Drug & supplement interaction

Ipriflavone + Barium Sulfate

Barium Sulfate brand names: E-Z-HD, Readi-Cat 2, Readi-Cat 2 Smoothies, Varibar.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 27, 2026
The bottom line No known interaction

We found no known interaction between Ipriflavone and Barium Sulfate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Ipriflavone and Barium Sulfate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Barium Sulfate and Ipriflavone in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Ipriflavone safety at a glance

Ipriflavone overall Use caution May lower white blood cell counts and has limited long-term safety data.
Pregnancy Avoid Not enough safety data and possible estrogen-like effects; avoid use.
Breastfeeding Avoid No reliable safety information during breastfeeding; best avoided.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Barium Sulfate and Ipriflavone? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Barium Sulfate

Interactions in our licensed database are recorded against drug classes, not just single drug names. Barium Sulfate is filed under a single classification — oral drugs. Ipriflavone has documented interactions with 4 drug classes — the most serious being cytochrome p450 1a2 (cyp1a2) substrates (moderate), cytochrome p450 2c9 (cyp2c9) substrates (moderate) and immunosuppressants (moderate) — and none of Barium Sulfate’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Ipriflavone Does Interact With Other Medications

Ipriflavone has 391 moderate known drug interactions in our database — Barium Sulfate isn’t one of them. If you take anything else, check it against the full list below.

Moderate 391 No known interaction 2,439 (incl. Barium Sulfate)
Taking anything else?

Check Another of Your Medications Against Ipriflavone

Covers the 2,830 medications we’ve checked against Ipriflavone. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Ipriflavone and Barium Sulfate May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Diarrhea reported in 6.2% of FDA reports for Barium Sulfate Additional detail

    Ipriflavone

    “Orally, ipriflavone is generally well-tolerated. However, some patients taking ipriflavone can experience epigastric pain, diarrhea, and dizziness. There is some concern that ipriflavone can cause lymphocytopenia when used for at least 6 months.”

    Ipriflavone · Natural Medicines adverse-effect record, reported in diarrhea.

    3 sources cited
    1. 432. Agnusdei D, Bufalino L. Efficacy of ipriflavone in established osteoporosis and long-term safety. Calcif Tissue Int 1997;61,Suppl 1:S23-7. PubMed
    2. 104208. Hu Q, Long C, Wu D, et al. The efficacy and safety of ipriflavone in postmenopausal women with osteopenia or osteoporosis: A systematic review and meta-analysis. Pharmacol Res. 2020;159:104860. PubMed
    3. 1196. Alexandersen P, Toussaint A, Christiansen C, et al. Ipriflavone in the treatment of postmenopausal osteoporosis: A randomized controlled trial. JAMA 2001;285:1482-8.

    “Orally, ipriflavone can cause epigastric pain and diarrhea in some people.”

    Ipriflavone · Natural Medicines adverse-effect record, reported in diarrhea.

    2 sources cited
    1. 432. Agnusdei D, Bufalino L. Efficacy of ipriflavone in established osteoporosis and long-term safety. Calcif Tissue Int 1997;61,Suppl 1:S23-7. PubMed
    2. 104208. Hu Q, Long C, Wu D, et al. The efficacy and safety of ipriflavone in postmenopausal women with osteopenia or osteoporosis: A systematic review and meta-analysis. Pharmacol Res. 2020;159:104860. PubMed

    Barium Sulfate

    Listed in the ADVERSE REACTIONS section of the FDA label for Barium Sulfate, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Reported for Ipriflavone but not commonly for Barium Sulfate: dizziness.

Effects for Barium Sulfate come from the ADVERSE REACTIONS section of its FDA label; effects for Ipriflavone come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 434 voluntary FDA FAERS reports for Barium Sulfate that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Everything else you take

See Every Supplement That Interacts With Barium Sulfate

This page covers Ipriflavone only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Barium Sulfate page lists 17 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 7 moderate · 9 minor.

From our pharmacist’s overview on the Barium Sulfate page

“Barium sulfate (Readi-Cat, Varibar, E-Z-HD) is the chalky liquid you drink so a CT scan or X-ray can see your stomach and intestines, and the 17 supplement interactions on file here deserve genuine attention before scan day. Every ingredient listed acts where barium works, in the gut.”

Reviewed by 2 · Jul 18, 2026

Open the Barium Sulfate interaction page

One more smart check

Taking Ipriflavone as Part of a Dietary Supplement Product? Check It for Interactions

We hold 204 real supplement products containing Ipriflavone, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Ipriflavone. Even though Ipriflavone itself has no known interaction with Barium Sulfate, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Ipriflavone and Barium Sulfate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Ipriflavone
Top half

#470 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Barium Sulfate
Top half

#1,358 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Ipriflavone reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 27, 2026. The Ipriflavone and Barium Sulfate records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Ipriflavone

What is Ipriflavone?

Ipriflavone
  • Bone density and osteoporosis
  • Postmenopausal bone loss
  • Athletic performance
  • Tinnitus related to bone disorders

Ipriflavone is a synthetic isoflavone studied mainly for bone health and osteoporosis, but high-quality research has not shown that it reliably prevents fractures or builds strong bone. Because it can lower white blood cell counts in some people and its long-term safety is not well established, talk with your pharmacist or doctor before using it.

Synthetic compound (a semi-synthetic isoflavone derived from soy isoflavones) · Tablets, capsules

An interaction check asks whether these two react with each other — it does not ask whether Ipriflavone is a good idea for someone in your situation. Here is what our Ipriflavone record says about it on its own.

Ipriflavone: dosing

There is no officially established or universally agreed dietary supplement dose for ipriflavone. Doses used in research were studied for osteoporosis and are not a recommendation for general use.If you choose to use a product, follow the directions on the label and do not exceed them. People considering it for bone health should also discuss adequate calcium and vitamin D intake.

From our Ipriflavone monograph — the full record covers uses, side effects and every documented interaction.

Read the full Ipriflavone monograph & all interactions
Medication

About Barium Sulfate

What Is Barium Sulfate Used For?

Brand names: E-Z-HD, Readi-Cat 2, Readi-Cat 2 Smoothies, Varibar

Barium sulfate is used before imaging studies to help doctors see the inside of the digestive tract on X-rays and CT scans. Different branded products are approved for different procedures and patient groups.

Readi-Cat 2 and Readi-Cat 2 Smoothie flavors are used to outline the GI tract during CT scans of the abdomen. E-Z-Paque and Liquid E-Z-Paque are used for single-contrast X-ray studies of the esophagus, stomach, and small bowel. E-Z-HD is used for double-contrast X-ray studies of the esophagus, stomach, and duodenum in patients 12 and older. E-Z-Disk tablets help evaluate whether the esophagus is open (patent) in patients 12 and older. ENTERO Vu 24% is used for small bowel X-ray exams in adults. E-Z-Paste is used in single-contrast X-rays of the esophagus, pharynx, and related areas. Varibar Pudding, Varibar Honey, Varibar Nectar, Varibar Thin Honey, and Varibar Thin Liquid are used in modified barium swallow studies to assess how well a person swallows.

See full Barium Sulfate drug information
Keep checking

Other Drugs & Ipriflavone

Browse every other medication we’ve checked against Ipriflavone — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
391Moderate
0Minor
2,438No known interaction
391 Moderate 2,438 No interaction
Moderate

391 interactions

Showing 60 of 391 moderate interactions — see all 391 on the Ipriflavone page.

No interaction 2,438 drugs checked — show the list

We also checked Ipriflavone against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,438 medications checked with no known interaction — see the full Ipriflavone list.

See the full Ipriflavone interactions page
See every supplement checked against Barium Sulfate, ranked by severity
Evidence & sources

Ipriflavone References

The 6 references that drive our Ipriflavone monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Agnusdei D, Bufalino L. Efficacy of ipriflavone in established osteoporosis and long-term safety. Calcif Tissue Int 1997;61,Suppl 1:S23-7. PubMed
  2. Alexandersen P, Toussaint A, Christiansen C, et al. Ipriflavone in the treatment of postmenopausal osteoporosis: A randomized controlled trial. JAMA 2001;285:1482-8.
  3. Agnusdei D, Camporeale A, Gonnelli S, et al. Short-term treatment of Paget's disease of bone with ipriflavone. Bone Miner 1992;19 Suppl 1:S35-42. PubMed
  4. Monostory K, Vereczkey L, Levai F, et al. Ipriflavone as an inhibitor of human cytochrome P450 enzymes. Br J Pharmacol 1998;123:605-10. PubMed
  5. Takahashi J, Kawakatsu K, Wakayama T, Sawaoka H. Elevation of serum theophylline levels by ipriflavone in a patient with chronic obstructive pulmonary disease. Eur J Clin Pharmacol 1992;43:207-8. PubMed
  6. Hu Q, Long C, Wu D, et al. The efficacy and safety of ipriflavone in postmenopausal women with osteopenia or osteoporosis: A systematic review and meta-analysis. Pharmacol Res. 2020;159:104860. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Ipriflavone and Barium Sulfate Together: Common Questions

Is it safe to take Ipriflavone with Barium Sulfate?
We do not list a known interaction between Ipriflavone and Barium Sulfate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Ipriflavone and Barium Sulfate have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Ipriflavone and Barium Sulfate combination checked?
Interactions in our licensed database are recorded against drug classes. Barium Sulfate is filed under 1 classification, and Ipriflavone has documented interactions with 4 drug classes — none of Barium Sulfate's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Ipriflavone interact with any other medications?
Yes. Ipriflavone has 391 documented drug interactions in our database — Barium Sulfate is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Barium Sulfate interact with any supplements?
Yes. Barium Sulfate has documented interactions with 17 supplements in our database — Ipriflavone is not one of them. The Barium Sulfate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Ipriflavone monograph Uses, safety profile, and every drug interaction in one place Barium Sulfate drug information The full plain-English guide to this medication Barium Sulfate supplement interactions Every supplement checked against Barium Sulfate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 6 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Barium Sulfate and Ipriflavone?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.