

178 interactions

Showing 60 of 178 minor interactions — see all 178 on the Chrysin page.

No interaction 2,472 drugs checked — show the list

We also checked Chrysin against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,472 medications checked with no known interaction — see the full Chrysin list.

See the full Chrysin interactions page
See every supplement checked against Toremifene Citrate, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Chrysin monograph › Uses, safety, and every drug interaction in one place Toremifene Citrate supplement interactions › Every supplement checked against Toremifene Citrate, ranked by severity Toremifene drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Chrysin and Toremifene Citrate Together: Common Questions

Can you take Chrysin with Toremifene Citrate?
There is only a minor interaction, which is usually not serious. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Chrysin and Toremifene Citrate interaction?
We rate it Minor. This interaction is generally not clinically significant, but it remains worth noting and discussing with your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Toremifene Citrate and Chrysin?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.