Drug & supplement interaction

Java Tea + Brexpiprazole

Brexpiprazole brand name: Rexulti.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Java Tea and Brexpiprazole in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Java Tea and Brexpiprazole

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Brexpiprazole and Java Tea in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Java Tea safety at a glance

Java Tea overall Use caution Generally considered well tolerated short-term, but human safety data are limited.
Pregnancy Avoid Not enough safety data, so it is best avoided during pregnancy.
Breastfeeding Avoid Not enough safety data, so it is best avoided while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Brexpiprazole and Java Tea? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Brexpiprazole

Interactions in our licensed database are recorded against drug classes, not just single drug names. Brexpiprazole is filed under 8 classifications — including dopamine agonists, antipsychotic drugs, serotonergic drugs. Java Tea has documented interactions with 2 drug classes — the most serious being antihypertensive drugs (moderate) and lithium (moderate) — and none of Brexpiprazole’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Java Tea Does Interact With Other Medications

Java Tea has 173 moderate known drug interactions in our database — Brexpiprazole isn’t one of them. If you take anything else, check it against the full list below.

Moderate 173 No known interaction 2,657 (incl. Brexpiprazole)
Taking anything else?

Check Another of Your Medications Against Java Tea

Covers the 2,830 medications we’ve checked against Java Tea. Pick one to open its full report.

What to actually watch for

What Brexpiprazole’s Own FDA Label Lists

This is not an interaction — none of it involves Java Tea. These are the most notable effects listed in the ADVERSE REACTIONS section of Brexpiprazole’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • Thoughts of self-harm Worth acting on mentioned in 3.4% of FDA reports for Brexpiprazole
  • Mania or an unusually elevated mood Worth acting on
  • Severe muscle breakdown Worth acting on
  • Trouble swallowing Worth acting on
  • Hallucinations Worth acting on
  • Fainting Worth acting on
  • Seizures Worth acting on
  • Shortness of breath Worth acting on
  • A low white blood cell count Worth acting on
  • A higher chance of infection Worth acting on

Showing the 10 most notable of 32 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Brexpiprazole. Read the label on DailyMed › Where a percentage is shown, it is the share of 16,505 voluntary FDA FAERS reports for Brexpiprazole that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Java Tea’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Java Tea side to compare — that is a limit of the record, not a statement that Java Tea has no side effects.

Everything else you take

See Every Supplement That Interacts With Brexpiprazole

This page covers Java Tea only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Brexpiprazole page lists 177 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), Indian Snakeroot (major), Lithium (major) and Rauvolfia Vomitoria (major).

By severity: 6 major · 130 moderate · 41 minor.

From our pharmacist’s overview on the Brexpiprazole page

“Brexpiprazole (Rexulti) treats schizophrenia and is added to antidepressants for depression, and its supplement list warrants real care before you add anything to it. The bulk of the 177 entries change how your liver clears the drug, so grapefruit can push levels up while St.”

Reviewed by 2 · Jul 18, 2026

Open the Brexpiprazole interaction page

One more smart check

Taking Java Tea as Part of a Dietary Supplement Product? Check It for Interactions

We hold 64 real supplement products containing Java Tea, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Java Tea. Even though Java Tea itself has no known interaction with Brexpiprazole, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Java Tea and Brexpiprazole Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Java Tea
Top half

#614 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Brexpiprazole
Top half

#728 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Java Tea reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Java Tea and Brexpiprazole records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Java Tea

What is Java Tea?

  • Urinary tract health
  • Mild fluid retention
  • Kidney and bladder support
  • Mild diuretic ('water pill') effect
  • Digestive complaints

Java Tea is a Southeast Asian herb traditionally used as a gentle diuretic and for urinary tract and kidney support. Some early lab, animal, and small human studies are encouraging, but high-quality evidence in people is limited, so it should not replace proven treatments. Talk to a pharmacist or doctor before using it, especially if you have kidney problems or take other medicines.

Orthosiphon stamineus · Lamiaceae · Leaves and stems (aerial parts) · Tea, dried herb, capsules, liquid extracts, tinctures

An interaction check asks whether these two react with each other — it does not ask whether Java Tea is a good idea for someone in your situation. Here is what our Java Tea record says about it on its own.

Java Tea: dosing

There is no well-established standardized dose for Java Tea. The right amount can vary depending on the form (tea, capsule, or extract) and the strength of the product.The safest approach is to follow the directions on the product label and not exceed the recommended amount. Because Java Tea has a diuretic effect, it is also wise to stay well hydrated.

From our Java Tea monograph — the full record covers uses, side effects and every documented interaction.

Read the full Java Tea monograph & all interactions
Medication

About Brexpiprazole

What Is Brexpiprazole Used For?

Brand name: Rexulti

Brexpiprazole tablets are approved for two uses in adults: as an add-on (adjunctive) treatment alongside antidepressants for major depressive disorder (MDD), and as a treatment for schizophrenia. These uses apply to both the generic brexpiprazole tablets and Rexulti.

Rexulti has one additional approved use: treating agitation associated with dementia due to Alzheimer's disease in adults. Rexulti is also approved for schizophrenia in adolescents ages 13 and older. Note that Rexulti is not approved for dementia-related psychosis without agitation from Alzheimer's disease, and it is not meant to be used on an as-needed basis for Alzheimer's-related agitation.

Most-Reported Side Effects for Brexpiprazole

From FAERS, the FDA’s public side-effect reporting system (16,505 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Weight increased 1,702 reports
Akathisia 869 reports
Tremor 654 reports
Anxiety 612 reports
Tardive dyskinesia 599 reports
See full Brexpiprazole drug information
Keep checking

Other Drugs & Java Tea

Browse every other medication we’ve checked against Java Tea — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
173Moderate
0Minor
2,656No known interaction
173 Moderate 2,656 No interaction
Moderate

173 interactions

Showing 60 of 173 moderate interactions — see all 173 on the Java Tea page.

No interaction 2,656 drugs checked — show the list

We also checked Java Tea against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,656 medications checked with no known interaction — see the full Java Tea list.

See the full Java Tea interactions page
See every supplement checked against Brexpiprazole, ranked by severity
Evidence & sources

Java Tea References

The 2 references that drive our Java Tea monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Cicero AF, De Sando V, Izzo R, Vasta A, Trimarco A, Borghi C. Effect of a combined nutraceutical containing Orthosiphon stamineus effect on blood pressure and metabolic syndrome components in hypertensive dyslipidaemic patients: a randomized clinical tria
  2. Vahlensieck W, Lorenz H, Schumacher-Stimpfl A, Fischer R, Naber KG. Effect of a herbal therapy on clinical symptoms of acute lower uncomplicated urinary tract infections in women: Secondary analysis from a randomized controlled trial. Antibiotics (Basel). PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Java Tea and Brexpiprazole Together: Common Questions

Is it safe to take Java Tea with Brexpiprazole?
We do not list a known interaction between Java Tea and Brexpiprazole. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Java Tea and Brexpiprazole combination checked?
Interactions in our licensed database are recorded against drug classes. Brexpiprazole is filed under 8 classifications, and Java Tea has documented interactions with 2 drug classes — none of Brexpiprazole's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Java Tea interact with any other medications?
Yes. Java Tea has 173 documented drug interactions in our database — Brexpiprazole is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Brexpiprazole interact with any supplements?
Yes. Brexpiprazole has documented interactions with 177 supplements in our database — Java Tea is not one of them. The Brexpiprazole interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Java Tea monograph Uses, safety profile, and every drug interaction in one place Brexpiprazole drug information The full plain-English guide to this medication Brexpiprazole supplement interactions Every supplement checked against Brexpiprazole, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Brexpiprazole and Java Tea?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.