Coconut Water - Raxar (Grepafloxacin) Interaction
Herbal: Coconut Water
Also Known As: Cocos nucifera
Drug: Grepafloxacin
Brand names:
Raxar
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Jul 07, 2024
Interaction Details
Grepafloxacin is classified as belonging to the following category: Quinolone Antibiotics
Many quinolone antibiotics, such as ciprofloxacin and levofloxacin, may have reduced absorption when taken with calcium-containing products due to chelation. It is generally recommended to take quinolones at least 2 hours before or 6 hours after consuming oral products that contain calcium. The calcium content of coconut water varies by product but is generally between 100mg-300mg per 1,000mL. Consumption of a small amount of coconut water may be safe but it would be prudent to avoid drinking large amounts at the same time as a quinolone antibiotic. Reference: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/019537s086lbl.pdf
Interaction Rating
Likelihood of Occurrence
ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
Coconut Water Overview
Coconut water is the clear liquid found inside green, immature coconuts. As the coconut matures, this water decreases and is replaced by coconut meat. The fluid content in immature coconuts ranges from about 500-1000 mL. Unlike coconut water, coconut milk is produced from an emulsion of the grated meat and water of a mature coconut. Coconut water has a pH ranging from 4.2 to 6 and contains various electrolytes, with sodium concentrations in commercial coconut water ranging from 0.7 to 46.3 mEq/L, typically around 5-10 mEq/L. Potassium concentrations range from 35 to 82 mEq/L, chloride from 21 to 63 mEq/L, glucose from 1.2 to 2.8 grams/L, calcium from 5 to 17 mEq/L, and magnesium from 5 to 25 mEq/L. Additionally, coconut water is rich in flavonoids, anthocyanins, benzaldehydes, amino acids, and phenolic acids, which contribute to its health benefits.
Coconut Water - More Interactions
Coconut Water interacts with 273 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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